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Erratum to: Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met
(Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - April 1, 2022 Category: Universities & Medical Training Source Type: research

Genetic diversity analysis of forty-three insertion/deletion loci for forensic individual identification in Han Chinese from Beijing based on a novel panel
摘要目的评估新研发的43个InDel位点复合体系在北京汉族群体中的法医学应用效能, 并探究北京汉族群体的遗传结构。创新点基于课题组自主研发的所有位点扩增子小于200bp, 适宜于降解检材分型的43个用于个体识别的InDel位点。研究为北京汉族群体的个体识别提供有效的分子遗传标记, 丰富北京汉族群体的InDel遗传数据。方法采集301名来自北京地区无血缘关系的健康个体血样, 通过毛细管电泳平台对这些样本的43个InDel位点进行复合扩增分型检测, 计算43个InDel位点在北京汉族群体...
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

Emerging role of protein modification in inflammatory bowel disease
AbstractThe onset of inflammatory bowel disease (IBD) involves many factors, including environmental parameters, microorganisms, and the immune system. Although research on IBD continues to expand, the specific pathogenesis mechanism is still unclear. Protein modification refers to chemical modification after protein biosynthesis, also known as post-translational modification (PTM), which causes changes in the properties and functions of proteins. Since proteins can be modified in different ways, such as acetylation, methylation, and phosphorylation, the functions of proteins in different modified states will also be diffe...
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

Evaluation and simplification of risk factors in FIGO 2000 scoring system for gestational trophoblastic neoplasia: a 19-year retrospective analysis
ConclusionsPretreatment serum hCG level and interval from antecedent pregnancy were independent predictors for both first-line and subsequent single-agent chemoresistance, and they had greater weight than other non-independent factors in predicting single-agent chemoresistance. The simplified model composed of certain selected factors is a promising alternative to the original FIGO 2000 prognostic system, and it shows comparable performance. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

A new benzaldehyde from the coral-derived fungus Aspergillus terreus C23-3 and its anti-inflammatory effects via suppression of MAPK signaling pathway in RAW264.7 cells
摘要目的研究从一株徐闻牡丹珊瑚来源的土曲霉C23-3的发酵液中所提取出来的新化合物(S)-3-(2,3- 二羟基-3-甲基丁基)-4-羟基苯甲醛((S)-3-(2,3-dihydroxy-3-methylbutyl)-4-hydroxybenzaldehyde)(1) 以及已知天然产物4-羟基-3-(3-甲基丁-2-烯-1-基)-苯甲醛(4-hydroxy-3-(3-methylbut-2-en-1-yl)-benzaldehyde)(2) 的抗氧化和抗炎活性及其机制。创新点从一株徐闻牡丹珊瑚来源的土曲霉C23-3的发酵液中所提取出来了一种新化合物1及已知天然产物2, 目前这两种苯甲醛的炎症相关研究尚未有报道。此外, 这两种苯甲醛在未来...
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

Modification of polyetheretherketone (PEEK) physical features to improve osteointegration
AbstractPolyetheretherketone (PEEK) has been widely applied in orthopedics because of its excellent mechanical properties, radiolucency, and biocompatibility. However, the bioinertness and poor osteointegration of PEEK have greatly limited its further application. Growing evidence proves that physical factors of implants, including their architecture, surface morphology, stiffness, and mechanical stimulation, matter as much as the composition of their surface chemistry. This review focuses on the multiple strategies for the physical modification of PEEK implants through adjusting their architecture, surface morphology, and...
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information
摘要目的头颈鳞癌是常见的恶性肿瘤之一, 预后较差。开发新的预后分子标志物对于改善头颈鳞癌患者的预后具有重要意义。因此, 本研究通过整合公共癌症数据库中的头颈鳞癌表达谱数据及临床生存信息, 开发了头颈鳞癌在线生存分析工 具OShnscc(Online consensus Survival tool for Head and Neck Squamous Cell Carcinoma), 用于评价基因mRNA表达量与头颈鳞癌患者生存时间的相关性。创新点本研究开发的OShnscc是目前为止包含头颈鳞癌预后数据集最多、样本量最大的在线生存分析工具。用户不仅可...
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

Ameliorative effect of scutellarin on acute alcohol brain injury in mice
概要随着酗酒导致的死亡比例逐年增加, 酒精对机体造成的伤害越来越受到重视。氧化应激和炎症是酗酒引起的最常见的病理现象。灯盏花乙素是从灯盏花中提取的黄酮类化合物。它具有抗炎症和抗氧化活性, 常被用于高血压、糖尿病 、神经炎等多种疾病。但是灯盏花乙素对酒精性脑损伤的是否具有保护作用尚不明确。因此, 本研究基于灯盏花乙素抗炎和抗氧化这两大靶点, 建立了小鼠急性酒精性脑损伤模型, 并进行组织病理学观察、生化指标检测和炎性因子 表达测定。结果...
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

Transition of autophagy and apoptosis in fibroblasts depends on dominant expression of HIF-1 α or p53
AbstractIt has been revealed that hypoxia is dynamic in hypertrophic scars; therefore, we considered that it may have different effects on hypoxia-inducible factor-1 α (HIF-1α) and p53 expression. Herein, we aimed to confirm the presence of a teeterboard-like conversion between HIF-1α and p53, which is correlated with scar formation and regression. Thus, we obtained samples of normal skin and hypertrophic scars to identify the differences in HIF-1α and autop hagy using immunohistochemistry and transmission electron microscopy. In addition, we used moderate hypoxia in vitro to simulate the proliferative scar, and silenc...
Source: Journal of Zhejiang University. Science. B. - March 1, 2022 Category: Universities & Medical Training Source Type: research

Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications
AbstractCancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppr...
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research

A high-efficiency and versatile CRISPR/Cas9-mediated HDR-based biallelic editing system
AbstractClustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 nuclease (Cas9), the third-generation genome editing tool, has been favored because of its high efficiency and clear system composition. In this technology, the introduced double-strand breaks (DSBs) are mainly repaired by non-homologous end joining (NHEJ) or homology-directed repair (HDR) pathways. The high-fidelity HDR pathway is used for genome modification, which can introduce artificially controllable insertions, deletions, or substitutions carried by the donor templates. Although high-level knock-out can be easily ...
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research

Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1
概要目的探究腹腔肿瘤微环境内脂肪因子趋化素 (chemerin) 与程序性死亡配体-1 (PD-L1) 是否存在关联, 及其对卵巢癌细胞系 HO8910 细胞生物学功能的影响.创新点首次发现了 chemerin 可以上调卵巢癌细胞 PD-L1 的表达, 促进肿瘤增殖和迁移. 这对进一步研究免疫抑制剂在卵巢癌治疗中的应用、 卵巢癌的早期诊断, 以及血清和腹水中 chemerin 的检测具有一定的指导意义. 此外, chemerin 结合其他脂肪 因子是否能成为卵巢癌诊断的标志物, 需进一步的研究证实.方法使用酶联免疫吸附剂测定 (ELI...
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research

Molecular hydrogen is a promising therapeutic agent for pulmonary disease
AbstractMolecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants. Short- or long-term exposure to these harmful substances often results in lung injury, causing respiratory and lung diseases. Acute and chronic respiratory diseases have high rates of morbidity and mortality and have become a major public health concern worldwide. For example, coronavirus disease 2019 (COVID-1...
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research

Analysis of volatile organic compounds in exhaled breath after radiotherapy
概要放射治疗具有一定风险, 主要是因为其在杀死癌细胞的同时可对正常细胞造成严重损伤. 呼气中的挥发性有机化合物 (VOCs) 可以提供人体内生理以及病理相关过程的信息, 具有监测机体损伤的潜力. 本研究收集了 10 名肺癌患者的 110 份呼气样本, 使用固相微萃取气相色谱-质谱技术 (SPME-GC/MS) 进行检测. 通过热图分析可发现 28 种 VOCs (包括芳香族化合物、 烷烃、 醛类、 酸类、 酮类、 醇类和酯类) 在放疗后 6 小时内发生规律性的变化. 通过对放疗前后 0.5 小时 的呼气样本进行 M...
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research

Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
概要目的探讨人类端粒酶逆转录酶 (h-TERT) 和 Ki-67 与子宫内膜异位症复发的相关性.创新点第一次将 h-TERT 和 Ki-67 联合表达水平可作为卵巢子宫内膜异位症复发的有用预测标志物.方法收集 30 例术后 30 个月复发的卵巢子宫内膜异位症患者、 30 例术后 30 个月未复发的卵巢子宫内膜异位症患者和 30 例对照组的子宫内膜异位症组织样本. 采用免疫组织化学方法检测异位子宫内膜组织中 h-TERT 和 Ki-67 的表达.结论h-TERT 和 Ki-67 联合表达水平可作为卵巢子宫内膜异位症复发的有用预测标...
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research