Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS
Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial dysfunction, alveolar-capillary leakage, and worsening res... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 16, 2023 Category: Allergy & Immunology Authors: Petra Kosutova, Pavol Mikolka, Daniela Mokra and Andrea Calkovska Tags: Research Source Type: research
Components of the sympathetic nervous system as targets to modulate inflammation – rheumatoid arthritis synovial fibroblasts as neuron-like cells?
Catecholamines are major neurotransmitters of the sympathetic nervous system (SNS) and they are of pivotal importance in regulating numerous physiological and pathological processes. Rheumatoid arthritis (RA) ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 14, 2023 Category: Allergy & Immunology Authors: Xinkun Cheng, Torsten Lowin, Nadine Honke and Georg Pongratz Tags: Research Source Type: research
Anti-inflammatory therapy of atherosclerosis: focusing on IKK β
Chronic low-grade inflammation has been identified as a major contributor in the development of atherosclerosis. Nuclear Factor- κappa B (NF-κB) is a critical transcription factors family of the inflammatory pa... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 23, 2023 Category: Allergy & Immunology Authors: Jiali Gan, Lin Guo, Xiaolu Zhang, Qun Yu, Qiuyue Yang, Yilin Zhang, Wenyun Zeng, Xijuan Jiang and Maojuan Guo Tags: Review Source Type: research
C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice
Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections.... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 21, 2023 Category: Allergy & Immunology Authors: Sofia Malm Tillgren, Juan Jos é Nieto-Fontarigo, Samuel Cerps, Sangeetha Ramu, Mandy Menzel, Irma Mahmutovic Persson, Anja Meissner, Hamid Akbarshahi and Lena Uller Tags: Research Source Type: research
Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related a... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 21, 2023 Category: Allergy & Immunology Authors: Xue Cao, Yanhong Li, Yubin Luo, Tianshu Chu, Hang Yang, Ji Wen, Yi Liu, Yi Zhao and Martin Herrmann Tags: Research Source Type: research
Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF- κB pathway
Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity in autoimmune diseases, but its role in acute lung injury in sepsis remains unclear. T... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 3, 2023 Category: Allergy & Immunology Authors: Xinxin Zhang, Xingsheng Wang, Li Sun, Guangsheng Gao and Yun Li Tags: Research Source Type: research
Anti-inflammatory effects of β-FNA are sex-dependent in a pre-clinical model of LPS-induced inflammation
Inflammation is present in neurological and peripheral disorders. Thus, targeting inflammation has emerged as a viable option for treating these disorders. Previous work indicated pretreatment with beta-funalt... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 25, 2023 Category: Allergy & Immunology Authors: Stephanie Myers, Kelly McCracken, Daniel J. Buck, J. Thomas Curtis and Randall L. Davis Tags: Research Source Type: research
Correction: Evaluation of asthma –chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease
(Source: Journal of Inflammation)
Source: Journal of Inflammation - January 20, 2023 Category: Allergy & Immunology Authors: Yong Suk Jo, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, Tai Joon An and Jung Hur Tags: Correction Source Type: research
Progranulin (PGRN) as a regulator of inflammation and a critical factor in the immunopathogenesis of cardiovascular diseases
Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). Notably, the innate and adaptive immune responses under physiological conditions are typ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 19, 2023 Category: Allergy & Immunology Authors: Ali Saeedi-Boroujeni, Daryush Purrahman, Ali Shojaeian, Łukasz A. Poniatowski, Fatemeh Rafiee and Mohammad-Reza Mahmoudian-Sani Tags: Review Source Type: research
Neutrophil extracellular traps and pulmonary fibrosis: an update
Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellula... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 19, 2023 Category: Allergy & Immunology Authors: Suyan Yan, Meiqi Li, Baocheng Liu, Zhenzhen Ma and Qingrui Yang Tags: Review Source Type: research
Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19
Hypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our previous studies demonstrated that SARS-CoV-2 infection as well as viral spike protein exp... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 30, 2022 Category: Allergy & Immunology Authors: Tapas Patra and Ranjit Ray Tags: Research Source Type: research
Efficacy of probiotic Streptococcus thermophilus in counteracting TGF- β1-induced fibrotic response in normal human dermal fibroblasts
Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, the investigation of alternat... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 19, 2022 Category: Allergy & Immunology Authors: Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Blerina Bahiti, Jenna Marie Sheldon, Maurizio Giuliani, Maria Grazia Cifone, Paola Palumbo and Benedetta Cinque Tags: Research Source Type: research
Combination of IL-17A/F and TNF- α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration
The heterodimer interleukin (IL)-17A/F is elevated in the lungs in chronic respiratory disease such as severe asthma, along with the pro-inflammatory cytokine tumor necrosis factor- α (TNF-α). Although IL-17A/F... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 14, 2022 Category: Allergy & Immunology Authors: Anthony Altieri, Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Breann Recksiedler, Victor Spicer, Pieter S Hiemstra, Andrew J Halayko and Neeloffer Mookherjee Tags: Research Source Type: research
Evaluation of asthma –chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease
Features of asthma and chronic obstructive pulmonary disease (COPD) can coexist in the same patient, in a condition termed asthma – chronic obstructive pulmonary disease overlap (ACO). ACO is heterogeneous cond... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 6, 2022 Category: Allergy & Immunology Authors: Yong Suk Jo, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, An Tai Joon and Jung Hur Tags: Research Source Type: research
The immunological function of CXCR2 in the liver during sepsis
The chemokine receptor CXCR2 and its ligands, especially CXCL8, are crucial mediators for the progression of liver inflammation and liver failure in sepsis. Neutrophils have the highest CXCR2 expression in mi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 30, 2022 Category: Allergy & Immunology Authors: Na Liu, Michael Bauer and Adrian T. Press Tags: Review Source Type: research
