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Naphthoquinone derivatives targeting melanoma
Curr Top Med Chem. 2023 Sep 1. doi: 10.2174/1568026623666230901124059. Online ahead of print.ABSTRACTCancer is responsible for high mortality rates worldwide, representing a serious health problem. In this sense, melanoma corresponds to the most aggressive type of skin cancer, being the cause of the highest death rates. Therapeutic strategies for the treatment of melanoma remain limited, with problems associated with toxicity, serious side effects, and mechanisms of resistance. The potential of natural products for the prevention and treatment of melanoma has been reported in different studies. Among these compounds, napht...
Source: Current Topics in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: J éssica Alves Nunes Adrielle Firmino da Silva Nunes Dimas Jos é da Paz Lima Edeildo Ferreira da Silva-J únior Source Type: research

Novel Biomarkers in Cardiovascular Diseases: Going Beyond Troponins and Natriuretic Peptides - (Part II)
Curr Top Med Chem. 2023;23(22):2131. doi: 10.2174/156802662322230818122703.NO ABSTRACTPMID:37681657 | DOI:10.2174/156802662322230818122703 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: Panagiotis Theofilis Dimitris Tousoulis Source Type: research

Orchids of Dibru-Saikhowa: A Systematic Review on Their Traditional Use, Pharmacological Activity and Phytochemistry
CONCLUSION: Orchids found in DSNPBR hold great significance in traditional culture for their medicinal properties and have been effectively studied for their bioactivities. Nevertheless, to confirm their effectiveness as therapeutics, conducting methodical research, examining their molecular mechanisms, and performing toxicity tests are necessary.PMID:37649298 | DOI:10.2174/1568026623666230830125205 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - August 31, 2023 Category: Chemistry Authors: Pal Gogoi Saikat Sen Source Type: research

Natural Products: A Potential New Hope to Defeat Post-Acute Sequelae of COVID-19
Curr Top Med Chem. 2023 Aug 29. doi: 10.2174/1568026623666230829164156. Online ahead of print.ABSTRACTThe COVID-19 pandemic was the most significant public healthcare crisis worldwide. It was estimated that 80% of infected patients with COVID-19 have not fully recovered and developed one or more long-term symptoms, referred to as post-acute sequelae of COVID-19 (PASC). Seeking a treatment strategy for PASC has become a concerning topic since the sequelae can cause irreversible multiple organ damage and can severely compromise quality of life. It is indicated that PASC may be closely related to lung injury-induced hypoxia, ...
Source: Current Topics in Medicinal Chemistry - August 30, 2023 Category: Chemistry Authors: Shuang Zhao Aliya Abdurehim Yu Yuan Tan Yang Chao Li Yanqing Zhang Yaxin Li Xiuyan Sun Junbo Xie Source Type: research

Neurotrophic Factors In Cannabis-Induced Psychosis: An Update
CONCLUSION: Since altered levels of neurotrophins may participate in the pathogenesis of psychotic disorders which are common in drug users, one possible hypothesis is that repeated cannabis exposure can cause psychosis by interfering with neurotrophins synthesis and utilization by CNS neurons.PMID:37644743 | DOI:10.2174/1568026623666230829152150 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - August 30, 2023 Category: Chemistry Authors: Valerio Ricci Domenico de Berardis Giovanni Martinotti Giuseppe Maina Source Type: research