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Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology
AbstractTumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer. In addition to the common mechanisms underlying tumor recurrence, another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and metastasis. Transplant oncology is an emerging field that addresses oncological challenges in transplantation. In this context, a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of recipients. Double-negative T cells (DNTs) are a cl...
Source: Journal of Zhejiang University. Science. B. - May 1, 2023 Category: Universities & Medical Training Source Type: research

Rice bran oil supplementation protects swine weanlings against diarrhea and lipopolysaccharide challenge
AbstractEarly weaned piglets suffer from oxidative stress and enteral infection, which usually results in gut microbial dysbiosis, serve diarrhea, and even death. Rice bran oil (RBO), a polyphenol-enriched by-product of rice processing, has been shown to have antioxidant and anti-inflammatory properties both in vivo and in vitro. Here, we ascertained the proper RBO supplementation level, and subsequently determined its effects on lipopolysaccharide (LPS)-induced intestinal dysfunction in weaned piglets. A total of 168 piglets were randomly allocated into four groups of seven replicates (42 piglets each group, (21 ±1) d of...
Source: Journal of Zhejiang University. Science. B. - May 1, 2023 Category: Universities & Medical Training Source Type: research

Role of selenoprotein M knockdown in the melatonin antagonism of nickel-induced apoptosis and endoplasmic reticulum stress in mouse heart
AbstractThe aim of this study was to investigate the role of selenoprotein M (SelM) in endoplasmic reticulum stress and apoptosis in nickel-exposed mouse hearts and to explore the detoxifying effects of melatonin. At 21 d after intraperitoneal injection of nickel chloride (NiCl2) and/or melatonin into male wild-type (WT) and SelM knockout (KO) C57BL/6J mice, NiCl2 was found to induce changes in the microstructure and ultrastructure of the hearts of both WT and SelM KO mice, which were caused by oxidative stress, endoplasmic reticulum stress, and apoptosis, as evidenced by decreases in malondialdehyde (MDA) content and tota...
Source: Journal of Zhejiang University. Science. B. - May 1, 2023 Category: Universities & Medical Training Source Type: research

Dichloroacetic acid and rapamycin synergistically inhibit tumor progression
AbstractMammalian target of rapamycin (mTOR) controls cellular anabolism, and mTOR signaling is hyperactive in most cancer cells. As a result, inhibition of mTOR signaling benefits cancer patients. Rapamycin is a US Food and Drug Administration (FDA)-approved drug, a specific mTOR complex 1 (mTORC1) inhibitor, for the treatment of several different types of cancer. However, rapamycin is reported to inhibit cancer growth rather than induce apoptosis. Pyruvate dehydrogenase complex (PDHc) is the gatekeeper for mitochondrial pyruvate oxidation. PDHc inactivation has been observed in a number of cancer cells, and this alterati...
Source: Journal of Zhejiang University. Science. B. - May 1, 2023 Category: Universities & Medical Training Source Type: research

Network controllability analysis of awake and asleep conditions in the brain
摘要睡眠和清醒之间的差异对人类的健康至关重要, 清醒和睡眠之间的转换紊乱伴随脑部疾病, 因此需要深入研究其具体特征. 本研究引入网络可控性揭示大脑脑电活动中频率成分的功能特异性. 具体来说, 我们采用一个公开的颅内立体 脑电图数据集. 首先, 记录受试者清醒和睡眠条件下的脑电信号, 经过降噪、 伪迹去除等预处理方法, 通过带通滤波提取亚慢波 (0.1~1 Hz)、 δ (1~4 Hz)、 θ (4~8 Hz)、 α (8~13 Hz)、 β (13~30 Hz) 和 γ (30~45 Hz) 波段振荡. 其次, 利用锁相值 (PLV ) 和不重叠滑动...
Source: Journal of Zhejiang University. Science. B. - May 1, 2023 Category: Universities & Medical Training Source Type: research

Perforation of the esophagus: an overlooked cause of chest pain as a complication of esophageal foreign bodies
摘要胸痛是急诊科常见的主诉, 食管异物 (esophageal foreign body, EFB) 的摄入是导致胸痛的重要原因之一, 并可能引起一系列危及生命的情况. 在本文中我们报道了一例病例: 一名 67 岁的中国女性因胸痛入住当地医院, 因患者两年前曾有心肌 梗死病史, 当地医院以急性冠脉综合征对症治疗, 然而患者的症状始终不缓解且出现发热, 转至我院后行胸部 CT 提示食管异物伴食管穿孔. 患者紧急接受了内镜下食管异物取出术, 取出一根长约 3 cm 的鸭骨头. 考虑到中国有着多元的 饮食文化, 许多...
Source: Journal of Zhejiang University. Science. B. - May 1, 2023 Category: Universities & Medical Training Source Type: research

Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet
This study aimed to evaluate the dual regulatory effects and molecular mechanisms of diacylated anthocyanins from purple sweet potato (diacylated AF-PSPs) on hyperglycemia and hyperuricemia induced by a high-fructose/high-fat diet. The body weight, organ index, serum biochemical indexes, and liver antioxidant indexes of mice were measured, and the kidneys were observed in pathological sections. The relative expression levels of messenger RNAs (mRNAs) of fructose metabolism pathway enzymes in kidney were detected by fluorescent real-time quantitative polymerase chain (qPCR) reaction technique, and the expression of renal tr...
Source: Journal of Zhejiang University. Science. B. - April 15, 2023 Category: Universities & Medical Training Source Type: research

Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?
摘要为评估死亡供肾血栓和其诱导的受体血栓性微血管病（dir-TMA）对受体移植肾功能的影响，我们回顾性分析了33例活检病理显示微血栓的供体信息及受体预后。根据血栓累及肾小球范围是否大于50%，将33例供体分为弥漫血栓组（n=18 ）和局灶血栓组（n=15 ）。结果显示，弥漫血栓组的移植物延迟复功（DGF）发生率显著高于局灶血栓组（P=0.027 ），肾移植术后1个月，肾小球滤过率（eGFR）估值水平显著低于局灶血栓组（P=0.042 ）。此外，根据受体是否发生了dir-TMA，将33例受体进...
Source: Journal of Zhejiang University. Science. B. - April 15, 2023 Category: Universities & Medical Training Source Type: research

Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment
AbstractPeriodontitis is a complex chronic inflammatory disease. The invasion of pathogens induces the inflammatory microenvironment in periodontitis. Cell behavior changes in response to changes in the microenvironment, which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by cells. It has been confirmed that periodontal ligament stem cells (PDLSCs) are vital in the development of periodontal disease. Moreover, PDLSCs are the most effective cell type to be used for periodontium regeneration. This review focuses on changes in PDLSCs, their basic biological behavior, osteo...
Source: Journal of Zhejiang University. Science. B. - April 15, 2023 Category: Universities & Medical Training Source Type: research

Short-chain fatty acids ameliorate spinal cord injury recovery by regulating the balance of regulatory T cells and effector IL-17+ γδ T cells
AbstractSpinal cord injury (SCI) causes motor, sensory, and autonomic dysfunctions. The gut microbiome has an important role in SCI, while short-chain fatty acids (SCFAs) are one of the main bioactive mediators of microbiota. In the present study, we explored the effects of oral administration of exogenous SCFAs on the recovery of locomotor function and tissue repair in SCI. Allen ’s method was utilized to establish an SCI model in Sprague-Dawley (SD) rats. The animals received water containing a mixture of 150 mmol/L SCFAs after SCI. After 21 d of treatment, the Basso, Beattie, and Bresnahan (BBB) score increased, the r...
Source: Journal of Zhejiang University. Science. B. - April 1, 2023 Category: Universities & Medical Training Source Type: research

Iron accumulation and its impact on osteoporotic fractures in postmenopausal women
AbstractPostmenopausal osteoporosis is a kind of degenerative disease, also described as “invisible killer.” Estrogen is generally considered as the key hormone for women to maintain bone mineral content during their lives. Iron accumulation refers to a state of human serum ferritin that is higher than the normal value but less than 1000 µg/L. It has been found that iron accumulati on and osteoporosis could occur simultaneously with the decrease in estrogen level after menopause. In recent years, many studies indicated that iron accumulation plays a vital role in postmenopausal osteoporosis, and a significant correlat...
Source: Journal of Zhejiang University. Science. B. - April 1, 2023 Category: Universities & Medical Training Source Type: research

Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma
摘要为分析原发性开角型青光眼(primary open-angle glaucoma, POAG)黏小管成形术后早期短暂性高眼压的发生率及危险因素, 本研究纳入了本院顺利完成360°黏小管成形术的POAG患者。我们收集了以下数据: 术后各随访时间点眼压(intraocular pressure , IOP), 术后早期是否发生短暂性高眼压(定义: 术后1周至3月内IOP>21 mmHg 但能回落至≤21 mmHg)及术后一周最低IOP(IOPmin-1w)。根据是否发生术后早期短暂性高眼压, 将其分为正常眼压组(normal IOP, NIOP)和短暂性高眼压组(high IOP, HIOP)。此外, 我们也对术后...
Source: Journal of Zhejiang University. Science. B. - April 1, 2023 Category: Universities & Medical Training Source Type: research

Chinese young people ’s perceptions and preferences with regard to various edible urban plants
概要如今, 城市居民80%以上的时间都待在室内, 很少有时间接触大自然, 尤其是年轻人。研究发现, 植物对人们的身心健康有明显的积极影响, 不同特性的植物所产生的干预效果是不同的, 而且在情绪调节方面存在较大的个体差异, 这可能 与人们的性别和教育水平等背景密切相关。然而, 这些问题仍然没有得到解答。本研究利用486名中国年轻人的横断面数据, 分析了人们对各种可食用城市植物的看法和偏好, 并进一步探讨了食用植物调节情绪的主要潜在途径。结果 显示, 77.4%的参...
Source: Journal of Zhejiang University. Science. B. - April 1, 2023 Category: Universities & Medical Training Source Type: research

Diagnostic strategies for diseases with fever in dental clinics
概要发热是机体的一种保护机制,指体温升高超过了正常范围,作为许多疾病常见的伴随症状。其病因复杂多变,常牵扯全身系统病变。发热不仅在传染病的监测预警中起着重要作用,而且在口腔诊疗中也是常见症状。本文通过对口腔感染 途径及口腔相关发热疾病进行分类和总结,明确各种口腔发热疾病(包括新型冠状病毒感染)的发热特点和临床表现,增加“黏膜相关性感染”以及“黏膜相关性发热”作为感染途径及发热种类的补充,提出“六步一体”口腔发热疾病辨 析策略,并归纳...
Source: Journal of Zhejiang University. Science. B. - April 1, 2023 Category: Universities & Medical Training Source Type: research

Erratum to: Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo
(Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - April 1, 2023 Category: Universities & Medical Training Source Type: research