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Navigating Molecular Pathways: An Update on Drugs in Colorectal Cancer Treatment
Curr Top Med Chem. 2023 Jun 14. doi: 10.2174/1568026623666230614165548. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a multifaceted and heterogeneous ailment that affects the colon or rectum of the digestive system. It is the second most commonly occurring form of cancer and ranks third in terms of mortality rate. The progression of CRC does not occur due to a single mutational event; rather, it is the result of the sequential and cumulative accumulation of mutations in key driver genes of signaling pathways. The most significant signaling pathways, which have oncogenic potential due to their deregulation, incl...
Source: Current Topics in Medicinal Chemistry - June 15, 2023 Category: Chemistry Authors: Neha Shree Maurya Ashutosh Mani Source Type: research

N-Heterocyclic Compounds, in silico Molecular Docking Studies, and in vitro Enzyme Inhibition Effect Against Acetylcholinesterase Inhibitors
CONCLUSION: These new syntheses are drugs that can be used as AChE inhibitors in Alzheimer's disease.PMID:37317917 | DOI:10.2174/1568026623666230614150520 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - June 15, 2023 Category: Chemistry Authors: Abdussamat Guzel Zeynep Is ık Yetkin Gok Tugba Taskin-Tok Ayd ın Aktas Source Type: research

Calotropis procera (Aiton) Dryand (Apocynaceae): state of the art of its use and applications
In conclusion, the need of bioassay-guided isolation of bioactive compounds, bioavailability and efficacy, as well as pharmacological and toxicity studies, are needed using in vivo models and clinical trials in order to support the traditionally claimed health benefits.PMID:37282633 | DOI:10.2174/1568026623666230606162556 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Ana Carolina Silveira Rabelo Giuliana D Noratto Jessica Borghesi Adriano Souza Fonseca Ant ônio José Cantanhede Filho Fernando Jos é Costa Carneiro Ana L úcia Abreu-Silva Maria Ang élica Miglino Source Type: research

Modulation of Expression Levels of Various Cytokines and Inflammatory Responses by Glucosinolate Derivatives
Curr Top Med Chem. 2023 Jun 5. doi: 10.2174/1568026623666230605120626. Online ahead of print.NO ABSTRACTPMID:37282634 | DOI:10.2174/1568026623666230605120626 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Venkidasamy Baskar Murugesan Krishnan Govindasamy Rajakumar Shivraj Hariram Nile Muthu Thiruvengadam Source Type: research