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Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma Pathogenesis
Curr Top Med Chem. 2024 Jan 3. doi: 10.2174/0115680266279228231219101233. Online ahead of print.ABSTRACTSignaling pathways in hepatocellular carcinoma are primarily mediated by the phosphorylation and ubiquitination of post-translational proteins. In mammalian cells, ubiquitin-specific proteases (USPs) account for the majority of protein deubiquitination activities. In addition to transcriptional and post-translational regulation, ubiquitination plays an important role in the regulation of key proteins. There is a possibility that altered biological processes may lead to serious human diseases, including cancer. Recent stu...
Source: Current Topics in Medicinal Chemistry - January 4, 2024 Category: Chemistry Authors: Xinwen Zhang Jiamin Jin Jiacheng Cong Siqi Chen Ting Wang Bin Gao Guanlin Huang Zhiqiang Huang Juzheng Zhang Zhenran Wang Jinfeng Yang Source Type: research

Challenges, Consequences and Possible Treatments of Anticancer Drug Discovery
Curr Top Med Chem. 2023;23(30):2805-2806. doi: 10.2174/156802662330231130162134.NO ABSTRACTPMID:38164721 | DOI:10.2174/156802662330231130162134 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 2, 2024 Category: Chemistry Authors: Marcus T Scotti Luciana Scotti Source Type: research

To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors
Curr Top Med Chem. 2023;23(30):2877-2972. doi: 10.2174/0115680266261150231110053650.ABSTRACTReceptor tyrosine kinase (RTK) regulates multiple pathways, including Mitogenactivated protein kinases (MAPKs), PI3/AKT, JAK/STAT pathway, etc. which has a significant role in the progression and metastasis of tumor. As RTK activation regulates numerous essential bodily processes, including cell proliferation and division, RTK dysregulation has been identified in many types of cancers. Targeting RTK is a significant challenge in cancer due to the abnormal upregulation and downregulation of RTK receptors subfamily EGFR, FGFR, PDGFR, ...
Source: Current Topics in Medicinal Chemistry - January 2, 2024 Category: Chemistry Authors: Debroop Basu Riya Pal Maitrayee Sarkar Soubhik Barma Sumit Halder Harekrishna Roy Sisir Nandi Asmita Samadder Source Type: research

Challenges, Consequences and Possible Treatments of Anticancer Drug Discovery
Curr Top Med Chem. 2023;23(30):2805-2806. doi: 10.2174/156802662330231130162134.NO ABSTRACTPMID:38164721 | DOI:10.2174/156802662330231130162134 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 2, 2024 Category: Chemistry Authors: Marcus T Scotti Luciana Scotti Source Type: research

To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors
Curr Top Med Chem. 2023;23(30):2877-2972. doi: 10.2174/0115680266261150231110053650.ABSTRACTReceptor tyrosine kinase (RTK) regulates multiple pathways, including Mitogenactivated protein kinases (MAPKs), PI3/AKT, JAK/STAT pathway, etc. which has a significant role in the progression and metastasis of tumor. As RTK activation regulates numerous essential bodily processes, including cell proliferation and division, RTK dysregulation has been identified in many types of cancers. Targeting RTK is a significant challenge in cancer due to the abnormal upregulation and downregulation of RTK receptors subfamily EGFR, FGFR, PDGFR, ...
Source: Current Topics in Medicinal Chemistry - January 2, 2024 Category: Chemistry Authors: Debroop Basu Riya Pal Maitrayee Sarkar Soubhik Barma Sumit Halder Harekrishna Roy Sisir Nandi Asmita Samadder Source Type: research

Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266277024231113114017. Online ahead of print.ABSTRACTCordia dichotoma is a valuable medicinal plant belonging to the family Boraginaceae. It consists of several beneficial secondary metabolite components, including alkaloids, carbohydrates, flavonoids, glycosides, saponins, and tannins. Numerous studies have been conducted to assess the anticancer properties of Cordia dichotoma on MCF-7, A-549, PC3, and HeLa cancer cell lines, primarily utilizing ethanolic extract, methanolic extract, and chloroform extract. The results of these studies have demonstrated significant effec...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Sankha Bhattacharya Saurav Madhavrao Patil Source Type: research

Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266273944231213070916. Online ahead of print.ABSTRACTSesamol, one of the key bioactive ingredients of sesame seeds (sesamum indicum L.), is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, and mental disorders. Sesamol is a benign molecule that inhibits the expression of inflammatory indicators like numerous enzymes...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Hayate Javed Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Ghulam Md Ashraf Shreesh Ojha Source Type: research

Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266277024231113114017. Online ahead of print.ABSTRACTCordia dichotoma is a valuable medicinal plant belonging to the family Boraginaceae. It consists of several beneficial secondary metabolite components, including alkaloids, carbohydrates, flavonoids, glycosides, saponins, and tannins. Numerous studies have been conducted to assess the anticancer properties of Cordia dichotoma on MCF-7, A-549, PC3, and HeLa cancer cell lines, primarily utilizing ethanolic extract, methanolic extract, and chloroform extract. The results of these studies have demonstrated significant effec...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Sankha Bhattacharya Saurav Madhavrao Patil Source Type: research

Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266273944231213070916. Online ahead of print.ABSTRACTSesamol, one of the key bioactive ingredients of sesame seeds (sesamum indicum L.), is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, and mental disorders. Sesamol is a benign molecule that inhibits the expression of inflammatory indicators like numerous enzymes...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Hayate Javed Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Ghulam Md Ashraf Shreesh Ojha Source Type: research

Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266277024231113114017. Online ahead of print.ABSTRACTCordia dichotoma is a valuable medicinal plant belonging to the family Boraginaceae. It consists of several beneficial secondary metabolite components, including alkaloids, carbohydrates, flavonoids, glycosides, saponins, and tannins. Numerous studies have been conducted to assess the anticancer properties of Cordia dichotoma on MCF-7, A-549, PC3, and HeLa cancer cell lines, primarily utilizing ethanolic extract, methanolic extract, and chloroform extract. The results of these studies have demonstrated significant effec...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Sankha Bhattacharya Saurav Madhavrao Patil Source Type: research

Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266273944231213070916. Online ahead of print.ABSTRACTSesamol, one of the key bioactive ingredients of sesame seeds (sesamum indicum L.), is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, and mental disorders. Sesamol is a benign molecule that inhibits the expression of inflammatory indicators like numerous enzymes...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Hayate Javed Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Ghulam Md Ashraf Shreesh Ojha Source Type: research

Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266277024231113114017. Online ahead of print.ABSTRACTCordia dichotoma is a valuable medicinal plant belonging to the family Boraginaceae. It consists of several beneficial secondary metabolite components, including alkaloids, carbohydrates, flavonoids, glycosides, saponins, and tannins. Numerous studies have been conducted to assess the anticancer properties of Cordia dichotoma on MCF-7, A-549, PC3, and HeLa cancer cell lines, primarily utilizing ethanolic extract, methanolic extract, and chloroform extract. The results of these studies have demonstrated significant effec...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Sankha Bhattacharya Saurav Madhavrao Patil Source Type: research

Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266273944231213070916. Online ahead of print.ABSTRACTSesamol, one of the key bioactive ingredients of sesame seeds (sesamum indicum L.), is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, and mental disorders. Sesamol is a benign molecule that inhibits the expression of inflammatory indicators like numerous enzymes...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Hayate Javed Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Ghulam Md Ashraf Shreesh Ojha Source Type: research

Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266277024231113114017. Online ahead of print.ABSTRACTCordia dichotoma is a valuable medicinal plant belonging to the family Boraginaceae. It consists of several beneficial secondary metabolite components, including alkaloids, carbohydrates, flavonoids, glycosides, saponins, and tannins. Numerous studies have been conducted to assess the anticancer properties of Cordia dichotoma on MCF-7, A-549, PC3, and HeLa cancer cell lines, primarily utilizing ethanolic extract, methanolic extract, and chloroform extract. The results of these studies have demonstrated significant effec...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Sankha Bhattacharya Saurav Madhavrao Patil Source Type: research

Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise in Neurodegenerative Diseases
Curr Top Med Chem. 2023 Dec 20. doi: 10.2174/0115680266273944231213070916. Online ahead of print.ABSTRACTSesamol, one of the key bioactive ingredients of sesame seeds (sesamum indicum L.), is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, and mental disorders. Sesamol is a benign molecule that inhibits the expression of inflammatory indicators like numerous enzymes...
Source: Current Topics in Medicinal Chemistry - December 23, 2023 Category: Chemistry Authors: Hayate Javed Mohamed Fizur Nagoor Meeran Niraj Kumar Jha Ghulam Md Ashraf Shreesh Ojha Source Type: research