World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): ESCEO-WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Ageing Symposium Abstracts (ESCEO-WHO CC)
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): EUGMS-ESCEO-IOF Symposium Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): ESCEO-IOF-SFR-GRIO Symposium Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): Special Lectures Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): ESCEO-IOF-WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging Symposium Abstracts (ESCEO-IOF-WHO CC)
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): ESCEO-IOF USA Symposium Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

World congress on osteoporosis, osteoarthritis and musculoskeletal diseases
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): Posters Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

Correction to: The factor-of-risk biomechanical approach predicts hip fracture in men and women: the Framingham Study
The original version of this article, published 23 February 2011, unfortunately contained a mistake. The following correction has therefore been made in the original: (Source: Osteoporosis International)
Source: Osteoporosis International - July 1, 2019 Category: Orthopaedics Source Type: research

Use of anti-osteoporosis medication dispensing by patients with hip fracture: could we do better?
ConclusionsLess than one-third of hip fracture patients had dispensing of anti-osteoporosis medication up to 1  year after hip fracture. We observed only a slight increase in dispensing after hip fracture over the study period, irrespective of patient sex, age, and comorbidity at the time of hip fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - June 29, 2019 Category: Orthopaedics Source Type: research

Assessing risk factors of non-fatal outcomes amid a competing risk of mortality: the example of hip fracture
ConclusionsCause-specific Cox models provide appropriate estimates of hazard for non-fatal outcomes like hip fracture even in the presence of competing risk of mortality. The Cox approach estimates hazard in the population of individuals who have not yet had an incident hip fracture and remain alive, which is typically the group of clinical interest. The Fine-Gray method estimates hazard in a hypothetical population that can yield misleading inferences about risk factors in populations of clinical interest. (Source: Osteoporosis International)
Source: Osteoporosis International - June 29, 2019 Category: Orthopaedics Source Type: research

A multicenter, randomized, rater-blinded, parallel-group, phase 3 study to compare the efficacy, safety, and immunogenicity of biosimilar RGB-10 and reference once-daily teriparatide in patients with osteoporosis
ConclusionsThe therapeutic equivalence of RGB-10 to reference teriparatide was demonstrated. RGB-10 had comparable safety profile to that of reference teriparatide. (Source: Osteoporosis International)
Source: Osteoporosis International - June 26, 2019 Category: Orthopaedics Source Type: research

Thoracic kyphosis assessment in postmenopausal women: an examination of the Flexicurve method in comparison to radiological methods
This study shows that Flexicurve can estimate radiographic vertebral centroid angles with less error than Cobb angles but that its accuracy would be inadequate for most clinical purposes.IntroductionThe Flexicurve ruler provides a non-radiological method of measuring thoracic kyphosis (TK) that has moderately strong correlations with the gold-standard radiographic Cobb angle method, while consistently underestimating the TK angle. Cobb angles can include measurement errors that may contribute to poor agreement, particularly in older populations. The vertebral centroid angle could be a better radiographic reference method f...
Source: Osteoporosis International - June 22, 2019 Category: Orthopaedics Source Type: research

Biochemical markers of bone turnover and risk of incident hip fracture in older women: the Cardiovascular Health Study
ConclusionCTX, but not OC, levels were associated with incident hip fracture in post-menopausal women, a relationship characterized by an inverted U-shape. These findings highlight the complex relationship of bone turnover markers with hip fracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - June 21, 2019 Category: Orthopaedics Source Type: research

Decreased physical health-related quality of life —a persisting state for older women with clinical vertebral fracture
AbstractSummaryIn a population-based study of older Swedish women, we investigated if clinical vertebral fracture was associated with lower health-related quality of life (HRQoL) and determined whether the association remained over time. Clinical vertebral fracture was associated with lower HRQoL and the effect persisted for up to 18.9  years.IntroductionVertebral fractures are often associated with back pain and reduced physical function, which might result in isolation and depression. As a result, women with vertebral fractures often have lower health-related quality of life (HRQoL), but during what time frame the d...
Source: Osteoporosis International - June 21, 2019 Category: Orthopaedics Source Type: research

Professor Howard A. Morris
(Source: Osteoporosis International)
Source: Osteoporosis International - June 21, 2019 Category: Orthopaedics Source Type: research

Heart failure and fracture risk: a meta-analysis
AbstractThis meta-analysis was conducted to investigate whether heart failure is associated with an increased risk of fractures by summarizing all the available evidence. The PubMed, EMBASE, and Cochrane Library databases were searched for all relevant studies published from the date of database inception to April 2018. Studies that investigated the association between heart failure and fracture risk and conducted a comparison with controls were included. Seven cohort studies were finally identified as eligible for inclusion in the meta-analysis. All included studies were of high quality as evaluated by the Newcastle-Ottaw...
Source: Osteoporosis International - June 19, 2019 Category: Orthopaedics Source Type: research

Correction to: Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/ β-catenin signaling pathway in OVX rats
There was a mistake in the part ofOVX rats model and RRP intervention in the original publication. (Source: Osteoporosis International)
Source: Osteoporosis International - June 18, 2019 Category: Orthopaedics Source Type: research

Association between trabecular bone score and type 2 diabetes: a quantitative update of evidence
ConclusionPatients with type 2 diabetes have a lower TBS than non-diabetic individuals, suggesting that TBS can be a useful measurement for the assessment of fracture risk in diabetic patients. (Source: Osteoporosis International)
Source: Osteoporosis International - June 18, 2019 Category: Orthopaedics Source Type: research

Saving bones without risking brain —bisphosphonates and risk of stroke: matched case-control study
ConclusionsWe found no association between bisphosphonate treatment and risk of stroke, after adjusting for other confounders. (Source: Osteoporosis International)
Source: Osteoporosis International - June 17, 2019 Category: Orthopaedics Source Type: research

The renin-angiotensin aldosterone system and osteoporosis: findings from the Women ’s Health Initiative
ConclusionsIn postmenopausal women, use of RAAS inhibitors, including ACE inhibitors and ARBs, is associated with an increased risk for fracture among new users of these medications in the first 3  years of use. However, long-term use (>  3 years) is associated with a reduced risk. Consideration for fracture risk may be part of the decision-making process for initiation of these medications for other disease states. (Source: Osteoporosis International)
Source: Osteoporosis International - June 17, 2019 Category: Orthopaedics Source Type: research

A comprehensive assessment of risk factors for falls in middle-aged adults: co-ordinated analyses of cohort studies in four countries
ConclusionRisk factors known to be associated with falls in older adults were also associated with falls in middle age. Compared with findings from previous studies of older adults, there is a suggestion that specific risk factors, for example musculoskeletal conditions, may be more important in middle age. These findings suggest that available preventive interventions for falls in older adults may also benefit middle-aged adults, but tailoring by age, sex and country is required. (Source: Osteoporosis International)
Source: Osteoporosis International - June 15, 2019 Category: Orthopaedics Source Type: research

Long-term denosumab treatment restores cortical bone loss and reduces fracture risk at the forearm and humerus: analyses from the FREEDOM Extension cross-over group
AbstractSummaryUpper limb fractures (including wrist, forearm, and humerus) represent a significant burden among postmenopausal women with osteoporosis. Up to 7  years of treatment with denosumab resulted in an increase in bone mineral density and decrease in fractures in upper limb sites.IntroductionUpper limb (wrist, forearm, and humerus) fractures are a significant burden in osteoporosis, associated with significant morbidity and mortality. Denosumab, a monoclonal antibody against RANK ligand, increases bone mineral density (BMD) and decreases vertebral, nonvertebral, and hip fractures. Here, we evaluated the long-...
Source: Osteoporosis International - June 14, 2019 Category: Orthopaedics Source Type: research

Bone mass density and bone metabolism marker are associated with progression of carotid and cardiac calcified plaque in Chinese elderly population
ConclusionThis study suggested that lower BMD and change of bone metabolism biomarker were associated with a higher risk of carotid and cardiac calcified plaque development. (Source: Osteoporosis International)
Source: Osteoporosis International - June 10, 2019 Category: Orthopaedics Source Type: research

Correlation between hip osteoarthritis and proximal femoral fracture site: could it be protective for intracapsular neck fractures? A retrospective study on 320 cases
AbstractSummaryProximal femoral fractures affect elderly people, showing high morbidity and mortality incidence resulting in a major economic burden on national healthcare systems. Understanding the causes of these injuries is of paramount importance to prevent the serious consequences of these fractures.IntroductionHip osteoarthritis and proximal femoral fractures mainly affect elderly patients. Several authors, in their studies, tried to document a correlation between these conditions, but the results are conflicting. The aim of this study was to evaluate the relationship between hip osteoarthritis and the fracture site....
Source: Osteoporosis International - June 8, 2019 Category: Orthopaedics Source Type: research

Fracture risk following intermission of osteoporosis therapy
ConclusionsThe view that patients on long-term treatment with bisphosphonates or denosumab should always be offered a drug holiday is not supported by the existing evidence. Different pharmacokinetic properties for different therapies require different strategies to manage drug intermission. In contrast, long-term treatment with anti-resorptives is not associated with increased risk of fragility fractures and skeletal adverse events remain rare. (Source: Osteoporosis International)
Source: Osteoporosis International - June 7, 2019 Category: Orthopaedics Source Type: research

Secondary prevention of osteoporotic fractures: evaluation of the Lille University Hospital ’s Fracture Liaison Service between January 2016 and January 2018
ConclusionsSecondary prevention of osteoporotic fractures has improved since the implementation of the FLS. However, patient identification, patient evaluation, and post-fracture assessment timing still need to be improved. (Source: Osteoporosis International)
Source: Osteoporosis International - June 5, 2019 Category: Orthopaedics Source Type: research

Vertebral bone attenuation in Hounsfield Units and prevalent vertebral fractures are associated with the short-term risk of vertebral fractures in current and ex-smokers with and without COPD: a 3-year chest CT follow-up study
ConclusionsOn CT scans performed for pulmonary evaluation in (former) smokers with and without COPD, the combination of BA and prevalent VFs was strongly associated with the short-term risk of incident VFs. (Source: Osteoporosis International)
Source: Osteoporosis International - June 3, 2019 Category: Orthopaedics Source Type: research

Five-year refracture rates of a province-wide fracture liaison service
ConclusionsOne in ten patients in our cohort refractured within 5  years after baseline. Presenting with multiple fractures was an indicator of a higher refracture risk, while presenting with an ankle fracture was associated with a lower refracture risk. A more targeted FLS approach may be appropriate for patients at a higher refracture risk. (Source: Osteoporosis International)
Source: Osteoporosis International - May 31, 2019 Category: Orthopaedics Source Type: research

Diffuse, fracturing systemic skeletal histiocytosis of unknown type: a novel metabolic bone disease
AbstractWe  describe a novel disease of diffuse skeletal histiocytosis associated with multiple fragility fractures and high osteoclast activity. Clinical, radiographic, biochemical, genetic, and histopathological investigations were performed to characterize the diagnosis of an Asian man who presented with h ip fracture and diffuse skeletal lytic lesions. After excluding malignancy and other common metabolic bone diseases, open bone biopsy yielded several pathological samples all showing extensive skeletal histiocytosis likely to explain the diffuse axial and appendicular lytic lesions. Rare disorders s uch as Langer...
Source: Osteoporosis International - May 30, 2019 Category: Orthopaedics Source Type: research

Nutritional hypophosphatemic rickets secondary to Neocate ® use
We describe two, medically complex and feeding tube dependent, patients exclusively fed with Neocate ® who subsequently developed hypophosphatemic rickets. Both patients had gross motor decline and pain with physical touch. They were found to have low serum phosphorus, normal calcium, and vitamin D studies, with elevated alkaline phosphatase suggestive of nutritional hypophosphatemia. Both courses were complicated by hypocalcemia following formula change and phosphorus supplementation, highlighting the need for careful management of phosphate repletion in affected individuals. Diligent serial electrolyte monitoring as ...
Source: Osteoporosis International - May 29, 2019 Category: Orthopaedics Source Type: research

A case-control pilot study of stress fracture in adolescent girls: the discriminative ability of two imaging technologies to classify at-risk athletes
AbstractSummarySince stress fractures are common among adolescent athletes, it is important to identify bone assessment tools that accurately identify risk. We investigated the discriminative ability of two imaging technologies to classify at-risk athletes. Findings suggested that peripheral quantitative computed tomography (pQCT) has the ability to distinguish differences in bone structure in injured vs. uninjured limbs.IntroductionGiven the high stress fracture (SFX) prevalence among adolescent girls, an understanding of the most informative assessment tools to identify SFX risks are required. We investigated the discrim...
Source: Osteoporosis International - May 29, 2019 Category: Orthopaedics Source Type: research

Dietary inflammatory index ® and cortical bone outcomes in healthy adolescent children
ConclusionThe DII-scores were not related to biomarkers of inflammation or bone; however, the biomarker of inflammation, MCP-1 was negatively associated with tibia CtTh. Future prospective pediatric studies should be conducted to better understand this relationship and determine if there are long-term implications in adulthood. (Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2019 Category: Orthopaedics Source Type: research

Antiretroviral therapy options in people living with HIV at risk of or with osteoporosis
(Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2019 Category: Orthopaedics Source Type: research

Reply to “Antiretroviral therapy options in people living with HIV at risk of or with osteoporosis. Comment on: Diagnosis, prevention, and treatment of bone fragility in people living with HIV: a position statement from the Swiss Association against Osteoporosis” by S. Noe, H. Jaeger, E. Wolf
(Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2019 Category: Orthopaedics Source Type: research

Correction to: Hypophosphatasia: Canadian update on diagnosis and management
In the article mentioned above an author ’s name was misspelled. (Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2019 Category: Orthopaedics Source Type: research

Association between objective sleep duration and bone mineral density in older postmenopausal women from the Study of Osteoporotic Fractures (SOF)
AbstractSummaryMethodological limitations preclude determination of the association between sleep duration and bone mineral density (BMD) from existing literature. This was the first study to useobjective sleep duration to determine its association with BMD. Nocturnal sleep duration, assessed objectively (actigraphy) or subjectively (questionnaire), was not independently associated with BMD in postmenopausal women.IntroductionBoth long and shortself-reported sleep durations are associated with low bone mineral density (BMD) in men and women. The association between sleep duration measured by actigraphy and BMD in postmenop...
Source: Osteoporosis International - May 28, 2019 Category: Orthopaedics Source Type: research

Risk of fracture with dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors in real-world use: systematic review and meta-analysis of observational studies
ConclusionsCumulative real-world evidence does not support an association between the use of DPP-4i, GLP-1ra, or SGLT2i and the risk of fracture. Our findings, together with the cumulative evidence from RCTs, should reassure policy makers and medical practitioners that the use of these medications is unlikely to increase the risk of fracture among type 2 diabetes mellitus patients in general. Further studies need to investigate the long-term impact of these drugs on the fracture risk, particularly in high-risk populations. (Source: Osteoporosis International)
Source: Osteoporosis International - May 27, 2019 Category: Orthopaedics Source Type: research

Hypoglycaemia and type 1 diabetes are associated with an increased risk of fractures
ConclusionsHypoglycaemic episodes are associated with increased fracture risk, and the frequency of hypoglycaemic episodes leading to hospital admission was above 16% for T1D subjects. Prevention of hypoglycaemia is thus an important focus area in the prevention of fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - May 25, 2019 Category: Orthopaedics Source Type: research

Challenges and opportunities to improve fracture liaison service attendance: fracture registration and patient characteristics and motivations
ConclusionFracture entry registration inaccuracies, male gender, frailty, living alone, having low general education, or low interest in bone health and subsequent fracture risk were independently associated with FLS non-attendance. Adequately perceived advice (to have a bone densitometry and attend the FLS) was strongly associated with FLS attendance. (Source: Osteoporosis International)
Source: Osteoporosis International - May 25, 2019 Category: Orthopaedics Source Type: research

Increased risk of osteoporotic vertebral fracture in rheumatoid arthritis patients with new-onset cardiovascular diseases: a retrospective nationwide cohort study in Taiwan
We examined the incidence rate and risk factors of osteoporotic vertebral fracture in RA patients with new-onset CVD (RA-CVD) and evaluated the effects of medications on such fracture risk.MethodsA retrospective study was conducted using a nationwide database from 2000 to 2010: 1267 RA-CVD and 1267 non-CVD patients were enrolled from 30,507 patients with newly diagnosed RA. The main outcome was the development of osteoporotic vertebral fracture. After being adjusted for age, gender, and comorbidities, the Cox proportional hazard model was used to identify independent factors contributing to osteoporotic vertebral fracture....
Source: Osteoporosis International - May 24, 2019 Category: Orthopaedics Source Type: research

Prevalent vertebral fractures and minor vertebral deformities analyzed by vertebral fracture assessment (VFA) increases the risk of incident fractures in postmenopausal women: the FRODOS study
ConclusionsThe presence of prevalent VF assessed by VFA is associated with further incident spinal fractures in postmenopausal women. In addition, having MVD confers an increased risk of new VF. (Source: Osteoporosis International)
Source: Osteoporosis International - May 23, 2019 Category: Orthopaedics Source Type: research

Glucagon-like peptide-1 receptor agonists and fracture risk —limitations to current knowledge
(Source: Osteoporosis International)
Source: Osteoporosis International - May 22, 2019 Category: Orthopaedics Source Type: research

Effects of zoledronic acid on bone mineral density around prostheses and bone metabolism markers after primary total hip arthroplasty in females with postmenopausal osteoporosis
ConclusionsReceiving an intravenous infusion of 5  mg zoledronic acid after THA can effectively reduce periprosthetic BMD loss and improve bone remodeling in females with postmenopausal osteoporosis.SummaryZoledronic acid significantly inhibited bone mass loss in zones 1, 2, 4, 6, and 7 after THA and inhibited bone-resorption marker ( β-CTX) to improve bone remodeling. Zoledronic acid treatment is potentially important for patients with osteoporosis after THA. (Source: Osteoporosis International)
Source: Osteoporosis International - May 21, 2019 Category: Orthopaedics Source Type: research

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2019): Committee of National Societies Abstracts
(Source: Osteoporosis International)
Source: Osteoporosis International - May 17, 2019 Category: Orthopaedics Source Type: research

Patients ’ reasons for adhering to long-term alendronate therapy
ConclusionsEducation and disease awareness are associated with long-term alendronate adherence while competing health problems negatively impact adherence. (Source: Osteoporosis International)
Source: Osteoporosis International - May 14, 2019 Category: Orthopaedics Source Type: research

Diffuse osteosclerosis as a presentation of recurrent breast cancer: role of endothelin 1
ConclusionsRecurrent breast cancer may present with diffuse osteosclerosis. Endothelin-1 may be a paracrine factor responsible for increased bone formation and osteosclerosis. (Source: Osteoporosis International)
Source: Osteoporosis International - May 11, 2019 Category: Orthopaedics Source Type: research

Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials
Conclusions For post-menopausal or osteoporotic patients, there is no evidence that vitamin K affects bone mineral density or vertebral fractures; it may reduce clinical fractures; however, the evidence is insufficient to confirm this. There are too few trials to draw conclusions for other patient groups. (Source: Osteoporosis International)
Source: Osteoporosis International - May 10, 2019 Category: Orthopaedics Source Type: research

Parathyroid suppression therapy normalizes chronic kidney disease-induced elevations in cortical bone vascular perfusion: a pilot study
AbstractSummaryInterventions that alter PTH levels in an animal model of chronic kidney disease have effects on the perfusion of bone and bone marrow.IntroductionPatients with chronic kidney disease (CKD) have accelerated bone loss, vascular calcification, and abnormal biochemistries, together contributing to an increased risk of cardiovascular disease and fracture-associated mortality. Despite evidence of vascular pathologies and dysfunction in CKD, our group has shown that cortical bone tissue perfusion is higher in a rat model of high-turnover CKD. The goal of the present study was to test the hypothesis that parathyroi...
Source: Osteoporosis International - May 8, 2019 Category: Orthopaedics Source Type: research

Longitudinal assessment of health-related quality of life in osteoporosis: data from the population-based Canadian Multicentre Osteoporosis Study
ConclusionsThis study provides evidence of substantially reduced HRQOL in women and men with self-reported and/or BMD-confirmed osteoporosis, even in the absence of fragility fracture. HRQOL should be thoroughly investigated even prior to fracture, to develop appropriate interventions for all stages of the disease. (Source: Osteoporosis International)
Source: Osteoporosis International - May 8, 2019 Category: Orthopaedics Source Type: research