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Sortilin-induced lipid accumulation and atherogenesis are suppressed by HNF1b SUMOylation promoted by flavone of Polygonatum odoratum
This study aims to investigate the impact of hepatocyte nuclear factor 1 β (HNF1b) on macrophage sortilin-mediated lipid metabolism and aortic atherosclerosis and explore the role of the flavone ofPolygonatum odoratum (PAOA-flavone)-promoted small ubiquitin-related modifier (SUMO) modification in the atheroprotective efficacy of HNF1b. HNF1b was predicted to be a transcriptional regulator of sortilin expression via bioinformatics, dual-luciferase reporter gene assay, and chromatin immunoprecipitation. HNF1b overexpression decreased sortilin expression and cellular lipid contents in THP-1 macrophages, leading to a depressi...
Source: Journal of Zhejiang University. Science. B. - November 1, 2023 Category: Universities & Medical Training Source Type: research

Spatial expression of the nonsense-mediated mRNA decay factors UPF3A and UPF3B among mouse tissues
摘要无义介导的信使RNA(mRNA)降解途径(nonsense-mediated mRNA decay,简称为NMD)是真核生物细胞内一种重要的基因转录后表达调控机制,它积极参与一系列细胞生理和生化过程,控制细胞命运和生命体的组织稳态。NMD的缺陷会导致人类疾病,如神经 发育障碍、肿瘤发生和自身免疫疾病等。UPF3(Up-frameshift protein 3)是一个核心的NMD因子,它最早在酵母中被发现。UPF3A和UPF3B是UPF3在生物进化到脊椎动物阶段出现的两个旁系同源物,在NMD中具有激活或抑制的作用。以往研究发现,UPF3B蛋 白几乎在所有哺...
Source: Journal of Zhejiang University. Science. B. - November 1, 2023 Category: Universities & Medical Training Source Type: research

Spatiotemporal coding of natural odors in the olfactory bulb
摘要气味是评价食品新鲜度最重要的参数之一。当气味以其自然浓度存在时,会在嗅觉系统中引发不同的神经活动 模式。本研究提出了一种通过检测食物气味进行食物检测与评价的在体生物传感系统。我们通过将多通道微电极植入 在 清醒大鼠嗅球的僧帽/丛状细胞层上,进而对神经信号进行实时检测。结果表明,不同的气味可以引起不同的神经振 荡活动,每个僧帽/丛状细胞会表现出特定气味的锋电位发放模式。单个大鼠的少量细胞携带足够的信息,可以根据锋 电 位发放频率变...
Source: Journal of Zhejiang University. Science. B. - November 1, 2023 Category: Universities & Medical Training Source Type: research

Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine
AbstractSilk fibroin (SF) as a natural biopolymer has become a popular material for biomedical applications due to its minimal immunogenicity, tunable biodegradability, and high biocompatibility. Nowadays, various techniques have been developed for the applications of SF in bioengineering. Most of the literature reviews focus on the SF-based biomaterials and their different forms of applications such as films, hydrogels, and scaffolds. SF is also valuable as a coating on other substrate materials for biomedicine; however, there are few reviews related to SF-coated biomaterials. Thus, in this review, we focused on the surfa...
Source: Journal of Zhejiang University. Science. B. - October 20, 2023 Category: Universities & Medical Training Source Type: research

Application of interim PET-CT in first-line treatment decision-making for lymphoma
AbstractRecent advances in lymphoma treatment have significantly improved the survival of patients; however, the current approaches also have varying side effects. To overcome these, it is critical to implement individualized treatment according to the patient ’s condition. Therefore, the early identification of high-risk groups and targeted treatment are important strategies for prolonging the survival time and improving the quality of life of patients. Interim positron emission tomography-computed tomography (PET-CT) has a high prognostic value, which can reflect chemosensitivity and identify patients for whom treatmen...
Source: Journal of Zhejiang University. Science. B. - October 1, 2023 Category: Universities & Medical Training Source Type: research

Cellulose nanofibril matrix drives the dynamic formation of spheroids
This study introduces an efficient method to drive rapid multicellular spheroid formation by a cellulose nanofibril matrix. This matrix enables the facilitated growth of spheroids (within 48 h) through multiple cell assembly into size-controllable aggregates with well-organized physiological microstructure. The efficiency, dimension, and conformation of the as-formed spheroids depend on the concentration of extracellular nanofibrils, the number of assembled cells, and the heterogeneity of cell types. The above strategy allows the robust formation mechanism of compacted tumoroids and hepatocyte spheroids. (Source: Journal o...
Source: Journal of Zhejiang University. Science. B. - October 1, 2023 Category: Universities & Medical Training Source Type: research

Development and validation of a risk-prediction model for immune-related adverse events in patients with non-small-cell lung cancer receiving PD-1/PD-L1 inhibitors
摘要在非小细胞肺癌(NSCLC)患者中,程序性细胞死亡蛋白-1/程序性细胞死亡蛋白-配体1(PD-1/PD-L1)抑制剂治疗后的免疫相关不良事件(irAEs)已被广泛报道。然而,在NSCLC患者中缺少PD-1/PD-L1抑制剂使用后发生irAEs的预测模型。本回顾性研究纳入了 357例接受PD-1/PD-L1抑制剂治疗的NSCLC患者,从电子病历系统中收集了治疗前一周内患者的基线人口统计学特征和实验室参数。通过随访采集患者PD-1/PD-L1抑制剂治疗后发生irAEs的情况及长期预后,包括无进展生存期(PFS)和总生存期(OS)。首 先,应用Cox比...
Source: Journal of Zhejiang University. Science. B. - October 1, 2023 Category: Universities & Medical Training Source Type: research

Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives
AbstractOver the past decade, dramatic progress has been made in dental research areas involving laser therapy. The photobiomodulatory effect of laser light regulates the behavior of periodontal tissues and promotes damaged tissues to heal faster. Additionally, photobiomodulation therapy (PBMT), a non-invasive treatment, when applied in orthodontics, contributes to alleviating pain and reducing inflammation induced by orthodontic forces, along with improving tissue healing processes. Moreover, PBMT is attracting more attention as a possible approach to prevent the incidence of orthodontically induced inflammatory root reso...
Source: Journal of Zhejiang University. Science. B. - September 27, 2023 Category: Universities & Medical Training Source Type: research

Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of mim-1 promoter
This study aims to gain insight into the DNA-specific recognition mechanism of c-Myb transcription factor during the regulation of cell early differentiation and proliferation. Therefore, we chose the chicken myeloid gene, mitochondrial import protein 1 (mim-1), as a target to study the binding specificity between potential dual-Myb-binding sites. The c-Myb-binding site inmim-1 is a pseudo-palindromic sequence AACGGTT, which contains two AACNG consensuses. Simulation studies in different biological scenarios revealed that c-Myb binding withmim-1 in the forward strand (complex F) is more stable than that in the reverse stra...
Source: Journal of Zhejiang University. Science. B. - September 23, 2023 Category: Universities & Medical Training Source Type: research

Third molar-related knowledge, attitudes, behaviors, and medical history of 904 Chinese adults: a cross-sectional survey
In conclusion, the population investigated had a shortage of knowledge about M3s and adopted negative attitudes and actions about M3-related problems. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - September 23, 2023 Category: Universities & Medical Training Source Type: research

Effects of Aeriscardovia aeriphila on growth performance, antioxidant functions, immune responses, and gut microbiota in broiler chickens
In conclusion, oral administration ofA. aeriphila could improve the growth performance, serum antioxidant capacity, immune modulation, and gut health of broilers. Our findings may provide important information for the application ofA. aeriphila in poultry production. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - September 22, 2023 Category: Universities & Medical Training Source Type: research

Detection and quantitative analysis of tumor-associated tertiary lymphoid structures
This study reviews the latest research progress on TLS detection and quantification, proposes new directions for TLS assessment, and addresses issues for the quantitative application of TLSs in the clinic. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - September 1, 2023 Category: Universities & Medical Training Source Type: research

Current insights on rice (Oryza sativa L.) bakanae disease and exploration of its management strategies
AbstractBakanae is an emerging rice disease caused by the seed- and soil-borne pathogenFusarium fujikuroi. It is becoming a more serious threat to sustainable rice production throughout rice-growing regions. Bakanae disease infection is responsible for high yield losses ranging from 3% to 95%, and disease incidence varies based on the region and cultivars. Hence, understanding the nature of the pathogen, its pathogenicity, disease epidemiology, symptoms, host –pathogen interaction, and the role of secondary metabolites in the disease cycle will be helpful in the development of effective and sustainable management strateg...
Source: Journal of Zhejiang University. Science. B. - September 1, 2023 Category: Universities & Medical Training Source Type: research

Genetic and histological relationship between pheromone-secreting tissues of the musk gland and skin of juvenile Chinese forest musk deer (Moschus berezovskii Flerov, 1929)
ConclusionsThe musk gland of Chinese FMD may be a derivative of skin tissue, and Sox9, Cav-1, and AR may play significant roles in musk gland development. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - September 1, 2023 Category: Universities & Medical Training Source Type: research

OCT4 ’s role and mechanism underlying oral squamous cell carcinoma
AbstractOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem cells (ESCs). According to recent studies, OCT4 participates in retaining the s...
Source: Journal of Zhejiang University. Science. B. - September 1, 2023 Category: Universities & Medical Training Source Type: research