Current Topics in Medicinal Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases
Curr Top Med Chem. 2024 Mar 29. doi: 10.2174/0115680266289898240322073258. Online ahead of print.ABSTRACTRespiratory viruses have caused many pandemics from past to present and are among the top global public health problems due to their rate of spread. The recently experienced COVID-19 pandemic has led to an understanding of the importance of rapid diagnostic tests to prevent epidemics and the difficulties of developing new vaccines. On the other hand, the emergence of resistance to existing antiviral drugs during the treatment process poses a major problem for society and global health systems. Therefore, there is a need...
Source: Current Topics in Medicinal Chemistry - April 1, 2024 Category: Chemistry Authors: Yasemin Budama-Kilinc Ozan Baris Kurtur Bahar Gok Nisanur Cakmakci Serda Kecel-Gunduz Necdet Mehmet Unel Taylan Kurtulus Ozturk Source Type: research

A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques
Curr Top Med Chem. 2024 Feb 15:e150224227031. doi: 10.2174/0115680266281358240206112605. Online ahead of print.ABSTRACTPeptides acquire target affinity based on the combination of residues in their sequences and the conformation formed by their flexible folding, an ability that makes them very attractive biomaterials in therapeutic, diagnostic, and assay fields. With the development of computer technology, computer-aided design and screening of affinity peptides has become a more efficient and faster method. This review summarizes successful cases of computer-aided design and screening of affinity peptide ligands in recent...
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Zheng Wei Meilun Chen Xiaoling Lu Yijie Liu Guangnan Peng Jie Yang Chunhua Tang Peng Yu Source Type: research

Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research

Immunomodulatory Effect of Phytoactive Compounds on Human Health: A Narrative Review Integrated with Bioinformatics Approach
CONCLUSION: The present study presents a cumulative picture of phytochemicals with therapeutic benefits. Additionally, the study also reported a few novel genes and pathways in Echinacea extracts by re-analyzing GSE 12259, indicating its anti-inflammatory, anti-viral, and immunomodulatory properties.PMID:38551050 | DOI:10.2174/0115680266274272240321065039 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Saumya Choudhary Sheeba Khan Shivani Rustagi Vijay Rani Rajpal Noor Saba Khan Neeraj Kumar George Thomas Anamika Pandey Mehmet Hamurcu Sait Gezgin Sajad Majeed Zargar Mohd Kamran Khan Source Type: research

Phytochemicals for Cancer Treatment: An Update on Plant-Derived Anti-Cancer Compounds and their Mechanisms of Action
Curr Top Med Chem. 2024 Mar 27. doi: 10.2174/0115680266268185240320085619. Online ahead of print.ABSTRACTCancer remains one of the major causes of morbidity and mortality worldwide. Scientists from different fields are working to devise an efficient treatment strategy in order to reduce the global burden of cancer. Commonly used treatment approaches for cancer treatment include chemotherapy, immunotherapy, photodynamic therapy, radiation, surgery, etc. These treatment procedures have several pitfalls, such as toxicity, limited bioavailability, rapid elimination, poor specificity, and high cost. On the other side, plant-der...
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Sana Ullah Tariq Khan Taimoor Khan Muhammad Ali Abdul Khaliq Jan Zabta Khan Shinwari Ajmal Khan Mohamed Al-Farsi Muhammad Waqas Source Type: research

Food-Derived Peptides as Promising Neuroprotective Agents: Mechanism and Therapeutic Potential
This article highlights various pathways, such as inflammatory pathways, major oxidant pathways, apoptotic pathways, neurotransmitter modulation, and gene regulation through which food-derived peptides interact at the cellular level.PMID:38551052 | DOI:10.2174/0115680266289248240322061723 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Kavita Patel Ashutosh Mani Source Type: research