High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats
Obesity is a risk factor for chronic kidney disease (CKD). While the exact mechanisms remain unclear, inflammation may be a consequence of obesity that directly impacts the kidneys. The aim of this study was t... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 25, 2019 Category: Allergy & Immunology Authors: Thea Laurentius, Ute Raffetseder, Claudia Fellner, Robert Kob, Mahtab Nourbakhsh, J ürgen Floege, Thomas Bertsch, Leo Cornelius Bollheimer and Tammo Ostendorf Tags: Research Source Type: research
The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis
Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for... (Source: Journal of Inflammation)
Source: Journal of Inflammation - June 6, 2019 Category: Allergy & Immunology Authors: Qihong Que, Xinghua Guo, Longxin Zhan, Shaodong Chen, Zengli Zhang, Xiaoming Ni, Bin Ye and Shuanglin Wan Tags: Research Source Type: research
Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF- β1
Radiation-induced lung fibrosis (RILF) is a severe and life-threatening complication of thoracic radiotherapy. Cell death is the key issue in RILF. Ferroptosis is a form programmed cell death implicated in the... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2019 Category: Allergy & Immunology Authors: Xuan Li, Lijie Duan, Sujuan Yuan, Xibing Zhuang, Tiankui Qiao and Jian He Tags: Research Source Type: research
Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice
Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 29, 2019 Category: Allergy & Immunology Authors: Jordan R. Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda M. Tafoya, Barbara H. Munk, Dara N. Wakefield, Jorge Fuentes, Bruno J. Marques, Krishna Harripersaud, Mee Yong Bartee, Jennifer A. Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richar Tags: Short Report Source Type: research
Evidence for the important role of inflammation in xenotransplantation
There is increasing evidence of a sustained state of systemic inflammation after pig-to-nonhuman primate (NHP) xenotransplantation (that has been termed systemic inflammation in xenograft recipients [SIXR]). I... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 28, 2019 Category: Allergy & Immunology Authors: Juan Li, Hidetaka Hara, Yi Wang, Charles Esmon, David K. C. Cooper and Hayato Iwase Tags: Review Source Type: research
Anti-vascular endothelial growth factor agent reduces inflammation in macular edema with central retinal vein occlusion
Correlations among the aqueous flare value (an indicator of inflammation), functional-morphologic parameters, and aqueous humor levels of growth factors/receptors and inflammatory factors/cytokines were invest... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 22, 2019 Category: Allergy & Immunology Authors: Asako Mashima, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto and Masahiko Shimura Tags: Research Source Type: research
Role of autophagy in atherosclerosis: foe or friend?
Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular walls. Different mechanisms and pathological features are evident at the onset of atherosclerotic changes via the enga... (Source: Journal of Inflammation)
Source: Journal of Inflammation - May 2, 2019 Category: Allergy & Immunology Authors: Mehdi Hassanpour, Reza Rahbarghazi, Mohammad Nouri, Nasser Aghamohammadzadeh, Nasser Safaei and Mahdi Ahmadi Tags: Review Source Type: research
Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease
Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 2, 2019 Category: Allergy & Immunology Authors: Cheng-Maw Ho, Shu-Li Ho, Yung-Ming Jeng, Yu-Sheng Lai, Ya-Hui Chen, Shao-Chun Lu, Hui-Ling Chen, Po-Yuan Chang, Rey-Heng Hu and Po-Huang Lee Tags: Research Source Type: research
Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 18, 2019 Category: Allergy & Immunology Authors: Urban Alehagen, Jan Alexander, Jan Aaseth and Anders Larsson Tags: Research Source Type: research
SNP variations in IL10, TNF α and TNFAIP3 genes in patients with dry eye syndrome and Sjogren’s syndrome
In this study we compared single nucleotide polymorphism (SNP) variations in genes encoding cytokine le... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 18, 2019 Category: Allergy & Immunology Authors: Hadas Ben-Eli, Nir Gomel, Doron Jacob Aframian, Rania Abu-Seir, Riki Perlman, Eldad Ben-Chetrit, dror Mevorach, Geffen Kleinstern, Ora Paltiel and Abraham Solomon Tags: Research Source Type: research
Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone
Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular protei... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 19, 2019 Category: Allergy & Immunology Authors: Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima and Tamotsu Ishizuka Tags: Research Source Type: research
LDK378 improves micro- and macro-circulation via alleviating STING-mediated inflammatory injury in a Sepsis rat model induced by Cecal ligation and puncture
Sepsis is a systemic inflammatory response syndrome caused by severe infections. LDK378, a second-generation ALK inhibitor, exhibits a potential anti-inflammatory function against sepsis. Micro- and macro-circ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 18, 2019 Category: Allergy & Immunology Authors: Weiwei Ge, Qiaohua Hu, Xiangshao Fang, Juanhua Liu, Jing Xu, Juntao Hu, Xuefen Liu, Qin Ling, Yue Wang, He Li, Ming Gao, Longyuan Jiang, Zhengfei Yang and Wanchun Tang Tags: Research Source Type: research
Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis
In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 29, 2019 Category: Allergy & Immunology Authors: Sandra P érez-Baos, Paula Gratal, Juan I. Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont and Raquel Largo Tags: Research Source Type: research
Biomarkers for Acute Respiratory Distress syndrome and prospects for personalised medicine
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region o... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 15, 2019 Category: Allergy & Immunology Authors: Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T. Hansel, Gaetano Caramori and Carlo Alberto Volta Tags: Review Source Type: research
The role of N-glycosylation of CD200-CD200R1 interaction in classical microglial activation
Microglial inflammatory activation is the common feature of the central nervous system (CNS) diseases. Microglia can be activated and particularly polarized toward a dual role in the injured CNS. The CD200 rec... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 19, 2018 Category: Allergy & Immunology Authors: Chao Liu, Yifen Shen, Ying Tang and Yongchun Gu Tags: Research Source Type: research
