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A Comprehensive Review on Phytochemistry and Pharmacology of Rosa Species (Rosaceae)
Curr Top Med Chem. 2023 Nov 1. doi: 10.2174/0115680266274385231023075011. Online ahead of print.ABSTRACTThe Rosa L. genus is a significant plant family in the Rosaceae group, consisting of around 200 species, primarily shrubs. In India, it has 37 species, most located in the Western Himalayan region of Jammu and Kashmir and Himachal Pradesh. Roses are highly regarded for their beauty and growth and are popular worldwide for their nutritional, therapeutic, ornamental, and cosmetic value. The rose hips are utilized in creating various food and drink items, such as jams, jellies, teas, and alcoholic beverages. The Rosa specie...
Source: Current Topics in Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Faheem Fayaz Kanwaljeet Singh Sumeet Gairola Zabeer Ahmed Bhahwal Ali Shah Source Type: research

Natural Plant Products Mediated Prevention of Cancer Facilitated through Immune Suppression of Treg Cells
Curr Top Med Chem. 2023 Nov 3. doi: 10.2174/0115680266275768231027100120. Online ahead of print.ABSTRACTCancer is one of the leading causes of death, and numerous methods have been tested and used to figure out an optimum way of treatment. Besides targeted therapy, immunotherapy has proven to be effective by controlling certain immune cells. Traditional cancer therapy is met with the consequences of adverse side effects that have been a major issue for treatment; hence, a leap towards naturally occurring immunomodulators was taken to develop safer methods of treatment. One of the major immune cells responsible for the grow...
Source: Current Topics in Medicinal Chemistry - November 8, 2023 Category: Chemistry Authors: Oishi Mukherjee Sudeshna Rakshit Geetha Shanmugan Koustav Sarkar Source Type: research

Enhancing Opiorphin's Metabolic Stability and Preserving its Potent Analgesic Effect: A Systematic Review
CONCLUSION: This paper presents the first systematic review discussing opiorphin and opiorphin analogs and identifies the most promising candidates for future research.PMID:37933217 | DOI:10.2174/0115680266260621231102195044 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - November 7, 2023 Category: Chemistry Authors: Joana Tome Mohammed Nurudeen Ibrahim Logan T Cowan Source Type: research

Protein Dynamics Mediated by Cardiolipin in Bacteria
Curr Top Med Chem. 2023 Oct 27. doi: 10.2174/0115680266266646231023091215. Online ahead of print.ABSTRACTBacterial proteins targeting the appropriate subcellular sites are the base for their proper function. Several studies have shown that the anionic phospholipid cardiolipin (CL), a conical lipid preferring negative membrane curvature, modulates the lipid bilayers' structure, which impacts the activity of their resident proteins. Due to the favor of negative membrane curvature, CL is not randomly distributed in the bacterial plasma membrane. In contrast, it gathers in particular parts of the cell membrane to form microdom...
Source: Current Topics in Medicinal Chemistry - November 6, 2023 Category: Chemistry Authors: Yanyang Wang Jiawen Chen Liyang Hang Jichao Zhu Xinhua Qiang Mingjian Yang Xiangliang Sun Sha Wang Hongchang Zhou Yibin Lin Shengwen Shao Source Type: research

n-3 PUFAs Show Promise as Adjuvants in Chemotherapy, Enhancing their Efficacy while Safeguarding Hematopoiesis and Promoting Bone Generation
Curr Top Med Chem. 2023 Oct 27. doi: 10.2174/0115680266258838231020102401. Online ahead of print.ABSTRACTCancer ranks as the second leading cause of mortality in high-income countries, underscoring the critical need for effective therapeutic strategies. One prominent approach, chemotherapy, is widely employed for treating solid tumors. However, the significant adverse effects associated with chemotherapy, notably myeloablation and osteonecrosis, impart considerable challenges by compromising immune function and diminishing patients' quality of life. Furthermore, the emergence of chemotherapy resistance poses a formidable h...
Source: Current Topics in Medicinal Chemistry - November 1, 2023 Category: Chemistry Authors: Pradnya Gurav Suraj Garad Kedar R N Source Type: research

Recent Development in the Search for Epidermal Growth Factor Receptor (EGFR) Inhibitors based on the Indole Pharmacophore
Curr Top Med Chem. 2023 Oct 31. doi: 10.2174/0115680266264206231020111820. Online ahead of print.ABSTRACTThe signal transduction and cell proliferation are regulated by the epidermal growth factor receptor. The proliferation of tumor cells, apoptosis, invasion, and angiogenesis is inhibited by the epidermal growth factor receptor. Thus, breast cancer, non-small cell lung cancer, cervical cancer, glioma, and bladder cancer can be treated by targeting the epidermal growth factor receptor. Although third-generation epidermal growth factor receptor inhibitors are potent drugs, patients exhibit drug resistance after treatment. ...
Source: Current Topics in Medicinal Chemistry - November 1, 2023 Category: Chemistry Authors: Shweta Mishra Adarsh Sahu Avneet Kaur Maninder Kaur Jayendra Kumar Pranay Wal Source Type: research