Prevalence of denosumab-induced hypocalcemia: a retrospective observational study of patients routinely monitored with ionized calcium post-injection
ConclusionsDenosumab-induced hypocalcemia is a prevalent adverse event, which occurs independently of the number of injections. However, severe hypocalcemia is a rare occurrence, and severe renal failure and nutritional status appear to be important predictive factors. Magnesium and phosphate might add value in the pre-injection risk assessment; however, this observation needs to be confirmed in larger cohorts. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research
Proposed diagnostic criteria for the diagnosis of hypophosphatasia in children and adolescents: results from the HPP International Working Group
AbstractHypophosphatasia (HPP) is a rare inborn error of metabolism that presents variably in both age of onset and severity. HPP is caused by pathogenic variants in the ALPL gene, resulting in low activity of tissue nonspecific alkaline phosphatase (TNSALP). Patients with HPP tend have a similar pattern of elevation of natural substrates that can be used to aid in diagnosis. No formal diagnostic guidelines currently exist for the diagnosis of this condition in children, adolescents, or adults. The International HPP Working Group is a comprised of a multidisciplinary team of experts from Europe and North America who have e...
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research
Establish and validate the reliability of predictive models in bone mineral density by deep learning as examination tool for women
ConclusionWhile FRAX with BMD could be more precise in estimating the fracture risk, DL-based models were validated to slightly reduce the number of under- and over-treated patients when no BMD measurements were available. The validated models could be used to screen for patients at a high risk of fracture and osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research
Development and usability of a decision aid to initiate anti-osteoporosis medication treatment in patients visiting the fracture liaison service with a recent fracture
ConclusionProfessionals and persons with osteoporosis were supportive of the proposed DA and its usability. The DA could help in a shared decision-making process between patients and HCPs. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research
Determining patient preferences for the medical management of osteoporosis using conjoint analysis
ConclusionsWhile about 60% of patients prioritized efficacy when selecting an osteoporosis therapy, the remaining 40% valued other factors more highly. Furthermore, individual patient characteristics and clinical factors did not reliably predict patient decision making, suggesting that development and implementation of shared decision-making tools is warranted. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2024 Category: Orthopaedics Source Type: research
Falsely elevated parathyroid hormone in a patient with osteoporosis: a case report and review
We report a case of falsely high PTH levels due to assay interference and review the literature on cases of spuriously elevated PTH.Case reportAn 87-year-old woman attending our bone health clinic with osteoporosis had persistently elevated PTH (383 –784 pg/ml) using the Roche Cobas e801 immunoassay despite having normal serum calcium, phosphate, 25 hydroxyvitamin D (> 50 nmol/l) and eGFR (> 60 ml/min). To rule out falsely elevated PTH, a polyethylene glycol precipitation (PEG) test was performed which recovered less than 10% of the hormone resulting in a normal level. PTH was also tested on a different a...
Source: Osteoporosis International - December 28, 2023 Category: Orthopaedics Source Type: research
Utility of MRI-based vertebral bone quality scores and CT-based Hounsfield unit values in vertebral bone mineral density assessment for patients with diffuse idiopathic skeletal hyperostosis
ConclusionDXA-based T-scores may overestimate BMD in DISH. VBQ scores and HU values could effectively complement BMD assessment, particularly in DISH patients or those with advanced lumbar degeneration. (Source: Osteoporosis International)
Source: Osteoporosis International - December 27, 2023 Category: Orthopaedics Source Type: research
Transient osteoporosis of the hip following discontinuation of denosumab and switch to alendronate treatment
(Source: Osteoporosis International)
Source: Osteoporosis International - December 26, 2023 Category: Orthopaedics Source Type: research
Effect of recreational cannabis use on bone mineral density: a systematic review
AbstractThe recreational use of cannabis products has risen considerably worldwide over the past decade. As the cannabis legal market grows, a critical challenge has been to make substantiated claims about the benefits and adverse health problems triggered by cannabis exposure. Despite accumulating evidence from animal studies demonstrating the role of cannabinoids on bone metabolism, there are conflicting results in clinical literature regarding their effects on bone health outcomes.We undertook a systematic review to assess the evidence for the safety of cannabis use on bone health. We searched the databases MEDLINE, EMB...
Source: Osteoporosis International - December 23, 2023 Category: Orthopaedics Source Type: research
Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma: from genetic and prospective evidence
ConclusionsBoth COA and AOA have a genetically causal effect on osteoporosis, and the risk of osteoporosis is greatly higher in AOA. Besides corticosteroids, the increased risk of osteoporosis among asthma patients should be attributed to genetic susceptibility and other asthma medications. (Source: Osteoporosis International)
Source: Osteoporosis International - December 23, 2023 Category: Orthopaedics Source Type: research
Effect of recreational cannabis use on bone mineral density: a systematic review
AbstractThe recreational use of cannabis products has risen considerably worldwide over the past decade. As the cannabis legal market grows, a critical challenge has been to make substantiated claims about the benefits and adverse health problems triggered by cannabis exposure. Despite accumulating evidence from animal studies demonstrating the role of cannabinoids on bone metabolism, there are conflicting results in clinical literature regarding their effects on bone health outcomes.We undertook a systematic review to assess the evidence for the safety of cannabis use on bone health. We searched the databases MEDLINE, EMB...
Source: Osteoporosis International - December 23, 2023 Category: Orthopaedics Source Type: research
Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma: from genetic and prospective evidence
ConclusionsBoth COA and AOA have a genetically causal effect on osteoporosis, and the risk of osteoporosis is greatly higher in AOA. Besides corticosteroids, the increased risk of osteoporosis among asthma patients should be attributed to genetic susceptibility and other asthma medications. (Source: Osteoporosis International)
Source: Osteoporosis International - December 23, 2023 Category: Orthopaedics Source Type: research
