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Cellular Senescence and Senolytic Agents: Recent Updates on Their Role and Applications
Curr Top Med Chem. 2023 Nov 30. doi: 10.2174/0115680266273698231107110956. Online ahead of print.ABSTRACTCellular senescence, an eternal condition of cell cycle arrest due to cellular stressors, is a sign of aging. Senescent cells (SCs) build up in tissues as they age, impairing their ability to repair themselves by causing the cell cycle to seize in progenitor cells and producing proinflammatory and the senescence-associated secretory phenotype (SASP) or matrix-degrading molecules. SASP aids in the emergence of several age-related diseases. Genetic studies have shown that removing SCs can delay aging and prolong life. Sen...
Source: Current Topics in Medicinal Chemistry - December 1, 2023 Category: Chemistry Authors: Lokesh Chandrakar Gopal Khatik Ramesh Ambatwar Source Type: research

Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids
CONCLUSION: Overall, this review article explains the pharmacological activity of cinchonine, its synthesis, and physicochemical properties, toxicological aspects, and pharmacokinetics.PMID:38031797 | DOI:10.2174/0115680266270796231109171808 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - November 30, 2023 Category: Chemistry Authors: Shahnaz Parveen Nidhi Maurya Abha Meena Suaib Luqman Source Type: research

Recent Trends in Computer-aided Drug Design for Anti-cancer Drug Discovery
Curr Top Med Chem. 2023 Nov 29. doi: 10.2174/0115680266258467231107102643. Online ahead of print.ABSTRACTCancer is considered one of the deadliest diseases globally, and continuous research is being carried out to find novel potential therapies for myriad cancer types that affect the human body. Researchers are hunting for innovative remedies to minimize the toxic effects of conventional therapies being driven by cancer, which is emerging as pivotal causes of mortality worldwide. Cancer progression steers the formation of heterogeneous behavior, including self-sustaining proliferation, malignancy, and evasion of apoptosis,...
Source: Current Topics in Medicinal Chemistry - November 30, 2023 Category: Chemistry Authors: Iashia Tur Razia Ayesha Kanwal Hafiza Fatima Riaz Abbeha Malik Muhammad Ahsan Muhammad Saleem Khan Ali Raza Sumera Sabir Zureesha Sajid Muhammad Fardeen Khan Rana Adnan Tahir Sheikh Arslan Sehgal Source Type: research

A Comprehensive Review on Phytochemistry and Pharmacology of Rosa Species (Rosaceae)
Curr Top Med Chem. 2023 Nov 1. doi: 10.2174/0115680266274385231023075011. Online ahead of print.ABSTRACTThe Rosa L. genus is a significant plant family in the Rosaceae group, consisting of around 200 species, primarily shrubs. In India, it has 37 species, most located in the Western Himalayan region of Jammu and Kashmir and Himachal Pradesh. Roses are highly regarded for their beauty and growth and are popular worldwide for their nutritional, therapeutic, ornamental, and cosmetic value. The rose hips are utilized in creating various food and drink items, such as jams, jellies, teas, and alcoholic beverages. The Rosa specie...
Source: Current Topics in Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Faheem Fayaz Kanwaljeet Singh Sumeet Gairola Zabeer Ahmed Bhahwal Ali Shah Source Type: research

Natural Plant Products Mediated Prevention of Cancer Facilitated through Immune Suppression of Treg Cells
Curr Top Med Chem. 2023 Nov 3. doi: 10.2174/0115680266275768231027100120. Online ahead of print.ABSTRACTCancer is one of the leading causes of death, and numerous methods have been tested and used to figure out an optimum way of treatment. Besides targeted therapy, immunotherapy has proven to be effective by controlling certain immune cells. Traditional cancer therapy is met with the consequences of adverse side effects that have been a major issue for treatment; hence, a leap towards naturally occurring immunomodulators was taken to develop safer methods of treatment. One of the major immune cells responsible for the grow...
Source: Current Topics in Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Oishi Mukherjee Sudeshna Rakshit Geetha Shanmugan Koustav Sarkar Source Type: research