Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury
Excessive autophagic activity in alveolar epithelial cells is one of the main causes of acute lung injury (ALI), but the underlying molecular mechanism has not been fully elucidated. Previous studies have show... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 3, 2021 Category: Allergy & Immunology Authors: Hao-Yu Tan, Bei Qing, Xian-Mei Luo and Heng-Xing Liang Tags: Research Source Type: research
TGF- β gene polimorphisms as risk factors for asthma control among clinic patients
TGF- β and its receptors play a crucial role in asthma pathogenesis, bronchial hyperreactivity, and bronchial remodeling. Expression of isoforms 1–3 of TGFβ cytokine is influenced by tagging polymorphisms in th... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 7, 2021 Category: Allergy & Immunology Authors: Panek Micha ł, Stawiski Konrad and Kuna Piotr Tags: Research Source Type: research
Downregulation of lncRNA-PVT1 participates in the development of progressive chronic kidney disease among patients with congestive heart failure
This study aimed ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 25, 2021 Category: Allergy & Immunology Authors: Yingwei Chang, Chunmei Liu, Jing Wang, Jing Feng, Yulan Chen, Mufang Qi and Yaguang Guo Tags: Research Source Type: research
Therapeutic potential of a novel semi-synthetic-sulfated-polysaccharide to suppress inflammatory mediators in P. gingivalis LPS stimulated human monocytes/macrophages
Chronic periodontitis is associated with an increased risk for systemic conditions such as cardiovascular disease, diabetes, and osteoporosis. During chronic periodontitis, endotoxin (lipopolysaccharide, LPS) ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 4, 2021 Category: Allergy & Immunology Authors: Ying Gu, Veena Raja, Hsi-Ming Lee, Houlin Hong, Glenn Prestwich and Maria E. Ryan Tags: Research Source Type: research
USP10 alleviates sepsis-induced acute kidney injury by regulating Sirt6-mediated Nrf2/ARE signaling pathway
Severe sepsis, a major health problem worldwide, has become one of the leading causes of death in ICU patients. Further study on the pathogenesis and treatment of acute kidney injury (AKI) is of great signific... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 19, 2021 Category: Allergy & Immunology Authors: Fei Gao, Mingjiang Qian, Guoyue Liu, Wanping Ao, Dahua Dai and Cunzhi Yin Tags: Research Source Type: research
Increased levels of S100A8/A9, IL-1 ß and IL-18 as a novel biomarker for recurrent tonsillitis
Acute tonsillitis represents one of the most frequent reasons patients seek primary medical care and otorhinolaryngology consultation. Therefore, recurrent episodes of acute tonsillitis (RAT), also called chro... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 29, 2021 Category: Allergy & Immunology Authors: Christoph Spiekermann, Alicia Seethaler, Annika McNally, Markus Stenner, Claudia Rudack, Johannes Roth and Thomas Vogl Tags: Research Source Type: research
Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones
It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD). However, only a limited number of ICD-in... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 10, 2021 Category: Allergy & Immunology Authors: Fangtian Fan, Peiliang Shen, Yue Ma, Wangbo Ma, Hongyan Wu, Hao Liu and Qing An Tags: Research Source Type: research
The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain
Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabil... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 5, 2021 Category: Allergy & Immunology Authors: Hsin-Hui Hsieh, Yen-An Chen, Yao-Jen Chang, Hsin-Hui Wang, Ya-Han Yu, Sheng-Wei Lin, Yin-Jung Huang, Steven Lin and Ching-Jin Chang Tags: Research Source Type: research
Luteolin transforms the polarity of bone marrow-derived macrophages to regulate the cytokine storm
Macrophages are indispensable regulators of inflammatory responses. Macrophage polarisation and their secreted inflammatory factors have an association with the outcome of inflammation. Luteolin, a flavonoid a... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 31, 2021 Category: Allergy & Immunology Authors: Shuxia Wang, Shuhang Xu, Jing Zhou, Li Zhang, Xiaodong Mao, Xiaoming Yao and Chao Liu Tags: Research Source Type: research
Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway
Liver injury seriously threatens the health of people. Meanwhile, dexmedetomidine hydrochloride (DEX) can protect against liver injury. However, the mechanism by which Dex mediates the progression of liver inj... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 26, 2021 Category: Allergy & Immunology Authors: Xiao-Xia Gu, Xiao-Xia Xu, Hui-Hua Liao, Ruo-Na Wu, Wei-Ming Huang, Li-Xia Cheng, Yi-Wen Lu and Jian Mo Tags: Research Source Type: research
VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation
Anti-vascular endothelial growth factor (VEGF) has been used as a therapeutic drug for the treatment of some human diseases. However, no systematic evidence is performed for assessing the role of VEGF in perio... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 22, 2021 Category: Allergy & Immunology Authors: Bo Ren, Que Feng, Shan He, Yanfeng Li, Jiadong Fan, Guangquan Chai, Le Liu, Haiyun Liu, Chunhao Yang, Yingdi Wang, Huihui Liu, Huanyue Liu and Yafan Song Tags: Research Source Type: research
AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke
The role inflammasomes play in chronic obstructive pulmonary disease (COPD) is unclear. We hypothesised that the AIM2 inflammasome is activated in the airways of COPD patients, and in response to cigarette smoke. (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 22, 2021 Category: Allergy & Immunology Authors: Hai B. Tran, Rhys Hamon, Hubertus Jersmann, Miranda P. Ween, Patrick Asare, Rainer Haberberger, Harshita Pant and Sandra J. Hodge Tags: Research Source Type: research
Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway
Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3 –4 years of diagnosis. Repetitive lung injur... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 19, 2021 Category: Allergy & Immunology Authors: Afshin Ebrahimpour, Min Wang, Li Li, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A. Hanania, Ivan O. Rosas and Yohannes T. Ghebre Tags: Research Source Type: research
The impact of E-cigarette vaping and vapour constituents on bone health
In contrast to cigarettes, electronic cigarette use (E-cigarettes) has grown substantially over the last decade. This is due to their promotion as both a safer alternative to cigarettes and as an aide to stop ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 5, 2021 Category: Allergy & Immunology Authors: Thomas Nicholson, Aaron Scott, Matthew Newton Ede and Simon W. Jones Tags: Review Source Type: research
Correction to: Research Cigarette Smoke Exposure Alters mSin3a and Mi-2 α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 23, 2021 Category: Allergy & Immunology Authors: John A. Marwick, Christopher S. Stevenson, Kian Fan Chung, Ian M. Adcock and Paul A. Kirkham Tags: Correction Source Type: research
