The challenge of hypophosphatasia diagnosis in adults: results from the HPP International Working Group Literature Surveillance
AbstractHypophosphatasia (HPP) is an inborn error of metabolism caused by reduced or absent activity of the tissue non-specific alkaline phosphatase (TNSALP) enzyme, resulting from pathogenic variants in theALPL gene. Clinical presentation of HPP is highly variable, including lethal and severe forms in neonates and infants, a benign perinatal form, mild forms manifesting in adulthood, and odonto-HPP. Diagnosis of HPP remains a challenge in adults, as signs and symptoms may be mild and non-specific. Disease presentation varies widely; there are no universal signs or symptoms, and the disease often remains underdiagnosed or ...
Source: Osteoporosis International - November 20, 2023 Category: Orthopaedics Source Type: research
Deprescribing bisphosphonates for older adults with dementia: perspectives of caregivers
ConclusionConversations grounded in caregiver experiences and “what matters most” may help optimize fracture prevention treatment for older adults with dementia. (Source: Osteoporosis International)
Source: Osteoporosis International - November 18, 2023 Category: Orthopaedics Source Type: research
Effect of denosumab on bone mineral density in a postmenopausal osteoporotic woman with prolonged chronic mild hyponatremia
(Source: Osteoporosis International)
Source: Osteoporosis International - November 15, 2023 Category: Orthopaedics Source Type: research
Patients ’ preferences for fracture risk communication: the Risk Communication in Osteoporosis (RICO) study
ConclusionsThere is a significant communication gap between healthcare professionals and patients when discussing osteoporosis fracture risk. The RICO study provides insight into preferred approaches to rectify this communication gap. (Source: Osteoporosis International)
Source: Osteoporosis International - November 13, 2023 Category: Orthopaedics Source Type: research
The joint effects of physical activity and sleep duration on risk of osteoporosis in Taiwanese adult population: The Taiwan Biobank Study
ConclusionThe findings emphasize the joint role of sleep duration and physical activity in association with osteoporosis. Adults with high physical activity plus high sleep hours have the highest BMD and lowest risk of osteoporosis. (Source: Osteoporosis International)
Source: Osteoporosis International - November 10, 2023 Category: Orthopaedics Source Type: research
LMS-based continuous pediatric reference values for soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG) in the HARP cohort
ConclusionThis is the first report of LMS-based continuous pediatric reference percentiles for sRANKL, OPG and sRANKL/OPG ratio that allows calculation of standardized patient z-scores to assess bone metabolic turnover in children. (Source: Osteoporosis International)
Source: Osteoporosis International - November 9, 2023 Category: Orthopaedics Source Type: research
Evaluation of costs, osteoporosis treatment, and re-fractures in German collaborative orthogeriatric care after fragility fractures
ConclusionThe observed healthcare costs were higher in ATZ and OGCM hospitals within 12 months. Antiosteoporotic medication was prescribed more often in both groups for most fracture sites, although the corresponding medication costs did not increase. (Source: Osteoporosis International)
Source: Osteoporosis International - November 9, 2023 Category: Orthopaedics Source Type: research
Correction to: The comparison of alendronate and raloxifene after denosumab (CARD) study: A comparative efficacy trial
(Source: Osteoporosis International)
Source: Osteoporosis International - November 9, 2023 Category: Orthopaedics Source Type: research
LMS-based continuous pediatric reference values for soluble receptor activator of nuclear factor kappa B ligand (sRANKL) and osteoprotegerin (OPG) in the HARP cohort
ConclusionThis is the first report of LMS-based continuous pediatric reference percentiles for sRANKL, OPG and sRANKL/OPG ratio that allows calculation of standardized patient z-scores to assess bone metabolic turnover in children. (Source: Osteoporosis International)
Source: Osteoporosis International - November 9, 2023 Category: Orthopaedics Source Type: research
Evaluation of costs, osteoporosis treatment, and re-fractures in German collaborative orthogeriatric care after fragility fractures
ConclusionThe observed healthcare costs were higher in ATZ and OGCM hospitals within 12 months. Antiosteoporotic medication was prescribed more often in both groups for most fracture sites, although the corresponding medication costs did not increase. (Source: Osteoporosis International)
Source: Osteoporosis International - November 9, 2023 Category: Orthopaedics Source Type: research
Correction to: The comparison of alendronate and raloxifene after denosumab (CARD) study: A comparative efficacy trial
(Source: Osteoporosis International)
Source: Osteoporosis International - November 9, 2023 Category: Orthopaedics Source Type: research
Effect of educational intervention on preventing osteoporosis in postmenopausal women
ConclusionsThe theory of planned behavior affected nutrition and walking performance in osteoporosis prevention of subjects. This theory can be used as a framework for designing and performing educational interventions for preventing osteoporosis and promoting women ’s health. (Source: Osteoporosis International)
Source: Osteoporosis International - November 8, 2023 Category: Orthopaedics Source Type: research
The incremental risk of fragility fractures in aging men
ConclusionIn men without a pre-existing history of osteoporosis, the risk of fragility fractures starts to increase after the age of 70. Further work building upon these data may help to identify a specific age at which routine bone health screening in males can help to minimize fractures and their associated morbidity and mortality. (Source: Osteoporosis International)
Source: Osteoporosis International - November 8, 2023 Category: Orthopaedics Source Type: research
