Current Topics in Medicinal Chemistry 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.An Updated Overview of Synthetic α-glucosidase Inhibitors: Chemistry and Bioactivities
This article aims to provide useful information for medicinal chemists in further developing clinically available anti-type 2 diabetes drugs.PMID:37818579 | DOI:10.2174/0115680266260682230921054652 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Yong-Si Cai Hong-Xu Xie Jin-He Zhang Yue Li Juan Zhang Kai-Ming Wang Cheng-Shi Jiang Source Type: research
Gamma Secretase as an Important Drug Target for Management of Alzheimer's Disease: A Comprehensive Review
In this report, each of the four subunits of GS is described in detail, along with the interactions between GS and its inhibitors or modulators. In addition, the FDA-approved drugs are enlisted.PMID:37818580 | DOI:10.2174/0115680266259174231006070637 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Fady Tadros Hakem Youstina Farid Fouad Reem K Arafa Source Type: research
Natural Products and Biological Activities of Plants from Genus Morus: 2011-2023
Curr Top Med Chem. 2023 Oct 5. doi: 10.2174/0115680266257370230920055003. Online ahead of print.ABSTRACTSpecies of genus Morus (family Moraceae) have been used as traditional medicinal and edible resources since ancient times. Genus Morus has been acknowledged as a promising resource for the exploration of novel compounds with various bioactivities. Phytochemical investigations of the genus have led to the discovery of more than approximately 453 natural products from 2011 to 2023, mainly including flavonoids, Diels-Alder adducts, 2-arylbenzfuran, alkaloids and stilbenes. Bioactive constituents and extracts of this genus d...
Source: Current Topics in Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Yan-Ao Wang Chao Liu Xu Guo Meng-Qi Zhang Shutao Sun Jin-Yue Sun Afsar Khan Lu Liu Ying-Ying Chen Source Type: research
Insight into Structure-Activity Relationship of New Compounds for Breast Cancer Treatment
Conclusion: Through the structural optimization of kinase inhibitors, microtubule-targeted drugs, and metal complexes, it is expected to obtain more advantageous breast cancer treatment drugs. It cannot be ignored that epigenetic inhibitors, dual inhibitors and degraders may bring new breast cancer treatment strategies.PMID:37818582 | DOI:10.2174/0115680266253686230921054429 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - October 11, 2023 Category: Chemistry Authors: Lu Li Qiangsheng Zhang Source Type: research
Gut Microbiome and Circadian Interactions with Platelets Across Human Diseases, including Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Cancer
This article reviews platelet function and interactions with the gut microbiome and circadian systems, highlighting the role of the platelet mitochondrial melatonergic pathway in determining platelet activation, fluxes and plasticity. This provides a number of novel conceptualizations of platelet function and mode of interaction with other cell types, including the pathoetiology and pathophysiology of diverse medical conditions, such as cancer, Alzheimer's disease, and amyotrophic lateral sclerosis. It is proposed that a platelet-gut axis allows platelets to contribute to many of the pathophysiological processes linked to ...
Source: Current Topics in Medicinal Chemistry - October 9, 2023 Category: Chemistry Authors: George Anderson Source Type: research
Current Pharmaceutical Research on the Significant Pharmacophore Mannich bases in Drug Design
Curr Top Med Chem. 2023 Oct 4. doi: 10.2174/0115680266256102230922101939. Online ahead of print.ABSTRACTA multitude of distinct Mannich bases have been synthesized and evaluated as potential therapeutics for a wide variety of diseases and medical conditions, either in the form of prodrugs or as molecules that trigger a biological response from specific targets. The Mannich reaction has been utilized to enhance the biological activity of numerous compounds, resulting in notable progress in various areas such as anticonvulsant, antimalarial, anticancer, anti-inflammatory, antiproliferative, antibacterial, antimicrobial, anti...
Source: Current Topics in Medicinal Chemistry - October 9, 2023 Category: Chemistry Authors: Cem Yamali Mustafa Gul Halise Inci Gul Source Type: research
Gut Microbiome and Circadian Interactions with Platelets Across Human Diseases, including Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Cancer
This article reviews platelet function and interactions with the gut microbiome and circadian systems, highlighting the role of the platelet mitochondrial melatonergic pathway in determining platelet activation, fluxes and plasticity. This provides a number of novel conceptualizations of platelet function and mode of interaction with other cell types, including the pathoetiology and pathophysiology of diverse medical conditions, such as cancer, Alzheimer's disease, and amyotrophic lateral sclerosis. It is proposed that a platelet-gut axis allows platelets to contribute to many of the pathophysiological processes linked to ...
Source: Current Topics in Medicinal Chemistry - October 9, 2023 Category: Chemistry Authors: George Anderson Source Type: research
Current Pharmaceutical Research on the Significant Pharmacophore Mannich bases in Drug Design
Curr Top Med Chem. 2023 Oct 4. doi: 10.2174/0115680266256102230922101939. Online ahead of print.ABSTRACTA multitude of distinct Mannich bases have been synthesized and evaluated as potential therapeutics for a wide variety of diseases and medical conditions, either in the form of prodrugs or as molecules that trigger a biological response from specific targets. The Mannich reaction has been utilized to enhance the biological activity of numerous compounds, resulting in notable progress in various areas such as anticonvulsant, antimalarial, anticancer, anti-inflammatory, antiproliferative, antibacterial, antimicrobial, anti...
Source: Current Topics in Medicinal Chemistry - October 9, 2023 Category: Chemistry Authors: Cem Yamali Mustafa Gul Halise Inci Gul Source Type: research
Gut Microbiome and Circadian Interactions with Platelets Across Human Diseases, including Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Cancer
This article reviews platelet function and interactions with the gut microbiome and circadian systems, highlighting the role of the platelet mitochondrial melatonergic pathway in determining platelet activation, fluxes and plasticity. This provides a number of novel conceptualizations of platelet function and mode of interaction with other cell types, including the pathoetiology and pathophysiology of diverse medical conditions, such as cancer, Alzheimer's disease, and amyotrophic lateral sclerosis. It is proposed that a platelet-gut axis allows platelets to contribute to many of the pathophysiological processes linked to ...
Source: Current Topics in Medicinal Chemistry - October 9, 2023 Category: Chemistry Authors: George Anderson Source Type: research
Current Pharmaceutical Research on the Significant Pharmacophore Mannich bases in Drug Design
Curr Top Med Chem. 2023 Oct 4. doi: 10.2174/0115680266256102230922101939. Online ahead of print.ABSTRACTA multitude of distinct Mannich bases have been synthesized and evaluated as potential therapeutics for a wide variety of diseases and medical conditions, either in the form of prodrugs or as molecules that trigger a biological response from specific targets. The Mannich reaction has been utilized to enhance the biological activity of numerous compounds, resulting in notable progress in various areas such as anticonvulsant, antimalarial, anticancer, anti-inflammatory, antiproliferative, antibacterial, antimicrobial, anti...
Source: Current Topics in Medicinal Chemistry - October 9, 2023 Category: Chemistry Authors: Cem Yamali Mustafa Gul Halise Inci Gul Source Type: research
Molecular Dynamics Simulations of HDAC-Ligand Complexes Towards the Design of New Anticancer Compounds ±
Curr Top Med Chem. 2023 Sep 28. doi: 10.2174/0115680266250924230920042845. Online ahead of print.ABSTRACTQuantitative Structure-Activity Relationship (QSAR) studies gained a foothold in the mid-1960s to rationalise the biological activity of medicinally important compounds. Since then, the advancements in computer hardware and software added many new techniques and areas to this field of study. Molecular dynamics (MD) simulations are one such technique in direct drug design approaches. MD simulations have a special place in drug design studies because they decode the dynamics of intermolecular interactions between a biolog...
Source: Current Topics in Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Varun Dewaker Yenamandra S Prabhakar Source Type: research
Molecular Dynamics Simulations of HDAC-Ligand Complexes Towards the Design of New Anticancer Compounds ±
Curr Top Med Chem. 2023 Sep 28. doi: 10.2174/0115680266250924230920042845. Online ahead of print.ABSTRACTQuantitative Structure-Activity Relationship (QSAR) studies gained a foothold in the mid-1960s to rationalise the biological activity of medicinally important compounds. Since then, the advancements in computer hardware and software added many new techniques and areas to this field of study. Molecular dynamics (MD) simulations are one such technique in direct drug design approaches. MD simulations have a special place in drug design studies because they decode the dynamics of intermolecular interactions between a biolog...
Source: Current Topics in Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Varun Dewaker Yenamandra S Prabhakar Source Type: research
Molecular Dynamics Simulations of HDAC-Ligand Complexes Towards the Design of New Anticancer Compounds ±
Curr Top Med Chem. 2023 Sep 28. doi: 10.2174/0115680266250924230920042845. Online ahead of print.ABSTRACTQuantitative Structure-Activity Relationship (QSAR) studies gained a foothold in the mid-1960s to rationalise the biological activity of medicinally important compounds. Since then, the advancements in computer hardware and software added many new techniques and areas to this field of study. Molecular dynamics (MD) simulations are one such technique in direct drug design approaches. MD simulations have a special place in drug design studies because they decode the dynamics of intermolecular interactions between a biolog...
Source: Current Topics in Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Varun Dewaker Yenamandra S Prabhakar Source Type: research
Molecular Dynamics Simulations of HDAC-Ligand Complexes Towards the Design of New Anticancer Compounds ±
Curr Top Med Chem. 2023 Sep 28. doi: 10.2174/0115680266250924230920042845. Online ahead of print.ABSTRACTQuantitative Structure-Activity Relationship (QSAR) studies gained a foothold in the mid-1960s to rationalise the biological activity of medicinally important compounds. Since then, the advancements in computer hardware and software added many new techniques and areas to this field of study. Molecular dynamics (MD) simulations are one such technique in direct drug design approaches. MD simulations have a special place in drug design studies because they decode the dynamics of intermolecular interactions between a biolog...
Source: Current Topics in Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Varun Dewaker Yenamandra S Prabhakar Source Type: research
Molecular Dynamics Simulations of HDAC-Ligand Complexes Towards the Design of New Anticancer Compounds ±
Curr Top Med Chem. 2023 Sep 28. doi: 10.2174/0115680266250924230920042845. Online ahead of print.ABSTRACTQuantitative Structure-Activity Relationship (QSAR) studies gained a foothold in the mid-1960s to rationalise the biological activity of medicinally important compounds. Since then, the advancements in computer hardware and software added many new techniques and areas to this field of study. Molecular dynamics (MD) simulations are one such technique in direct drug design approaches. MD simulations have a special place in drug design studies because they decode the dynamics of intermolecular interactions between a biolog...
Source: Current Topics in Medicinal Chemistry - October 2, 2023 Category: Chemistry Authors: Varun Dewaker Yenamandra S Prabhakar Source Type: research
