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Ionizing Radiation: Chemical kinetics, chemical bounds, and radiation chemistry on polymers
Curr Top Med Chem. 2023 Mar 15. doi: 10.2174/1568026623666230315122855. Online ahead of print.ABSTRACTIonizing radiation has been used for decades and expanded to several applications in multivariate sectors, becoming an important tool to promote controlled chemical reactions in polymeric structures, according to their chemical properties for developing new materials. In addition, the use of radiation can also be applied in order to reduce or eliminate compounds from solutions that may be harmful or of low interest. In this review, we overviewed the chemistry behind material irradiation and the attractive use of ionizing r...
Source: Current Topics in Medicinal Chemistry - March 16, 2023 Category: Chemistry Authors: Martha Sahyl í Ortega Pijeira Tais Monteiro Magne Nat ália Cristina Gomes da Silva Elisabete Regina Fernandes Ramos Ribeiro Yuri Jos é Albuquerque Silva Eduardo Ricci-Junior Luciana Magalh ães Rebelo Alencar Ralph Santos-Oliveira Source Type: research

Recent Advances in the Discovery of Antiparasitic Drugs for Chagas Disease and Malaria
Curr Top Med Chem. 2023;23(3):158. doi: 10.2174/156802662303230202104841.NO ABSTRACTPMID:36919344 | DOI:10.2174/156802662303230202104841 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 15, 2023 Category: Chemistry Authors: Josu é de Moraes Source Type: research

Contributions of Medicinal Chemistry During the Pandemic of Covid-19
Curr Top Med Chem. 2023;23(2):114. doi: 10.2174/156802662302230131095541.NO ABSTRACTPMID:36919361 | DOI:10.2174/156802662302230131095541 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 15, 2023 Category: Chemistry Authors: Shampa Ghosh Jitendra Kumar Sinha Source Type: research

Current Trends in the Development of Electrochemical Sensors and Biosensors for Biomolecule Analysis (Part I)
Curr Top Med Chem. 2023 Mar 7;23(4):283. doi: 10.2174/156802662304230217154140.NO ABSTRACTPMID:36915944 | DOI:10.2174/156802662304230217154140 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 14, 2023 Category: Chemistry Authors: Gulsah Congur Source Type: research

Recent Advances in Computer Aided Drug Design
Curr Top Med Chem. 2023;23(1):30. doi: 10.2174/156802662301230113160655.NO ABSTRACTPMID:36891921 | DOI:10.2174/156802662301230113160655 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 9, 2023 Category: Chemistry Authors: Riccardo Concu Amit K Goyal Umesh Gupta Source Type: research

Wnt/ β-catenin signaling inhibitors
We describe the structure, mechanisms, and functions of these small molecules during cancer treatment in preclinical and clinical trials. We also review several Wnt/β-catenin inhibitors reported to exhibit anti-angiogenic effects. Finally, we explain various challenges in the targeting of the Wnt/β-catenin signaling pathway in human cancer treatment and suggest potential therapeutic approaches to human cancer.PMID:36872364 | DOI:10.2174/1568026623666230303101810 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 5, 2023 Category: Chemistry Authors: Xun Zhang Nazhen Dong Xiaoyan Hu Source Type: research

Ferrocene Derivatives as New Generation of Antimalarial Agents: Opportunity or Illusion?
Curr Top Med Chem. 2023 Feb 28. doi: 10.2174/1568026623666230228153114. Online ahead of print.ABSTRACTDespite significant scientific progress over the last two decades, malaria remains a global burden that causes thousands of deaths every year. In the absence of effective and practical preventive measures, the only current option for reducing the mortality and morbidity of malaria is chemotherapy. However, due to the minimal stock of active antiparasitic analogs, issues of toxicity, and the repeated appearance of drug resistance, scientists must broaden the arsenal of existing therapies beyond conventional medicinal chemis...
Source: Current Topics in Medicinal Chemistry - February 28, 2023 Category: Chemistry Authors: Shrawan Kumar Mangawa Shailja Singh Source Type: research