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Prominent Perspective on Existing Biological Hallmarks of Alzheimer's Disease
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266292514240404040341. Online ahead of print.ABSTRACTBiomarkers are the most significant diagnosis tools tending towards unique approaches and solutions for the prevention and cure of Alzheimer's Disease (AD). The current report provides a clear perception of the concept of various biomarkers and their prominent features through analysis to provide a possible solution for the inhibition of events in AD. Scientists around the world truly believe that crucial hallmarks can serve as critical tools in the early diagnosis, cure, and prevention, as well as the future of medicine...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Namrata Singh Srishti Sharma Kallol K Ghosh Bhanushree Gupta Kamil Kuca Source Type: research

Alleviating Neurodegenerative Diseases Associated with Mitochondrial Defects by Therapeutic Biomolecules
Curr Top Med Chem. 2024 Apr 5. doi: 10.2174/0115680266299148240329062647. Online ahead of print.ABSTRACTNeurodegenerative diseases are emerging as a global health concern in the current sce-nario, and their association with mitochondrial defects has been a potential area of research. Mi-tochondria, one of the essential organelles of the cell, serve as the cell's powerhouse, producing energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and Pelizaeus-Merzbacher disease have been found to be primarily triggered by mitochondrial malfunct...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Tanmoy Roy Swarupanjali Padhi Rupa Mazumder Chandana Majee Saumya Das Monika Monika Rashmi Mishra Bhupinder Kapoor Source Type: research

Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry
Curr Top Med Chem. 2024 Apr 8. doi: 10.2174/0115680266300736240403075307. Online ahead of print.ABSTRACTQuinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various proteins and enzymes involved in cancer cell growth, such as topoisomerase, mi-crotubules, protein kinases, phosphoinositide 3...
Source: Current Topics in Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Nursyuhada Azzman Sirajudheen Anwar Wan Ahmad Syazani Mohamed Nafees Ahemad Source Type: research

Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications
Curr Top Med Chem. 2024 Apr 4. doi: 10.2174/0115680266304711240327072348. Online ahead of print.ABSTRACTThis review explores the advancements in nanomaterial-based electrochemical sensors for the multiplex detection of medicinal compounds. The growing demand for efficient and selective detection methods in the pharmaceutical field has prompted significant research into the development of electrochemical sensors employing nanomaterials. These materials, defined as functional materials with at least one dimension between 1 and 100 nanometers, encompass metal nanoparticles, polymers, carbon-based nanocomposites, and nano-biop...
Source: Current Topics in Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Surinya Traipop Whitchuta Jesadabundit Wisarut Khamcharoen Tavechai Pholsiri Sarida Naorungroj Sakda Jampasa Orawon Chailapakul Source Type: research

Antimicrobial Potential of Natural Compounds of Zingiberaceae Plants and their Synthetic Analogues: A Scoping Review of In vitro and In silico Approaches
CONCLUSION: To date, researchers have proposed the application of bioactive compounds derived from Zingiberaceae plants and their synthetic analogues as antimicrobial agents. Nevertheless, more investigations are required to ascertain their efficacy and to broaden their commercial applicability.PMID:38584545 | DOI:10.2174/0115680266294573240328050629 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kok-Hou Yit Zamirah Zainal-Abidin Source Type: research

Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective
Curr Top Med Chem. 2024 Apr 1. doi: 10.2174/0115680266299847240328045737. Online ahead of print.ABSTRACTAbout 60% to 70% of people with dementia have Alzheimer's Disease (AD), a neuro-degenerative illness. One reason for this disorder is the misfolding of naturally occurring proteins in the human brain, specifically β-amyloid (Aβ) and tau. Certain diagnostic imaging techniques, such as amyloid PET imaging, tau PET imaging, Magnetic Resonance Imaging (MRI), Comput-erized Tomography (CT), and others, can detect biomarkers in blood, plasma, and cerebral spinal fluids, like an increased level of β-amyloid, plaques, and tang...
Source: Current Topics in Medicinal Chemistry - April 3, 2024 Category: Chemistry Authors: Deepali Shukla Anjali Suryavanshi Sanjay Kumar Bharti Vivek Asati Debarshi Kar Mahapatra Source Type: research

The Role of Selenium Nanoparticles in Addressing Diabetic Complications: A Comprehensive Study
Curr Top Med Chem. 2024 Mar 29. doi: 10.2174/0115680266299494240326083936. Online ahead of print.ABSTRACTDiabetes, as an emerging epidemic, has put forward a significant spotlight on the evolving population worldwide grounded upon the remarkable affliction of healthcare along with economical conflict. Various studies suggested that, in modern society, lack of maintenance of a healthy life style leads to the occurrence of diabetes as insulin resistant, later having a damaging effect on the pancreatic β-cells, suggesting various complications. Furthermore, diabetes management is controversial owing to different opinions bas...
Source: Current Topics in Medicinal Chemistry - April 1, 2024 Category: Chemistry Authors: Siddharth Satpathy Lipsa Leena Panigrahi Manoranjan Arakha Source Type: research

Approaches Towards Better Immunosuppressive Agents
Curr Top Med Chem. 2024 Mar 29. doi: 10.2174/0115680266292661240322072908. Online ahead of print.ABSTRACTSeveral classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophenolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs and novel derivatives are still being reported to attempt better accessibility and therapeu...
Source: Current Topics in Medicinal Chemistry - April 1, 2024 Category: Chemistry Authors: Juliusz Walczak Dorota Iwaszkiewicz-Grze ś Grzegorz Cholewi ński Source Type: research