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Impact of Cannabinoid Receptors in the Design of Therapeutic Agents against Human Ailments
Curr Top Med Chem. 2023 May 2. doi: 10.2174/1568026623666230502120956. Online ahead of print.ABSTRACTThe cannabinoid (CB) signalling cascade is widely located in the human body and is as-sociated with several pathophysiological processes. The endocannabinoid system comprises canna-binoid receptors CB1 and CB2, which belong to G-protein coupled receptors (GPCRs). CB1 recep-tors are primarily located on nerve terminals, prohibiting neurotransmitter release, whereas CB2 are present predominantly on immune cells, causing cytokine release. The activation of CB system con-tributes to the development of several diseases which mig...
Source: Current Topics in Medicinal Chemistry - May 3, 2023 Category: Chemistry Authors: Ankush Kumar Ojasvi Gupta Rohit Bhatia VikramDeep Monga Source Type: research

Preclinical to Clinical profile of Curcuma longa as Antidiabetic Therapeutics
Curr Top Med Chem. 2023 Apr 28. doi: 10.2174/1568026623666230428101440. Online ahead of print.ABSTRACTNatural product substances have historically served as the most significant source of new leads for pharmaceutical development. Presently, drug discovery and development have adopted rational approaches to explore herbal resources for treating lifestyle-related diseases such as diabetes. For the treatment of diabetes, Curcumin longa has been extensively studied for evaluation of its antidiabetic potential using various in vivo and in vitro models. Literature resources such as PubMed and Google Scholar have been extensively...
Source: Current Topics in Medicinal Chemistry - May 3, 2023 Category: Chemistry Authors: Shikha Kaushik Neeraj Masand Malliga R Iyer Vaishali M Patil Source Type: research

The Gut Microbiota - Brain Axis: Potential Mechanism of Drug Addiction
CONCLUSION: Finally, the treatment of probiotics and fecal transplantation was summarized. This was done to further understand the role of intestinal microecology in the pathogenesis of drug addiction and to explore new methods for the treatment of drug addiction.PMID:37106510 | DOI:10.2174/1568026623666230418114133 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 28, 2023 Category: Chemistry Authors: Xiao Luo Hong Li Xuan Fan Xiaocong Wu Ruiyi Zhou Yi Lei Dan Xue Fazheng Yang Yu Xu Kunhua Wang Source Type: research

Natural Flavonoids as Potential Therapeutics in the Management of Diabetic Wound: A Review
Curr Top Med Chem. 2023 Apr 19. doi: 10.2174/1568026623666230419102140. Online ahead of print.ABSTRACTFlavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyperglycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, antitumor, and wound healing property. Quercetin, he...
Source: Current Topics in Medicinal Chemistry - April 28, 2023 Category: Chemistry Authors: Nongmaithem Randhoni Chanu Pal Gogoi Pervej Alom Barbhuiya Partha Pratim Dutta Manash Pratim Pathak Saikat Sen Source Type: research

Current Trends and Future Prospects on the Therapeutic Potential of Cordia dichotoma G. Forst.-A Valuable Folk Medicine
CONCLUSION: This review will help lay grounds to facilitate state-of-art research intended to acquire additional information about the plant. The study offers opportunities to explore bio-guided isolation strategies for isolating and purifying phytochemical constituents that are biologically effective including pharmacological and pharmaceutical aspects to better understand its clinical relevance. Exploring pure isolated phytoconstituents for their mode of action including estimation of their bioavailability and pharmacokinetic parameters would be of considerable interest in assessing the attained pharmacological effect. C...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Rati Kailash Prasad Tripathi Source Type: research

Application of Biomimetic Nanoparticles Based on the Cell Membrane in Tumor Therapy
Curr Top Med Chem. 2023 Apr 27. doi: 10.2174/1568026623666230427114622. Online ahead of print.ABSTRACTDue to their unique biological functionality, nanocarriers can be designed to deliver various anti-tumor drugs in vivo, which has a wide and important application prospect in the field of tumor therapy. However, poor biosafety, short blood circulation time, and weak targeting ability still limit the application of nanoparticles in tumor therapy. In recent years, with the development of biomedicine, the biomimetic technology-based biomembrane-mediated drug delivery system is expected to achieve a breakthrough in tumor-targe...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Ya Gong Jingbin Huang Source Type: research

Employing "Red Flags" to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis
Curr Top Med Chem. 2023 Apr 27. doi: 10.2174/1568026623666230427114840. Online ahead of print.ABSTRACTNitroaromatic compounds have been used for treating parasitic diseases since the 1960s. Pharmacological alternatives to treat them are under observation. However, for the most neglected diseases, such as those caused by worms and less known protozoans, nitro compounds are still among the drugs of choice, despite their well-known collateral effects. In this review, we describe the chemistry and the uses of the still most employed nitroaromatic compounds for treating parasitosis caused by worms or lesser-known protozoans. We...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Daniela Gon çales Galasse Rando Helena G O Costa Thais Fernanda Heitor Josu é de Moraes Thais Fernanda Amorim Pavani Source Type: research