Current Topics in Medicinal Chemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Profiling of Polyphenolic Compounds, Antioxidant, Antidyslipidemic and Cardiac risk Preventive Effect of Keteki Joha and Kola Joha Rice Cultivars Grown in Assam, India: A Comparative Study
CONCLUSION: This paper profiled polyphenolic compounds for the first time. Keteki joha exhibited better results than Kola joha. Observations offer novel insights into the hypothesis for the first time that unpolished Keteki and Kola joha rice can be beneficial in averting hyperlipidemia and its associated coronary events.PMID:37469158 | DOI:10.2174/1568026623666230719113121 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Saikat Sen Pratap Kalita Raja Chakraborty Source Type: research

1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the Treatment of Neurodegenerative Diseases
Curr Top Med Chem. 2023 Jul 19. doi: 10.2174/1568026623666230719124850. Online ahead of print.ABSTRACT1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered heterocyclic ring, have achieved a unique significant place in drug design and development because of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral, antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted in a large number of clinically u...
Source: Current Topics in Medicinal Chemistry - July 20, 2023 Category: Chemistry Authors: Jasmine Chaudhary Akash Jain Ashwani Dhingra Bhawna Chopra Vishal Sharma Jatin Gupta Aditi Kaushik Source Type: research

Exploring New Vista for Alzheimer's Disease Drug Targets (Part II)
Curr Top Med Chem. 2023;23(13):1211-1213. doi: 10.2174/156802662313230626121232.NO ABSTRACTPMID:37464550 | DOI:10.2174/156802662313230626121232 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Andrew A Bolinger Jia Zhou Source Type: research

Sustainable Production of Drugs and Fine Chemicals
Curr Top Med Chem. 2023;23(11):956. doi: 10.2174/156802662311230620111505.NO ABSTRACTPMID:37464556 | DOI:10.2174/156802662311230620111505 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Vitor Francisco Ferreira Fernando de Carvalho da Silva Luana da Silva Magalh ães Forezi Source Type: research

Interleukin-6 signaling in atherosclerosis: from molecular mechanisms to clinical outcomes
Curr Top Med Chem. 2023 Jul 18. doi: 10.2174/1568026623666230718141235. Online ahead of print.ABSTRACTInterleukin-6 (IL-6) is a cytokine centrally involved in several immunological processes and has been recognized as a driver of enhanced atherothrombotic risk. Immunity and inflammation are intrinsically involved in atherosclerosis progression. This generated 'inflammation hypothesis', which is now validated in large-scale clinical trials. Abundant evidence supports the distinctive role of IL-6 in coronary artery disease. The focus on this cytokine stems from epidemiological studies linking high plasma concentrations of IL...
Source: Current Topics in Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Charalampos Papastamos Alexios S Antonopoulos Spyridon Simantiris Nikolaos Koumallos Marios Sagris Panagiotis Theofilis Evangelos Oikonomou Gerasimos Siasos Konstantinos Tsioufis Dimitris Tousoulis Source Type: research

Recent Advances of Optical Biosensors in Veterinary Medicine: Moving Towards the Point of Care Applications
Curr Top Med Chem. 2023 Jul 18. doi: 10.2174/1568026623666230718163613. Online ahead of print.ABSTRACTWhile food safety issues are attracting public concern due to their detrimental effects on human health, monitoring livestock health is urgently needed to diagnose animal diseases at an early stage by applying proper treatments, controlling, and preventing outbreaks, particularly in resource-limited countries. In addition, unhealthy farms are not only a threat to livestock but also to human lives. The available diagnostic techniques for the detection of key health threats within both the food and livestock sectors require ...
Source: Current Topics in Medicinal Chemistry - July 19, 2023 Category: Chemistry Authors: Niloufar Amin Ameneh Almasi Tugba Ozer Charles S Henry Leila Hosseinzadeh Zahra Keshavarzi Source Type: research

Current Fragment-to-Lead Approaches Starting From the 7-Azaindole: The Pharmacological Versatility of a Privileged Molecular Fragment
Curr Top Med Chem. 2023 Jul 18. doi: 10.2174/1568026623666230718100541. Online ahead of print.ABSTRACTFragment-based drug discovery is one of the most powerful paradigms in the recent context of medicinal chemistry and is being widely practiced by academic and industrial researchers. Currently, azaindoles are among the most exploited molecular fragments in pharmaceutical innovation projects inspired by fragment-to-lead strategies. The 7-azaindole is the most prominent representative within this remarkable family of pyrrolopyridine fragments, as it is present in the chemical structure of several approved antitumor drugs and...
Source: Current Topics in Medicinal Chemistry - July 18, 2023 Category: Chemistry Authors: Leandro Marcos Santos Nelson Jos é Freitas da Silveira Source Type: research

Emerging Therapies and Therapeutic Targets for Composite Liver Disease: NASH
CONCLUSION: Efforts have been made to provide an update on research in the area of NASH, including the pharmacological agents that are currently undergoing clinical trials for the treatment of NASH. Besides the massive research, still, gaps and challenges are there in the drug development for NASH that also have been discussed.PMID:37455455 | DOI:10.2174/1568026623666230714113808 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 17, 2023 Category: Chemistry Authors: M Elizabeth Sobhia Sonia Kumari Harish Kumar Akshata Gandhe Dhriti Kaushik Harish Kumar Jethender Jain None Ankita Moyim Mallick Bommana Pavani Mridula Moudgil Deepesh Patel Source Type: research

Pyrazole; A Privileged Scaffold of Medicinal Chemistry: A Comprehensive Review
Curr Top Med Chem. 2023 Jul 14. doi: 10.2174/1568026623666230714161726. Online ahead of print.ABSTRACTPyrazole is considered an important active scaffold that possesses various types of pharmacological activities. The overwhelming literature reported earlier reflects the immense biological potential of pyrazole derivatives. The presence of this moiety in various FDA-approved drugs, including celecoxib (anti-inflammatory), apixaban (anticoagulant), rimonabant (anti-obesity), difenamizole (analgesic), and sildenafil (for erectile dysfunction), has proved its pharmacological potential. Owing to its diversity in the biological...
Source: Current Topics in Medicinal Chemistry - July 17, 2023 Category: Chemistry Authors: Ram Kumar Raksha Sharma D K Sharma Source Type: research

Research progress on small-molecule inhibitors of protein arginine methyltransferase 5 (PRMT5) for treating cancer
CONCLUSION: These inhibitors are beneficial to the treatment of tumors. Some drugs are being used in clinical trials. PRMT5 inhibitors have broad application prospects in tumor therapy.PMID:37438905 | DOI:10.2174/1568026623666230712120527 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 13, 2023 Category: Chemistry Authors: Chaohua Guo Lintao Wu Xumei Zheng Lin Zhao Xiaojia Hou Zhijun Wang Chun Han Source Type: research