Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice
Obesity is associated with vascular inflammation, fibrosis and reduced high-density lipoproteins (HDL)-cholesterol. We aimed to investigate whether adenoviral gene transfer with human apolipoprotein (apo) A-I (Ad... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 2, 2016 Category: Allergy & Immunology Authors: Frank Spillmann, Bart De Geest, Ilayaraja Muthuramu, Ruhul Amin, Kapka Miteva, Burkert Pieske, Carsten Tsch öpe and Sophie Van Linthout Source Type: research
A comparative study of blood endotoxin detection in haemodialysis patients
Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endot... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 30, 2016 Category: Allergy & Immunology Authors: Jonathan Wong, Nathan Davies, Hasan Jeraj, Enric Vilar, Adie Viljoen and Ken Farrington Source Type: research
Phenotypic analysis of peripheral B cell populations during Mycobacterium tuberculosis infection and disease
Mycobacterium tuberculosis (Mtb) remains an unresolved threat resulting in great annual loss of life. The role of B cells during the protective immunity to Mtb is still unclear. B cell... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 29, 2016 Category: Allergy & Immunology Authors: Willem J. du Plessis, Alana Keyser, Gerhard Walzl and Andr é G. Loxton Source Type: research
MicroRNAs differentially expressed in Beh çet disease are involved in interleukin-6 production
Behcet ’s disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)–α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gai... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 19, 2016 Category: Allergy & Immunology Authors: Min-Yeong Woo, Su Jin Yun, Okki Cho, Kyongmin Kim, Eun-So Lee and Sun Park Source Type: research
MicroRNAs differentially expressed in Behçet disease are involved in interleukin-6 production
Behcet’s disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)–α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gai... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 19, 2016 Category: Allergy & Immunology Authors: Min-Yeong Woo, Su Jin Yun, Okki Cho, Kyongmin Kim, Eun-So Lee and Sun Park Source Type: research
Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment
Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 14, 2016 Category: Allergy & Immunology Authors: Regina M. Krohn, Sean A. Parsons, Jakub Fichna, Kamala D. Patel, Robin M. Yates, Keith A. Sharkey and Martin A. Storr Source Type: research
A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic eczematous lesions that are commonly treated with topical corticosteroids and calcineurin inhibitors. Side-effects... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 22, 2016 Category: Allergy & Immunology Authors: Niklas Palmqvist, Max Siller, Cecilia Klint and Anders Sjödin Source Type: research
Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells
Endothelin-1 (ET-1) is involved in pulmonary vascular remodeling. The aim of this study was to investigate the biochemical interactions between PPAR-γ, TGF-β1 and ET-1 in vitro. (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 10, 2016 Category: Allergy & Immunology Authors: Shulin Xiang, Yi Zeng, Bin Xiong, Yueqiu Qin, Xia Huang, Yujie Jiang, Weigui Luo, Suren R. Sooranna and Liao Pinhu Source Type: research
AG490 suppresses EPO-mediated activation of JAK2-STAT but enhances blood flow recovery in rats with critical limb ischemia
In this study, we used an experimental critical limb ischemia (CLI) rat model to reveal the und... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 4, 2016 Category: Allergy & Immunology Authors: Han-Tan Chai, Hon-Kan Yip, Cheuk-Kwan Sun, Shu-Yuan Hsu and Steve Leu Source Type: research
Erratum to: Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with 31P MRS-detectable energy failure
(Source: Journal of Inflammation)
Source: Journal of Inflammation - May 23, 2016 Category: Allergy & Immunology Authors: Raman Saggu Source Type: research
Effects of CpG Oligodeoxynucleotide 1826 on transforming growth factor-beta 1 and radiation-induced pulmonary fibrosis in mice
Cytosine-phosphate-guanine (CpG) oligodeoxyribonucleotides (ODNs) are synthetic DNA fragments containing unmethylated cytosine-guanine motifs with potential immune modulatory effects and have recently been sug... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 17, 2016 Category: Allergy & Immunology Authors: Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan, Xibing Zhuang, Jihong Zhang and Hui Bin Sun Source Type: research
The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets
In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs are sensitive to the action o... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 5, 2016 Category: Allergy & Immunology Authors: Torsten Lowin, Georg Pongratz and Rainer H. Straub Source Type: research
The effect of high glucose on the inhibitory action of C21, a selective AT2R agonist, of LPS-stimulated tissue factor expression in human mononuclear cells
Intimate links connect tissue factor (TF), the principal initiator of the clotting cascade, to inflammation, a cross-talk amplified by locally generated Angiotensin (AT) II, the effector arm of the Renin Angio... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 4, 2016 Category: Allergy & Immunology Authors: Cristina Balia, Valentina Scalise, Silvana Cianchetti, Francesca Faita, Tommaso Neri, Vittoria Carnicelli, Riccardo Zucchi, Alessandro Celi and Roberto Pedrinelli Source Type: research
The association between blood glucose levels and matrix-metalloproteinase-9 in early severe sepsis and septic shock
Hyperglycemia is a frequent and important metabolic derangement that accompanies severe sepsis and septic shock. Matrix-Metalloproteinase 9 (MMP-9) has been shown to be elevated in acute stress hyperglycemia, ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 22, 2016 Category: Allergy & Immunology Authors: Gul R. Sachwani, Anja K. Jaehne, Namita Jayaprakash, Mark Kuzich, Violet Onkoba, Dione Blyden and Emanuel P. Rivers Source Type: research
Pathogenesis of eosinophilic chronic rhinosinusitis
Eosinophilic chronic rhinosinusitis (ECRS) is considered a refractory and intractable disease. Patients with ECRS present with thick mucus production, long-term nasal congestion, loss of sense of smell, and in... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 6, 2016 Category: Allergy & Immunology Authors: Said Ahmad Shah, Hajime Ishinaga and Kazuhiko Takeuchi Source Type: research
