The relationship between maternal and child bone density in Nigerian children with and without nutritional rickets
ConclusionIn Nigerian children with and without rickets, forearm aBMD Z-scores were positively associated with maternal aBMD Z-scores. Active rickets in the child marginally modified the relationship at the diaphyseal site only. After treatment, children with rickets had greater metaphyseal aBMD Z-scores than children without rickets. (Source: Osteoporosis International)
Source: Osteoporosis International - February 27, 2018 Category: Orthopaedics Source Type: research

Correction to: Global dietary calcium intake among adults: a systematic review
AbstractThe original Electronic Supplementary Material file  3 contained an erroneous reference for Mali. A link to the corrected file is provided here. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Correction to: Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis
AbstractThere were two errors in this article. 1. In the section “Ethical considerations”, the registration number of the study was incorrectly given as UMIN000024492. The correct number is UMIN0000 20267. 2. The Acknowledgments paragraph was incomplete. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Association of sitting time and breaks in sitting with muscle mass, strength, function, and inflammation in community-dwelling older adults
ConclusionIn older community-dwelling adults, greater sitting time was associated with a lower percentage lean mass, while more frequent breaks in sitting time were associated with lower odds of having pre-sarcopenia. This suggests that reducing sedentary time and introducing frequent breaks in sedentary time may be beneficial for improving body composition in healthy older adults. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Prior fragility fracture and risk of incident ischaemic cardiovascular events: results from UK Biobank
ConclusionsPrior fragility fracture is an independent risk factor for incident ischaemic cardiovascular events in men. Further work may clarify whether this association is causal or represents shared risk factors, but these findings are likely to be of value in risk assessment of both osteoporosis and cardiovascular disease. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Multiple vertebral fractures associated with glucocorticoid-induced osteoporosis treated with teriparatide followed by kyphosis correction fusion: a case report
ConclusionThere is no established method for treatment of multiple vertebral fractures caused by glucocorticoid-induced osteoporosis. Initial treatment with teriparatide to improve osteoporosis followed by treatment of kyphosis with correction fusion may result in a more favorable outcome. (Source: Osteoporosis International)
Source: Osteoporosis International - February 23, 2018 Category: Orthopaedics Source Type: research

Comments on Minisola et al.: Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens
(Source: Osteoporosis International)
Source: Osteoporosis International - February 22, 2018 Category: Orthopaedics Source Type: research

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens: response to comments by Chen et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - February 22, 2018 Category: Orthopaedics Source Type: research

Health-related quality of life during the first year after a hip fracture: results of the Mexican arm of the International Cost and Utility Related to Osteoporotic Fractures Study (MexICUROS)
ConclusionsHip fractures reduce dramatically the HRQoL, with the loss sustained at least over the first year post-fracture in Mexico. The utility values derived from this study can be used in future economic evaluations. (Source: Osteoporosis International)
Source: Osteoporosis International - February 20, 2018 Category: Orthopaedics Source Type: research

After the fall: improving osteoporosis treatment following hip fracture
ConclusionsResident education and an electronic order set dramatically improved the percentage of patients meeting standard of care with osteoporosis pharmacotherapy following fragility fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - February 20, 2018 Category: Orthopaedics Source Type: research

Economic impact and cost-effectiveness of fracture liaison services: a systematic review of the literature
This study summarizes the economic impact and cost-effectiveness of FLS implemented to reduce subsequent fractures in individuals with osteoporosis. This systematic review identified studies reporting economic outcomes for FLS in osteoporotic patients aged 50 and older through a comprehensive search of MEDLINE, EMBASE, Cochrane Central, and PubMed of studies published January, 2000 to December, 2016. Grey literature (e.g., Google scholar, conference abstracts/posters) were also hand searched through February 2017. Two independent reviewers screened titles and abstracts and conducted full-text review on qualified articles. ...
Source: Osteoporosis International - February 19, 2018 Category: Orthopaedics Source Type: research

The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation: response to comments by Marcus
(Source: Osteoporosis International)
Source: Osteoporosis International - February 19, 2018 Category: Orthopaedics Source Type: research

Pulse-echo ultrasound method for detection of post-menopausal women with osteoporotic BMD
ConclusionsThe study data demonstrate that a strategy of combining ultrasound measurement with added DXA measurements in cases with intermediate ultrasound results (about 30%) can be useful for identifying subjects at risk for a low bone mineral density in the osteoporotic range. (Source: Osteoporosis International)
Source: Osteoporosis International - February 19, 2018 Category: Orthopaedics Source Type: research

Parkinson ’s disease and the risk of osteoporotic vertebral compression fracture: a nationwide population-based study
AbstractSummaryPatients with Parkinson ’s disease (PD) were at higher risk of osteoporotic vertebral compression fractures (OVCF) compared to controls and had elevated mortality rates. Compared to conservative treatment, surgical treatment for OVCF in PD patients seemed to be associated with better outcomes.IntroductionThe purpose of this study was to evaluate the risk of OVCF in patients with PD.MethodsData from patients over the age of 60  years who were diagnosed with PD were collected between 2004 and 2013 from the Korean National Health Insurance Database (n = 3370). The comparison group (non-...
Source: Osteoporosis International - February 19, 2018 Category: Orthopaedics Source Type: research

Comments on Galli et al.: The effect of magnesium on early osseointegration in osteoporotic bone: a histological and gene expression investigation
(Source: Osteoporosis International)
Source: Osteoporosis International - February 19, 2018 Category: Orthopaedics Source Type: research

Multiple vertebral fractures following osteoporosis treatment discontinuation: a case-report after long-term Odanacatib
ConclusionsThis case mimics observations following denosumab discontinuation, but, to our knowledge, is the first reported with ODN and the first documenting substantial decline in TBS. While not directly clinically relevant as ODN is no longer being developed, this case raises the possibility that a syndrome of multiple vertebral fractures could follow discontinuation of various potent osteoporosis therapies that produce major BMD increases but do not have persisting bone effects (i.e., all non-bisphosphonates). Use of antiresorptive therapies to prevent rapid bone loss following discontinuation of potent bone active agen...
Source: Osteoporosis International - February 18, 2018 Category: Orthopaedics Source Type: research

Systematic review and meta-analysis of prevalence of sarcopenia in post acute inpatient rehabilitation
Conclusions:  Original research examining sarcopenia prevalence in inpatient rehabilitation is scarce. Patient populations studied to date are not representative of general rehabilitation population with regard to both age and admission diagnoses. Sarcopenia may be present in approximately half of rehabilitatio n patients and its prevalence may vary with admission diagnosis. (Source: Osteoporosis International)
Source: Osteoporosis International - February 18, 2018 Category: Orthopaedics Source Type: research

Are there effects of age, gender, height, and body fat on the functional muscle-bone unit in children and adults?
ConclusionsWhen assessing TBLH-BMC for LBM in children and adults, the effects of age, gender, body fat, and body height should be addressed. These effects were analyzed for the first time in such a large cohort. (Source: Osteoporosis International)
Source: Osteoporosis International - February 17, 2018 Category: Orthopaedics Source Type: research

Long-term experiences of pain after a fragility fracture
ConclusionsPain continues to influence many patients ’ lives more than 1 year after a fragility fracture. Patient narratives could be useful to help health care providers to better recognize and manage this long-term consequence of fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - February 17, 2018 Category: Orthopaedics Source Type: research

Effect of isolated vitamin D supplementation on bone turnover markers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial
AbstractSummaryVitamin D (VD) plays an important role in bone mineralization. The present study investigates the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. It has been shown that VD supplementation in postmenopausal women with hypovitaminosis D is associated with a reduction in bone turnover markers.PurposeThe purpose of this study is to evaluate the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women.MethodsIn this double-blind, placebo-controlled trial, 160 women were randomized into the VD group (supplementation with 1000  IU ...
Source: Osteoporosis International - February 15, 2018 Category: Orthopaedics Source Type: research

Dietary patterns and longitudinal change in hip bone mineral density among older men
ConclusionsGreater adherence to a Prudent dietary pattern may attenuate total hip BMD loss (% ΔBMD) in older men. (Source: Osteoporosis International)
Source: Osteoporosis International - February 15, 2018 Category: Orthopaedics Source Type: research

Using a sequential explanatory mixed method to evaluate the therapeutic window of opportunity for initiating osteoporosis treatment following fragility fractures
ConclusionWhile incident FFs are an ideal opportunity for starting osteoporosis treatment, 1  year later, the therapeutic window of opportunity has already closed. (Source: Osteoporosis International)
Source: Osteoporosis International - February 14, 2018 Category: Orthopaedics Source Type: research

Bone health assessment in older people with or without muscle health impairment
This study investigated the relationship between muscle and bone status in elderly individuals. Our results suggested links between sarcopenia and osteoporosis; impairment in muscle status (i.e., muscle mass, muscle strength, and physical performance) is associated with deterioration in bone mass and texture subsequently leading to an increased risk of fracture.IntroductionAccumulating evidence has shown associations between sarcopenia and osteoporosis, but existing studies face inconsistencies in the clinical definition of both conditions. Thus, we sought to investigate bone health among older individuals with or without ...
Source: Osteoporosis International - February 14, 2018 Category: Orthopaedics Source Type: research

“Left to my own devices, I don’t know”: using theory and patient-reported barriers to move from physical activity recommendations to practice
ConclusionsBarriers unique to individuals with osteoporosis included the following: lack of knowledge on key exercise concepts, fear of fracturing, and trust in providers. Behavior change techniques may need tailoring to gender, age, or presence of comorbid conditions. (Source: Osteoporosis International)
Source: Osteoporosis International - February 13, 2018 Category: Orthopaedics Source Type: research

Diagnosis of vertebral deformities on chest CT and DXA compared to routine lateral thoracic spine X-ray
ConclusionsReproducibility of height measurements of vertebrae is excellent with all three imaging modalities. On subject level, diagnostic performance of CT (PPV 79 –82%; NPV 90–93%), and to a slightly lesser extend of DXA (PPV 73–77%; NPV 80–89%), indicates that these imaging techniques could be used for opportunistic screening of vertebral deformities in COPD patients. (Source: Osteoporosis International)
Source: Osteoporosis International - February 12, 2018 Category: Orthopaedics Source Type: research

Effect of selective serotonin reuptake inhibitors on bone mineral density: a systematic review and meta-analysis
AbstractOur work is the first systematic meta-analysis to investigate the effect of selective serotonin reuptake inhibitor (SSRI) medication on bone mineral density. Through meta-analyzed 11 studies, our findings suggested that compared with nonusers, use of SSRIs was significantly associated with lumbar spine BMD reduction, particularly for old people. The use of selective serotonin reuptake inhibitors (SSRIs) has already been associated with bone mass loss. Their effects on bone mineral density (BMD) for the different bone sections have, however, thus been inconsistent. Here, we aim to assess the effects of SSRIs on BMD ...
Source: Osteoporosis International - February 12, 2018 Category: Orthopaedics Source Type: research

Implementing a fracture liaison service open model of care utilizing a cloud-based tool
AbstractPurposeAlthough half of women and one-quarter of men aged 50 and older will sustain an acute low-trauma fracture, less than a quarter receive appropriate secondary fracture prevention. The goal of this quality improvement demonstration project was to implement a Fracture Liaison Service (FLS) focused on secondary prevention of an osteoporotic fracture in three open health care systems aided by a cloud-based tool.MethodsThe pre –post study design examined the proportion of men and women over age 50 who received appropriate assessment (bone mineral density, vitamin D levels) and treatment (calcium/vitamin D, ph...
Source: Osteoporosis International - February 10, 2018 Category: Orthopaedics Source Type: research

Modeling and simulation of bone mineral density in Japanese osteoporosis patients treated with zoledronic acid using tartrate-resistant acid phosphatase 5b, a bone resorption marker
ConclusionsThis is the first model to predict BMD for up to 2  years following two annual doses of ZOL using patients’ background characteristics and the early response of TRACP-5b. This model allows us to inform patients at the initial stage of ZOL treatment of their predicted response to treatment. (Source: Osteoporosis International)
Source: Osteoporosis International - February 8, 2018 Category: Orthopaedics Source Type: research

The utility of FRAX ® in predicting bone fractures in patients with chronic kidney disease on hemodialysis: a two-year prospective multicenter cohort study
ConclusionsFRAX ® enables a better assessment of major bone fracture risk in ESRD patients undergoing hemodialysis than any of its components and other risk factors considered in the analysis. (Source: Osteoporosis International)
Source: Osteoporosis International - February 6, 2018 Category: Orthopaedics Source Type: research

Reviewers 2017
(Source: Osteoporosis International)
Source: Osteoporosis International - February 5, 2018 Category: Orthopaedics Source Type: research

Performance of FRAX in clinical practice according to sex and osteoporosis definitions: the Manitoba BMD registry
AbstractSummaryAmong 62,275 women and 6455 men, FRAX stratified risk for incident major osteoporotic fracture (MOF) and incident hip fracture (HF) without sex interaction. Performance was good in those with osteoporosis regardless of how this was defined.IntroductionSome studies have reported that FRAX performance differs according to sex and/or osteoporosis definitions. We evaluated whether the performance of FRAX to predict incident MOF and HF in women and men was affected by the presence or absence of osteoporosis defined by World Health Organization (WHO) or National Osteoporosis Foundation (NOF) criteria.MethodsWe stu...
Source: Osteoporosis International - February 5, 2018 Category: Orthopaedics Source Type: research

Erratum to: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2016): Poster Abstracts
AbstractAn error occurred in the authorship of abstract P818 (Awareness of Osteoporosis Among Iranian Female Head of Household) of the article “World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2016). (Source: Osteoporosis International)
Source: Osteoporosis International - February 5, 2018 Category: Orthopaedics Source Type: research

FRAX calculated without BMD does not correctly identify Caucasian men with densitometric evidence of osteoporosis
ConclusionsOur results suggest that FRAX without BMD is not sensitive/specific enough to be used to identify Caucasian men 50 to 70  years old with BMD-defined osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - February 3, 2018 Category: Orthopaedics Source Type: research

Bisphosphonate use after clinical fracture and risk of new fracture
ConclusionsThere was a decrease in the relative risk of new fracture during bisphosphonate treatment, a trend that is consistent with a beneficial treatment effect, as bisphosphonates are prescribed to reduce high fracture risks. (Source: Osteoporosis International)
Source: Osteoporosis International - February 3, 2018 Category: Orthopaedics Source Type: research

Risk-equivalent T-score adjustment for using lumbar spine trabecular bone score (TBS): the Manitoba BMD registry
AbstractSummaryLumbar spine trabecular bone score (TBS) can be used to modify the output from the fracture risk assessment tool, FRAX, to enhance fracture prediction. An alternative approach for using TBS in clinical practice, based upon an adjustment to the bone mineral density (BMD) T-score, may be helpful in regions where intervention guidelines and/or reimbursement are primarily based on BMD T-score.IntroductionThe aim of this study is to develop an approach for using TBS in clinical practice based upon a “risk-equivalent” adjustment to the BMD T-score.MethodsWe identified 45,185 women age 40  years an...
Source: Osteoporosis International - February 1, 2018 Category: Orthopaedics Source Type: research

Bone density and microarchitecture in hepatitis C and HIV-coinfected postmenopausal minority women
AbstractSummaryWe found that HIV+/HCV+ women had 7 –8% lower areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) at the spine, hip, and radius (p 
Source: Osteoporosis International - February 1, 2018 Category: Orthopaedics Source Type: research

Gout as a risk factor for osteoporosis: epidemiologic evidence from a population-based longitudinal study involving 108,060 individuals
AbstractSummaryIs gout a risk factor for future osteoporosis? This large population-based study comprising two matched groups of individuals with and without gout demonstrates that patients with gout have a 20% increase in the risk of developing osteoporosis in future through an 8-year follow-up.IntroductionTo examine if gout is associated with an increased risk of osteoporosis.MethodsWe conducted a nationwide population-based retrospective matched-cohort study. Two matched cohorts (n = 36,458 with gout and 71,602 without gout) assembled and recruited from the Longitudinal Health Insurance Dataset containing ...
Source: Osteoporosis International - January 30, 2018 Category: Orthopaedics Source Type: research

Tumor-induced osteomalacia in association with PTEN-negative Cowden syndrome
We present a patient with TIO who also exhibited clinical findings suggestive of Cowden syndrome (CS), a rare autosomal dominant disorder characterized by numerous benign hamartomas, as well as an increased risk for multiple malignancies, such as thyroid cancer. While CS is a clinical diagnosis, most, but not all, harbor a mutation in the tumor suppressor genePTEN. Genetic testing revealed a somaticFN1-FGFR1 translocation in the FGF23-producing tumor causing TIO; however, a germlinePTEN mutation was not identified. To our knowledge, this is the first reported case of concurrent TIO and CS. (Source: Osteoporosis International)
Source: Osteoporosis International - January 29, 2018 Category: Orthopaedics Source Type: research

Lower risk of hip fractures among Swedish women with large hips?
ConclusionsA large HC is protective against hip fracture in midlife and in advanced age, but the association between proximal HC and hip fracture was explained by concurrent BMI suggesting that padding was not the main mechanism for the association. The independent protection seen in middle-aged women points to other mechanisms influencing bone strength. (Source: Osteoporosis International)
Source: Osteoporosis International - January 27, 2018 Category: Orthopaedics Source Type: research

The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study
ConclusionsAmong these older, community-dwelling men, we confirmed that fracture history is a strong predictor of wrist fractures in men. Medications such as SSRIs and corticosteroids also play a role in wrist fracture risk. We identified novel risk factors including kidney function and the inability to perform the grip strength test. (Source: Osteoporosis International)
Source: Osteoporosis International - January 17, 2018 Category: Orthopaedics Source Type: research

Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial
ConclusionsTwelve-week annatto-extracted TT supplementation decreased bone resorption and improved bone turnover rate via suppressing bone remodeling regulators in postmenopausal women with osteopenia. Such osteoprotective TT ’s effects may be, in part, mediated by an inhibition of oxidative stress.Trial registrationClinicalTrials.gov identifier: NCT02058420. Title: Tocotrienols and bone health of postmenopausal women. (Source: Osteoporosis International)
Source: Osteoporosis International - January 12, 2018 Category: Orthopaedics Source Type: research

Effects of whole-body vibration on muscle strength, bone mineral content and density, and balance and body composition of children and adolescents with Down syndrome: a systematic review
AbstractThe aim of this study is to verify the effects of whole-body vibration (WBV) training on the muscle strength of children and adolescents with Down syndrome. We searched MEDLINE, Cochrane, SciELO, Lilacs and PUBMED databases and included manual searches to identify randomised controlled trials to investigate the effects of WBV on the structure and body function of children and adolescents with Down syndrome. Two reviewers independently selected the studies and performed statistical analysis. In total, five studies with 171 patients that compared WBV with exercise and/or control were included. Two studies demonstrate...
Source: Osteoporosis International - January 12, 2018 Category: Orthopaedics Source Type: research

Low risk for hip fracture and high risk for hip arthroplasty due to osteoarthritis among Swedish farmers
ConclusionsOur results indicate that farming, representing an occupation with high physical activity, in men is associated with a lower risk of hip fracture but an increased risk of hip arthroplasty. (Source: Osteoporosis International)
Source: Osteoporosis International - January 12, 2018 Category: Orthopaedics Source Type: research

Is the timed loaded standing test a valid measure of back muscle endurance in people with vertebral osteoporosis?
ConclusionsThis study demonstrates that TLS challenges the ES muscles in the thoracic region and results in ES fatigue. Endurance time and the point at which the TLS test ends are strongly related to ES fatigue. (Source: Osteoporosis International)
Source: Osteoporosis International - January 10, 2018 Category: Orthopaedics Source Type: research

Urinary Pentosidine levels negatively associates with trabecular bone scores in patients with type 2 diabetes mellitus
ConclusionsTBS and pentosidine could be used as a method to assess bone quality to identify T2DM patients at risk of VFs. Our results also provide further evidence that AGEs are associated with the pathogenesis of bone fragility in patients with T2DM. (Source: Osteoporosis International)
Source: Osteoporosis International - January 10, 2018 Category: Orthopaedics Source Type: research

Feasibility of opportunistic osteoporosis screening in routine contrast-enhanced multi detector computed tomography (MDCT) using texture analysis
ConclusionsOpportunistic osteoporosis screening at the spine using specific texture parameters (energy, entropy, and homogeneity) and SVM can be performed in routine contrast-enhanced MDCT exams. (Source: Osteoporosis International)
Source: Osteoporosis International - January 10, 2018 Category: Orthopaedics Source Type: research

Exercise to improve functional outcomes in persons with osteoporosis: a systematic review and meta-analysis
ConclusionsA multicomponent exercise program of high-speed training combined with simulated functional tasks is promising to enhance functional outcomes. Due to substantial clinical heterogeneity of the target groups and specific demands of exercise modes, it is unclear which exercise program is optimal. (Source: Osteoporosis International)
Source: Osteoporosis International - January 6, 2018 Category: Orthopaedics Source Type: research

Analysis of the evolution of cortical and trabecular bone compartments in the proximal femur after spinal cord injury by 3D-DXA
AbstractSummaryMarked trabecular and cortical bone loss was observed at the proximal femur short-term after spinal cord injury (SCI). 3D-DXA provided measurement of vBMD evolution at both femoral compartments and cortical thinning, thereby suggesting that this technique could be useful for bone analysis in these patients.IntroductionSCI is associated with a marked increase in bone loss and risk of osteoporosis development short-term after injury. 3D-DXA is a new imaging analysis technique providing 3D analysis of the cortical and trabecular bone from DXA scans. The aim of this study was to assess the evolution of trabecula...
Source: Osteoporosis International - January 1, 2018 Category: Orthopaedics Source Type: research

Bone marrow failure and extramedullary hematopoiesis in McCune-Albright syndrome
We report the first detailed case of bone marrow failure and EMH in FD/MAS. The etiology of marrow failure is likely multifactorial and related to the loss of marrow reserve due to extensive polyostotic FD, exacerbated by iatrogenic thyrotoxicosis and hyperparathyroidism. Mini Abstract: A patient with fibrous dysplasia developed bone marrow failure and extramedullary hematopoiesis. The etiology likely involved loss of hematopoetic marrow space and uncontrolled endocrinopathies. Splenectomy was therapeutic. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2018 Category: Orthopaedics Source Type: research

Correction to: Characterization of trabecular bone microstructure in premenopausal women with distal radius fractures
AbstractOwing to an oversight by the corresponding author, the name of the third author of this article was rendered wrongly. His correct name is Kempland C. Walley. (Source: Osteoporosis International)
Source: Osteoporosis International - January 1, 2018 Category: Orthopaedics Source Type: research