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Tetrandrine for Targeting Therapy Resistance in Cancer
Curr Top Med Chem. 2024 Mar 5. doi: 10.2174/0115680266282360240222062032. Online ahead of print.ABSTRACTDuring the last five decades, there has been tremendous development in our understanding of cancer biology and the development of new and novel therapeutics to target cancer. However, despite these advances, cancer remains the second leading cause of death across the globe. Most cancer deaths are attributed to the development of resistance to current therapies. There is an urgent and unmet need to address cancer therapy resistance. Tetrandrine, a bis-benzyl iso-quinoline, has shown a promising role as an anti-cancer agen...
Source: Current Topics in Medicinal Chemistry - March 6, 2024 Category: Chemistry Authors: Ellen Nogueira Lima Santosh Lamichhane K C Pramod Elisa Silva Ferreira Hari K Koul Sweaty Koul Source Type: research

Highlights on Fluorine-Containing Drugs Approved by U.S. FDA in 2023
Curr Top Med Chem. 2024 Mar 5. doi: 10.2174/0115680266300245240223070242. Online ahead of print.ABSTRACTFluorine continues to show its potential applications in drug discovery and development, as reflected by twelve drugs being fluorinated out of the fifty-five approved by the FDA in 2023. This concise review highlights the discovery of each of these fluorine-containing drugs in the past year, including its brand name, date of approval, composition, sponsors, indication, and mechanism of action. The relevant future trend is also briefly discussed.PMID:38445700 | DOI:10.2174/0115680266300245240223070242 (Source: Current Top...
Source: Current Topics in Medicinal Chemistry - March 6, 2024 Category: Chemistry Authors: Saghir Ali Andrew A Bolinger Jia Zhou Source Type: research

Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential Therapeutic Applications
Curr Top Med Chem. 2024 Mar 4. doi: 10.2174/0115680266283661240226052054. Online ahead of print.ABSTRACTBACKGROUND: Traditional Chinese Medicine (TCM) has a long history of treating various diseases and is increasingly being recognized as a complementary therapy for cancer. A promising natural compound extracted from the Chinese herb ginseng is ginsenoside Rg3, which has demonstrated significant anticancer effects. It has been tested in a variety of cancers and tumors and has proven to be effective in suppressing cancer.OBJECTIVE: This work covers various aspects of the role of ginsenoside Rg3 in cancer treatment, includin...
Source: Current Topics in Medicinal Chemistry - March 5, 2024 Category: Chemistry Authors: Lei Wu Lin Bai Wenshu Dai Yaping Wu Pengjun Xi Lily Zheng Jie Zhang Source Type: research

The Unveiling of Therapeutic Targets for Alzheimer's Disease: An Integrative Review
In conclusion, the review emphasizes the growing importance of addressing various pathways in AD treatment. A holistic approach that targets different aspects of the disease holds promise for developing effective treatments and improving the quality of life for Alzheimer's patients and their caregivers.PMID:38424435 | DOI:10.2174/0115680266282492240220101049 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - February 29, 2024 Category: Chemistry Authors: Pratiksha Madar Pooja Nagalapur Somdatta Chaudhari Devesh Sharma Akshada Koparde Rahul Buchade Sandip Kshirsagar Pravin Uttekar Shailaja Jadhav Praveen Chaudhari Source Type: research

Microfluidics-mediated Liposomal Nanoparticles for Cancer Therapy: Recent Developments on Advanced Devices and Technologies
Curr Top Med Chem. 2024 Feb 28. doi: 10.2174/0115680266286460240220073334. Online ahead of print.ABSTRACTLiposomes, spherical particles with phospholipid double layers, have been extensively studied over the years as a means of drug administration. Conventional manufacturing techniques like thin-film hydration and extrusion have limitations in controlling liposome size and distribution. Microfluidics enables superior tuning of parameters during the self-assembly of liposomes, producing uniform populations. This review summarizes microfluidic methods for engineering liposomes, including hydrodynamic flow focusing, jetting, ...
Source: Current Topics in Medicinal Chemistry - February 29, 2024 Category: Chemistry Authors: Seyed Morteza Naghib Kave Mohammad-Jafari Source Type: research