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Study on molecular anti-tumor mechanism of 2-thiohydantoin derivative based on molecular docking and bioinformatic analyses
CONCLUSION: The relevance of this 2-thiohydantoin derivative was demonstrated by our experimental tests, docking studies, and bioinformatics analysis, and it may be investigated as a lead molecule for anticancer medicines, notably as AKT1 and CKD2 inhibitors.PMID:36617706 | DOI:10.2174/1568026623666230106121527 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 9, 2023 Category: Chemistry Authors: Ali A A Al-Shawi Amr Ahmed El Arabey Dakhil Zughayir Mutlaq Wafa Ali Eltayb Marcello Iriti Mohnad Abdalla Source Type: research

Plant-food-derived bioactives in managing hypertension: From current findings to upcoming effective pharmacotherapies
Curr Top Med Chem. 2023 Jan 6. doi: 10.2174/1568026623666230106144509. Online ahead of print.ABSTRACTA sedentary lifestyle has evoked a high risk of cardiovascular (CV) disease, diabetes, and obesity, all of them with high morbimortality rates and with a common denominator, hypertension. Numerous pharmacological drugs have been used for the treatment of hypertension. However, the side effects associated with the use of existing pharmacological therapies have triggered a demand for plant-based medications. In this connection, the aim of this review was to provide an in-depth analysis of the use of plant-derived bioactives f...
Source: Current Topics in Medicinal Chemistry - January 9, 2023 Category: Chemistry Authors: Monica Butnariu Deborah Fratantonio Jes ús Herrera-Bravo Sonal Sukreet Miquel Martorell Garsiya Ekaterina Robertovna Francisco Les V íctor López Manoj Kumar Marius Pentea Ioan Sarac Alexandra Becherescu Nat ália Cruz-Martins William N Setzer Marcello Source Type: research

Study on molecular anti-tumor mechanism of 2-thiohydantoin derivative based on molecular docking and bioinformatic analyses
CONCLUSION: The relevance of this 2-thiohydantoin derivative was demonstrated by our experimental tests, docking studies, and bioinformatics analysis, and it may be investigated as a lead molecule for anticancer medicines, notably as AKT1 and CKD2 inhibitors.PMID:36617706 | DOI:10.2174/1568026623666230106121527 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 9, 2023 Category: Chemistry Authors: Ali A A Al-Shawi Amr Ahmed El Arabey Dakhil Zughayir Mutlaq Wafa Ali Eltayb Marcello Iriti Mohnad Abdalla Source Type: research

Plant-food-derived bioactives in managing hypertension: From current findings to upcoming effective pharmacotherapies
Curr Top Med Chem. 2023 Jan 6. doi: 10.2174/1568026623666230106144509. Online ahead of print.ABSTRACTA sedentary lifestyle has evoked a high risk of cardiovascular (CV) disease, diabetes, and obesity, all of them with high morbimortality rates and with a common denominator, hypertension. Numerous pharmacological drugs have been used for the treatment of hypertension. However, the side effects associated with the use of existing pharmacological therapies have triggered a demand for plant-based medications. In this connection, the aim of this review was to provide an in-depth analysis of the use of plant-derived bioactives f...
Source: Current Topics in Medicinal Chemistry - January 9, 2023 Category: Chemistry Authors: Monica Butnariu Deborah Fratantonio Jes ús Herrera-Bravo Sonal Sukreet Miquel Martorell Garsiya Ekaterina Robertovna Francisco Les V íctor López Manoj Kumar Marius Pentea Ioan Sarac Alexandra Becherescu Nat ália Cruz-Martins William N Setzer Marcello Source Type: research

Study on molecular anti-tumor mechanism of 2-thiohydantoin derivative based on molecular docking and bioinformatic analyses
CONCLUSION: The relevance of this 2-thiohydantoin derivative was demonstrated by our experimental tests, docking studies, and bioinformatics analysis, and it may be investigated as a lead molecule for anticancer medicines, notably as AKT1 and CKD2 inhibitors.PMID:36617706 | DOI:10.2174/1568026623666230106121527 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - January 9, 2023 Category: Chemistry Authors: Ali A A Al-Shawi Amr Ahmed El Arabey Dakhil Zughayir Mutlaq Wafa Ali Eltayb Marcello Iriti Mohnad Abdalla Source Type: research