Implementation of the Western Australian Osteoporosis Model of Care: a fracture liaison service utilising emergency department information systems to identify patients with fragility fracture to improve current practice and reduce re-fracture rates: a 12-month analysis
This study evaluates the efficacy of a FLS linked to a tertiary hospital emergency department information system (EDIS) in reducing recurrent fractures.MethodsPatients aged ≥ 50 years with MTF identified from EDIS were invited to the FLS. Patient outcomes were compared to routine care (retrospective group—same hospital, and prospective group—other hospital) at 3- and 12-month follow-up.ResultsTwo hundred forty-one of 376 (64.1%) eligible patients participated in the FLS with 12  months of follow-up. Absolute risk of recurrent MTF at 12 months was reduced by 9.2 and 10.2% compared with t...
Source: Osteoporosis International - April 27, 2018 Category: Orthopaedics Source Type: research

The relation of low levels of bone mineral density with coronary artery calcium and mortality
This study investigated the relation of BMD levels with CAC and mortality in both genders across ethnicities.MethodsThis study consisted of 5590 consecutive at-risk subjects without known coronary artery disease (CAD), age 57  ± 12, and 69% male, who underwent non-enhanced cardiac computed tomography, and were followed for mean of 8 years. The subjects’ CAC (Agatston score) and thoracic BMD levels (mg/cm3) were measured. CAC stratified based on the severity to CAC 0, 1 –100, 101–400, and 400+. Low-BMD levels defined as BMD levels below median (180 mg/cm3). Physician verified...
Source: Osteoporosis International - April 27, 2018 Category: Orthopaedics Source Type: research

A proposal for an atypical femur fracture treatment and prevention clinical practice guideline
ConclusionsClinical practice guidelines for the treatment and prevention of AFF will benefit clinicians who are frequently faced with having to make clinical decisions in patients requiring antiresorptive medications. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2018 Category: Orthopaedics Source Type: research

Pitfalls in bone density monitoring in prostate cancer during anti-resorptive treatment
AbstractA 74-year-old man presented to the Andrology Clinic for management of potential complications of androgen deprivation therapy for prostate cancer. He had a rising prostate-specific antigen with a concurrent rise in alkaline phosphatase and bone remodeling markers. This was despite treatment with a radical prostatectomy, androgen deprivation, and anti-resorptive therapy. A follow-up dual-energy X-ray absorptiometry scan revealed a marked increase in his bone mineral density at both the lumbar spine and femoral neck. This increase, especially in the context of rising bone remodeling markers, was unlikely due to the e...
Source: Osteoporosis International - April 17, 2018 Category: Orthopaedics Source Type: research

Hip fracture patients who experience a greater fluctuation in RDW during hospital course are at heightened risk for all-cause mortality: a prospective study with 2-year follow-up
ConclusionHip fracture patients who experience a greater fluctuation in RDW during the hospital course are at a heightened risk for 2-year all-cause mortality. (Source: Osteoporosis International)
Source: Osteoporosis International - April 14, 2018 Category: Orthopaedics Source Type: research

Mediterranean diet and hip fracture incidence among older adults: the CHANCES project
ConclusionsIn this large sample of older adults from Europe and the USA, increased adherence to MD was associated with lower hip fracture incidence. (Source: Osteoporosis International)
Source: Osteoporosis International - April 14, 2018 Category: Orthopaedics Source Type: research

Bisphosphonates for the preservation of periprosthetic bone mineral density after total joint arthroplasty: a meta-analysis of 25 randomized controlled trials
AbstractSummaryThe present meta-analysis aimed to evaluate the long-term efficacy of bisphosphonates (BPs) on preservation of periprosthetic bone mineral density (BMD) after joint arthroplasty. It confirmed the protective effect of BPs in a long-term follow-up, and found the influence factors on this effect.IntroductionPeriprosthetic bone loss is believed to cause aseptic loosening and failed prosthetic fixation in joint arthroplasty. This meta-analysis which included high-quality randomized controlled trials aimed to analyze the effect of bisphosphonates on maintaining periprosthetic bone mineral density after total joint...
Source: Osteoporosis International - April 13, 2018 Category: Orthopaedics Source Type: research

The role of previous falls in major osteoporotic fracture prediction in conjunction with FRAX in older Chinese men and women: the Mr. OS and Ms. OS cohort study in Hong Kong
AbstractFalls are a major concern in terms of fracture risk. Although awareness rising for the absence of falls in the FRAX algorithm, our study only identified the independent predictive role of previous recurrent falls and their better conjunction use with FRAX for major osteoporotic fracture prediction in older Chinese men. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2018 Category: Orthopaedics Source Type: research

Correction to: Using self-reports of pain and other variables to distinguish between older women with back pain due to vertebral fractures and those with back pain due to degenerative changes
This article was originally published under a CC BY-NC-ND 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2018 Category: Orthopaedics Source Type: research

Association between gout and osteoporosis risk in the United Kingdom
(Source: Osteoporosis International)
Source: Osteoporosis International - April 10, 2018 Category: Orthopaedics Source Type: research

Gout as a risk factor for osteoporosis: response to comments by Kostev
(Source: Osteoporosis International)
Source: Osteoporosis International - April 10, 2018 Category: Orthopaedics Source Type: research

Anabolic agents: what is beyond osteoporosis?
AbstractOsteoporosis is a common skeletal disorder characterized by low bone mass, which leads to reduced bone strength and an increased risk of fractures. Anabolic agents have been shown to improve bone mass and decrease fracture risk in osteoporosis patients by directly stimulating osteoblasts to produce new bone. Currently, two anabolic agents are available in the USA: recombinantly produced teriparatide (TPTD), which is the fully active (1 –34) amino active sequence of human parathyroid hormone (PTH), and abaloparatide (APTD), a synthetic analog of parathyroid hormone-related peptide (PTHrP). At present, both age...
Source: Osteoporosis International - April 7, 2018 Category: Orthopaedics Source Type: research

Clinical and laboratory features of patients with osteomalacia initially presenting with neurological manifestations
AbstractSummaryPatients with osteomalacia often visit the neurology department with conditions mimicking other myopathies. We analyzed clinical features of osteomalacia patients who visited the neurology department. These patients frequently presented with hypocalcemia, hypovitaminosis D, and pain with less severe weakness. Osteomalacia should be considered when patients present with pain and weakness.IntroductionOsteomalacia is a disease of bone metabolism; however, some patients with osteomalacia initially visit the neurology department. As these patients often complain of weakness and gait disturbance, osteomalacia can ...
Source: Osteoporosis International - April 5, 2018 Category: Orthopaedics Source Type: research

Exercise effects on bone mineral density in older men: a systematic review with special emphasis on study interventions
AbstractThis systematic review detected only limited positive effects of exercise on bone mineral density in older men. Further, based on the present literature, we were unable to suggest dedicated exercise prescriptions for this male cohort that might differ from recommendations based on studies with postmenopausal women. The primary aim of this systematic review was to determine the effect of exercise on bone mineral density (BMD) in healthy older men. A systematic review of the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement included only randomized or non-randomi...
Source: Osteoporosis International - April 5, 2018 Category: Orthopaedics Source Type: research

Incidence and outcomes of humeral fractures in the older person
ConclusionHumeral fractures are common in the older population and cause a substantial amount of new nursing home admissions and mortality. Further study is required to ascertain appropriate guidelines for treatment and rehabilitation. (Source: Osteoporosis International)
Source: Osteoporosis International - April 4, 2018 Category: Orthopaedics Source Type: research

Systemic mastocytosis identified in two women developing fragility fractures during lactation
AbstractTwo women presenting with fragility fractures during lactation had bone mineral density (BMD) reduced more greatly than usually associated with lactation. The first woman was 29  years old with a BMD T-score of − 3.2 SD at the spine and− 2.0 SD at the femoral neck. The second woman was 35 years old with a BMD T-score of − 4.5 SD at the spine and − 2.8 SD at the femoral neck. Both women had increased cortical porosity and reduced trabecular density. Investi gation identified an elevated serum tryptase, and marrow biopsy confirmed the diagnosis of mastocyt...
Source: Osteoporosis International - April 4, 2018 Category: Orthopaedics Source Type: research

Understanding osteoporotic pain and its pharmacological treatment
AbstractOsteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic fractures can cause acute and chronic pain that mainly affects elderly patients with multiple comorbidities and commonly on different drug regimens. The aim of this paper is to summarize the pathogenesis and systemic treatment of osteoporotic pain. This narrative review summarizes the main pathogenetic aspects of osteoporotic pain and the cornerstones of its treatment. Osteoporotic fractures induce both acute and chron...
Source: Osteoporosis International - April 4, 2018 Category: Orthopaedics Source Type: research

Incidence of fractures among patients with rheumatoid arthritis: a systematic review and meta-analysis
ConclusionsPatients with RA are at high risk of incident overall and fragility fractures. Consideration of vertebral imaging for patients with additional OP risk factors, including RA-specific risk factors, may help with early OP diagnosis and timely intervention. (Source: Osteoporosis International)
Source: Osteoporosis International - March 15, 2018 Category: Orthopaedics Source Type: research

Effects of bone remodeling agents following teriparatide treatment
ConclusionsPatients who elected to discontinue osteoporosis treatment experienced a significant decline in the change in BMD compared to the change on teriparatide putting them at higher risk for recurrence of fragility fractures. Patients on denosumab following teriparatide had the largest increase in BMD. (Source: Osteoporosis International)
Source: Osteoporosis International - March 14, 2018 Category: Orthopaedics Source Type: research

The relationship between objectively assessed physical activity and bone health in older adults differs by sex and is mediated by lean mass
ConclusionsAssociations of accelerometer-determined sedentary behaviour and PA with bone health in older adults differ by sex and anatomical site and are mediated by body composition. (Source: Osteoporosis International)
Source: Osteoporosis International - March 12, 2018 Category: Orthopaedics Source Type: research

Depression and risk of fracture and bone loss: an updated meta-analysis of prospective studies
AbstractSummaryThis meta-analysis pooled results from 23 qualifying individual cohort studies and found that depression was significantly associated with an increased risk of fractures and bone loss.IntroductionThe association between depression and risk of fracture remains controversial. We conducted a comprehensive meta-analysis to examine the effect of depression on the risk of osteoporotic fractures and bone loss.MethodsWe searched databases and reviewed citations in relevant articles for eligible cohort studies. Two investigators independently conducted study selection, appraisal, and data abstraction through the use ...
Source: Osteoporosis International - March 12, 2018 Category: Orthopaedics Source Type: research

Identifying characteristics of an effective fracture liaison service: systematic literature review
AbstractFracture liaison services (FLS) have been demonstrated to improve outcomes following osteoporotic fracture. The aim of this systematic literature review (SLR) was to determine the characteristics of an FLS that lead to improved patient outcomes. We conducted a SLR, including articles published between 2000 and February 2017, using global (Medline, EMBASE, PubMed and Cochrane Library) and local databases. Studies including patients aged ≥ 50 years with osteoporotic fractures enrolled in an FLS were assessed. Information extracted from each article included key person coordinating the FLS (physician, n...
Source: Osteoporosis International - March 10, 2018 Category: Orthopaedics Source Type: research

Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density
AbstractSummaryThe antiresorptive potency varies between different bisphosphonates. We investigated the effect of stopping oral bisphosphonate treatment for postmenopausal osteoporosis (ibandronate, alendronate, risedronate) on BTMs and BMD. After stopping treatment, all three groups showed an increase in BTMs and a decrease in hip BMD; however, none returned to pre-treatment baseline values.IntroductionBisphosphonates (BPs) continue to suppress bone turnover markers (BTMs) after treatment has stopped, leading to the suggestion that a pause in treatment could be considered for low-risk patients. Indirect comparisons sugges...
Source: Osteoporosis International - March 10, 2018 Category: Orthopaedics Source Type: research

Pulsed electromagnetic fields preserve bone architecture and mechanical properties and stimulate porous implant osseointegration by promoting bone anabolism in type 1 diabetic rabbits
ConclusionWe reveal that PEMF improved bone architecture, mechanical properties, and pTi osseointegration by promoting bone anabolism through a canonical Wnt/ β-catenin signaling-associated mechanism. This study enriches our basic knowledge for understanding skeletal sensitivity in response to external electromagnetic signals, and also opens new treatment alternatives for T1DM-associated osteopenia/osteoporosis and osseous defects in an easy and highly e fficient manner. (Source: Osteoporosis International)
Source: Osteoporosis International - March 9, 2018 Category: Orthopaedics Source Type: research

Novel compound heterozygous mutations in SERPINH1 cause rare autosomal recessive osteogenesis imperfecta type X
ConclusionWe reported novel compound heterozygous mutations inSERPINH1 in a Chinese OI patient for the first time, which expanded the spectrum of phenotype and genotype of extremely rare OI type X. (Source: Osteoporosis International)
Source: Osteoporosis International - March 9, 2018 Category: Orthopaedics Source Type: research

Teriparatide treatment exerts differential effects on the central and peripheral skeleton: results from the MOAT study
ConclusionsTeriparatide exerts differential effects on the central and the peripheral skeleton. Central trabecular vBMD (L1 –L3) is improved, but there is a concomitant decrease in peripheral cortical vBMD and an increase in porosity. Overall, we did not observe a change in total body bone mineral. We acknowledge that our conclusions may be speculative and are constrained by the technical limitations of the imaging tec hniques used, the lack of a control group, and the small sample size studied. (Source: Osteoporosis International)
Source: Osteoporosis International - March 8, 2018 Category: Orthopaedics Source Type: research

Low peak jump power is associated with elevated odds of dysmobility syndrome in community-dwelling elderly individuals: the Korean Urban Rural Elderly (KURE) study
AbstractSummaryIn a community-dwelling elderly cohort (Korean Urban Rural Elderly), low peak jump power was associated with elevated odds of dysmobility syndrome and its components, independent of age and comorbidities. Jump power measurement improved discrimination of individuals with dysmobility syndrome when added to conventional risk factors.IntroductionDysmobility syndrome was proposed to encompass the risks affecting musculoskeletal outcomes. Jump power measurement is a safe, reproducible high-intensity test for physical function in elderly. However, the relationship between jump power and dysmobility syndrome remain...
Source: Osteoporosis International - March 8, 2018 Category: Orthopaedics Source Type: research

Estrogen therapy for osteoporosis in the modern era
AbstractMenopause predisposes women to osteoporosis due to declining estrogen levels. This results in a decrease in bone mineral density (BMD) and an increase in fractures. Osteoporotic fractures lead to substantial morbidity and mortality, and are considered one of the largest public health priorities by the World Health Organization (WHO). It is therefore essential for menopausal women to receive appropriate guidance for the prevention and management of osteoporosis. The Women ’s Health Initiative (WHI) randomized controlled trial first proved hormonal therapy (HT) reduces the incidence of all osteoporosis-related ...
Source: Osteoporosis International - March 8, 2018 Category: Orthopaedics Source Type: research

Opportunistic screening for bone disease using abdominal CT scans obtained for other reasons in newly diagnosed IBD patients
AbstractSummaryBone disease is prevalent among patients with inflammatory bowel disease (IBD), though bone density screening remains underutilized. We used CT scans performed for other indications in IBD patients to identify and monitor osteopenia using CT attenuation values at the lumbar spine. Significant rates of bone disease were detected which would have otherwise gone undiagnosed.IntroductionOsteoporosis affects about 14 –42% of patients with IBD. Though screening is recommended in IBD patients with risk factors, it remains underutilized. In patients with newly diagnosed IBD, we used CT scans performed for othe...
Source: Osteoporosis International - March 8, 2018 Category: Orthopaedics Source Type: research

The positive association of total protein intake with femoral neck strength (KNHANES IV)
AbstractSummaryData gathered from a nationally representative cohort demonstrate that higher dietary protein intake was positively associated with the composite indices of femoral neck strength in both men and women, suggesting that higher protein intake may contribute to lower risk of hip fracture through the improvement of bone strength.IntroductionDespite the general belief that higher protein intake may be helpful for bone homeostasis, its impact on human bone health is still debated. Furthermore, the association of dietary protein intake with femoral neck (FN) strength, which can predict fracture risk independently of...
Source: Osteoporosis International - March 6, 2018 Category: Orthopaedics Source Type: research

Mediterranean diet, diet quality, and bone mineral content in adolescents: the HELENA study
ConclusionAn overall dietary score or index is not associated with BMC in our adolescent Spanish sample. (Source: Osteoporosis International)
Source: Osteoporosis International - March 5, 2018 Category: Orthopaedics Source Type: research

Bone mineral density averaged over a region of interest on femur is affected by age-related change of bone geometry
AbstractSummaryFemur expansion occurs during normal aging in both men and women. Average bone mineral density (BMD) over a region of interest (ROI) on the femur may considerably decrease with age even in healthy people, and therefore, it is inaccurate if used to monitor treatment-induced bone change.IntroductionAreal bone mineral density (BMD), averaged over a region of interest (ROI) on the femur, is widely used in the diagnosis of osteoporosis, assessment of fracture risk, and monitoring of treatment effectiveness. We studied the effect of age-related change in femur geometry on average BMD.MethodsThe effect of age-relat...
Source: Osteoporosis International - March 5, 2018 Category: Orthopaedics Source Type: research

Correction to: Remarkable improvement in serum 25-hydroxyvitamin levels among hip fracture patients over a 12-year period: a prospective study in South-eastern Finland
AbstractThe presentation of Table  4 was unclear in the original publication. The article has now been corrected in this respect. (Source: Osteoporosis International)
Source: Osteoporosis International - March 5, 2018 Category: Orthopaedics Source Type: research

Acquired resistance to pamidronate treated effectively with zoledronate in juvenile Paget ’s disease
AbstractJuvenile Paget ’s disease (JPD) is a rare autosomal recessive osteopathy. There is still a question about the most effective treatment modality in long-term prognosis. A 9-month-old boy who suffered from bone pain and deformities with a very high alkaline phosphatase level was diagnosed as JPD by radiographic fi ndings. Genetic analysis showed a homozygous large deletion inTNFRSF11B gene encoding osteoprotegerin. Clinical improvement was observed with intravenous pamidronate therapy. However, the effect of drug reduced in time so the annual dose per kilogram body weight was increased after 2  years. Desp...
Source: Osteoporosis International - March 3, 2018 Category: Orthopaedics Source Type: research

Association of sarcopenia and fractures in community-dwelling older adults: a systematic review and meta-analysis of cohort studies
In conclusion, we found that compared to nonsarcopenic, the association between sarcopenia and fractures among community-dwelling older people was significant when using the AWGS definition, and only for males. Future studies are needed to establish a possible association between sarco penia definitions and risk of fractures of different sites. (Source: Osteoporosis International)
Source: Osteoporosis International - March 2, 2018 Category: Orthopaedics Source Type: research

Changes in bone mineral density after kidney transplantation: 2-year assessment of a French cohort
AbstractIntroductionIn renal transplant patients, bone loss may be related to the drugs patients are taking but also to their past history of chronic kidney disease. The purpose of this study was to assess changes in BMD 2  years after an initial assessment (performed 9 months post transplantation) and the factors associated with these changes.MethodsThis longitudinal study included patients who had undergone a renal transplantation between 2005 and 2011, and who were followed up at the Lille Regional University Hospital. Patients were included if they had a first bone evaluation (including bone densitometry, spi...
Source: Osteoporosis International - March 2, 2018 Category: Orthopaedics Source Type: research

Comments on Feskanich et al.: Milk and other dairy foods and risk of hip fracture in men and women
(Source: Osteoporosis International)
Source: Osteoporosis International - March 2, 2018 Category: Orthopaedics Source Type: research

Interpretation of milk research results
(Source: Osteoporosis International)
Source: Osteoporosis International - March 1, 2018 Category: Orthopaedics Source Type: research

A randomized double-blind placebo-controlled trial of vitamin D supplementation in juvenile-onset systemic lupus erythematosus: positive effect on trabecular microarchitecture using HR-pQCT
ConclusionThis study suggests that cholecalciferol supplementation for 24  weeks effectively improved the bone microarchitecture parameters, mainly the trabecular number, in JoSLE patients.Trial RegistrationNCT01892748 (Source: Osteoporosis International)
Source: Osteoporosis International - March 1, 2018 Category: Orthopaedics Source Type: research

Interpretation of milk research results: response to comments by Michaelsson and Byberg
(Source: Osteoporosis International)
Source: Osteoporosis International - March 1, 2018 Category: Orthopaedics Source Type: research

Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism
AbstractEvaluation of bone is of great importance in chronic kidney disease patients, as these patients are at an increased risk for fractures. We treated a hemodialysis patient suffering from hyperparathyroid bone disease with cinacalcet hydrochloride and concurrent administration of maxacalcitol and alfacalcidol for a year. Hyperparathyroid bone disease is characterized by cortical thinning, increased cortical porosity, reduced trabecular bone volume, and increased hypomineralized matrix volume, and there is little information to date about the effects of treatment with cinacalcet hydrochloride on the bone fragility in p...
Source: Osteoporosis International - February 28, 2018 Category: Orthopaedics Source Type: research

The relationship between maternal and child bone density in Nigerian children with and without nutritional rickets
ConclusionIn Nigerian children with and without rickets, forearm aBMD Z-scores were positively associated with maternal aBMD Z-scores. Active rickets in the child marginally modified the relationship at the diaphyseal site only. After treatment, children with rickets had greater metaphyseal aBMD Z-scores than children without rickets. (Source: Osteoporosis International)
Source: Osteoporosis International - February 27, 2018 Category: Orthopaedics Source Type: research

Correction to: Global dietary calcium intake among adults: a systematic review
AbstractThe original Electronic Supplementary Material file  3 contained an erroneous reference for Mali. A link to the corrected file is provided here. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Correction to: Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis
AbstractThere were two errors in this article. 1. In the section “Ethical considerations”, the registration number of the study was incorrectly given as UMIN000024492. The correct number is UMIN0000 20267. 2. The Acknowledgments paragraph was incomplete. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Association of sitting time and breaks in sitting with muscle mass, strength, function, and inflammation in community-dwelling older adults
ConclusionIn older community-dwelling adults, greater sitting time was associated with a lower percentage lean mass, while more frequent breaks in sitting time were associated with lower odds of having pre-sarcopenia. This suggests that reducing sedentary time and introducing frequent breaks in sedentary time may be beneficial for improving body composition in healthy older adults. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Prior fragility fracture and risk of incident ischaemic cardiovascular events: results from UK Biobank
ConclusionsPrior fragility fracture is an independent risk factor for incident ischaemic cardiovascular events in men. Further work may clarify whether this association is causal or represents shared risk factors, but these findings are likely to be of value in risk assessment of both osteoporosis and cardiovascular disease. (Source: Osteoporosis International)
Source: Osteoporosis International - February 26, 2018 Category: Orthopaedics Source Type: research

Multiple vertebral fractures associated with glucocorticoid-induced osteoporosis treated with teriparatide followed by kyphosis correction fusion: a case report
ConclusionThere is no established method for treatment of multiple vertebral fractures caused by glucocorticoid-induced osteoporosis. Initial treatment with teriparatide to improve osteoporosis followed by treatment of kyphosis with correction fusion may result in a more favorable outcome. (Source: Osteoporosis International)
Source: Osteoporosis International - February 23, 2018 Category: Orthopaedics Source Type: research

Comments on Minisola et al.: Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens
(Source: Osteoporosis International)
Source: Osteoporosis International - February 22, 2018 Category: Orthopaedics Source Type: research

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens: response to comments by Chen et al.
(Source: Osteoporosis International)
Source: Osteoporosis International - February 22, 2018 Category: Orthopaedics Source Type: research

Health-related quality of life during the first year after a hip fracture: results of the Mexican arm of the International Cost and Utility Related to Osteoporotic Fractures Study (MexICUROS)
ConclusionsHip fractures reduce dramatically the HRQoL, with the loss sustained at least over the first year post-fracture in Mexico. The utility values derived from this study can be used in future economic evaluations. (Source: Osteoporosis International)
Source: Osteoporosis International - February 20, 2018 Category: Orthopaedics Source Type: research