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Anti-tumoral Titanium(IV) Complexes Stabilized with Phenolato Ligands and Structure-Activity Relationship
Curr Top Med Chem. 2023 May 5. doi: 10.2174/1568026623666230505104626. Online ahead of print.ABSTRACTTitanocene dichloride and budotitane have opened a new chapter in medicinal chemistry of titanium(IV) complexes being novel non-platinum antitumor metallic agents. Numerous efforts have led to the discovery of the diamino bis-phenolato titanium(IV) complexes. Among which, the [ONNO] and [ONON] type ligands namely Salan, Salen and Salalen coordinated titanium(IV) alkoxyl complexes have demonstrated significantly enhanced aqueous stability, their in vitro and in vivo antitumor efficacy, mechanism of action, structure-activity...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Tiankun Zhao Peng Wang Xupeng Zhang Nan Liu Wenzhuo Zhao Yong Zhang Pengpeng Yuan Shanjia Li Mingjun Yang Zhongduo Yang Thomas Huhn Source Type: research

Advances in exosome research in the management of lung cancer
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504101208. Online ahead of print.ABSTRACTLung cancer is one of the most common malignant tumors, and its death rate is much higher than that of colon, kidney, breast, and prostate cancers, and its 5-year survival rate is only 18%. Lung cancer has no specific clinical symptoms in its early stages and lacks effective detection, making early detection difficult. The survival rate for advanced lung cancer is meager, with a median survival of only 12 months for stage IIIB/IV non-small cell lung cancer treated with platinumbased chemotherapy. Exosomes could provide vita...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Huiqing Shen Dawei Cao Xinri Zhang Source Type: research

The applications of CRISPR/Cas9 System for Urinary System Tumor
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504100706. Online ahead of print.ABSTRACTTumors of the urinary system include those in the urinary and reproductive systems, of which tumors of the prostate, bladder, and kidney have the highest incidence. In recent years, due to changes in dietary structure, prostate cancer has become the most common type of male genitourinary system cancer. Furthermore, due to tobacco consumption, increases in industrialization, and the age of the population, the incidence of bladder cancer in both males and females in both urban and rural areas, has shown an increasing trend. T...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Shulin Li Xiangwei Wang Yuqi Wu Source Type: research

Cocrystallizing and Codelivering Complementary Drugs to MultidrugResistant Tuberculosis Bacteria in Perfecting Multidrug Therapy
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504094521. Online ahead of print.ABSTRACTBacteria cells exhibit multidrug resistance in one of two ways: by raising the genetic expression of multidrug efflux pumps or by accumulating several drug-resistant components in many genes. Multidrug-resistive tuberculosis bacteria are treated by multidrug therapy, where a few certain antibacterial drugs are administered together to kill a bacterium jointly. A major drawback of conventional multidrug therapy is that the administration never ensures the reaching of different drug molecules to a particular bacterium cell at...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Pathik Sahoo Source Type: research

AmpC inhibition: An Explicit Approach against Multi-Drug Resistance (MDR)
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504095005. Online ahead of print.ABSTRACTMulti-drug resistance and its transmission is a ubiquitous health issue worldwide. The beta-lactamase AmpC resistance is a major concern among all health settings like hospitals and child care centers, etc. The clinical pipeline of the new antibiotics remains dry due to the production of AmpC beta-lactamases by the bacteria to develop resistance against antibiotics. According to the global antimicrobial resistance and use surveillance system, the rate of resistance to ciprofloxacin an antibiotic commonly used to treat urina...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Manish Kaushik Aditi Kaushik Akash Jain Jasmine Chaudhary Vrinda Gupta Source Type: research

Oxidative stress biomarkers in coronary artery disease
Curr Top Med Chem. 2023 May 2. doi: 10.2174/1568026623666230502140614. Online ahead of print.ABSTRACTOxidative stress plays a central role in atherogenesis, implicated in endothelial dysfunction, coronary plaque formation, and destabilization. Therefore, identifying oxidative stress in the vascular wall by reliable biomarkers could aid in early diagnosis and better coronary artery disease (CAD) prognostication. Because of the short half-life of reactive oxygen species, the current approach is to measure stable products generated by the oxidation of macromolecules in plasma or urine. Most popular oxidative stress biomarkers...
Source: Current Topics in Medicinal Chemistry - May 4, 2023 Category: Chemistry Authors: Spyridon Simantiris Charalampos Papastamos Alexios S Antonopoulos Panagiotis Theofilis Marios Sagris Martha Bounta Georgia Konisti Nikolaos Galiatsatos Anna Xanthaki Konstantinos Tsioufis Dimitris Tousoulis Source Type: research