Efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia, a multicenter, randomized, double-blind, placebo-controlled trial
To investigate the efficacy and safety of aerosol inhalation of recombinant human interferon α1b (IFNα1b) injection for noninfluenza viral pneumonia. (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 14, 2020 Category: Allergy & Immunology Authors: Rongmeng Jiang, Bing Han, Meihua Song, Bing Xue, Yongxiang Zhang, Yanyan Ding, Jin Chen, Jing Zhu, Jianhua Liu, Qingrong Nie, Xuefeng Han, Xiuhong Jin, Xiaoyin Shan, Weian Guo, Erming Zhang, Zuoqing Zhang & hellip; Tags: Research Source Type: research
Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine
In this study, the inhibitory effect of Dex on i... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 1, 2020 Category: Allergy & Immunology Authors: Gang Lv, Guanhua Zhu, Maohua Xu, Xingping Gao and Qingfeng Xiao Tags: Research Source Type: research
MiRNA-494 enhances M1 macrophage polarization via Nrdp1 in ICH mice model
Ubiquitination-mediated M1/M2 macrophage polarization plays important roles in the pathogenesis of immune disease. However, the regulatory mechanism of ubiquitination during M1/M2 macrophage polarization follo... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 25, 2020 Category: Allergy & Immunology Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Qijiang Xiong, Ling Yang, Zhongyan Huang and Zhao Yang Tags: Research Source Type: research
Ulcerative colitis: understanding its cellular pathology could provide insights into novel therapies
Dynamic interactions between the gastrointestinal epithelium and the mucosal immune system normally contribute to ensuring intestinal homeostasis and optimal immunosurveillance, but destabilisation of these in... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 21, 2020 Category: Allergy & Immunology Authors: Amandip Kaur and Paraskevi Goggolidou Tags: Review Source Type: research
Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model
Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enha... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 21, 2020 Category: Allergy & Immunology Authors: Hai B. Tran, Matthew G. Macowan, Adrian Abdo, Martin Donnelley, David Parsons and Sandra Hodge Tags: Research Source Type: research
Elevated soluble TNF α levels and upregulated TNFα mRNA expression in purified peripheral blood monocyte subsets associated with high-grade hepatocellular carcinoma
Chronic inflammation is involved in the initiation and progression of various cancers, including liver cancer. The current study focuses on the characterization of the peripheral immune response in hepatocellu... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 30, 2020 Category: Allergy & Immunology Authors: C. Mart ín-Sierra, R. Martins, M. Coucelo, A. M. Abrantes, R. C. Oliveira, J. G. Tralhão, M. F. Botelho, E. Furtado, M. R. Domingues, A. Paiva and P. Laranjeira Tags: Research Source Type: research
Urolithin a attenuates IL-1 β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation and is one of the most common chronic degenerative joint diseases that causes pain and disability in adults. Urol... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 24, 2020 Category: Allergy & Immunology Authors: Sheng-long Ding, Zhi-ying Pang, Xue-mei Chen, Zheng Li, Xin-xin Liu, Qi-lin Zhai, Jun-ming Huang and Zhi-yong Ruan Tags: Research Source Type: research
The role of SOCS3 in the hypothalamic paraventricular nucleus in rat model of inflammatory pain
Inflammatory molecular signals are modulated by a variety of intracellular transduction pathways, the activation of which may induce and amplify the spread of inflammatory response. Suppresser of cytokine sign... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 27, 2020 Category: Allergy & Immunology Authors: Na Meng, Ning-Ning Ji, Ziming Zhou, Yicheng Qian, Yu Tang, Kangbo Yang, Binbin Chen and Yong-Mei Zhang Tags: Research Source Type: research
Prediction and identification of novel HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from endocan
Prediction and identification of cytotoxic T lymphocyte (CTL) epitopes from tumor associated antigens is a crucial step for the development of tumor immunotherapy strategy. Endocan has been identified as antig... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 19, 2020 Category: Allergy & Immunology Authors: Gaohai Shao, Qingjun Liu, Ling Yang, Guibo Feng, Wang Zhao, Zhongyan Huang and Zhao Yang Tags: Research Source Type: research
Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression
The antisense cerebellar degenerative-related protein-1 (CDR1as) has been identified as a sponge for several microRNAs. MiR-641 has been shown to be downregulated in osteoarthritic human chondrocytes, but its ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 18, 2020 Category: Allergy & Immunology Authors: Wei Zhang, Chi Zhang, Chengfang Hu, Congfeng Luo, Biao Zhong and Xiaowei Yu Tags: Research Source Type: research
Low-intensity ultrasound attenuates paw edema formation and decreases vascular permeability induced by carrageenan injection in rats
Therapeutic potential of low-intensity ultrasound (LIUS) has become evident in various musculoskeletal diseases. We have previously shown that LIUS has an inhibitory effect on local edema in various diseases i... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 13, 2020 Category: Allergy & Immunology Authors: Kil Hwan Kim, Hyeon-Woo Im, Mrigendra Bir Karmacharya, Sejong Kim, Byoung-Hyun Min, So Ra Park and Byung Hyune Choi Tags: Research Source Type: research
Real-state of autophagy signaling pathway in neurodegenerative disease; focus on multiple sclerosis
The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination i... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 11, 2020 Category: Allergy & Immunology Authors: Mehdi Hassanpour, Fateme Hajihassani, Amirataollah Hiradfar, Nasser Aghamohammadzadeh, Reza Rahbarghazi, Nasser Safaie, Mohammad Nouri and Yunes Panahi Tags: Review Source Type: research
Acupoint application inhibits nerve growth factor and attenuates allergic inflammation in allergic rhinitis model rats
Acupoint application therapy (AAT) has been widely used to treat allergic inflammation induced by allergic rhinitis (AR). The therapeutic effect of acupoint application is obvious. But the underlying therapeut... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 10, 2020 Category: Allergy & Immunology Authors: Wenzhan Tu, Xiaolong Chen, Qiaoyun Wu, Xinwang Ying, Rong He, Xinfa Lou, Guanhu Yang, Kecheng Zhou and Songhe Jiang Tags: Research Source Type: research
Different signaling pathways involved in the anti-inflammatory effects of unfractionated heparin on lipopolysaccharide-stimulated human endothelial cells
There is a complex interplay between inflammatory response and coagulation in sepsis. Heparin is used as a recognized anticoagulant and possesses multiple biological properties that possibly affect sepsis. Thi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 10, 2020 Category: Allergy & Immunology Authors: Xu Li, Lu Li, Yuequan Shi, Sihan Yu and Xiaochun Ma Tags: Research Source Type: research
Dendritic cells transduced with glioma-expressed antigen 2 recombinant adenovirus induces specific cytotoxic lymphocyte response and anti-tumor effect in mice
Glioma is an aggressive common cancer with high mortality worldwide. Up to date, the effective medical therapeutical strategy is limited. Numerous previous studies have indicated that glioma-expressed antigen ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 31, 2020 Category: Allergy & Immunology Authors: Gaohai Shao, Changlong Zhou, Kunlong Ma, Wang Zhao, Guibo Feng, Qijiang Xiong, Ling Yang and Zhao Yang Tags: Research Source Type: research
