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Pyrazole; A Privileged Scaffold of Medicinal Chemistry: A Comprehensive Review
Curr Top Med Chem. 2023 Jul 14. doi: 10.2174/1568026623666230714161726. Online ahead of print.ABSTRACTPyrazole is considered an important active scaffold that possesses various types of pharmacological activities. The overwhelming literature reported earlier reflects the immense biological potential of pyrazole derivatives. The presence of this moiety in various FDA-approved drugs, including celecoxib (anti-inflammatory), apixaban (anticoagulant), rimonabant (anti-obesity), difenamizole (analgesic), and sildenafil (for erectile dysfunction), has proved its pharmacological potential. Owing to its diversity in the biological...
Source: Current Topics in Medicinal Chemistry - July 17, 2023 Category: Chemistry Authors: Ram Kumar Raksha Sharma D K Sharma Source Type: research

Emerging Therapies and Therapeutic Targets for Composite Liver Disease: NASH
CONCLUSION: Efforts have been made to provide an update on research in the area of NASH, including the pharmacological agents that are currently undergoing clinical trials for the treatment of NASH. Besides the massive research, still, gaps and challenges are there in the drug development for NASH that also have been discussed.PMID:37455455 | DOI:10.2174/1568026623666230714113808 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 17, 2023 Category: Chemistry Authors: M Elizabeth Sobhia Sonia Kumari Harish Kumar Akshata Gandhe Dhriti Kaushik Harish Kumar Jethender Jain None Ankita Moyim Mallick Bommana Pavani Mridula Moudgil Deepesh Patel Source Type: research

Research progress on small-molecule inhibitors of protein arginine methyltransferase 5 (PRMT5) for treating cancer
CONCLUSION: These inhibitors are beneficial to the treatment of tumors. Some drugs are being used in clinical trials. PRMT5 inhibitors have broad application prospects in tumor therapy.PMID:37438905 | DOI:10.2174/1568026623666230712120527 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 13, 2023 Category: Chemistry Authors: Chaohua Guo Lintao Wu Xumei Zheng Lin Zhao Xiaojia Hou Zhijun Wang Chun Han Source Type: research

Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin
Curr Top Med Chem. 2023 Jul 10. doi: 10.2174/1568026623666230710162217. Online ahead of print.ABSTRACTFlavonoids effectively treat cancer, inflammatory disorders (cardiovascular and nervous systems), and oxidative stress. Fisetin, derived from fruits and vegetables, suppresses cancer growth by altering cell cycle parameters that lead to cell death and angiogenesis without affecting healthy cells. Clinical trials are needed in humans to prove the effectiveness of this treatment for a wide range of cancers. According to the results of this study, fisetin can be used to prevent and treat a variety of cancers. Despite early de...
Source: Current Topics in Medicinal Chemistry - July 11, 2023 Category: Chemistry Authors: Abdur Rauf Tareq Abu-Izneid Muhammad Imran Hassan A Hemeg Kashif Bashir Abdullah S M Aljohani Mona S M Aljohani Fahad A Alhumaydhi Ishaq N Khan Talha Bin Emran Tanweer Aslam Gondal Nikhil Nath Ishtiaque Ahmad Muthu Thiruvengadam Source Type: research

Addressing the Current Knowledge and Gaps in Research Surrounding Lysergic Acid Diethylamide (LSD), Psilocybin, and Psilocin in Rodent Models
Curr Top Med Chem. 2023 Jul 5. doi: 10.2174/1568026623666230705151922. Online ahead of print.ABSTRACTLysergic acid diethylamide (LSD), psilocybin, and psilocin are being intensively evaluated as potential therapeutics to treat depression, anxiety, substance use disorder, and a host of other psychiatric illnesses. Pre-clinical investigation of these compounds in rodent models forms a key component of their drug development process. In this review, we will summarize the evidence gathered to date surrounding LSD, psilocybin, and psilocin in rodent models of the psychedelic experience, behavioural organization, substance use, ...
Source: Current Topics in Medicinal Chemistry - July 6, 2023 Category: Chemistry Authors: Udoka C Ezeaka Hye Ji J Kim Robert B Laprairie Source Type: research

Recent advances in computer-aided virtual screening and docking optimization for aptamer
Curr Top Med Chem. 2023 Jun 23. doi: 10.2174/1568026623666230623145802. Online ahead of print.ABSTRACTAptamers, as artificially synthesized short nucleotide sequences, have been widely used in protein analysis, gene engineering, and molecular diagnostics. Currently, the screening process of aptamers still relies on the traditional SELEX process, which is cumbersome and complex. Moreover, the success rate of aptamer screening through the SELEX process is not high, which has become a major challenge. In recent years, the development of computers has facilitated virtual screening, which can greatly accelerate the screening pr...
Source: Current Topics in Medicinal Chemistry - June 26, 2023 Category: Chemistry Authors: Yijie Liu Jie Yang Meilun Chen Xiaoling Lu Zheng Wei Chunhua Tang Peng Yu Source Type: research