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Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore
Curr Top Med Chem. 2023 Oct 31. doi: 10.2174/0115680266264206231020111820. Online ahead of print.ABSTRACTThe signal transduction and cell proliferation are regulated by the epidermal growth factor receptor. The proliferation of tumor cells, apoptosis, invasion, and angiogenesis is inhibited by the epidermal growth factor receptor. Thus, breast cancer, non-small cell lung cancer, cervical cancer, glioma, and bladder cancer can be treated by targeting the epidermal growth factor receptor. Although third-generation epidermal growth factor receptor inhibitors are potent drugs, patients exhibit drug resistance after treatment. ...
Source: Current Topics in Medicinal Chemistry - November 1, 2023 Category: Chemistry Authors: Shweta Mishra Adarsh Sahu Avneet Kaur Maninder Kaur Jayendra Kumar Pranay Wal Source Type: research

n-3 PUFAs Show Promise as Adjuvants in Chemotherapy, Enhancing their Efficacy while Safeguarding Hematopoiesis and Promoting Bone Generation
Curr Top Med Chem. 2023 Oct 27. doi: 10.2174/0115680266258838231020102401. Online ahead of print.ABSTRACTCancer ranks as the second leading cause of mortality in high-income countries, underscoring the critical need for effective therapeutic strategies. One prominent approach, chemotherapy, is widely employed for treating solid tumors. However, the significant adverse effects associated with chemotherapy, notably myeloablation and osteonecrosis, impart considerable challenges by compromising immune function and diminishing patients' quality of life. Furthermore, the emergence of chemotherapy resistance poses a formidable h...
Source: Current Topics in Medicinal Chemistry - November 1, 2023 Category: Chemistry Authors: Pradnya Gurav Suraj Garad Kedar R N Source Type: research

Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy
Curr Top Med Chem. 2023 Oct 20. doi: 10.2174/0115680266253222231011102151. Online ahead of print.ABSTRACTMetabolic reprogramming is defined as the skill of cells to change their metabolism to support the induced energy demand due to continuous growth. Metabolic reprogramming is a well-known occurrence in the progression of neoplastic cells, although, evidence has shown that it is present in fibrotic disorders. Post-surgical adhesion as a fibrotic disorder is a medical challenge and is defined by fibrotic bands connected between organs with the abdominal wall. Despite many investigations carried out about the pathogenesis o...
Source: Current Topics in Medicinal Chemistry - October 23, 2023 Category: Chemistry Authors: Mohsen Aliakbarian Rozita Khodashahi Mahmoud Tavakkoli Kiarash Ashrafzadeh Hoda Rahimi Ebrahim Khaleghi Majid Ghayour-Mobarhan Mohammad-Hassan Arjmand Source Type: research

Quantitative Structure Activity/Toxicity Relationship through Neural Networks for Drug Discovery or Regulatory Use
Curr Top Med Chem. 2023 Oct 20. doi: 10.2174/0115680266251327231017053718. Online ahead of print.ABSTRACTQuantitative structure - activity relationship (QSAR) modelling is widely used in medicinal chemistry and regulatory decision making. The large amounts of data collected in recent years in materials and life sciences projects provide a solid foundation for data-driven modelling approaches that have fostered the development of machine learning and artificial intelligence tools. An overview and discussion of the principles of QSAR modelling focus on the assembly and curation of data, computation of molecular descriptor, o...
Source: Current Topics in Medicinal Chemistry - October 23, 2023 Category: Chemistry Authors: Marjana Novi č Source Type: research

Phytochemicals Showing Antiangiogenic Effect in Pre-clinical Models and their Potential as an Alternative to Existing Therapeutics
Curr Top Med Chem. 2023 Oct 20. doi: 10.2174/0115680266264349231016094456. Online ahead of print.ABSTRACTAngiogenesis, the formation of new blood vessels from a pre-existing vascular network, is an important hallmark of several pathological conditions, such as tumor growth and metastasis, proliferative retinopathies, including proliferative diabetic retinopathy and retinopathy of prematurity, age-related macular degeneration, rheumatoid arthritis, psoriasis, and endometriosis. Putting a halt to pathology-driven angiogenesis is considered an important therapeutic strategy to slow down or reduce the severity of pathological ...
Source: Current Topics in Medicinal Chemistry - October 23, 2023 Category: Chemistry Authors: Anna Senrung Tanya Tripathi Nikita Aggarwal Divya Janjua Joni Yadav Apoorva Chaudhary Arun Chhokar Udit Joshi Alok Chandra Bharti Source Type: research