Journal of Zhejiang University. Science. B. 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Layers of interstitial fluid flow along a “slit-shaped” vascular adventitia
AbstractInterstitial fluid (ISF) flow through vascular adventitia has been discovered recently. However, its kinetic pattern was unclear. We used histological and topographical identification to observe ISF flow along venous vessels in rabbits. By magnetic resonance imaging (MRI) in live subjects, the inherent pathways of ISF flow from the ankle dermis through the legs, abdomen, and thorax were enhanced by paramagnetic contrast. By fluorescence stereomicroscopy and layer-by-layer dissection after the rabbits were sacrificed, the perivascular and adventitial connective tissues (PACTs) along the saphenous veins and inferior ...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances
AbstractLactic acid bacteria (LAB) are a representative probiotic. As the dominant flora in the human intestinal tract, LAB can regulate the balance of human intestinal flora and improve host health. The purpose of this study was to isolate and screen LAB that are well suited to the intestinal characteristics of the Chinese population, with excellent probiotics and high antibacterial activity. After 16S ribosomal RNA (rRNA) homology and phylogenetic tree analysis, potential probiotics were tested for their antibacterial activity, resistance to artificial gastrointestinal fluid and drugs, surface hydrophobicity, and safety....
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
Arthrospira maxima (Spirulina) prevents endoplasmic reticulum stress in the kidney through its C-phycocyanin
概要极大节螺藻 (Arthrospira maxima) 细胞内含有C-藻蓝蛋白, 其具有抗氧化和细胞保护作用, 因此该藻全细胞和C-藻蓝蛋白均被确认为保健品. 然而, 它们的保健效应尚未被充分认识. 由于它们可以降低未折叠蛋白反应, 我们推测, 极大节螺藻 细胞及其C-藻蓝蛋白可以防止肾脏内质网胁迫(ERS). 本文旨在研究极大节螺藻细胞及其C-藻蓝蛋白通过ERS反应对氯化汞 (HgCl2) 引起的肾损伤的影响. 实验公鼠先用极大节螺藻细胞或C-藻蓝蛋白处理30 min, 再用5 mg HgCl2/kg 体重处理, 之后三天均饲喂藻细...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
New insights on the utilization of ultrasonicated mustard seed cake: chemical composition and antagonistic potential for root-knot nematode, Meloidogyne javanica
This study focused, for the first time, on the effect of ultrasonic features on the extraction efficiency of secondary metabolites in mustard seed cake (MSC). The nematostatic potential of sonicated seed cake was examined against the second-stage juveniles (J2s) of root-knot nematode,Meloidogyne javanica. The results show that a 35 ppm (parts per million) concentration of a sonicated extract (SE) sample of MSC caused 65% J2s mortality at 18 h exposure period in vitro. It also significantly suppressed the root-knot index (RKI=0.94) in tomato roots. The lethal concentration values for SE were 51.76, 29.79, and 13.34 ppm, res...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
Potential effect of EGCG on the anti-tumor efficacy of metformin in melanoma cells
AbstractMetformin, a first-line drug for type 2 diabetes mellitus, has been recognized as a potential anti-tumor agent in recent years. Epigallocatechin-3-gallate (EGCG), as the dominant catechin in green tea, is another promising adjuvant agent for tumor prevention. In the present work, the potential effect of EGCG on the anti-tumor efficacy of metformin in a mouse melanoma cell line (B16F10) was investigated. Results indicated that EGCG and metformin exhibited a synergistic effect on cell viability, migration, and proliferation, as well as signal transducer and activator of transcription 3/nuclear factor- κB (STAT3/NF-...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
Inhibitory mechanism of angiotensin-converting enzyme inhibitory peptides from black tea
AbstractThe aim of this work is to discover the inhibitory mechanism of tea peptides and to analyse the affinities between the peptides and the angiotensin-converting enzyme (ACE) as well as the stability of the complexes using in vitro and in silico methods. Four peptide sequences identified from tea, namely peptides I, II, III, and IV, were used to examine ACE inhibition and kinetics. The half maximal inhibitory concentration (IC50) values of the four peptides were (210.03 ±18.29), (178.91±5.18), (196.31±2.87), and (121.11±3.38) µmol/L, respectively. The results of Lineweaver-Burk plots showed that peptides I, II, a...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats
摘要目的研究抗病毒药物洛匹那韦/利托那韦和阿比多尔在大鼠体内的药代动力学相互作用.创新点洛匹那韦/利托那韦联合阿比多尔作为国内多家医疗单位治疗 COVID-19 患者的基础抗病毒方案, 两者的药物相互作用未有研究报道, 本论文通过开展体内药动学实验, 探索合用后药物体内暴露量的改变, 为该方案的临床治疗有效性和安 全性提供保障.方法建立大鼠洛匹那韦/利托那韦与阿比多尔药动学相互作用模型. 将大鼠分为3组(阿比多尔组、洛匹那韦/利托那韦组及联用组). 洛匹那韦/...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response
In this study, we identified the dramatic expression changes of more than half of potential miR-155-targeted genes upon lipopolysaccharide (LPS) stimulation; 223 genes were down-regulated and 85 genes were up-regulated, including suppressor of cytokine signaling 1 (SOCS1) and transforming growth factor- β-activated kinase 1-binding protein 2 (TAB2), two well-known genes involved in miR-155-mediated regulation of the Toll-like receptor 4 (TLR4) signaling pathway. We also found that miR-155 acted as an anti-inflammatory mediator in the initial stage of LPS-induced inflammatory response mainly through repressing TAB2 protein...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
How silicon fertilizer improves nitrogen and phosphorus nutrient availability in paddy soil?
AbstractIn order to reveal the mechanism of silicon (Si) fertilizer in improving nitrogen (N) and phosphorus (P) nutrient availability in paddy soil, we designed a series of soil culture experiments by combining application of varying Si fertilizer concentrations with fixed N and P fertilizer concentrations. Following the recommendations of fertilizer manufacturers and local farmers, we applied Si in concentrations of 0, 5.2, 10.4, 15.6, and 20.8 µg/kg. At each concentration of added Si, the availability of soil N and P nutrients, soil microbial activity, numbers of ammonia-oxidizing bacteria and P-decomposing bacteria wh...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research
3D brain glioma segmentation in MRI through integrating multiple densely connected 2D convolutional neural networks
AbstractTo overcome the computational burden of processing three-dimensional (3D) medical scans and the lack of spatial information in two-dimensional (2D) medical scans, a novel segmentation method was proposed that integrates the segmentation results of three densely connected 2D convolutional neural networks (2D-CNNs). In order to combine the low-level features and high-level features, we added densely connected blocks in the network structure design so that the low-level features will not be missed as the network layer increases during the learning process. Further, in order to resolve the problems of the blurred bound...
Source: Journal of Zhejiang University. Science. B. - June 1, 2021 Category: Universities & Medical Training Source Type: research
Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulose
In this study, the fibers of invasive speciesAgave americana L. andRicinus communis L. were successfully used for the first time as new sources to produce cytocompatible and highly crystalline cellulose nanofibers. Cellulose nanofibers were obtained by two methods, based on either alkaline or acid hydrolysis. The morphology, chemical composition, and crystallinity of the obtained materials were characterized by scanning electron microscopy (SEM) together with energy-dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy. The crystalli...
Source: Journal of Zhejiang University. Science. B. - June 1, 2021 Category: Universities & Medical Training Source Type: research
Clinically applicable artificial intelligence algorithm for the diagnosis, evaluation, and monitoring of acute retinal necrosis
AbstractThe prompt detection and proper evaluation of necrotic retinal region are especially important for the diagnosis and treatment of acute retinal necrosis (ARN). The potential application of artificial intelligence (AI) algorithms in these areas of clinical research has not been reported previously. The present study aims to create a computational algorithm for the automated detection and evaluation of retinal necrosis from retinal fundus photographs. A total of 149 wide-angle fundus photographs from 40 eyes of 32 ARN patients were collected, and the U-Net method was used to construct the AI algorithm. Thereby, a nov...
Source: Journal of Zhejiang University. Science. B. - June 1, 2021 Category: Universities & Medical Training Source Type: research
Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit
AbstractJujube (Ziziphus jujuba Mill.), a highly nutritious and functional fruit, is reported to have various health benefits and has been extensively planted worldwide, especially in China. Many studies have shown that bioactive components derived from jujube fruit have significant nutritional and potential biological effects. In this paper, the latest progress in research on major bioactive compounds obtained from jujube is reviewed, and the potential biological functions of jujube fruit resources are discussed. As a dietary supplement, jujube fruit is well recognized as a healthy food which contains a variety of bioacti...
Source: Journal of Zhejiang University. Science. B. - June 1, 2021 Category: Universities & Medical Training Source Type: research
Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study
Conclusions: Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - June 1, 2021 Category: Universities & Medical Training Source Type: research
Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis
AbstractDysregulated crosstalk between different signaling pathways contributes to tumor development, including resistance to cancer therapy. In the present study, we found that the mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway, while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase (ERK) signaling. In particular, the most...
Source: Journal of Zhejiang University. Science. B. - June 1, 2021 Category: Universities & Medical Training Source Type: research
