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Natural Flavonoids as Potential Therapeutics in the Management of Diabetic Wound: A Review
Curr Top Med Chem. 2023 Apr 19. doi: 10.2174/1568026623666230419102140. Online ahead of print.ABSTRACTFlavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyperglycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, antitumor, and wound healing property. Quercetin, he...
Source: Current Topics in Medicinal Chemistry - April 28, 2023 Category: Chemistry Authors: Nongmaithem Randhoni Chanu Pal Gogoi Pervej Alom Barbhuiya Partha Pratim Dutta Manash Pratim Pathak Saikat Sen Source Type: research

The Gut Microbiota - Brain Axis: Potential Mechanism of Drug Addiction
CONCLUSION: Finally, the treatment of probiotics and fecal transplantation was summarized. This was done to further understand the role of intestinal microecology in the pathogenesis of drug addiction and to explore new methods for the treatment of drug addiction.PMID:37106510 | DOI:10.2174/1568026623666230418114133 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 28, 2023 Category: Chemistry Authors: Xiao Luo Hong Li Xuan Fan Xiaocong Wu Ruiyi Zhou Yi Lei Dan Xue Fazheng Yang Yu Xu Kunhua Wang Source Type: research

Current Trends and Future Prospects on the Therapeutic Potential of Cordia dichotoma G. Forst.-A Valuable Folk Medicine
CONCLUSION: This review will help lay grounds to facilitate state-of-art research intended to acquire additional information about the plant. The study offers opportunities to explore bio-guided isolation strategies for isolating and purifying phytochemical constituents that are biologically effective including pharmacological and pharmaceutical aspects to better understand its clinical relevance. Exploring pure isolated phytoconstituents for their mode of action including estimation of their bioavailability and pharmacokinetic parameters would be of considerable interest in assessing the attained pharmacological effect. C...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Rati Kailash Prasad Tripathi Source Type: research

Application of Biomimetic Nanoparticles Based on the Cell Membrane in Tumor Therapy
Curr Top Med Chem. 2023 Apr 27. doi: 10.2174/1568026623666230427114622. Online ahead of print.ABSTRACTDue to their unique biological functionality, nanocarriers can be designed to deliver various anti-tumor drugs in vivo, which has a wide and important application prospect in the field of tumor therapy. However, poor biosafety, short blood circulation time, and weak targeting ability still limit the application of nanoparticles in tumor therapy. In recent years, with the development of biomedicine, the biomimetic technology-based biomembrane-mediated drug delivery system is expected to achieve a breakthrough in tumor-targe...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Ya Gong Jingbin Huang Source Type: research

Employing "Red Flags" to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis
Curr Top Med Chem. 2023 Apr 27. doi: 10.2174/1568026623666230427114840. Online ahead of print.ABSTRACTNitroaromatic compounds have been used for treating parasitic diseases since the 1960s. Pharmacological alternatives to treat them are under observation. However, for the most neglected diseases, such as those caused by worms and less known protozoans, nitro compounds are still among the drugs of choice, despite their well-known collateral effects. In this review, we describe the chemistry and the uses of the still most employed nitroaromatic compounds for treating parasitosis caused by worms or lesser-known protozoans. We...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Daniela Gon çales Galasse Rando Helena G O Costa Thais Fernanda Heitor Josu é de Moraes Thais Fernanda Amorim Pavani Source Type: research

A Quinquennial Review on Recent Advancements and Developments in Search of Anti- malarial Agents
Curr Top Med Chem. 2023 Apr 27. doi: 10.2174/1568026623666230427115241. Online ahead of print.ABSTRACTMalaria has been a major parasitic disease in tropical and subtropical regions and is estimated to kill between one and two million people (mainly children) every year. Novel anti-malarial agents are urgently needed to combat the malarial parasites enduring resistance to the current medications, leading to increased morbidity and mortality. The heterocycles, holding a prominent position in chemistry and found in both natural and synthetic sources, have shown several biological activities including anti-malarial activity. T...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Tejas M Dhameliya Deepika Kathuria Tanvi M Patel Bhavarth P Dave Amit Z Chaudhari Drashtiben D Vekariya Source Type: research

Review of the Application of PAT in the Pharmaceutical Continuous Crystallization Process
Curr Top Med Chem. 2023 Apr 20. doi: 10.2174/1568026623666230420112709. Online ahead of print.ABSTRACTAs an important pharmaceutical process, crystallization greatly impacts the final product. In recent years, the continuous crystallization process has attracted more attention from researchers, with the promotion of continuous manufacturing (CM) by the Food and Drug Administration (FDA). The continuous crystallization process has the advantages of high economic benefit, stable and uniform quality, a short production cycle, and personalization. To carry out continuous crystallization, some related process analytical technol...
Source: Current Topics in Medicinal Chemistry - April 20, 2023 Category: Chemistry Authors: Bing Zhao Hengchang Zang Liang Zhong Xiaobo Ma Haowei Wang Hui Zhang Lian Li Source Type: research

Chronic Hepatitis B Infection: Current and Emerging Therapeutic Strategies
This article summarizes the current landscape of HBV treatments, and drugs in clinical trials and highlights the most recent anti-HBV small molecules designed to directly target HBV or to improve immune response during chronic infection.PMID:37069708 | DOI:10.2174/1568026623666230413094331 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 18, 2023 Category: Chemistry Authors: Ankita Singh Jitendra Kumar Vijay Kumar Source Type: research

Natural products as antifungal agents against invasive fungi
CONCLUSION: In this review, we attempted to review the available literature on natural antifungal products and their derivatives. Most of the studied compounds showed potent activity against Candida species, Aspergillus species, or Cryptococcus species. Some of the studied compounds also demonstrated the ability to impair the cell membrane and cell wall, inhibit hypha and biofilms, and cause mitochondrial dysfunction. Although the MoAs of these compounds are not well understood yet, they can be used as lead components for the development of new, effective, and safe antifungal agents through their novel mechanisms.PMID:3707...
Source: Current Topics in Medicinal Chemistry - April 18, 2023 Category: Chemistry Authors: Fang-Rui Dong Lu Gao Liang Wang Yuan-Ying Jiang Yong-Sheng Jin Source Type: research