Neutrophil extracellular traps and pulmonary fibrosis: an update
Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellula... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 19, 2023 Category: Allergy & Immunology Authors: Suyan Yan, Meiqi Li, Baocheng Liu, Zhenzhen Ma and Qingrui Yang Tags: Review Source Type: research
Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19
Hypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our previous studies demonstrated that SARS-CoV-2 infection as well as viral spike protein exp... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 30, 2022 Category: Allergy & Immunology Authors: Tapas Patra and Ranjit Ray Tags: Research Source Type: research
Efficacy of probiotic Streptococcus thermophilus in counteracting TGF- β1-induced fibrotic response in normal human dermal fibroblasts
Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, the investigation of alternat... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 19, 2022 Category: Allergy & Immunology Authors: Francesca Lombardi, Francesca Rosaria Augello, Serena Artone, Blerina Bahiti, Jenna Marie Sheldon, Maurizio Giuliani, Maria Grazia Cifone, Paola Palumbo and Benedetta Cinque Tags: Research Source Type: research
Combination of IL-17A/F and TNF- α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration
The heterodimer interleukin (IL)-17A/F is elevated in the lungs in chronic respiratory disease such as severe asthma, along with the pro-inflammatory cytokine tumor necrosis factor- α (TNF-α). Although IL-17A/F... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 14, 2022 Category: Allergy & Immunology Authors: Anthony Altieri, Hadeesha Piyadasa, Mahadevappa Hemshekhar, Natasha Osawa, Breann Recksiedler, Victor Spicer, Pieter S Hiemstra, Andrew J Halayko and Neeloffer Mookherjee Tags: Research Source Type: research
Evaluation of asthma –chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease
Features of asthma and chronic obstructive pulmonary disease (COPD) can coexist in the same patient, in a condition termed asthma – chronic obstructive pulmonary disease overlap (ACO). ACO is heterogeneous cond... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 6, 2022 Category: Allergy & Immunology Authors: Yong Suk Jo, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, An Tai Joon and Jung Hur Tags: Research Source Type: research
The immunological function of CXCR2 in the liver during sepsis
The chemokine receptor CXCR2 and its ligands, especially CXCL8, are crucial mediators for the progression of liver inflammation and liver failure in sepsis. Neutrophils have the highest CXCR2 expression in mi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 30, 2022 Category: Allergy & Immunology Authors: Na Liu, Michael Bauer and Adrian T. Press Tags: Review Source Type: research
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages
Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading cause of death worldwide. 5-Methoxyflavone, a methylated flavonoid, is... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 30, 2022 Category: Allergy & Immunology Authors: Panqiao Liang, Linxin Wang, Sushan Yang, Xiping Pan, Jiashun Li, Yuehan Zhang, Yueyun Liang, Jing Li and Beixian Zhou Tags: Research Source Type: research
Neutrophil reverse migration
The behavior of neutrophils is very important for the resolution of inflammation and tissue repair. People have used advanced imaging techniques to observe the phenomenon of neutrophils leaving the injured or ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 24, 2022 Category: Allergy & Immunology Authors: Qichao Xu, Wenqi Zhao, Mingyang Yan and Hongxia Mei Tags: Review Source Type: research
The antigen CD300e drives T cell inflammation in adipose tissue and elicits an antibody response predictive of the insulin sensitivity recovery in obese patients
Obesity and insulin resistance (IR), the key features of metabolic syndrome, are closely associated with a state of chronic, low-grade inflammation. Bariatric surgery leads to a considerable reduction in the a... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 22, 2022 Category: Allergy & Immunology Authors: Sara Coletta, Elisabetta Trevellin, Marisa Benagiano, Jacopo Romagnoli, Chiara Della Bella, Mario Milco D ’Elios, Roberto Vettor and Marina de Bernard Tags: Brief Report Source Type: research
Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype
Macrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury and repair. These cells are most often classified as proinflammatory M1 and anti-inflamm... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 18, 2022 Category: Allergy & Immunology Authors: Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman, Jennifer E. Van Eyk and Justyna Fert-Bober Tags: Research Source Type: research
Induction of pyroptotic cell death as a potential tool for cancer treatment
Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restricted potential due to a lack of cancer cell targeting specificity, cytotoxicity, bioavail... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 14, 2022 Category: Allergy & Immunology Authors: Sara Socorro Faria, Anuruddika Jayawanthi Fernando, Vladmir Cl áudio Cordeiro de Lima, Adriano Giorgio Rossi, Juliana Maria Andrade de Carvalho and Kelly Grace Magalhães Tags: Review Source Type: research
Extracellular vesicles isolated from hyperuricemia patients might aggravate airway inflammation of COPD via senescence-associated pathway
Chronic obstructive pulmonary disease (COPD) is a major health issue resulting in significant mortality worldwide. Due to the high heterogeneity and unclear pathogenesis, the management and therapy of COPD are... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 2, 2022 Category: Allergy & Immunology Authors: Xuanqi Liu, Zheng Li, Yang Zheng, Wenhao Wang, Peiqing He, Kangwei Guan, Tao Wu, Xiaojun Wang and Xuelin Zhang Tags: Research Source Type: research
Disulfiram alleviates acute lung injury and related intestinal mucosal barrier impairment by targeting GSDMD-dependent pyroptosis
Pyroptosis was implicated in acute lung injury (ALI). Disulfiram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD). However, the function of pyroptosis executor GSDMD and treatm... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 20, 2022 Category: Allergy & Immunology Authors: Jiping Zhao, Hong Wang, Jintao zhang, Fuwei Ou, Junfei Wang, Tian Liu and Jinxiang Wu Tags: Research Source Type: research
Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in mice
Chronic inflammation and oxidant/antioxidant imbalance are two main pathological features associated with lipopolysaccharide (LPS)-induced acute lung injury (ALI). The following study investigated the protecti... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 17, 2022 Category: Allergy & Immunology Authors: Hongling Yin, Yajing Feng, Yi Duan, Shaolin Ma, Zhongliang Guo and Youzhen Wei Tags: Research Source Type: research
Retraction Note: Impact of NF- κB pathway on the intervertebral disc inflammation and degeneration induced by over-mechanical stretching stress
(Source: Journal of Inflammation)
Source: Journal of Inflammation - October 10, 2022 Category: Allergy & Immunology Authors: Hui Xu, Guobao Qi, Kunpeng Li, Keshi Yang, Dawei Luo and Zhongxu Cai Tags: Retraction Note Source Type: research
