Contribution of bone turnover markers to the variation in bone mineral density: a study in Vietnamese men and women
ConclusionThe elevation in bone formation marker PINP and bone resorption marker beta-CTX in postmenopausal women was greater than in elderly men. However, only beta-CTX was modestly but significantly associated with BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - September 8, 2018 Category: Orthopaedics Source Type: research

Notch in skeletal physiology and disease
In conclusion, Notch signaling is a novel pathway that regulates skeletal homeostasis in health and disease. (Source: Osteoporosis International)
Source: Osteoporosis International - September 7, 2018 Category: Orthopaedics Source Type: research

Impact of mild and moderate/severe vertebral fractures on physical activity: a prospective study of older women in the UK
ConclusionThis is the first study of older women from the UK that explored the prospective association between vertebral fracture and physical activity duration. Moderate/severe fractures were associated with reduced walking duration. Mild fractures had no impact on future physical ability. (Source: Osteoporosis International)
Source: Osteoporosis International - September 7, 2018 Category: Orthopaedics Source Type: research

Incorporating the patient perspective in the study of rare bone disease: insights from the osteogenesis imperfecta community
ConclusionsThis work will help guide the incorporation of PROs into the next phase of the BBDC Natural History Study of OI and underscores the importance of including PROs in the study of rare diseases. (Source: Osteoporosis International)
Source: Osteoporosis International - September 6, 2018 Category: Orthopaedics Source Type: research

Impaired residual renal function predicts denosumab-induced serum calcium decrement as well as increment of bone mineral density in non-severe renal insufficiency
This study assessed the risk factors for reduced cCa concentration following denosumab administration and anal yzed factors predictive of changes in bone mineral density (BMD).MethodsSeventy-seven osteoporotic patients, not including those with CKD stages 4 –5D, were treated with 60 mg denosumab once every 6 months. Biochemical parameters and BMD were analyzed from prior to the initial dose until 1 month after the second dose.ResultsFollowing the first administration of denosumab, cCa levels decreased, reaching a minimum on day 7. Multiple linear regression analyses showed that baseline cCa, estimated ...
Source: Osteoporosis International - September 5, 2018 Category: Orthopaedics Source Type: research

Radiofrequency echographic multispectrometry compared with dual X-ray absorptiometry for osteoporosis diagnosis on lumbar spine and femoral neck
ConclusionsThe REMS approach can be used for non-ionizing osteoporosis diagnosis directly on lumbar spine and femoral neck with a good level of accuracy and precision. However, a more rigorous operator training is needed to limit the erroneous acquisitions and to ensure the full clinical practicability. (Source: Osteoporosis International)
Source: Osteoporosis International - September 4, 2018 Category: Orthopaedics Source Type: research

Bone management in hematologic stem cell transplant recipients
AbstractAutologous and allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for patients with some malignant and non-malignant hematological diseases. Advances in transplantation techniques and supportive care measures have substantially increased the number of long-term HSCT survivors. This has led to an increasing patient population suffering from the late effects of HSCT, of which, bone loss and its consequent fragility fractures lead to substantial morbidity. Altered bone health, with consequent fragility fractures, and chronic graft-versus-host disease (GVHD) are factors affecting long-...
Source: Osteoporosis International - September 3, 2018 Category: Orthopaedics Source Type: research

Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands
ConclusionThis study provides evidence that antidepressants should be used with caution following a major osteoporotic fracture. It provides needed insights that can be used to inform clinicians when assessing subsequent fracture risk in patients. (Source: Osteoporosis International)
Source: Osteoporosis International - August 15, 2018 Category: Orthopaedics Source Type: research

The effects of teriparatide on acceleration of bone healing following atypical femoral fracture: comparison between daily and weekly administration
AbstractSummaryWe compared the effectiveness of promoting bone healing between two teriparatide preparations for atypical femoral fracture (AFF). A total of 45 AFFs were included in this study, and we compared the duration of bone union. Teriparatide administered by daily injection enhanced bone union more than weekly administration in complete AFFs.IntroductionThe efficacy of teriparatide for atypical femoral fracture (AFF) has been recently reported. Although two different teriparatide preparations can be used to treat osteoporosis in Japan, daily or weekly injection, all previous reports on the effectiveness of teripara...
Source: Osteoporosis International - August 13, 2018 Category: Orthopaedics Source Type: research

Osteoporosis and osteopenia in the distal forearm predict all-cause mortality independent of grip strength: 22-year follow-up in the population-based Troms ø Study
ConclusionMen and women with low distal forearm BMD values, consistent with osteoporosis or osteopenia, had an increased mortality compared to normal BMD participants. High grip strength did not modify this association, and the association remained after adjustment for a range of health-related factors. (Source: Osteoporosis International)
Source: Osteoporosis International - August 9, 2018 Category: Orthopaedics Source Type: research

Short-term association between outdoor air pollution and osteoporotic hip fracture
This study examines the association of the levels of different airborne pollutants on the incidence of osteoporotic hip fracture in a southern European region. Association was detected between SO2 and NO2 and hospital admissions due to hip fracture.IntroductionTo examine the short-term effects of outdoor air pollution on the incidence of osteoporotic hip fracture in a southern European region.MethodsThis is an ecological retrospective cohort study based on data obtained from three databases. In a time-series analysis, we examined the association between hip fracture incidence and different outdoor air pollutants (sulfur di...
Source: Osteoporosis International - August 9, 2018 Category: Orthopaedics Source Type: research

Decreasing trend of bone mineral density in US multiethnic population: analysis of continuous NHANES 2005 –2014
ConclusionsAge-adjusted mean BMD decreased in 2013 –2014 in both men and women, and this significant decrease was also observed in sensitivity and subgroup analyses. The decreased BMD in 2013–2014 still remained significant even after being adjusted for multiple potentially confounding effects. (Source: Osteoporosis International)
Source: Osteoporosis International - August 8, 2018 Category: Orthopaedics Source Type: research

Build better bones with exercise (B3E pilot trial): results of a feasibility study of a multicenter randomized controlled trial of 12  months of home exercise in older women with vertebral fracture
ConclusionAn RCT of home exercise in women with vertebral fractures is feasible but  recruitment was a challenge. Suggestions are made for the conduct of future trials. (Source: Osteoporosis International)
Source: Osteoporosis International - August 8, 2018 Category: Orthopaedics Source Type: research

Glucagon-like peptide-1 receptor agonists and fracture risk: a network meta-analysis of randomized clinical trials
ConclusionThe Bayesian network meta-analysis suggests that GLP-1 RAs were associated with a decreased bone fracture risk compared to users of placebo or other anti-hyperglycemic drugs in type 2 diabetes mellitus patients, and exenatide is the best option agent with regard to the risk of fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - August 6, 2018 Category: Orthopaedics Source Type: research

Oral bisphosphonate prescription and non-adherence at 12 months in patients with hip fractures treated in an acute geriatric unit
ConclusionsAt 12  months, there was low adherence to treatment with oral bisphosphonates in our model. A lower BI prior to treatment is a predictive factor for non-adherence treatment with oral bisphosphonate. (Source: Osteoporosis International)
Source: Osteoporosis International - August 3, 2018 Category: Orthopaedics Source Type: research

Sleep duration and the risk of osteoporosis among middle-aged and elderly adults: a dose-response meta-analysis
AbstractIt remains unclear how many hours of sleep are associated with the lowest risk of osteoporosis. This meta-analysis was performed to assess the dose-response relationship between sleep duration and risk of osteoporosis. PubMed and Web of Science were searched from inception to December 3, 2017, supplemented by manual searches of the bibliographies of retrieved articles. Data were pooled using fixed- and random-effects models. Restricted cubic spline analysis with four knots was used to model the sleep duration and osteoporosis association. Four cross-sectional studies with eight records were eligible for inclusion i...
Source: Osteoporosis International - August 1, 2018 Category: Orthopaedics Source Type: research

Diagnosis and management of bone fragility in diabetes: an emerging challenge
AbstractFragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabete...
Source: Osteoporosis International - July 31, 2018 Category: Orthopaedics Source Type: research

Antihistamine use and the risk of injurious falls or fracture in elderly patients: a systematic review and meta-analysis
ConclusionsFirst-generation antihistamine use is considerably associated with increased risk of injurious falls or fracture among the elderly. Clinicians need to exercise caution when prescribing first-generation antihistamines to elderly patients. (Source: Osteoporosis International)
Source: Osteoporosis International - July 25, 2018 Category: Orthopaedics Source Type: research

Bone mineral density and vertebral fractures and their relationship with pulmonary dysfunction in patients with chronic obstructive pulmonary disease
AbstractSummaryTo evaluate bone mineral density (BMD) and morphometric vertebral fractures (MVF) in chronic obstructive pulmonary disease (COPD) patients in comparison with two control groups. BMD was lower in the disease group (DG) and was associated with the worst disease severity and prognosis. The prevalence of MVF was high and greater in the DG than in the control groups.IntroductionChronic obstructive pulmonary disease (COPD) is associated with osteoporosis and vertebral fractures. It is still unclear whether the presence of fractures and changes in bone mineral density (BMD) are associated with disease severity and ...
Source: Osteoporosis International - July 25, 2018 Category: Orthopaedics Source Type: research

Sex hormone-binding globulin and risk of fracture in older adults: systematic review and meta-analysis of observational studies
ConclusionsThe present meta-analysis suggests that higher SHBG levels predict an increased risk of fracture in older adults. Further studies should aim to elucidate the complex biological mechanisms by which SHBG may affect fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - July 24, 2018 Category: Orthopaedics Source Type: research

Incidence, risk factors, and fracture healing of atypical femoral fractures: a multicenter case-control study
AbstractSummaryThe incidence of atypical femoral fractures (AFFs) was 2.95% among 6644 hip and femoral fractures. Independent risk factors included the use of bisphosphonates (BPs), osteopenia or osteoporosis, rheumatoid arthritis, increased femoral curvatures, and thicker femoral cortices. Patients with AFFs and BP treatment were more likely to have problematic healing than those with typical femoral fractures (TFFs) and no BP treatment.IntroductionTo determine the incidence and risk factors of atypical femoral fractures (AFFs), we performed a multicenter case-control study. We also investigated the effects of bisphosphon...
Source: Osteoporosis International - July 23, 2018 Category: Orthopaedics Source Type: research

The tamoxifen paradox —influence of adjuvant tamoxifen on fracture risk in pre- and postmenopausal women with breast cancer
AbstractSummaryOur data demonstrate that tamoxifen does not reduce fracture risk. Close surveillance is necessary to prevent bone loss in premenopausal women with breast cancer upon treatment initiation.IntroductionEndocrine treatment of breast cancer may interfere with bone turnover and influence fracture risk.MethodsOut of a cohort of almost 5 million patients in total, we identified 5520 women between 18 and 90  years of age with breast cancer receiving tamoxifen, matched them with 5520 healthy controls using the Disease Analyzer Database, and investigated the fracture risk.ResultsWe found a cumulative incidence of...
Source: Osteoporosis International - July 21, 2018 Category: Orthopaedics Source Type: research

A modification and validation of quantitative morphometry classification system for osteoporotic vertebral compressive fractures in mainland Chinese
ConclusionsOur mQM system is suitable for classification of fractures, detection of vertebral height restoration, and correlation of cement leakage after PKP in Mainland Chinese population. (Source: Osteoporosis International)
Source: Osteoporosis International - July 20, 2018 Category: Orthopaedics Source Type: research

Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50  years or older
ConclusionPatients suffering a fracture have a high incidence of a subsequent fracture. Our findings demonstrate the importance of fracture prevention in patients with a history of a fracture by adequate medical diagnosis and treatment. (Source: Osteoporosis International)
Source: Osteoporosis International - July 20, 2018 Category: Orthopaedics Source Type: research

Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus
ConclusionsThis is the first study to show that in addition to BMD measurement, the assessment using serum IGF-I is useful to estimate the prevalence of VF in patients with T2DM. (Source: Osteoporosis International)
Source: Osteoporosis International - July 20, 2018 Category: Orthopaedics Source Type: research

The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial
AbstractSummarySome antihyperglycemic medications have been found to affect bone metabolism. We assessed the long-term effects of metformin compared with placebo on bone mineral density (BMD) and trabecular bone score (TBS) in patients with type 2 diabetes. Metformin had no significant effect on BMD in the spine and hip or TBS compared with a placebo.IntroductionPatients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures despite a high bone mass. Some antihyperglycemic medications have been found to affect bone metabolism. We assessed the long-term effects of metformin compared with placebo on bone mi...
Source: Osteoporosis International - July 19, 2018 Category: Orthopaedics Source Type: research

Medication persistence and risk of fracture among female Medicare beneficiaries diagnosed with osteoporosis
This study aimed to examine the relationship between medication persistence and fracture risk among female Medicare beneficiaries diagnosed with osteoporosis.MethodsElderly female Medicare beneficiaries diagnosed with osteoporosis and initiated on osteoporosis medication January 1, 2009 –June 30, 2011, were included. Persistent medication use was defined as continuous use (no gap ≥ 60 days) for 1 year or longer. The key outcome was fragility fracture. A difference-in-difference analysis was performed at the log scale of fracture rate using a Poisson regression model with mo nths 1–6 before m...
Source: Osteoporosis International - July 18, 2018 Category: Orthopaedics Source Type: research

VIT amin D and OmegA-3 TriaL (VITAL) bone health ancillary study: clinical factors associated with trabecular bone score in women and men
AbstractSummaryWe investigated the association of clinical variables with TBS at baseline in the bone health sub-cohort of the VITamin D and OmegA-3 TriaL (VITAL). Lower TBS was associated with female sex, aging, BMI  ≥ 25 kg/m2, SSRI use, high alcohol intake, and presence of diabetes; there was a trend towards significance between lower TBS and history of fragility fractures.IntroductionWe investigated whether TBS differs by sex, race, body mass index (BMI), and other clinical variables.MethodsThe VITamin D and OmegA-3 TriaL (VITAL) is determining effects of vitamin D3 and/or omega-3 fatty acid (FA) ...
Source: Osteoporosis International - July 18, 2018 Category: Orthopaedics Source Type: research

LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis patients
ConclusionSignificant associations between LRP5 SNPs (p.A1330V, p.N740N, and p.V667M) and the severity of radiographic damage reinforce the evidence of bone destruction heritability in RA. (Source: Osteoporosis International)
Source: Osteoporosis International - July 17, 2018 Category: Orthopaedics Source Type: research

Nonlinear association between bone mineral density and all-cause mortality: the Dong-gu study
AbstractSummaryThere was a U-shaped association between hip BMD and all-cause mortality, with the lowest mortality in the 90th percentile in males. However, there was an inverse linear relationship in females. In contrast, the association between lumbar spine BMD and mortality was less evident in males, with no association in females.IntroductionBone mineral density (BMD) is reported inversely associated with mortality. Although some previous studies provided evidence for nonlinear associations, these were not adequately assessed in most previous works.MethodsWe evaluated the nonlinear relationship between BMD and mortalit...
Source: Osteoporosis International - July 16, 2018 Category: Orthopaedics Source Type: research

Bisphosphonate use after clinical fracture and risk of new fracture: response to comments by Wu et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - July 16, 2018 Category: Orthopaedics Source Type: research

Role of musculoskeletal disorders in falls of postmenopausal women
AbstractSummaryWe aimed to investigate the role of musculoskeletal disorders (MSDs) as risk factors for falls among postmenopausal women. Our results indicate that MSDs are common and are associated with increased falling risk, especially nonslip falls. Excess number of falls due to MSDs is greater than that due to any other disease class.PurposeFalls are a major public health problem worldwide. The aim of the study was to investigate the role of MSDs as risk factors for falls among postmenopausal women.MethodsThis cohort study utilized data from a population-based, prospective cohort study (OSTPRE). The study population c...
Source: Osteoporosis International - July 16, 2018 Category: Orthopaedics Source Type: research

Phosphate wasting disorders in adults
AbstractA cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the F...
Source: Osteoporosis International - July 16, 2018 Category: Orthopaedics Source Type: research

Does primary lactase deficiency reduce bone mineral density in postmenopausal women? A systematic review and meta-analysis
ConclusionsPostmenopausal women with PLD had lower Z-scores at most anatomic sites compared to healthy controls. (Source: Osteoporosis International)
Source: Osteoporosis International - July 16, 2018 Category: Orthopaedics Source Type: research

Monocytes from male patients with ankylosing spondylitis display decreased osteoclastogenesis and decreased RANKL/OPG ratio
ConclusionMonocytes from male AS patients display a lower capacity to generate osteoclasts in vitro compared to cells from controls. Osteoclastogenesis was negatively correlated with disease duration. This finding supports the idea that osteoclasts play a role in the physiopathology of bone disease in AS patients. (Source: Osteoporosis International)
Source: Osteoporosis International - July 13, 2018 Category: Orthopaedics Source Type: research

The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study
AbstractSummaryThe association between alcohol consumption and hip fracture differed by gender: Men aged 30 –59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was seen in older men. Women not drinking alcohol had higher risk than those drinking moderately both regarding frequency and amount.IntroductionWe aimed to examine alcohol consumption and risk of hip fracture according to age and gender in the population-based Cohort of Norway (1994 –2003).MethodsSocio-demographics, lifestyle, and health were self-reported and weight and height were measur...
Source: Osteoporosis International - July 13, 2018 Category: Orthopaedics Source Type: research

Breech presentation is associated with lower bone mass and area: findings from the Southampton Women ’s Survey
ConclusionsThese results suggest that breech presentation is associated with lower neonatal whole-body BMC and BA, which may relate to altered prenatal loading in babies occupying a breech position; these differences did not persist into later childhood. Modest differences in 4-year hip BMC and BA require further investigation. (Source: Osteoporosis International)
Source: Osteoporosis International - July 12, 2018 Category: Orthopaedics Source Type: research

Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures
ConclusionsSystemic bone loss following fracture may increase the risk of future fractures at all skeletal sites. There is a need for improved understanding of mechanisms leading to apparent accelerated bone loss following a fracture in order to reduce subsequent fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - July 10, 2018 Category: Orthopaedics Source Type: research

Understanding osteoporotic pain and its pharmacological treatment: supplementary presentation
AbstractOsteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic fractures can cause acute and chronic nociceptive and neuropathic pain that mainly affects elderly patients with multiple comorbidities and commonly on different drug regimens. Central sensitization seems to play a pivotal role in developing and maintaining chronicity of post-fracture pain in osteoporosis. Antiosteoporosis drugs are able to partially control pain, but additional analgesics are always necessary for pain...
Source: Osteoporosis International - July 10, 2018 Category: Orthopaedics Source Type: research

Correction to: Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone
This article was originally published under a CC BY-NC-ND 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. (Source: Osteoporosis International)
Source: Osteoporosis International - July 9, 2018 Category: Orthopaedics Source Type: research

Genome-wide identification of m 6 A-associated SNPs as potential functional variants for bone mineral density
This study investigated the effect of the N6-methyladenosine (m6A)-associated SNPs on bone mineral density (BMD) and found plenty of m6A-SNPs that were associated with BMD. This study increases our understanding on the regulation patterns of SNP and may provide new clues for further detection of functional mechanism underlying the associations between SNPs and osteoporosis.Introductionm6A plays critical roles in many fundamental biological processes and a variety of diseases. The m6A-associated SNPs may be potential functional variants for BMD. The aim of this study was to investigate the effect of the genome-wide m6A-SNPs...
Source: Osteoporosis International - July 7, 2018 Category: Orthopaedics Source Type: research

Genetic variation in Wnt/ β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study
AbstractSummaryThe association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/ β-catenin and ER pathways.IntroductionSome athletes (e.g. gymnasts, dancers, swimmers) are at increased risk for low bone mineral density (BMD) which, if untreated, can lead to osteoporosis. To investigate the association of genetic polymorphisms in the oestrogen receptor (ER) and the Wnt/ β-catenin signalling pathways with low BMD in elite and pre-eli...
Source: Osteoporosis International - July 5, 2018 Category: Orthopaedics Source Type: research

Maximal strength training improves musculoskeletal health in amphetamine users in clinical treatment
This study investigated if MST-induced improvements in force generating capacity improved bone mineral density (BMD), trabecular bone score, and body composition in amphetamine users participating in 3-months clinical treatment.MethodsOf 40 randomized patients, 23 completed the study: 11 in the supervised training group (TG; 8 men, 3 women, 34  ± 10 years) and 12 in the control group (CG; 9 men, 3 women, 32 ± 8 years). The TG performed hack-squat MST three times a week for 12 weeks with an intensity of ~90% of one repetition maximum (1RM). Both groups attended conven...
Source: Osteoporosis International - July 5, 2018 Category: Orthopaedics Source Type: research

The Forteo Patient Registry linkage to multiple state cancer registries: study design and results from the first 8  years
ConclusionsBased on the estimated 242,782 person-years of observation as of the eighth annual linkage and projecting current enrollment rate to study end in 2024, it is anticipated that the completed study will be able to detect a fourfold increase in the risk of osteosarcoma if one exists. (Source: Osteoporosis International)
Source: Osteoporosis International - July 5, 2018 Category: Orthopaedics Source Type: research

Comments on Bergman et al.: Bisphosphonate use after clinical fracture and risk of new fracture
(Source: Osteoporosis International)
Source: Osteoporosis International - July 5, 2018 Category: Orthopaedics Source Type: research

Effects of osteoporosis drug treatments on cortical and trabecular bone in the femur using DXA-based 3D modeling
ConclusionResults obtained in this head-to-head study are consistent with those obtained using computed tomography in the literature. DXA-based modeling techniques could complement standard DXA examination to monitor treatment effects on trabecular and cortical compartments. (Source: Osteoporosis International)
Source: Osteoporosis International - July 4, 2018 Category: Orthopaedics Source Type: research

The association of cortisol and adrenal androgen with trabecular bone score in patients with adrenal incidentaloma with and without autonomous cortisol secretion
AbstractSummaryDespite ethnic differences in cortisol sensitivity, only one study in Caucasians has assessed trabecular bone score (TBS) in patients with subclinical hypercortisolism (SH). We showed that both subtle cortisol excess and reduced adrenal androgen may contribute to impaired bone quality in Asian women with SH.IntroductionOne study in Caucasians has assessed trabecular bone score (TBS), an index of bone microstructure, in adrenal incidentaloma (AI) patients with subclinical hypercortisolism (SH). There are ethnic differences in cortisol sensitivities between Caucasian and Asian populations. We investigated the ...
Source: Osteoporosis International - July 3, 2018 Category: Orthopaedics Source Type: research

Correction to: The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation
This article was originally published under a CC BY-NC-ND 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. (Source: Osteoporosis International)
Source: Osteoporosis International - July 3, 2018 Category: Orthopaedics Source Type: research

Reappearance of hypomineralized bone after discontinuation of asfotase alfa treatment for severe childhood hypophosphatasia
(Source: Osteoporosis International)
Source: Osteoporosis International - July 2, 2018 Category: Orthopaedics Source Type: research

Long-term oral bisphosphonates delay healing after tooth extraction: a single institutional prospective study
This study aimed to evaluate the clinical safety of continuing oral bisphosphonate therapy in patients undergoing tooth extraction.MethodsWe prospectively enrolled 132 patients (20 men, 112 women) who were receiving oral bisphosphonates for the prevention or treatment of osteoporosis and required tooth extraction. All patients were managed using an identical protocol, which included preoperative antibiotic prophylaxis and did not necessarily require complete wound closure. The patients were classified into groups according to the duration of bisphosphonate administration:  10 years (n = 12). The g...
Source: Osteoporosis International - July 2, 2018 Category: Orthopaedics Source Type: research