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Computational Analysis of Gastric Canceromics Data to Identify Putative Biomarkers
CONCLUSION: The molecular basis of the illness is well understood by computational approaches, which also provide biomarkers for targeted cancer therapy. These putative biomarkers may be useful in the early detection of disease. This study also shows that in H. pylori infection in early-stage gastric cancer, the top 10 hub genes constitute an essential component of the epithelial cell signaling pathways. These genes can further contribute to the future development of effective biomarkers.PMID:37861003 | DOI:10.2174/0115680266259310230924190213 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Renu Vyas Sagarika Saha Source Type: research

Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism
Curr Top Med Chem. 2023 Oct 11. doi: 10.2174/0115680266252617231010070539. Online ahead of print.ABSTRACTAs far as malignant tumors of the central nervous system are concerned, glioblastoma (GB) and neuroblastoma (NB) are the most prevalent, aggressive, and fatal forms in adult and pediatric populations, respectively. NB is the most prominent childhood extracranial compact neoplasm in pediatrics when the embryo develops from undifferentiated neural crest cells. Regarding malignant primary brain tumors, GB is the most lethal and difficult to treat. Currently, there are few effective treatments available for either condition...
Source: Current Topics in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Mohammad Barati Amir Modarresi Chahardehi Yasaman Hosseini Source Type: research

Clinical Research Progress of BTK Inhibitors in the Treatment of Autoimmune Diseases
This article briefly summarizes the role of BTK in the BCR signaling pathway, the development process of BTK inhibitors, and especially the latest progress of their clinical trials for the treatment of AD.PMID:37861005 | DOI:10.2174/0115680266264515230921052521 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 20, 2023 Category: Chemistry Authors: Pei Lin Dandan Zhang Jun Lin Source Type: research

Targeting Various Pathogenic Pathways for the Development of Antialzheimer's Drugs: An Update
Curr Top Med Chem. 2023 Oct 5. doi: 10.2174/0115680266274924231002110733. Online ahead of print.ABSTRACTAlzheimer's disease (AD) has been recognized as the most important cause of dementia, which is estimated to contribute more than 2 trillion USD in medical costs. AD patients encounter progressive neurodegenerative dementia associated with behavioural, linguistic, and visuospatial deficits. Although studies on the discovery of amyloid β (Aβ) and tau (the essential elements of plaques and tangles in AD) have shed light on the molecular pathological processes of AD, the exact cause of the condition is still largely unknow...
Source: Current Topics in Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Subiya Ambreen Naurin Fatima Mohammad Umar Mohd Shaququzzaman Mohammad Mumtaz Alam Ruhi Ali Source Type: research

Ethnopharmacology, Nutritional value, Therapeutic effects, Phytochemistry, and Toxicology of Salvia hispanica L.: A Review
CONCLUSION: The current evaluation focuses on the distribution, chemical composition, nutritional value, and principal uses of S. hispanica in order to determine future research requirements and examine its pharmacological applications through clinical studies.PMID:37855294 | DOI:10.2174/0115680266248117230922095003 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 19, 2023 Category: Chemistry Authors: Smail Amtaghri Mohamed Eddouks Source Type: research

Exploring the Potential of Natural Products as Antiparasitic Agents for Neglected Tropical Diseases
Curr Top Med Chem. 2023 Oct 10. doi: 10.2174/0115680266256963230921061925. Online ahead of print.ABSTRACTRecent developments in the use of natural product-based molecules as antiparasitic agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis (HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry, emphasizing the structural characteristics of natural m...
Source: Current Topics in Medicinal Chemistry - October 16, 2023 Category: Chemistry Authors: Dayanna Orosco Arturo Ren é Mendoza Carlos Mario Mel éndez Source Type: research

Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review
CONCLUSION: This review article provides a thorough examination of piperine and the source plant. The best extraction technique for the extraction of piperine and the synthesis of its analogs with various biological activities, including antihypertensive, antidiabetic, insecticidal, antibacterial, and antibiotic properties, are covered in the article. This review aims to provide an updated analysis of the literature on the synthesis of piperine analogs.PMID:37828679 | DOI:10.2174/0115680266256255231009075303 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 13, 2023 Category: Chemistry Authors: Sagar Joshi None Salahuddin Avijit Mazumder Rajnish Kumar Km Shabana Sonakshi Tyagi Kavita Rana Mohamed Jawed Ahsan Mohammad Shahar Yar Arvind Arya Navneet Khurana Source Type: research