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Calotropis procera (Aiton) Dryand (Apocynaceae): state of the art of its use and applications
In conclusion, the need of bioassay-guided isolation of bioactive compounds, bioavailability and efficacy, as well as pharmacological and toxicity studies, are needed using in vivo models and clinical trials in order to support the traditionally claimed health benefits.PMID:37282633 | DOI:10.2174/1568026623666230606162556 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Ana Carolina Silveira Rabelo Giuliana D Noratto Jessica Borghesi Adriano Souza Fonseca Ant ônio José Cantanhede Filho Fernando Jos é Costa Carneiro Ana L úcia Abreu-Silva Maria Ang élica Miglino Source Type: research

Modulation of Expression Levels of Various Cytokines and Inflammatory Responses by Glucosinolate Derivatives
Curr Top Med Chem. 2023 Jun 5. doi: 10.2174/1568026623666230605120626. Online ahead of print.NO ABSTRACTPMID:37282634 | DOI:10.2174/1568026623666230605120626 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - June 7, 2023 Category: Chemistry Authors: Venkidasamy Baskar Murugesan Krishnan Govindasamy Rajakumar Shivraj Hariram Nile Muthu Thiruvengadam Source Type: research

Recent Insights into Osimertinib Analogues against EGFR Positive Nonsmall Cell Lung Cancer
CONCLUSION: Anticancer mechanistic insights, analytical prospects, drug interactions, pharmacokinetic considerations, and resistance profile of osimertinib are also highlighted in the current manuscript.PMID:37272462 | DOI:10.2174/1568026623666230602143605 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - June 5, 2023 Category: Chemistry Authors: Jatin Chhabra Priyanka Kashyap Rakesh Pahwa Rakesh Narang Harish Dureja Sukhbir Lal Sangeeta Verma Source Type: research

Engineered biosynthesis through the adenylation domains from nonribosomal peptide synthetases
This study should provide a framework for the combinatorial biosynthesis or synthetic biology-driven microbial production of novel nonribosomal peptides.PMID:37264622 | DOI:10.2174/1568026623666230601142757 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - June 2, 2023 Category: Chemistry Authors: Zhenhua Lu Xiao-Huan Liu Xinsong Yuan Fei Liu Tao Wang Source Type: research

Recent Advances in Drug Discovery for Parasitic Diseases
Curr Top Med Chem. 2023;23(9):711-712. doi: 10.2174/156802662309230522141052.NO ABSTRACTPMID:37254528 | DOI:10.2174/156802662309230522141052 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 31, 2023 Category: Chemistry Authors: Josu é de Moraes Source Type: research

5-Membered Heterocyclic Compounds as Antiviral Agents
Curr Top Med Chem. 2023;23(7):520-538. doi: 10.2174/1568026623666230325153927.ABSTRACTViral infections range from self-limiting to more serious and fatal infections; therefore, some viral infections are of great public health concern worldwide, e.g., Hepatitis B virus, Hepatitis C virus, and HIV. Recently, the world faced a new infection due to the coronavirus, COVID-19, which was announced as a pandemic in early 2020. This virus infected more than 500 million people, killing around 6 million people worldwide. On the other hand, the increase in drug-resistant strains is also creating serious health problems. Thus, developi...
Source: Current Topics in Medicinal Chemistry - May 31, 2023 Category: Chemistry Authors: Christophe Tratrat Anthi Petrou Maria Fesatidou Michelyne Haroun Geronikaki Athina Katharigatta Venugopala Nagaraja Sreeharsha Jad Chemali Source Type: research