Characterizing heterogeneity in the response of synovial mesenchymal progenitor cells to synovial macrophages in normal individuals and patients with osteoarthritis
Resident macrophages in OA synovial tissue contribute to synovitis through pro-inflammatory mediators driving cartilage loss. What remains unknown is how these macrophages interact with synovial mesenchymal pr... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 6, 2016 Category: Allergy & Immunology Authors: Akash Fichadiya, Karri L Bertram, Guomin Ren, Robin M Yates and Roman J Krawetz Source Type: research
Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance
Pretreatment with low doses of LPS (lipopolysaccharide, bacterial endotoxin) reduces the pro-inflammatory response to a subsequent higher LPS dose, a phenomenon known as endotoxin tolerance. Moreover, hydrogen... (Source: Journal of Inflammation)
Source: Journal of Inflammation - April 1, 2016 Category: Allergy & Immunology Authors: Ester C. S. Rios, Francisco G. Soriano, Gabor Olah, Domokos Gerö, Bartosz Szczesny and Csaba Szabo Source Type: research
Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with 31P MRS-detectable energy failure
It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1β), in juvenile rats induces a chronic reduction in the apparent diffusion coeffi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 17, 2016 Category: Allergy & Immunology Authors: Raman Saggu Source Type: research
Mycobacterium leprae alters classical activation of human monocytes in vitro
Macrophages play a central role in the pathogenesis of leprosy, caused by Mycobacterium leprae. The polarized clinical presentations in leprosy are associated with differential immune activation. In tuberculoid l... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 11, 2016 Category: Allergy & Immunology Authors: Dorothy Fallows, Blas Peixoto, Gilla Kaplan and Claudia Manca Source Type: research
Lipopolysaccharide-induced inflammation or unilateral ureteral obstruction yielded multiple types of glycosylated Lipocalin 2
The amount of urinary glycoprotein lipocalin 2 (LCN2) has been known to increase after kidney injury because of failed reabsorption by the proximal tubules or direct secretion from injured tissues. However, th... (Source: Journal of Inflammation)
Source: Journal of Inflammation - March 5, 2016 Category: Allergy & Immunology Authors: Yoko Fujiwara, Hiroyoshi Tsuchiya, Nobuya Sakai, Katsushi Shibata, Akio Fujimura and Taka-aki Koshimizu Source Type: research
ERK2 and Akt are negative regulators of insulin and Tumor Necrosis Factor-α stimulated VCAM-1 expression in rat aorta endothelial cells
Diabetes is quickly becoming the most widespread disorder in the Western world. Among the most prevalent effects of diabetes is atherosclerosis, which in turn is driven in part by inflammation. Both insulin an... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 25, 2016 Category: Allergy & Immunology Authors: Gregory B. Pott, Mark Tsurudome, Nadia Bamfo and Marc L. Goalstone Source Type: research
Role of goblet cell protein CLCA1 in murine DSS colitis
The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunction... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 4, 2016 Category: Allergy & Immunology Authors: Nancy A. Erickson, Lars Mundhenk, Samoa Giovannini, Rainer Glauben, Markus M. Heimesaat and Achim D. Gruber Source Type: research
Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains larg... (Source: Journal of Inflammation)
Source: Journal of Inflammation - February 2, 2016 Category: Allergy & Immunology Authors: Xiu-Ming Li, Shen Zhang, Xiao-Shun He, Peng-Da Guo, Xing-Xing Lu, Jing-Ru Wang, Jian-Ming Li and Hua Wu Source Type: research
Non-unions treated with bone morphogenic protein 7: introducing the quantitative measurement of human serum cytokine levels as promising tool in evaluation of adjunct non-union therapy
In this study we sought to determine if application of bone morphogenic protein 7 (BMP-7) promotes physiological bone healing of non-unions and to investigate if serum cytokine analysis may serve as a promisin... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 22, 2016 Category: Allergy & Immunology Authors: Arash Moghaddam, Lisa Breier, Patrick Haubruck, Daniel Bender, Bahram Biglari, Andreas Wentzensen and Gerald Zimmermann Source Type: research
Arterial stiffness and ankle brachial index in patients with rheumatoid arthritis and inflammatory bowel disease
(Source: Journal of Inflammation)
Source: Journal of Inflammation - January 8, 2016 Category: Allergy & Immunology Authors: Kadir Ozturk Source Type: research
Arterial stiffness and ankle brachial index in patients with rheumatoid arthritis and inflammatory bowel disease
No description available (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 8, 2016 Category: Allergy & Immunology Authors: Kadir Ozturk Source Type: research
CXCL14 as an emerging immune and inflammatory modulator
CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migratio... (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 5, 2016 Category: Allergy & Immunology Authors: Jing Lu, Mita Chatterjee, Hannes Schmid, Sandra Beck and Meinrad Gawaz Source Type: research
CXCL14 as an emerging immune and inflammatory modulator
CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migration, also executes antimicrobial immunity. The identity of the receptor for CXCL14 still remains obscure and therefore the intracellular signaling pathway is not entirely delineated. The present review summarizes the contribution of CXCL14 in these two aspects and discusses the biological mechanisms regulating CXCL14 expression and potential CXCL14 mediated functional implications in a variety of cells. (Source: Journal of Inflammation)
Source: Journal of Inflammation - January 5, 2016 Category: Allergy & Immunology Authors: Jing LuMita ChatterjeeHannes SchmidSandra BeckMeinrad Gawaz Source Type: research
The prognostic influence of tumor infiltrating Foxp3 + CD4 + , CD4 + and CD8 + T cells in resected non-small cell lung cancer
Background:
Different subsets of tumor infiltrating T lymphocytes are believed to play essential role in the immune response to cancer cells. The data of these cells in NSCLC are relatively rare and controversial therefore we aimed to evaluate the infiltration patterns of Foxp3 + CD4+, CD4+ and CD8+ T cells in NSCLC and to analyze their relations to survival.
Methods:
Lung tissue specimens from 80 newly diagnosed and untreated patients who underwent surgery for NSCLC (stages I-III), and 16 control group subjects, who underwent surgery due to recurrent spontaneous pneumothorax, were analyzed. Foxp3 + CD4+, CD4+ and ...
Source: Journal of Inflammation - November 23, 2015 Category: Allergy & Immunology Authors: Jurgita JackuteMarius ZemaitisDarius PranysBrigita SitkauskieneSkaidrius MiliauskasVytis BajoriunasSimona LavinskieneRaimundas Sakalauskas Source Type: research
CFTR Knockdown induces proinflammatory changes in intestinal epithelial cells
Conclusion:
Collectively, these data underscore the role played by CFTR in regulating the intestinal inflammatory responses. Such findings lend support to the theory that CFTR exerts functions that may go beyond its role as a chloride channel whereby its disruption may prevent cells to optimally respond to exogenous or endogenous challenges. These observations are of particular interest to CF patients who were found to display alterations in their intestinal microbiota, thus predisposing them to pathogens that may elicit exaggerated inflammatory responses. (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 7, 2015 Category: Allergy & Immunology Authors: Karoline CritesGeneviève MorinValérie OrlandoNatacha PateyCatherine CantinJudith MartelEmmanuelle BrochieroGeneviève Mailhot Source Type: research
