A Review of Phytochemical and Pharmacological Properties of Alpinia malaccensis (Burm. F.) Roscoe. (Zingiberaceae)
CONCLUSION: A detailed study of the available resources for A. malaccensis confirmed its native and distribution, traditional values, chemical properties, and medicinal values. Its essential oils and extracts are the reservoir of a wide range of important chemical constituents. Traditionally, it is being used to treat nausea, vomiting and wounds along with as a seasoning agent in meat processing and as perfume. Apart from traditional values, it has been reported for several pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory etc. We believe that this review will help to provide the collective i...
Source: Current Topics in Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Sonu Mahawer Ravendra Kumar Om Prakash Shailja Singh Dharmendra Singh Rawat Shiv Kumar Dubey Mozaniel Oliveira Source Type: research

Aberrant Lipid Metabolism in Cancer: Current Status and Emerging Therapeutic Perspectives
Curr Top Med Chem. 2023 May 22. doi: 10.2174/1568026623666230522103321. Online ahead of print.ABSTRACTIt is now an undisputed fact that cancer cells undergo metabolic reprogramming to support their malignant phenotype, and it is one of the crucial hallmarks which enables cancer cells to facilitate their survival under variable conditions ranging from lack of nutrients to conditions, such as hypoxia. Recent developments in technologies, such as lipidomics and machine learning, have underlined the critical effects of altered lipid metabolism in tumorigenesis. The cancer cells show elevated de novo fatty acid synthesis, an in...
Source: Current Topics in Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Rasha Irshad Sazi Tabassum Mohammad Husain Source Type: research

A Review of Phytochemical and Pharmacological Properties of Alpinia malaccensis (Burm. F.) Roscoe. (Zingiberaceae)
CONCLUSION: A detailed study of the available resources for A. malaccensis confirmed its native and distribution, traditional values, chemical properties, and medicinal values. Its essential oils and extracts are the reservoir of a wide range of important chemical constituents. Traditionally, it is being used to treat nausea, vomiting and wounds along with as a seasoning agent in meat processing and as perfume. Apart from traditional values, it has been reported for several pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory etc. We believe that this review will help to provide the collective i...
Source: Current Topics in Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Sonu Mahawer Ravendra Kumar Om Prakash Shailja Singh Dharmendra Singh Rawat Shiv Kumar Dubey Mozaniel Oliveira Source Type: research

Aberrant Lipid Metabolism in Cancer: Current Status and Emerging Therapeutic Perspectives
Curr Top Med Chem. 2023 May 22. doi: 10.2174/1568026623666230522103321. Online ahead of print.ABSTRACTIt is now an undisputed fact that cancer cells undergo metabolic reprogramming to support their malignant phenotype, and it is one of the crucial hallmarks which enables cancer cells to facilitate their survival under variable conditions ranging from lack of nutrients to conditions, such as hypoxia. Recent developments in technologies, such as lipidomics and machine learning, have underlined the critical effects of altered lipid metabolism in tumorigenesis. The cancer cells show elevated de novo fatty acid synthesis, an in...
Source: Current Topics in Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Rasha Irshad Sazi Tabassum Mohammad Husain Source Type: research

A Review of Phytochemical and Pharmacological Properties of Alpinia malaccensis (Burm. F.) Roscoe. (Zingiberaceae)
CONCLUSION: A detailed study of the available resources for A. malaccensis confirmed its native and distribution, traditional values, chemical properties, and medicinal values. Its essential oils and extracts are the reservoir of a wide range of important chemical constituents. Traditionally, it is being used to treat nausea, vomiting and wounds along with as a seasoning agent in meat processing and as perfume. Apart from traditional values, it has been reported for several pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory etc. We believe that this review will help to provide the collective i...
Source: Current Topics in Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Sonu Mahawer Ravendra Kumar Om Prakash Shailja Singh Dharmendra Singh Rawat Shiv Kumar Dubey Mozaniel Oliveira Source Type: research

Aberrant Lipid Metabolism in Cancer: Current Status and Emerging Therapeutic Perspectives
Curr Top Med Chem. 2023 May 22. doi: 10.2174/1568026623666230522103321. Online ahead of print.ABSTRACTIt is now an undisputed fact that cancer cells undergo metabolic reprogramming to support their malignant phenotype, and it is one of the crucial hallmarks which enables cancer cells to facilitate their survival under variable conditions ranging from lack of nutrients to conditions, such as hypoxia. Recent developments in technologies, such as lipidomics and machine learning, have underlined the critical effects of altered lipid metabolism in tumorigenesis. The cancer cells show elevated de novo fatty acid synthesis, an in...
Source: Current Topics in Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Rasha Irshad Sazi Tabassum Mohammad Husain Source Type: research

A Review of Phytochemical and Pharmacological Properties of Alpinia malaccensis (Burm. F.) Roscoe. (Zingiberaceae)
CONCLUSION: A detailed study of the available resources for A. malaccensis confirmed its native and distribution, traditional values, chemical properties, and medicinal values. Its essential oils and extracts are the reservoir of a wide range of important chemical constituents. Traditionally, it is being used to treat nausea, vomiting and wounds along with as a seasoning agent in meat processing and as perfume. Apart from traditional values, it has been reported for several pharmacological activities such as antioxidant, antimicrobial, anti-inflammatory etc. We believe that this review will help to provide the collective i...
Source: Current Topics in Medicinal Chemistry - May 23, 2023 Category: Chemistry Authors: Sonu Mahawer Ravendra Kumar Om Prakash Shailja Singh Dharmendra Singh Rawat Shiv Kumar Dubey Mozaniel Oliveira Source Type: research

Novel Biomarkers in Cardiovascular Diseases: Going Beyond Troponins and Natriuretic Peptides - (Part II)
Curr Top Med Chem. 2023;23(6):453. doi: 10.2174/156802662306230321112300.NO ABSTRACTPMID:37203182 | DOI:10.2174/156802662306230321112300 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Panagiotis Theofilis Dimitris Tousoulis Source Type: research

Novel Biomarkers in Cardiovascular Diseases: Going Beyond Troponins and Natriuretic Peptides - (Part II)
Curr Top Med Chem. 2023;23(6):453. doi: 10.2174/156802662306230321112300.NO ABSTRACTPMID:37203182 | DOI:10.2174/156802662306230321112300 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Panagiotis Theofilis Dimitris Tousoulis Source Type: research

Novel Biomarkers in Cardiovascular Diseases: Going Beyond Troponins and Natriuretic Peptides - (Part II)
Curr Top Med Chem. 2023;23(6):453. doi: 10.2174/156802662306230321112300.NO ABSTRACTPMID:37203182 | DOI:10.2174/156802662306230321112300 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Panagiotis Theofilis Dimitris Tousoulis Source Type: research

Novel Biomarkers in Cardiovascular Diseases: Going Beyond Troponins and Natriuretic Peptides - (Part II)
Curr Top Med Chem. 2023;23(6):453. doi: 10.2174/156802662306230321112300.NO ABSTRACTPMID:37203182 | DOI:10.2174/156802662306230321112300 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Panagiotis Theofilis Dimitris Tousoulis Source Type: research

Medicinal Chemistry for Sustainable Development
This article intends to provide insight into some relevant topics that can stimulate researchers toward medicinal chemistry that can contribute to a sustainable future of the biosphere. This article is structured around four interconnected themes that influence how green chemistry can be important for a future where science, technology and innovation are key to mitigating climate change and increasing global sustainability.PMID:37198981 | DOI:10.2174/1568026623666230517114621 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 18, 2023 Category: Chemistry Authors: Luana da S M Forezi Patricia G Ferreira Alcione Silva de Carvalho Fernando de C da Silva Vitor F Ferreira Source Type: research

Medicinal Chemistry for Sustainable Development
This article intends to provide insight into some relevant topics that can stimulate researchers toward medicinal chemistry that can contribute to a sustainable future of the biosphere. This article is structured around four interconnected themes that influence how green chemistry can be important for a future where science, technology and innovation are key to mitigating climate change and increasing global sustainability.PMID:37198981 | DOI:10.2174/1568026623666230517114621 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - May 18, 2023 Category: Chemistry Authors: Luana da S M Forezi Patricia G Ferreira Alcione Silva de Carvalho Fernando de C da Silva Vitor F Ferreira Source Type: research

The Role of Phytochemicals in Cancer Prevention: A Review with Emphasis on Baicalein, Fisetin, and Biochanin A
Curr Top Med Chem. 2023 May 16. doi: 10.2174/1568026623666230516161827. Online ahead of print.ABSTRACTCancer is a disease in which repeated rounds of mutations cause uncontrolled growth of cells, which prospers at the expense of their neighbor cells and then eventually leads to the destruction of the whole cellular community. Chemopreventive drugs either prevent DNA damage, which results in malignancy, or they stop or reverse the division of premalignant cells with DNA damage, which inhibits the growth of cancer. There is an obvious need for an alternate strategy given the ongoing rise in cancer incidence, the ineffectiven...
Source: Current Topics in Medicinal Chemistry - May 17, 2023 Category: Chemistry Authors: Juhi Rais Habiba Khan Mohd Arshad Source Type: research

Advances in Medicinal Chemistry of Estrogen-related receptor alpha (ERR α) inverse agonists
Curr Top Med Chem. 2023 May 15. doi: 10.2174/1568026623666230515145822. Online ahead of print.ABSTRACTEstrogen-related receptor alpha (ERRα), a member of the nuclear receptor superfamily, is strongly expressed in breast cancer cells. Its overexpression is associated with poor prognosis in triple-negative breast cancer (TNBC). ERRα expression could be inhibited by the downregulation of upstream oncogenic growth factors mTOR, HER2, and PI3K. Low expression of ERRα could suppress the migration and angiogenesis of tumor cells by inhibiting the activity of its downstream signals VEGF and WNT11. Studies have confirmed that ER...
Source: Current Topics in Medicinal Chemistry - May 16, 2023 Category: Chemistry Authors: Haibin Zhang Yongli Du Yong Zheng Huiting Lv Zhijia Yan Ning Dong Yaling Zhu Jingkang Shen Source Type: research