Evaluation of bone mineral density and microarchitectural parameters by DXA and HR-pQCT in 37 children and adults with X-linked hypophosphatemic rickets
AbstractSummaryIn X-linked hypophosphatemic (XLH) rickets, dual-energy X-ray absorptiometry (DXA) measurements must be analyzed with caution. High-resolution peripheral quantitative computed tomography (HR-pQCT) analysis suggested that XLH primarily affects the cancellous compartment, with the tibia more affected than the radius. Effective treatment of XLH appears to positively affect bone mineralization, mainly in the bone cortex.IntroductionThe purpose of this study is to evaluate bone mineral density (BMD) and microarchitecture in 37 patients (13 children and 24 adults) with XLH confirmed byPHEX mutations from a tertiar...
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Standardizing 25-hydroxyvitamin D data from the HunMen cohort
AbstractSummaryStandardization of 25-hydroxyvitamin D (25OHD) values is still a challenge. We propose standardization by correction of the measured 25OHD values using the linear regression bias from the National Institute of Standards and Technology (NIST) ‘total’ target values reported by Vitamin D External Quality Assessment Scheme (DEQAS). Our approach could perhaps be a practical solution to the anomaly surrounding non-standardized 25OHD values.IntroductionStandardization of 25OHD values is still a challenge. We propose standardization by correction of the measured 25OHD values using the linear regression e...
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Significant improvement of bone mineral density and bone turnover markers by denosumab therapy in bisphosphonate-unresponsive patients: response to comments
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Skeletal effects of vitamin D deficiency among patients with primary hyperparathyroidism
AbstractSummaryLittle is known about the association between vitamin D deficiency and the skeletal phenotypes in primary hyperparathyroidism (PHPT) patients. A low 25-hydroxyvitamin D level was associated with a low bone mineral density and deteriorated hip geometry in women with PHPT in an Asian population where vitamin D deficiency is prevalent.IntroductionFew studies have examined the effect of vitamin D deficiency on the bone health of primary hyperparathyroidism (PHPT) patients.MethodsWe investigated the skeletal effects of vitamin D deficiency in 79 PHPT patients by assessing bone mineral density (BMD), the trabecula...
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Cost effective measures to standardize serum 25(OH)D values from completed studies
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Pharmacokinetics of coadministration of levothyroxine sodium and alendronate sodium new effervescent formulation
ConclusionsThere was no clinically important pharmacokinetic interference between the Aln-NEF formulation and LT4. Aln-NEF does not materially affect LT4 absorption. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Biopsy vs. peripheral computed tomography to assess bone disease in CKD patients on dialysis: differences and similarities
ConclusionsThere was an agreement between HR-pQCT and bone biopsy parameters, particularly in cortical compartment, which may point to a new perspective on the fracture risk assessment for CKD patients. Besides classical bone resorption markers, HR-pQCT provided some clues on the turnover status by measurements of cortical density at radius, although the significance of this finding warrants further studies. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Erratum to: Use of antipsychotics increases the risk of fracture: a systematic review and meta-analysis
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Comments on Kamimura et al.: significant improvement of bone mineral density and bone turnover markers by denosumab therapy in bisphosphonate-unresponsive patients
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

A role for thiazide diuretic therapy in preventing bone loss, fracture, and nephrolithiasis in individuals with thalassemia and hypercalciuria?
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Response to: A role for thiazide diuretic therapy in preventing bone loss, fracture and nephrolithiasis in individuals with thalassemia and hypercalciuria?
(Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

High and pointed type of femoral localized reaction frequently extends to complete and incomplete atypical femoral fracture in patients with autoimmune diseases on long-term glucocorticoids and bisphosphonates
ConclusionsOnce a localized reaction was detected, discontinuation of BPs and switching to vitamin D supplementation or teriparatide therapy effectively improved it. When the localized reaction was high, of the pointed type, and/or accompanied by prodromal pain, the risks of complete and incomplete AFF increased and consideration of prophylactic fixation for such patients was required. (Source: Osteoporosis International)
Source: Osteoporosis International - April 13, 2017 Category: Orthopaedics Source Type: research

Reduced bone mass and preserved marrow adipose tissue in patients with inflammatory bowel diseases in long-term remission
ConclusionsIBD patients in long-term, steroid-free remission may have a low bone mass in spite of preserved BMAT. These findings confirm the heterogeneity of bone disorders in IBD and may indicate that factors involved in bone loss in active disease may have long-lasting effects on these patients. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2017 Category: Orthopaedics Source Type: research

Dietary acid load, trabecular bone integrity, and mineral density in an ageing population: the Rotterdam study
ConclusionsHigh NEAP was associated with low TBS. Associations of AnPro/K and VegPro/K and TBS were non-linear and differently shaped. No significant associations of DAL with BMD were observed, nor was there any significant interaction between DAL and renal function. Mainly in participants with high intake of dietary fibre, DAL might be detrimental to bone. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2017 Category: Orthopaedics Source Type: research

Mutational and biochemical findings in adults with persistent hypophosphatasemia
ConclusionAdults with persistent hypophosphatasemia frequently harborALPL mutations and have elevated ALP substrates. These adults may fall within the spectrum of the adult form of hypophosphatasia. Clinicians should take note of persistent hypophosphatasemia in their patients and be cautious in prescribing bisphosphonates when present. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2017 Category: Orthopaedics Source Type: research

Sex-related variations in cortical and trabecular bone of the femoral neck in an elderly Chinese population
This study included 207 male (67.9  ± 7.7 years; range, 55–87 years) and 400 female subjects (68.0 ± 8.7 years; range, 55–96 years). BIT module was used to measure cortical and trabecular bone in anatomic quadrants of the femoral neck. Measurements of cortical thickness (Ct.Th), cortical vBMD (Ct.vBMD), trabecular vBMD (Tb.vBMD), and integral vBMD (It.vBMD) at the femoral neck were determined in four anatomical sectors.ResultsThe greatest difference between sexes, after adjusting for age, height, and weight, was in Ct.Th of Quadrant Supero-anterior (SA), whi...
Source: Osteoporosis International - April 12, 2017 Category: Orthopaedics Source Type: research

Progressive skeletal benefits of physical activity when young as assessed at the midshaft humerus in male baseball players
AbstractSummaryPhysical activity benefits the skeleton, but there is contrasting evidence regarding whether benefits differ at different stages of growth. The current study demonstrates that physical activity should be encouraged at the earliest age possible and be continued into early adulthood to gain most skeletal benefits.IntroductionThe current study explored physical activity-induced bone adaptation at different stages of somatic maturity by comparing side-to-side differences in midshaft humerus properties between male throwing athletes and controls. Throwers present an internally controlled model, while inclusion of...
Source: Osteoporosis International - April 10, 2017 Category: Orthopaedics Source Type: research

The comparability of HR-pQCT bone measurements is improved by scanning anatomically standardized regions
ConclusionVariability in limb length introduces significant bias to HR-pQCT measures, confounding cross-sectional analyses and limiting the clinical application for individual assessment of skeletal status. We propose to standardize scan positioning using 4.0 and 7.3% of total bone length for the distal radius and tibia, respectively. (Source: Osteoporosis International)
Source: Osteoporosis International - April 8, 2017 Category: Orthopaedics Source Type: research

Sarcopenia is associated with disability status —results from the KORA-Age study
ConclusionThe prevalence of sarcopenia is consistent with estimates from other European studies using this algorithm. Our results suggest that sarcopenia can contribute to higher disability scores in older adults. However, our study was not able to show any influence of sarcopenia on the rate of functional decline using the EWGSOP diagnostic algorithm for sarcopenia. This directs attention to an accurate diagnosis of sarcopenia as the onset may be influenced, but its rate may not. (Source: Osteoporosis International)
Source: Osteoporosis International - April 6, 2017 Category: Orthopaedics Source Type: research

Vibrational spectroscopic techniques to assess bone quality
AbstractAlthough musculoskeletal diseases such as osteoporosis are diagnosed and treatment outcome is evaluated based mainly on routine clinical outcomes of bone mineral density (BMD) by DXA and biochemical markers, it is recognized that these two indicators, as valuable as they have proven to be in the everyday clinical practice, do not fully account for manifested bone strength. Thus, the term bone quality was introduced, to complement considerations based on bone turnover rates and BMD. Bone quality is an “umbrella” term that incorporates the structural and material/compositional characteristics of bone tiss...
Source: Osteoporosis International - April 5, 2017 Category: Orthopaedics Source Type: research

Circulating periostin levels increase in association with bone density loss and healing progression during the early phase of hip fracture in Chinese older women
This study enrolled 261 older women with osteoporotic hip fracture and 106 age-matched women without fracture serving as controls. Clinical features, bone mineral density (BMD), and bone turnover markers including sPostn level were measured after fracture within 2  days. Follow-up sPostn levels during 1 year after 2 days were available for 128 patients.ResultsInitial levels of sPostn after fracture were significantly higher in patients than controls. sPostn was correlated with BMD of femoral neck (r = −0.529,P 
Source: Osteoporosis International - April 5, 2017 Category: Orthopaedics Source Type: research

Molecular diagnosis in children with fractures but no extraskeletal signs of osteogenesis imperfecta
ConclusionsDNA sequence analysis of currently known OI-associated genes identified disease-causing variants in more than a quarter of individuals with a significant fracture history but without extraskeletal manifestations of OI. (Source: Osteoporosis International)
Source: Osteoporosis International - April 4, 2017 Category: Orthopaedics Source Type: research

Associations between hip bone mineral density, aortic calcification and cardiac workload in community-dwelling older Australians
AbstractSummaryIn older adults, lower bone density in the proximal femur was associated with increased heart burden, and this association was linked to calcification in the aorta. These results were seen in women but not in men.PurposeTo determine whether there is an association between lower bone mineral density (BMD) and increased cardiac workload in older adults, and if this association was independent of abdominal aortic calcification (AAC).MethodsThree hundred thirty-seven participants [mean  ± SD age = 70 ± 5 years and BMI = 28 ± 5 kg/m2...
Source: Osteoporosis International - April 4, 2017 Category: Orthopaedics Source Type: research

Severe hypoglycemia and hip fracture in patients with type 2 diabetes: a nationwide population-based cohort study
The objective of the study was to assess the risk of hip fracture among patients with type 2 diabetes mellitus (T2DM) and severe hypoglycemia.MethodsUsing the National Health Insurance Research database in Taiwan, we identified 2588 patients with T2DM who had developed severe hypoglycemia from 2001 to 2009. A comparison cohort who had never developed severe hypoglycemia was frequency matched at a ratio of approximately 1:2. Multivariate Cox proportional hazard regression analysis was used to evaluate the risk of hip fracture.ResultsDuring a median follow-up period of 3.9 years, there were 219 hip fracture events in 5173 co...
Source: Osteoporosis International - April 3, 2017 Category: Orthopaedics Source Type: research

Socioeconomic inequality in clinical outcome among hip fracture patients: a nationwide cohort study
ConclusionsHigher education and higher family income were associated with substantially lower 30-day mortality and risk of readmission after hip fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - March 18, 2017 Category: Orthopaedics Source Type: research

Impact of attention deficit hyperactivity disorder therapy on fracture risk in children treated in German pediatric practices
ConclusionADHD therapy was associated with a decrease in the risk of fracture in children and adolescents treated by German pediatricians. (Source: Osteoporosis International)
Source: Osteoporosis International - March 18, 2017 Category: Orthopaedics Source Type: research

Relationship between baseline characteristics and response to risedronate treatment for osteoporosis: data from three Japanese phase III trials
AbstractSummaryWe evaluated the influence of baseline age, bone mineral density (BMD), and serum levels of vitamin D on the response to risedronate treatment. Risedronate consistently increased BMD, but our results suggest vitamin D supplementation may be necessary to achieve optimal treatment effect. Furthermore, early intervention may help prevent bone fractures.IntroductionWe aimed to investigate the influence of baseline age, BMD, and vitamin D insufficiency on the response to risedronate treatment.MethodsData regarding 1447 patients was obtained from the registries of three phase III clinical trials of risedronate. Th...
Source: Osteoporosis International - March 18, 2017 Category: Orthopaedics Source Type: research

Serum 25-hydroxyvitamin D cutoffs for functional bone measures in postmenopausal osteoporosis
This study sought to determine the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health in postmenopausal women with low bone mass. A serum 25(OH)D concentration of 20  ng/mL rather than 30 ng/mL was appropriate for bone health.IntroductionThere is no consensus on the minimal serum 25-hydroxyvitamin D [25(OH)D] concentration required to maintain bone health. The aim of this study was to investigate the relationship between 25(OH)D measured via liquid chromatography-mass spectrometry (LC –MS/MS), which is the current gold standard, and biochemical markers of bone turnove...
Source: Osteoporosis International - March 18, 2017 Category: Orthopaedics Source Type: research

The incidence of hip fracture in Shiraz, Iran: a promising rate comparing to previous studies
ConclusionThe rate of osteoporotic hip fracture was relatively low in southern Iran. However, by aging population, this rate will increase and health policy makers should implement targeted osteoporosis screening and management programs. (Source: Osteoporosis International)
Source: Osteoporosis International - March 16, 2017 Category: Orthopaedics Source Type: research

Factors associated with acute-phase response of bisphosphonate-na ïve or pretreated women with osteoporosis receiving an intravenous first dose of zoledronate or ibandronate
AbstractSummaryA first intravenous dose of bisphosphonates may be associated with an acute-phase response (APR). In bisphosphonate-na ïve women with postmenopausal osteoporosis, the characteristics and frequency of APR may differ by compound. Prior bisphosphonate exposure was predictive of APR risk and severity.IntroductionIntravenous (IV) administration of bisphosphonates (BP), such as zoledronate (ZOL) and ibandronate (IBN), may be associated with an APR. The characteristics of APR may differ by compound. The aim of the present study was to evaluate the characteristics of APR (rates, signs and symptoms, severity), i...
Source: Osteoporosis International - March 15, 2017 Category: Orthopaedics Source Type: research

Bone mineral density among Korean females aged 20 –50 years: influence of age at menarche (The Korea National Health and Nutrition Examination Survey 2008–2011)
ConclusionsAge at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20 –50 years. Females with late menarche may achieve lower peak bone mass at some skeletal sites, which may put them at greater risk for osteoporosis in later life. (Source: Osteoporosis International)
Source: Osteoporosis International - March 14, 2017 Category: Orthopaedics Source Type: research

Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin
AbstractUndercarboxylated osteocalcin (ucOC) may play a role in glucose homeostasis and cardiometabolic health. This review examines the epidemiological and interventional evidence associating osteocalcin (OC) and ucOC with metabolic risk and cardiovascular disease. The complexity in assessing such correlations, due to the observational nature of human studies, is discussed. Several studies have reported that higher levels of ucOC and OC are correlated with lower fat mass and HbA1c. In addition, improved measures of glycaemic control via pharmacological and non-pharmacological (e.g. exercise or diet) interventions are ofte...
Source: Osteoporosis International - March 13, 2017 Category: Orthopaedics Source Type: research

Comments on Diez-Perez et al.: Recommendations for the screening of adherence to oral bisphosphonates
(Source: Osteoporosis International)
Source: Osteoporosis International - March 10, 2017 Category: Orthopaedics Source Type: research

Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis
ConclusionsAlthough our sample size was small, our data do not support the hypothesis that HBM-causing LRP5 mutations, associated with increased Wnt signaling, improve glucose metabolism in humans. However, it does appear that LRP5 variants may affect LDL metabolism, a major risk factor for coronary artery disease. The molecular mechanisms underpinning this effect warrant further study. (Source: Osteoporosis International)
Source: Osteoporosis International - March 10, 2017 Category: Orthopaedics Source Type: research

Recommendations for the screening of adherence to oral bisphosphonates: reply to comments by Zhou and Sheng
(Source: Osteoporosis International)
Source: Osteoporosis International - March 10, 2017 Category: Orthopaedics Source Type: research

Conclusions stand firm with additional data
(Source: Osteoporosis International)
Source: Osteoporosis International - March 9, 2017 Category: Orthopaedics Source Type: research

Economic evaluation of a population-based osteoporosis intervention for outpatients with non-traumatic non-hip fractures: the “Catch a Break” 1i [type C] FLS
AbstractSummaryFracture liaison services (FLS) are advocated to improve osteoporosis treatment after fragility fracture, but there are few economic analyses of different models. A population-based 1i [=type C] FLS for non-hip fractures was implemented and it costs $44 per patient and it was very cost-effective ($9200 per QALY gained). Small operational changes would convert it from cost-effective to cost-saving.IntroductionAfter fragility fracture,
Source: Osteoporosis International - March 9, 2017 Category: Orthopaedics Source Type: research

Cost-effectiveness analysis of once-yearly injection of zoledronic acid for the treatment of osteoporosis in Japan
ConclusionAlthough zoledronic acid is dominated by alendronate, the incremental QALY is quite small in extent. Considering the advantage of annual zoledronic acid treatment in compliance and persistence, zoledronic acid may be a cost-effective treatment option compared to alendronate. (Source: Osteoporosis International)
Source: Osteoporosis International - March 6, 2017 Category: Orthopaedics Source Type: research

Health state utility values and patient-reported outcomes before and after vertebral and non-vertebral fractures in an osteoporosis clinical trial
ConclusionsThe results suggest that incident morphometric vertebral fracture was associated with impairment of the HSUV for patients with osteoporosis not only immediately but also several months after the fracture. (Source: Osteoporosis International)
Source: Osteoporosis International - March 6, 2017 Category: Orthopaedics Source Type: research

The importance of physical function to people with osteoporosis
ConclusionMore information on how treatments impact physical function would benefit healthcare professionals and persons with OP in making treatment decisions and improving treatment compliance/persistence, as these impacts may be more salient to patients than fracture incidence. (Source: Osteoporosis International)
Source: Osteoporosis International - March 6, 2017 Category: Orthopaedics Source Type: research

Influence of systemic bone mineral density on atlantoaxial subluxation in patients with rheumatoid arthritis
ConclusionsOur study showed a possible association between lower BMD and AAS occurrence in patients with RA with lower BMI. Further studies are needed to confirm our findings. (Source: Osteoporosis International)
Source: Osteoporosis International - March 2, 2017 Category: Orthopaedics Source Type: research

Thoracolumbar kyphosis is associated with compressive vertebral fracture in postmenopausal women
ConclusionVertebral fracture prevalence in postmenopausal women was found to be associated with thoracolumbar kyphosis. A TLCobb sagittal angle>15 ° should be considered an indicator for vertebral fracture assessment. (Source: Osteoporosis International)
Source: Osteoporosis International - March 1, 2017 Category: Orthopaedics Source Type: research

Addition of a fracture risk assessment to a coordinator ’s role improved treatment rates within 6 months of screening in a fragility fracture screening program
ConclusionsAddition of a full-risk assessment to a coordinator-based program significantly improved treatment rates within 6  months of screening. (Source: Osteoporosis International)
Source: Osteoporosis International - February 9, 2017 Category: Orthopaedics Source Type: research

African Americans have lower TBS than whites among densitometry patients at a Chicago academic center
AbstractSummaryTrabecular bone score, an indirect measure of bone structure, may differ between ethnicities. We found that African Americans had lower trabecular bone score than do whites referred for densitometry, even when controlling for age and abdominal soft tissue thickness.PurposeTrabecular bone score (TBS), an indirect measure of bone structure, has been shown to predict fractures in predominantly white populations. Analysis of NHANES data revealed lower TBS in African Americans than in whites. However, it is not clear if this is true in patients referred for densitometry (where fracture risk stratification is most...
Source: Osteoporosis International - February 9, 2017 Category: Orthopaedics Source Type: research

The lumbar spine age-related degenerative disease influences the BMD not the TBS: the Osteolaus cohort
AbstractSummaryWe evaluated the influence of degenerative disease and fractured vertebra on lumbar spine bone mineral density (BMD) and trabecular bone score (TBS) in 1500 women aged 50 –80 years. TBS was not affected by a degenerative disease. While BMD increases after 62.5 years, TBS continues to decline. TBS should play a leading role in lumbar spine evaluation.IntroductionAfter menopause, lumbar spine (LS) BMD and TBS values decrease. Degenerative disease (DD) increases with age and affect LS BMD. The aim of this study was to measure changes in LS BMD and TBS in women 50 to 80  years old, taking in...
Source: Osteoporosis International - February 9, 2017 Category: Orthopaedics Source Type: research

The effectiveness of a multidisciplinary hip fracture care model in improving the clinical outcome and the average cost of manpower
ConclusionThis study proves that the GHFCP shortened the geriatric hip fracture patients ’ length of stay and improves the clinical outcomes. It is also cost-effective which proves better care is less costly. (Source: Osteoporosis International)
Source: Osteoporosis International - February 9, 2017 Category: Orthopaedics Source Type: research

Public health impact and economic evaluation of vitamin D-fortified dairy products for fracture prevention in France
ConclusionVitamin D-fortified dairy products have the potential to substantially reduce the burden of osteoporotic fractures in France and seem an economically beneficial strategy, especially in the general population aged above 70  years. (Source: Osteoporosis International)
Source: Osteoporosis International - February 7, 2017 Category: Orthopaedics Source Type: research

A novel accelerometer-based method to describe day-to-day exposure to potentially osteogenic vertical impacts in older adults: findings from a multi-cohort study
ConclusionsOur new accelerometer method appears to provide valid measures of higher vertical impacts in older adults. Results obtained from the three population-based cohorts indicate that older adults generally experience very limited higher impact weight-bearing PA. (Source: Osteoporosis International)
Source: Osteoporosis International - February 7, 2017 Category: Orthopaedics Source Type: research

Pre-fracture individual characteristics associated with high total health care costs after hip fracture
AbstractSummaryOlder women with pre-fracture slow walk speed, high body mass index, and/or a high level of multimorbidity have significantly higher health care costs after hip fracture compared to those without those characteristics. Studies to investigate if targeted health care interventions for these individuals can reduce hip fracture costs are warranted.IntroductionThe aim of this study is to estimate the associations of individual pre-fracture characteristics with total health care costs after hip fracture, using Study of Osteoporotic Fractures (SOF) cohort data linked to Medicare claims.MethodsOur study population w...
Source: Osteoporosis International - February 7, 2017 Category: Orthopaedics Source Type: research

Incident fracture associated with increased risk of mortality even after adjusting for frailty status in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study
ConclusionIncident clinical fracture was associated with an elevated risk of death independently of pre-fracture levels of frailty in community-dwelling elderly men. (Source: Osteoporosis International)
Source: Osteoporosis International - February 7, 2017 Category: Orthopaedics Source Type: research