Journal of Zhejiang University. Science. B. 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Index of microcirculatory resistance: state-of-the-art and potential applications in computational simulation of coronary artery disease
AbstractThe dysfunction of coronary microcirculation is an important cause of coronary artery disease (CAD). The index of microcirculatory resistance (IMR) is a quantitative evaluation of coronary microcirculatory function, which provides a significant reference for the prediction, diagnosis, treatment, and prognosis of CAD. IMR also plays a key role in investigating the interaction between epicardial and microcirculatory dysfunctions, and is closely associated with coronary hemodynamic parameters such as flow rate, distal coronary pressure, and aortic pressure, which have been widely applied in computational studies of CA...
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research
Erratum to: Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment
(Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - February 1, 2022 Category: Universities & Medical Training Source Type: research
Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering
AbstractCarbon nanotube (CNT) composite materials are very attractive for use in neural tissue engineering and biosensor coatings. CNT scaffolds are excellent mimics of extracellular matrix due to their hydrophilicity, viscosity, and biocompatibility. CNTs can also impart conductivity to other insulating materials improve mechanical stability guide neuronal cell behavior and trigger axon regeneration. The performance of chitosan (CS)/polyethylene glycol (PEG) composite scaffolds could be optimized by introducing multi-walled CNTs (MWCNTs). CS/PEG/CNT composite scaffolds with CNT content of 1%, 3%, and 5% (1%=0.01 g/mL) wer...
Source: Journal of Zhejiang University. Science. B. - January 1, 2022 Category: Universities & Medical Training Source Type: research
A comprehensive update: gastrointestinal microflora, gastric cancer and gastric premalignant condition, and intervention by traditional Chinese medicine
AbstractWith the recent upsurge of studies in the field of microbiology, we have learned more about the complexity of the gastrointestinal microecosystem. More than 30 genera and 1000 species of gastrointestinal microflora have been found. The structure of the normal microflora is relatively stable, and is in an interdependent and restricted dynamic equilibrium with the body. In recent years, studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer (GC) and precancerous lesions. So, restoring the balance of gastrointestinal microflora is of great significanc...
Source: Journal of Zhejiang University. Science. B. - January 1, 2022 Category: Universities & Medical Training Source Type: research
Efficient gene editing in a medaka (Oryzias latipes) cell line and embryos by SpCas9/tRNA-gRNA
In this study, we employed a poly-transfer RNA (tRNA)-gRNA (PTG) system driven by cytomegalovirus (CMV) promoter to target the medaka (Oryzias latipes) endogenous gene tyrosinase (tyr) or paired box 6.1 (pax6.1) and illustrated its function in a medaka cell line and embryos. The PTG system was combined with the CRISPR/Cas9 system under high levels of promoter to successfully induce gene editing in medaka. This is a valuable step forward in potential application of the CRISPR/Cas9 system in medaka and other teleosts. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - January 1, 2022 Category: Universities & Medical Training Source Type: research
Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios
AbstractMesenchymal stem/stromal cell (MSC)-based therapy has been regarded as one of the most revolutionary breakthroughs in the history of modern medicine owing to its myriad of immunoregulatory and regenerative properties. With the rapid progress in the fields of osteo- and musculoskeletal therapies, the demand for MSC-based treatment modalities is becoming increasingly prominent. In this endeavor, researchers around the world have devised new and innovative techniques to support the proliferation of MSCs while minimizing the loss of hallmark features of stem cells. One such example is electromagnetic field (EMF) exposu...
Source: Journal of Zhejiang University. Science. B. - January 1, 2022 Category: Universities & Medical Training Source Type: research
Chemical characterization of a new sulfated polysaccharide from Gracilaria chouae and its activation effects on RAW264.7 macrophages
概述目的脆江蓠是中国沿海广泛分布的重要经济红藻, 多糖是其主要生物成分, 通过对其多糖分离纯化, 化学表征及活性评价, 为脆江蓠的开发奠定实验基础。创新点首次从脆江蓠中得到均一硫酸化多糖GCP-3A, 并发现其多糖对巨噬细胞RAW264.7具有显著激活作用。方法以脆江蓠为原料, 采用水提醇沉, 柱层析等方法分离纯化得到脆江蓠硫酸化多糖GCP-3A; 采用凝胶渗透色谱(GPC), 气相色谱-质谱(GC-MS), 傅里叶变换红外光谱(FT-IR)和核磁共振(NMR)探究其化学特征; 采用扫描电镜(SEM)和刚果红研...
Source: Journal of Zhejiang University. Science. B. - January 1, 2022 Category: Universities & Medical Training Source Type: research
A dynamically evolving war between autophagy and pathogenic microorganisms
AbstractAutophagy is an intracellular degradation process that maintains cellular homeostasis. It is essential for protecting organisms from environmental stress. Autophagy can help the host to eliminate invading pathogens, including bacteria, viruses, fungi, and parasites. However, pathogens have evolved multiple strategies to interfere with autophagic signaling pathways or inhibit the fusion of autophagosomes with lysosomes to form autolysosomes. Moreover, host cell matrix degradation by different types of autophagy can be used for the proliferation and reproduction of pathogens. Thus, determining the roles and mechanism...
Source: Journal of Zhejiang University. Science. B. - January 1, 2022 Category: Universities & Medical Training Source Type: research
Basophils as a potential therapeutic target in cancer
AbstractBasophils, which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation, have been neglected by researchers in the past decades. Previous studies have revealed their vital roles in allergic diseases and parasitic infections. Intriguingly, recent studies even reported that basophils might be associated with cancer development, as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers. However, it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components; the answer may dep...
Source: Journal of Zhejiang University. Science. B. - December 1, 2021 Category: Universities & Medical Training Source Type: research
3D printing of bioinspired compartmentalized capsular structure for controlled drug release
In this study, inspired by successive opening of layered structures and compartmentalized structures in plants, we designed a multiple compartmentalized capsular structure for controlled drug delivery. The structure was designed as a series of compartments, defined by the gradient thickness of their external walls and internal divisions. Based on the careful choice and optimization of bioinks composed of gelatin, starch, and alginate, the capsular structures were successfully manufactured by fused deposition modeling three-dimensional (3D) printing. The capsules showed fusion and firm contact between printed layers, formin...
Source: Journal of Zhejiang University. Science. B. - December 1, 2021 Category: Universities & Medical Training Source Type: research
Effects of gibberellin priming on seedling emergence and transcripts involved in mesocotyl elongation in rice under deep direct-seeding conditions
AbstractMesocotyl elongation is a key trait influencing seedling emergence and establishment in direct-seeding rice cultivation. The phytohormone gibberellin (GA) has positive effects on mesocotyl elongation in rice. However, the physiological and molecular basis underlying the regulation of mesocotyl elongation mediated by GA priming under deep-sowing conditions remains largely unclear. In the present study, we performed a physiological and comprehensive transcriptomic analysis of the function of GA priming in mesocotyl elongation and seedling emergence using a direct-seedingjaponica rice cultivar ZH10 at a 5-cm sowing de...
Source: Journal of Zhejiang University. Science. B. - December 1, 2021 Category: Universities & Medical Training Source Type: research
Development of a novel chemokine signaling-based multigene signature to predict prognosis and therapeutic response in colorectal cancer
概要目的开发一种基于趋化因子信号通路的多基因模型, 可以有效预测结直肠癌患者的总生存期和治疗反应.创新点结直肠癌具有高度异质性, 迫切需要开发可靠的标志物用于预测患者的预后和治疗效果. 研究显示趋化因子信号通路关键基因表达变化与结直肠癌转移和预后密切相关, 但尚缺乏基于该信号通路的基因模型用来预测患者的临床预后 . 本研究基于趋化因子信号通路构建了一种新的多基因模型 (CSbMgSig), 用于结直肠癌患者的预后风险分层和总体生存时间预测, 为结直肠癌...
Source: Journal of Zhejiang University. Science. B. - December 1, 2021 Category: Universities & Medical Training Source Type: research
ER α promotes transcription of tumor suppressor gene ApoA-I by establishing H3K27ac-enriched chromatin microenvironment in breast cancer cells
AbstractApolipoprotein A-I (ApoA-I), the main protein component of high-density lipoprotein (HDL), plays a pivotal role in reverse cholesterol transport (RCT). Previous studies indicated a reduction of serum ApoA-I levels in various types of cancer, suggesting ApoA-I as a potential cancer biomarker. Herein, ectopically overexpressed ApoA-I in MDA-MB-231 breast cancer cells was observed to have antitumor effects, inhibiting cell proliferation and migration. Subsequent studies on the mechanism of expression regulation revealed that estradiol (E2)/estrogen receptor α(ERα) signaling activatesApoA-I gene transcription in brea...
Source: Journal of Zhejiang University. Science. B. - December 1, 2021 Category: Universities & Medical Training Source Type: research
Factors associated with red blood cell transfusion among hospitalized patients: a cross-sectional study
概要住院患者的红细胞输注量相关研究中, 医院层面和患者层面的因素未得到充分认识. 本研究从医院层面和患者层面这两个角度出发, 将血液中心的供给量纳入考虑范畴, 探讨影响患者红细胞输注数量的因素. 我们从浙江大学医学院附 属第一医院的医院信息系统中收集了从 2013 年 1 月至 2020 年 12 月期间病人红细胞的每日使用单位和相应的患者临床信息, 基于每周红细胞总使用单位采用三重指数平滑法进行时间序列分析, 并且以二元逻辑回归方法来追溯影响红细 胞输注量的患...
Source: Journal of Zhejiang University. Science. B. - December 1, 2021 Category: Universities & Medical Training Source Type: research
Primary duct closure versus T-tube drainage after laparoscopic common bile duct exploration: a meta-analysis
ConclusionsBased on the available evidence, compared with TTD, PDC is safe and effective, and can be used as the first choice after transductal LCBDE in patients with choledocholithiasis. (Source: Journal of Zhejiang University. Science. B.)
Source: Journal of Zhejiang University. Science. B. - December 1, 2021 Category: Universities & Medical Training Source Type: research
