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Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways
This study confirmed that LBPs, an effective hepatoprotective drug, may cure acute liver injury by lowering oxidative stress, repairing mitochondrial damage, and regulating metabolic pathways. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - February 1, 2023 Category: Universities & Medical Training Source Type: research

Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
概要本研究基于脂多糖 (LPS) 诱导的小鼠脓毒症模型, 探讨莲心碱 (LIE) 对脓毒症中脾损伤的潜在保护作用. 脓毒症常伴有炎症、 氧化应激和细胞凋亡, 并将导致身体器官功能障碍, 对脾脏损伤尤甚. 将 30 只小鼠随机分为 5 组 (n=6): 对照组、 LPS (10 mg/kg)、 LIE (10 mg/kg)+LPS、 LIE (20 mg/kg)+LPS 和 LIE (40 mg/kg)+LPS. 脾脏损伤通过苏木精–伊红染色 (H&E) 确定; 采用定量聚合酶链反应 (qPCR) 检测脾脏组织中肿瘤坏死因子 α (TNF-α)、 白细胞介素 6 (IL-6)、 IL-10、 IL-1β 和一氧化氮合酶 (iNOS) 的转录...
Source: Journal of Zhejiang University. Science. B. - February 1, 2023 Category: Universities & Medical Training Source Type: research

Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1 α pathways
In conclusion, our study revealed that targetingTRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy drugs. Thus,TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

Spatial transcriptome analysis of long non-coding RNAs reveals tissue specificity and functional roles in cancer
AbstractLong non-coding RNAs (lncRNAs) play a significant role in maintaining tissue morphology and functions, and their precise regulatory effectiveness is closely related to expression patterns. However, the spatial expression patterns of lncRNAs in humans are poorly characterized. Here, we constructed five comprehensive transcriptomic atlases of human lncRNAs covering thousands of major tissue samples in normal and disease states. The lncRNA transcriptomes exhibited high consistency within the same tissues across resources, and even higher complexity in specialized tissues. Tissue-elevated (TE) lncRNAs were identified i...
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

Exosome-mediated regulatory mechanisms in skeletal muscle: a narrative review
AbstractSkeletal muscle plays a paramount role in physical activity, metabolism, and energy balance, while its homeostasis is being challenged by multiple unfavorable factors such as injury, aging, or obesity. Exosomes, a subset of extracellular vesicles, are now recognized as essential mediators of intercellular communication, holding great clinical potential in the treatment of skeletal muscle diseases. Herein, we outline the recent research progress in exosomal isolation, characterization, and mechanism of action, and emphatically discuss current advances in exosomes derived from multiple organs and tissues, and enginee...
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

A novel defined risk signature of endoplasmic reticulum stress-related genes for predicting the prognosis and immune infiltration status of ovarian cancer
In conclusion, ER stress-related genes are vital factors predicting the prognosis of OvCa, and possess great application potential in the clinic. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

Multidisciplinary approach for the management of term pregnancy complicated by Eisenmenger syndrome
概要妊娠合并心脏病的发病率为0.5%~3.0%,是导致孕产妇死亡的非产科病因首位。而重度肺动脉高压的处理最为棘手,合并艾森曼格综合征的孕产妇死亡率高达30%~50%,剖宫产患者甚至达65%~75%。妊娠合并重度肺动脉高压属于妊娠禁忌,一旦诊 断需尽快终止妊娠,能达足月妊娠者临床非常罕见。本文报道一例足月妊娠合并重度肺动脉高压和艾森曼格综合征患者的成功诊治,旨在提高产科医师对该合并症的重视和多学科管理,并提高对该疾病围手术期的精细诊疗水平。 (Source: Journal of Zhejiang...
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin (Citrus reticulata Blanco) with citrine flavedo
摘要宽皮柑橘“柠檬不知火”是“不知火”的自然芽变品种,其果皮呈类似柠檬果皮的亮黄色,明显区别于“不知火”果皮的橘红色。本研究通过分析上述两种柑橘果皮中类胡罗卜素的含量和组分,及与其合成代谢相关基因的表达量,解析 两种柑橘果皮颜色的差异机制。测定结果显示,“不知火”中总类胡罗卜素含量显著高于芽变品种“柠檬不知火”,推测这是造成两种果皮颜色差异的主要原因。芽变品种中呈现橙色色素的组分β-隐黄质占比低于“不知火”;而与绿 -黄色调有关的�...
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

Role of melatonin receptor 1B gene polymorphism and its effect on the regulation of glucose transport in gestational diabetes mellitus
In conclusion, the rs10830963 variant was associated with an increased risk of GDM. The MT2 receptor is essential for melatonin to raise glucose uptake and transport, which may be mediated by PPARγ. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

Hypoxia-induced ROS aggravate tumor progression through HIF-1 α-SERPINE1 signaling in glioblastoma
AbstractHypoxia, as an important hallmark of the tumor microenvironment, is a major cause of oxidative stress and plays a central role in various malignant tumors, including glioblastoma. Elevated reactive oxygen species (ROS) in a hypoxic microenvironment promote glioblastoma progression; however, the underlying mechanism has not been clarified. Herein, we found that hypoxia promoted ROS production, and the proliferation, migration, and invasion of glioblastoma cells, while this promotion was restrained by ROS scavengersN-acetyl-l-cysteine (NAC) and diphenyleneiodonium chloride (DPI). Hypoxia-induced ROS activated hypoxia...
Source: Journal of Zhejiang University. Science. B. - January 1, 2023 Category: Universities & Medical Training Source Type: research

Isolated superior mesenteric artery rupture caused by abdominal trauma
概要肠系膜损伤在腹部钝性伤中发生率较低,但具有较高的致命性,临床诊治常具有挑战性。当钝性肠系膜损伤合并其他脏器损伤时,患者的临床症状明显,往往可以得到及时的诊断和治疗。但孤立性肠系膜损伤患者,病情隐匿,易发生漏诊 ,不能得到及时的诊治,影响患者的预后。本篇病例报道描述了一例在钢筋撞击后,发生孤立性肠系膜上动脉破裂出血的罕见病例。经检索发现,既往文献中未出现类似报道。该病例报道提示临床医生应该及时认识到这一隐匿的危重状 况,及时采取治�...
Source: Journal of Zhejiang University. Science. B. - December 1, 2022 Category: Universities & Medical Training Source Type: research

Macrophage migration inhibitory factor protects bone marrow mesenchymal stem cells from hypoxia/ischemia-induced apoptosis by regulating lncRNA MEG3
ConclusionsIn summary, we conclude that MIF protected BMSCs from H/I-induced apoptosis by downregulating the lncRNA MEG3/p53 signaling pathway, activating the Wnt/ β-catenin signaling pathway, and decreasing ROS levels. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - December 1, 2022 Category: Universities & Medical Training Source Type: research

Prevalence and risk factors of cardiovascular diseases and psychological distress among female scientists and technicians
This study aimed to explore the prevalence and risk factors of cardiovascular disease (CVD) and psychological distress among female scientists and technicians in China. Accordingly, we included scientists and technicians from representative research institutions, medical institutions, colleges, universities, and businesses in China, and the data were collected from July 1, 2019 to March 31, 2021 via online questionnaires. The parameters evaluated in this study included age, sex, marital status, educational background, monthly income, sleep hours, sleep problems, smoking, alcohol consumption, work-related stress, work burno...
Source: Journal of Zhejiang University. Science. B. - December 1, 2022 Category: Universities & Medical Training Source Type: research

Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening
In conclusion, for non-hibernating mice, moderate obesity had a certain protective effect on bones, demonstrating two-way regulation, incr easing both bone loss and bone formation. For pre-hibernating ground squirrels, the healthy obesity acquired before hibernation had a positive effect on the microstructure of bones, and also enhanced the expression levels of proteins related to bone formation, bone resorption, and Wnt signaling. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - December 1, 2022 Category: Universities & Medical Training Source Type: research

Development and validation of novel inflammatory response-related gene signature for sepsis prognosis
In conclusion, a signature consisting of nine IRRGs can be utilized to predict prognosis and influence the immunological status of sepsis patients. Thus, intervention based on these IRRGs may become a therapeutic option in the future. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - December 1, 2022 Category: Universities & Medical Training Source Type: research