Experimental murine acute lung injury induces increase of pulmonary TIE2-expressing macrophages
Breakdown of the alveolo-capillary wall is pathognomonic for Acute Lung Injury (ALI). Angiopoietins, vascular-specific growth factors, are linked to endothelial barrier dysfunction, and elevated Angiopoietin-2... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 14, 2018 Category: Allergy & Immunology Authors: Heidi Ehrentraut, Christina Weisheit, Marcel Scheck, Stilla Frede and Tobias Hilbert Tags: Research Source Type: research
The impact of septic stimuli on the systemic inflammatory response and physiologic insult in a preclinical non-human primate model of polytraumatic injury
Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 24, 2018 Category: Allergy & Immunology Authors: Diego A. Vicente, Matthew J. Bradley, Benjamin Bograd, Crystal Leonhardt, Eric A. Elster and Thomas A. Davis Tags: Research Source Type: research
CXCR-4 expression by circulating endothelial progenitor cells and SDF-1 serum levels are elevated in septic patients
In this study, we investigated, whether surface expression of chemokine receptors and other receptors imp... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 16, 2018 Category: Allergy & Immunology Authors: Christian Patry, Daniela Stamm, Christian Betzen, Burkhard T önshoff, Benito A. Yard, Grietje Ch. Beck and Neysan Rafat Tags: Research Source Type: research
Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis
Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory mediators that contribute to organ failure and death. T... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 9, 2018 Category: Allergy & Immunology Authors: K. L. C. da Silva, A. P. Camacho, F. C. Mittestainer, B. M. Carvalho, A. Santos, D. Guadagnini, A. G. Oliveira and M. J. A. Saad Tags: Research Source Type: research
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
There is currently an unmet clinical need to develop better pharmacological treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end, determining the effect of obesity-asso... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 9, 2018 Category: Allergy & Immunology Authors: Thomas Nicholson, Chris Church, David J. Baker and Simon W. Jones Tags: Review Source Type: research
Functional role of microRNA-135a in colitis
Inflammatory bowel disease (IBD) is one of the chronic gastrointestinal diseases with increasing risk of colon cancer development in the future. Apoptosis and inflammation play an important role in the etiolog... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 6, 2018 Category: Allergy & Immunology Authors: Chunyan Lou and Yanyang Li Tags: Research Source Type: research
Correction to: Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection
Upon publication of the original article [1] it was highlighted by the authors that the first affiliation of author Haiyan Yin was incorrectly cited in duplicate as “Department of Neurology, Affiliated Hospita... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 3, 2018 Category: Allergy & Immunology Authors: Haiyan Yin, Shuwen Song and Xudong Pan Tags: Correction Source Type: research
Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF- α expression in mice
Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments. Toll-like receptors (TLRs) play an im... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 22, 2018 Category: Allergy & Immunology Authors: Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen and Ian M. Adcock Tags: Research Source Type: research
Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model
Impairment of the blood-brain barrier (BBB) in severe acute pancreatitis (SAP) could result in life-threatening pancreatic encephalopathy. Interleukin-10 (IL-10) is a classical cytokine that is well-known for ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 27, 2018 Category: Allergy & Immunology Authors: Ronggui Lin, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan and Heguang Huang Tags: Research Source Type: research
Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we deve... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 10, 2018 Category: Allergy & Immunology Authors: Wen-Feng Fang, Yu-Mu Chen, Chiung-Yu Lin, Hui-Lin Huang, Hua Yeh, Ya-Ting Chang, Kuo-Tung Huang and Meng-Chih Lin Tags: Research Source Type: research
Plasma vascular non-inflammatory molecule 3 is associated with gastrointestinal acute graft-versus-host disease in mice
Gastrointestinal acute graft-versus-host disease (GI aGVHD) is a lethal complication following allogeneic hematopoietic stem cell transplantation (HSCT). However, it is still very difficult to make a diagnosis... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 5, 2018 Category: Allergy & Immunology Authors: Na Wang, Xiaoyi Qin, Yigeng Cao, Bin Liang, Kang Yu and Haige Ye Tags: Research Source Type: research
Anti-inflammatory cellular targets on neutrophils elucidated using a novel cell migration model and confocal microscopy: a clinical supplementation study
In vivo studies have shown grape seed-derived polyphenols (GSP) to benefit in recovery from muscle injury by modulation of neutrophil infiltration into damaged tissue, thereby reducing secondary damage, as wel... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 5, 2018 Category: Allergy & Immunology Authors: T. Smith, L. Engelbrecht and C. Smith Tags: Research Source Type: research
Neutrophil extracellular traps and the dysfunctional innate immune response of cystic fibrosis lung disease: a review
Cystic Fibrosis (CF) is a devastating genetic disease characterised primarily by unrelenting lung inflammation and infection resulting in premature death and significant morbidity. Neutrophil Extracellular Tra... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 28, 2017 Category: Allergy & Immunology Authors: Sheonagh M. Law and Robert D. Gray Tags: Review Source Type: research
Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy
An unmet need remains for safe and effective treatments to induce and maintain remission in inflammatory bowel disease (IBD) patients. The Janus kinase (JAK) inhibitor, tofacitinib, has demonstrated robust eff... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 6, 2017 Category: Allergy & Immunology Authors: David T. Beattie, M. Teresa Pulido-Rios, Fei Shen, Melissa Ho, Eva Situ, Pam R. Tsuruda, Patrick Brassil, Melanie Kleinschek and Sharath Hegde Tags: Research Source Type: research
Treatment with 24 h–delayed normo- and hyperbaric oxygenation in severe sepsis induced by cecal ligation and puncture in rats
Septic shock remains a leading cause of death worldwide. Hyperbaric oxygen treatment (HBO2) has been shown to alter the inflammatory response during sepsis and to reduce mortality. A therapeutic window of HBO2 tr... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 25, 2017 Category: Allergy & Immunology Authors: Nina Falcon B ærnthsen, Marco Bo Hansen, Anna Mygind Wahl, Ulf Simonsen and Ole Hyldegaard Tags: Research Source Type: research
