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Computer-aided Drug Design against Emerging Viruses: Part I
Curr Top Med Chem. 2022;22(29):2395. doi: 10.2174/156802662229221207124548.NO ABSTRACTPMID:36650744 | DOI:10.2174/156802662229221207124548 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 18, 2023 Category: Chemistry Authors: Igor Jos é Dos Santos Nascimento Source Type: research

Antibacterial and Antiviral Agents: Computational Insight
Curr Top Med Chem. 2022;22(32):2629. doi: 10.2174/156802662232221222112027.NO ABSTRACTPMID:36650750 | DOI:10.2174/156802662232221222112027 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 18, 2023 Category: Chemistry Authors: None Geronikaki Source Type: research

Recent Trends in Cancer Management
Curr Top Med Chem. 2022;22(30):2493. doi: 10.2174/156802662230221208104151.NO ABSTRACTPMID:36650753 | DOI:10.2174/156802662230221208104151 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 18, 2023 Category: Chemistry Authors: Shi-Gao Huang Ralph Santos-Oliveira Alejandro Perez Larios Source Type: research

Recent Developments in the Therapeutics for Endocrine Diseases
Curr Top Med Chem. 2022;22(31):2570. doi: 10.2174/156802662231221216162354.NO ABSTRACTPMID:36650824 | DOI:10.2174/156802662231221216162354 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 18, 2023 Category: Chemistry Authors: B Ravi Sankar Sridhar Muthusami R Ilangovan Source Type: research

Food Color Additives in Hazardous Consequences of Human Health: An Overview
Curr Top Med Chem. 2023 Jan 17. doi: 10.2174/1568026623666230117122433. Online ahead of print.ABSTRACTFood color additives are used to make food more appetizing. The United States Food and Drug Administration (FDA) permitted nine artificial colorings in foods, drugs, and cosmetics, whereas the European Union (EU) approved five artificial colors (E-104, 122, 124, 131, and 142) for food. However, these synthetic coloring materials raise various health hazards. The present review aimed to summarize the toxic effects of these coloring food additives on the brain, liver, kidney, lungs, urinary bladder, and thyroid gland. In thi...
Source: Current Topics in Medicinal Chemistry - January 18, 2023 Category: Chemistry Authors: Sharifa Sultana Md Mominur Rahman Farjana Islam Aovi Farhana Ishrat Jahan Md Sakhawat Hossain Shadia Afrin Brishti Md Yamin Muniruddin Ahmed Abdur Rauf Rohit Sharma Source Type: research

Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials
CONCLUSION: The virtual sample generation and screening methods proposed in this paper can effectively solve the modeling problem of small samples. The reliable process parameters can be obtained by optimizing the model trained by the semi-synthetic samples.PMID:36650652 | DOI:10.2174/1568026623666230117121531 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 18, 2023 Category: Chemistry Authors: Yalin Guan Juan Chen Cuiying Dong Source Type: research

The Potential of Melatonin to treat Atherosclerosis by Targeting Mitochondria
Curr Top Med Chem. 2023 Jan 16. doi: 10.2174/1568026623666230116102054. Online ahead of print.ABSTRACTAs a circadian rhythm hormone, melatonin is widely present in the body and has rich physiological functions. Compared to its prominent circadian role, melatonin has been extensively studied in many fields as an ancient antioxidant. In addition to being considered a potent antioxidant, melatonin has also been found to play an important role in mitochondrial homeostasis. Mitochondrial oxidative stress plays a crucial role in the occurrence and development of atherosclerosis. Therefore, the possible therapeutic value of melat...
Source: Current Topics in Medicinal Chemistry - January 17, 2023 Category: Chemistry Authors: Xuan Sun Li Chen Qing-Jun Guia Source Type: research

Impediment of cancer by dietary plant-derived alkaloids through oxidative stress: Implications of PI3K/AKT pathway in apoptosis, autophagy, and ferroptosis
Curr Top Med Chem. 2023 Jan 11. doi: 10.2174/1568026623666230111154537. Online ahead of print.ABSTRACTThe adverse toxicities and stemness are two major factors that constrained the usage of therapeutic strategies to target several cancer types. Previous studies explored the efficacy of PI3K/mTOR inhibitors, pan-PI3K inhibitors, and isoform-specific inhibitors against several cancer types, and many of them are currently in clinical trials. The current review described the efficacy of alkaloids derived from dietary plant sources in developing a new anti-cancer to reduce the prevalence of cancer through the modulation of apop...
Source: Current Topics in Medicinal Chemistry - January 13, 2023 Category: Chemistry Authors: Prasath Manogaran Narasimha M Beeraka Raja Singh Paulraj Perumal Sathiyachandran Mahadevaswamy T Source Type: research