Transient receptor potential ankyrin 1 (trpa1) mediates il-1 β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction
Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 17, 2018 Category: Allergy & Immunology Authors: Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang and Jun Mao Tags: Research Source Type: research
Dynamics of soluble vascular endothelial growth factor receptors and their ligands in aqueous humour during ranibizumab for age-related macular degeneration
Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF ... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 4, 2018 Category: Allergy & Immunology Authors: Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto and Masahiko Shimura Tags: Research Source Type: research
Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages
The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by r... (Source: Journal of Inflammation)
Source: Journal of Inflammation - December 4, 2018 Category: Allergy & Immunology Authors: Yu Du, Peng Ren, Qi Wang, Shu-Kun Jiang, Miao Zhang, Jiao-Yong Li, Lin-Lin Wang and Da-Wei Guan Tags: Research Source Type: research
Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling
Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 26, 2018 Category: Allergy & Immunology Authors: Yumiko Syoji, Ryota Kobayashi, Nako Miyamura, Tsukasa Hirohara, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu and Mamoru Takeda Tags: Research Source Type: research
Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis
Inflammatory cytokines contribute to the development of atherosclerosis. Natural antibodies in the circulation have protective effects on common diseases including atherosclerosis-related conditions. (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 16, 2018 Category: Allergy & Immunology Authors: Peng Wang, Huan Zhao, Zhenqi Wang and Xuan Zhang Tags: Research Source Type: research
Contribution of the inflammasome to inflammaging
Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer ’s d... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 16, 2018 Category: Allergy & Immunology Authors: Nancy H. Mejias, Camila C. Martinez, Marisa E. Stephens and Juan Pablo de Rivero Vaccari Tags: Research Source Type: research
The severity of LPS induced inflammatory injury is negatively associated with the functional liver mass after LPS injection in rat model
High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigate... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 15, 2018 Category: Allergy & Immunology Authors: Haoshu Fang, Anding Liu, Xulin Chen, Wenhui Cheng, Olaf Dirsch and Uta Dahmen Tags: Research Source Type: research
ZNF580 – a brake on Interleukin-6
Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 coul... (Source: Journal of Inflammation)
Source: Journal of Inflammation - October 22, 2018 Category: Allergy & Immunology Authors: Philipp Stenzel, Kaj Nagorsen, Jonathan Bernd, Ulrike Leppert, Andreas Zakrzewicz and Janine Berkholz Tags: Research Source Type: research
The roles of IL-19 and IL-20 in the inflammation of degenerative lumbar spondylolisthesis
Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokin... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 18, 2018 Category: Allergy & Immunology Authors: Kuo-Yuan Huang, Yu-Hsiang Hsu, Wei-Yu Chen, Hui-Ling Tsai, Jing-Jou Yan, Jung-Der Wang, Wen-Lung Liu and Ruey-Mo Lin Tags: Research Source Type: research
Contribution of diminished kidney transplant GFR to increased circulating chemokine ligand 27 level
Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stab... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 10, 2018 Category: Allergy & Immunology Authors: Ahmed Zahran, Ahmed Attia, Holly Mansell and Ahmed Shoker Tags: Research Source Type: research
In vitro suppression of inflammatory cytokine response by methionine sulfoximine
The glutamine synthetase inhibitor methionine sulfoximine (MSO), shown previously to prevent death caused by an inflammatory liver response in mice, was tested on in vitro production of cytokines by mouse peri... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 10, 2018 Category: Allergy & Immunology Authors: Tyler J. Peters, Amruta A. Jambekar and William S. A. Brusilow Tags: Research Source Type: research
Expression and clinical significance of the NEK7-NLRP3 inflammasome signaling pathway in patients with systemic lupus erythematosus
The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as... (Source: Journal of Inflammation)
Source: Journal of Inflammation - September 3, 2018 Category: Allergy & Immunology Authors: Zhen-Zhen Ma, Hong-Sheng Sun, Ji-Cai Lv, Lei Guo and Qing-Rui Yang Tags: Research Source Type: research
MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1 α
T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1 α (HIF-1α) is involved in allergic responses in asthma. Our previous studies ind... (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 20, 2018 Category: Allergy & Immunology Authors: Li Xu, Wen J. Sun, Ai J. Jia, Lu L. Qiu, Bing Xiao, Lin Mu, Jian M. Li, Xiu F. Zhang, Yan Wei, Cong Peng, Dong S. Zhang and Xu D. Xiang Tags: Research Source Type: research
Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair
Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair. Hesperi... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 20, 2018 Category: Allergy & Immunology Authors: Shipeng Xiao, Wenguang Liu, Jianqiang Bi, Shenghou Liu, Heng Zhao, Ningji Gong, Deguo Xing, Hongwei Gao and Mingzhi Gong Tags: Research Source Type: research
Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease
The CARD family plays an important role in innate immune response by the activation of NF- κB. The aim of this study was to determine the gene expression and to enumerate the protein-expressing cells of some me... (Source: Journal of Inflammation)
Source: Journal of Inflammation - July 11, 2018 Category: Allergy & Immunology Authors: Jes ús K. Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Andrea Sarmiento-Aguilar, Rafael Barreto-Zuñiga, Braulio Martínez-Benitez and Montserrat A. Lara-Velazquez Tags: Research Source Type: research
