PPAR α and PPARβ/δ are negatively correlated with proinflammatory markers in leukocytes of an obese pediatric population
Obesity configures a pathophysiological profile that predisposes the development of metabolic and cardiovascular diseases, critically impacting public health. The chronic dysregulation of immuno-metabolic comp... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 31, 2020 Category: Allergy & Immunology Authors: Karina Vargas-S ánchez, Laura Vargas, Yenny Urrutia, Iván Beltrán, Ana Beatriz Rossi, Hernán Yupanqui Lozano, Jorge Guarín and Monica Losada-Barragán Tags: Research Source Type: research
Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury
Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 30, 2020 Category: Allergy & Immunology Authors: James G. Macfarlane, David A. Dorward, Marie-H élène Ruchaud-Sparagano, Jonathan Scott, Christopher D. Lucas, Adriano G. Rossi and A. John Simpson Tags: Research Source Type: research
Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm
COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of 2019 and was rapidly spread in most countries. This respiratory virus has different symptoms from moderate to severe, and res... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 29, 2020 Category: Allergy & Immunology Authors: Mozhgan Jahani, Sadat Dokaneheifard and Kamran Mansouri Tags: Review Source Type: research
Association of intestinal and systemic inflammatory biomarkers with immune reconstitution in HIV+ patients on ART
HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal and systemic low-grade inflammation. With the use of antiretroviral treatm... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 15, 2020 Category: Allergy & Immunology Authors: Mariana del Rocio Ruiz-Brise ño, Judith Carolina De Arcos-Jiménez, Sarah Ratkovich-González, Karina Sánchez-Reyes, Luz A. González-Hernández, Jaime F. Andrade-Villanueva and Monserrat Alvarez-Zavala Tags: Research Source Type: research
LncRNA THRIL is upregulated in sepsis and sponges miR-19a to upregulate TNF- α in human bronchial epithelial cells
Long non-coding RNAs (lncRNAs) have been demonstrated to play critical roles in various diseases. Our bioinformatics analysis showed that lncRNA TNF α and heterogenous nuclear ribonucleoprotein L (hnRNPL) relat... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 10, 2020 Category: Allergy & Immunology Authors: Tao Liu, Jingbin Liu, Chunhua Tian, Hongyuan Wang, Min Wen and Mingyu Yan Tags: Research Source Type: research
Compound amino acid combined with high-dose vitamin B6 attenuate traumatic coagulopathy via inhibiting inflammation by HMGB1/TLR4/NF- κB pathway
Traumatic coagulopathy (TC) arises primarily from coagulation system failure to maintain adequate hemostasis after serious blood loss or trauma. Circulatory homeostasis restoration is the mainstay of the thera... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 28, 2020 Category: Allergy & Immunology Authors: Shi-Jian Yi, Yang Wu, Lan-Lan Li, Qian-Kun Liang and Yue Xiao Tags: Research Source Type: research
Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis
Inflammatory bowel disease (IBD) is the collective term for chronic immune-mediated diseases of unknown, multifactorial etiology, arising from the interplay between genetic and environmental factors and includ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 24, 2020 Category: Allergy & Immunology Authors: Pedro A. Ruiz Castro, Ulrike Kogel, Giuseppe Lo Sasso, Blaine W. Phillips, Alain Sewer, Bjorn Titz, Llenalia Garcia, Athanasios Kondylis, Emmanuel Guedj, Dariusz Peric, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Nikolai V. Ivanov, Manuel C. Tags: Research Source Type: research
Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest
Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor postoperative outcomes. Bovine intestinal alkaline phosphatase infusion rep... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 12, 2020 Category: Allergy & Immunology Authors: Ludmila Khailova, Justin Robison, James Jaggers, Richard Ing, Scott Lawson, Amy Treece, Danielle Soranno, Suzanne Osorio Lujan and Jesse A. Davidson Tags: Research Source Type: research
Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women
Mannose-binding lectin (MBL) mediates the innate immune response either through direct opsonisation of microorganisms or through activation of the complement system. There are conflicting data whether MBL defi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 12, 2020 Category: Allergy & Immunology Authors: Sofie Jacobson, Peter Larsson, Anna-Maja Åberg, Göran Johansson, Ola Winsö and Stefan Söderberg Tags: Research Source Type: research
Emodin alleviates LPS-induced inflammatory response in lung injury rat by affecting the function of granulocytes
Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are critical life-threatening syndromes characterized by the infiltration of a large number of granulocytes (mainly neutrophils) that l... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 8, 2020 Category: Allergy & Immunology Authors: Hongxia Mei, Ying Tao, Tianhao Zhang and Feng Qi Tags: Research Source Type: research
Offspring sex affects the susceptibility to maternal smoking-induced lung inflammation and the effect of maternal antioxidant supplementation in mice
Cigarette smoke exposure (SE) during pregnancy is the largest modifiable risk factor for the development of lung disorders in offspring. We have previously shown that maternal L-Carnitine treatment can reduce ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 5, 2020 Category: Allergy & Immunology Authors: Baoming Wang, Yik Lung Chan, Shengyu Zhou, Sonia Saad, Hui Chen and Brian G Oliver Tags: Research Source Type: research
N-acetylcysteine alleviates post-resuscitation myocardial dysfunction and improves survival outcomes via partly inhibiting NLRP3 inflammasome induced-pyroptosis
NOD-like receptor 3 (NLRP3) inflammasome is necessary to initiate acute sterile inflammation. Increasing evidence indicates the activation of NLRP3 inflammasome induced pyroptosis is closely related to reactiv... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 5, 2020 Category: Allergy & Immunology Authors: Fenglian He, Guanghui Zheng, Jingying Hou, Qiaohua Hu, Qin Ling, Gongfa Wu, Hui Zhao, Jin Yang, Yue Wang, Longyuan Jiang, Wanchun Tang and Zhengfei Yang Tags: Research Source Type: research
NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF- κB/COX-2/PG pathway
Primary dysmenorrhea (PD) constitutes a common gynecological disease among young women. The NLRP3 inflammasome may be activated and expressed in PD, but the mechanistic link between NLRP3 inflammasome activati... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 24, 2020 Category: Allergy & Immunology Authors: Biao Tang, Dan Liu, Lingyu Chen and Yu Liu Tags: Research Source Type: research
SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping
The current pandemic of COVID-19 has caused severe morbidity and mortality across the globe. People with a smoking history have severe disease outcomes by COVID-19 infection. Epidemiological studies show that ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 10, 2020 Category: Allergy & Immunology Authors: Gagandeep Kaur, Giuseppe Lungarella and Irfan Rahman Tags: Review Source Type: research
A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis
Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseas... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2020 Category: Allergy & Immunology Authors: Sae-Bom Yoon, Chang Hoon Lee, Hyun Young Kim, Daeyoung Jeong, Moon Kook Jeon, Sun-A Cho, Kwangmi Kim, Taeho Lee, Jung Yoon Yang, Young-Dae Gong and Heeyeong Cho Tags: Research Source Type: research
