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AmpC inhibition: An Explicit Approach against Multi-Drug Resistance (MDR)
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504095005. Online ahead of print.ABSTRACTMulti-drug resistance and its transmission is a ubiquitous health issue worldwide. The beta-lactamase AmpC resistance is a major concern among all health settings like hospitals and child care centers, etc. The clinical pipeline of the new antibiotics remains dry due to the production of AmpC beta-lactamases by the bacteria to develop resistance against antibiotics. According to the global antimicrobial resistance and use surveillance system, the rate of resistance to ciprofloxacin an antibiotic commonly used to treat urina...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Manish Kaushik Aditi Kaushik Akash Jain Jasmine Chaudhary Vrinda Gupta Source Type: research

Anti-tumoral Titanium(IV) Complexes Stabilized with Phenolato Ligands and Structure-Activity Relationship
Curr Top Med Chem. 2023 May 5. doi: 10.2174/1568026623666230505104626. Online ahead of print.ABSTRACTTitanocene dichloride and budotitane have opened a new chapter in medicinal chemistry of titanium(IV) complexes being novel non-platinum antitumor metallic agents. Numerous efforts have led to the discovery of the diamino bis-phenolato titanium(IV) complexes. Among which, the [ONNO] and [ONON] type ligands namely Salan, Salen and Salalen coordinated titanium(IV) alkoxyl complexes have demonstrated significantly enhanced aqueous stability, their in vitro and in vivo antitumor efficacy, mechanism of action, structure-activity...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Tiankun Zhao Peng Wang Xupeng Zhang Nan Liu Wenzhuo Zhao Yong Zhang Pengpeng Yuan Shanjia Li Mingjun Yang Zhongduo Yang Thomas Huhn Source Type: research

Oxidative stress biomarkers in coronary artery disease
Curr Top Med Chem. 2023 May 2. doi: 10.2174/1568026623666230502140614. Online ahead of print.ABSTRACTOxidative stress plays a central role in atherogenesis, implicated in endothelial dysfunction, coronary plaque formation, and destabilization. Therefore, identifying oxidative stress in the vascular wall by reliable biomarkers could aid in early diagnosis and better coronary artery disease (CAD) prognostication. Because of the short half-life of reactive oxygen species, the current approach is to measure stable products generated by the oxidation of macromolecules in plasma or urine. Most popular oxidative stress biomarkers...
Source: Current Topics in Medicinal Chemistry - May 4, 2023 Category: Chemistry Authors: Spyridon Simantiris Charalampos Papastamos Alexios S Antonopoulos Panagiotis Theofilis Marios Sagris Martha Bounta Georgia Konisti Nikolaos Galiatsatos Anna Xanthaki Konstantinos Tsioufis Dimitris Tousoulis Source Type: research

Impact of Cannabinoid Receptors in the Design of Therapeutic Agents against Human Ailments
Curr Top Med Chem. 2023 May 2. doi: 10.2174/1568026623666230502120956. Online ahead of print.ABSTRACTThe cannabinoid (CB) signalling cascade is widely located in the human body and is as-sociated with several pathophysiological processes. The endocannabinoid system comprises canna-binoid receptors CB1 and CB2, which belong to G-protein coupled receptors (GPCRs). CB1 recep-tors are primarily located on nerve terminals, prohibiting neurotransmitter release, whereas CB2 are present predominantly on immune cells, causing cytokine release. The activation of CB system con-tributes to the development of several diseases which mig...
Source: Current Topics in Medicinal Chemistry - May 3, 2023 Category: Chemistry Authors: Ankush Kumar Ojasvi Gupta Rohit Bhatia VikramDeep Monga Source Type: research

Preclinical to Clinical profile of Curcuma longa as Antidiabetic Therapeutics
Curr Top Med Chem. 2023 Apr 28. doi: 10.2174/1568026623666230428101440. Online ahead of print.ABSTRACTNatural product substances have historically served as the most significant source of new leads for pharmaceutical development. Presently, drug discovery and development have adopted rational approaches to explore herbal resources for treating lifestyle-related diseases such as diabetes. For the treatment of diabetes, Curcumin longa has been extensively studied for evaluation of its antidiabetic potential using various in vivo and in vitro models. Literature resources such as PubMed and Google Scholar have been extensively...
Source: Current Topics in Medicinal Chemistry - May 3, 2023 Category: Chemistry Authors: Shikha Kaushik Neeraj Masand Malliga R Iyer Vaishali M Patil Source Type: research

The Gut Microbiota - Brain Axis: Potential Mechanism of Drug Addiction
CONCLUSION: Finally, the treatment of probiotics and fecal transplantation was summarized. This was done to further understand the role of intestinal microecology in the pathogenesis of drug addiction and to explore new methods for the treatment of drug addiction.PMID:37106510 | DOI:10.2174/1568026623666230418114133 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - April 28, 2023 Category: Chemistry Authors: Xiao Luo Hong Li Xuan Fan Xiaocong Wu Ruiyi Zhou Yi Lei Dan Xue Fazheng Yang Yu Xu Kunhua Wang Source Type: research

Natural Flavonoids as Potential Therapeutics in the Management of Diabetic Wound: A Review
Curr Top Med Chem. 2023 Apr 19. doi: 10.2174/1568026623666230419102140. Online ahead of print.ABSTRACTFlavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyperglycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, antitumor, and wound healing property. Quercetin, he...
Source: Current Topics in Medicinal Chemistry - April 28, 2023 Category: Chemistry Authors: Nongmaithem Randhoni Chanu Pal Gogoi Pervej Alom Barbhuiya Partha Pratim Dutta Manash Pratim Pathak Saikat Sen Source Type: research