Journal of Zhejiang University. Science. B. Journal of Zhejiang University. Science. B. RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of the prognostic ability of serum uric acid for elderly acute coronary syndrome patients with diabetes mellitus: a prospective cohort study
Conclusions: Serum UA level is a strong independent predictor of long-term all-cause deat h and MACE in elderly ACS patients with DM. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - October 1, 2021 Category: Universities & Medical Training Source Type: research

Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway
Conclusions: These results indicated that LIPUS could ameliorate AngII-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway, providing new insights for the development of novel therapeutic apparatus in clinical practice. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - October 1, 2021 Category: Universities & Medical Training Source Type: research

Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure
In this study, we established a mouse model of repeated transient Spike IOP to investigate the direct damage to the retina following Spike IOP attacks, and elucidated the underlying molecular mechanism. We analyzed the changes in the number of retinal ganglion cells (RGCs) via immunofluorescence. Thereafter, we detected retinal cell apoptosis via terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick-end labeling (TUNEL) staining, and performed RNA sequencing (RNA-seq) to reveal the underlying molecular mechanism. Finally, we validated the expression of key molecules in the endoplasmic reticulum (ER) s...
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
This study aimed to uncover underlying mechanisms and promising intervention targets of heart failure (HF)-related stroke. HF-related dataset GSE42955 and stroke-related dataset GSE58294 were obtained from the Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules and hub genes. Gene Ontology (GO) and pathway enrichment analyses were performed on genes in the key modules. Genes in HF- and stroke-related key modules were intersected to obtain common genes for HF-related stroke, which were further intersected with hub genes of stroke-related key modu...
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies
概要低剂量率脉冲放射治疗(Pulsed low-dose rate, PLDR)是一种有效且安全的创新性放疗模式. 这种放疗模式可用于肿瘤复发的再程放疗, 同时肿瘤体积大、 无法耐受常规放疗模式的肿瘤患者也能从中获得较好的姑息治疗疗效。在本研究中, 我 们首次提出了胰腺癌和前列腺癌的最佳PLDR模型, 研究结果表明个性化的PLDR是一种有效的治疗腹部和盆腔癌的方法. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics
In conclusion, our study presents a comprehensive landscape of plasma metabolites in AAA and AS patients, and provides a research direction for pathogenetic mechanisms in atherosclerotic AAA. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size
In this study, the mRNA expression level ofIGF2BP2 was found to be significantly higher in a single-lamb group than in a multi-lamb group. Insertions/deletions (indels) within the goatIGF2BP2 gene, including P4-Ins-13bp and P5-Del-12bp, were verified in 918 Shaanbei White Cashmere (SBWC) female goats. The minor allelic frequencies (MAFs) of P4-Ins-13bp and P5-Del-12bp loci were 0.349 and 0.295, respectively. Analysis using the Chi-square (χ2) test showed that the genotype (χ2=14.479,P=0.006) distribution of P4-Ins-13bp was significantly different between the single-lamb and multi-lamb groups. Correlation analysis demonst...
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Effects of S-adenosylmethionine on production of secondary metabolites in Streptomyces diastatochromogenes 1628
概要目的考察S-腺苷甲硫氨酸(SAM)对淀粉酶产色链霉菌(Streptomyces diastatochromogenes)1628 次级代谢产物产量的影响.创新点SAM 是甲基的重要供体, 可为次级代谢产物提供前体, 同时也可以作为信号增强次级代谢产物合成基因的表达. 因此, 本研究首次探究了SAM与S. diastatochromogenes 1628 次级代谢产物合成的相关性.方法以S. diastatochromogenes 1628 为对象, 通过体外添加SAM以及在S. diastatochromogenes 1628 体内过表达、 敲除和回补SAM编码基因metKsd, 考察S. diastatochromogenes 1628 次级代谢产物产量的变化....
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF- κB pathways
概要目的以利用小鼠原代腹腔巨噬细胞建立了一种温和气单胞菌体外感染模型, 探究MAPK、 AKT和NF-κB信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制, 为防治温和气单胞菌造成的感染提供新的治疗靶点.创新点首次探究了丝裂原活化蛋白激酶(mitogen-activated protein kinase, MAPK)、 蛋白激酶B(protein kinase B, AKT)和核因子κB(nuclear factor kappa B, NF-κB)信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制, 并分别从正反向进行了 研究, 围绕NF-κB...
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Application of extracorporeal therapies in critically ill COVID-19 patients
AbstractThe coronavirus disease 2019 (COVID-19) pandemic is a major public health event caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has spread widely all over the world. A high proportion of patients become severely or critically ill, and suffer high mortality due to respiratory failure and multiple organ dysfunction. Therefore, providing timely and effective treatment for critically ill patients is essential to reduce overall mortality. Convalescent plasma therapy and pharmacological treatments, such as aerosol inhalation of interferon- α (IFN-α), corticosteroids, and tocilizumab, ha...
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses
AbstractToll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs) proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response. Studies have shown that unlike other TLR family members, TLR3 is the only RNA sensor that is utterly dependent on the Toll-interleukin-1 receptor (TIR)-domain-containing adaptor-inducing IFN- β (TRIF). However, the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear. In this review we focus on recent advances in understandin...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research

Hemin-induced increase in saponin content contributes to the alleviation of osmotic and cold stress damage to Conyza blinii in a heme oxygenase 1-dependent manner
This study revealed that hemin can increase the saponin content ofC. blinii and alleviate the damage caused by abiotic stress, and it also broadened the understanding of the relationship between hemin and secondary metabolites in plant abiotic stress relief. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research

LG-ESSs and HG-ESSs: underlying molecular alterations and potential therapeutic strategies
AbstractEndometrial stromal tumors (ESTs) include endometrial stromal nodule (ESN), low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and undifferentiated uterine sarcoma (UUS). Since these are rare tumor types, there is an unmet clinical need for the systematic therapy of advanced LG-ESS or HG-ESS. Cytogenetic and molecular advances in ESTs have shown that multiple recurrent gene fusions are present in a large proportion of LG-ESSs, and HG-ESSs are identified by the tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE)-family with sequence sim...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research

Successful treatment of refractory pure red cell aplasia with eltrombopag after ABO-incompatible allogeneic hematopoietic stem cell transplantation
摘要纯红细胞再生障碍性贫血是ABO血型不合的异基因造血干细胞移植后常见的并发症。治疗该并发症有多种方法可供选择,包括大剂量激素、促红细胞生成素、血浆置换、免疫吸附、供者淋巴细胞输注、利妥昔单抗、硼替佐米、达雷木 单抗以及减停免疫抑制剂等。在本文中,我们呈现了一个ABO血型不合的异基因造血干细胞移植后出现纯红细胞再生障碍性贫血的病例。重组人促红细胞生成素、糖皮质激素、供着淋巴细胞输注、血浆置换以及减停免疫抑制剂等方法 均对其无明显...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research

Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer
AbstractCopy number variations (CNVs), which can affect the role of long non-coding RNAs (lncRNAs), are important genetic changes seen in some malignant tumors. We analyzed lncRNAs with CNV to explore the relationship between lncRNAs and prognosis in bladder cancer (BLCA). Messenger RNA (mRNA) expression levels, DNA methylation, and DNA copy number data of 408 BLCA patients were subjected to integrative bioinformatics analysis. Cluster analysis was performed to obtain different subtypes and differently expressed lncRNAs and coding genes. Weighted gene co-expression network analysis (WGCNA) was performed to identify the co-...
Source: Journal of Zhejiang University. Science. B. - July 1, 2021 Category: Universities & Medical Training Source Type: research