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Insight into Tumor Hypoxia: Radionuclide-based Biomarker as Diagnostic Tools
Curr Top Med Chem. 2023 May 15. doi: 10.2174/1568026623666230515154442. Online ahead of print.ABSTRACTThe radiolabeled tracers have been extensively utilized to access various physiological and pathological conditions non-invasively, such as cancers, inflammation, and organ-specific imaging. These tracers demonstrate and study tumor hypoxia in several malignancies. Hypoxia is commonly seen in solid tumors.Tumor Hypoxia is a non-physiological condition of reduced oxygen concentration in the tumor. Hypoxia is associated with adverse outcomes such as treatment resistance and metastases in solid tumors. Tumor hypoxia may resul...
Source: Current Topics in Medicinal Chemistry - May 16, 2023 Category: Chemistry Authors: Priya Saxena Sanjay Gambhir Manish Dixit Source Type: research

Various effects of the GABAergic system on cancer: the conditions and specificities of its use in the treatment of some cancers
Curr Top Med Chem. 2023 May 15. doi: 10.2174/1568026623666230515163713. Online ahead of print.ABSTRACTGABA is an essential neurotransmitter in tissues other than the brain and has different functions. Cancer displays dysfunctional GABAergic system roles, comprising GAD, GABA, and GABA receptors. Both tumor-suppressing and carcinogenic characteristics of the GABAergic system have been reported in several malignancies. In the development of cancer cells, it plays oncogenesis-related roles. However, in some tumors, such as pancreatic cancer, it exhibits anti-cancer benefits in numerous human trials and animal models. As a res...
Source: Current Topics in Medicinal Chemistry - May 16, 2023 Category: Chemistry Authors: Hossein Tahmasebi Dehkordi Sorayya Ghasemi Masoumeh Eliyasi Source Type: research

Advances in Medicinal Chemistry of Estrogen-related receptor alpha (ERR α) inverse agonists
Curr Top Med Chem. 2023 May 15. doi: 10.2174/1568026623666230515145822. Online ahead of print.ABSTRACTEstrogen-related receptor alpha (ERRα), a member of the nuclear receptor superfamily, is strongly expressed in breast cancer cells. Its overexpression is associated with poor prognosis in triple-negative breast cancer (TNBC). ERRα expression could be inhibited by the downregulation of upstream oncogenic growth factors mTOR, HER2, and PI3K. Low expression of ERRα could suppress the migration and angiogenesis of tumor cells by inhibiting the activity of its downstream signals VEGF and WNT11. Studies have confirmed that ER...
Source: Current Topics in Medicinal Chemistry - May 16, 2023 Category: Chemistry Authors: Haibin Zhang Yongli Du Yong Zheng Huiting Lv Zhijia Yan Ning Dong Yaling Zhu Jingkang Shen Source Type: research

Antiproliferative Activity and Mechanisms of Action of Plant-Derived Flavonoids on Breast Cancer
Curr Top Med Chem. 2023 May 12. doi: 10.2174/1568026623666230512123500. Online ahead of print.ABSTRACTBreast cancer is one of the main global diseases with a high mortality rate that mainly affects the female population. Despite the important advances that have been made concerning the treatments for this disease, research on less invasive therapies that generate fewer side effects for patients continues to develop. Consequently, researchers have turned their attention to using natural compounds (such as flavonoids) involved in molecular processes implicated in this type of cancer and are studying how these processes can b...
Source: Current Topics in Medicinal Chemistry - May 15, 2023 Category: Chemistry Authors: Criollo Mendoza Marilyn S Heredia J Basilio Vazquez-Olivo Gabriela Avil és-Gaxiola Sara Erick P Guti érrez-Grijalva Garcia-Carrasco Melissa Source Type: research

Advances in exosome research in the management of lung cancer
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504101208. Online ahead of print.ABSTRACTLung cancer is one of the most common malignant tumors, and its death rate is much higher than that of colon, kidney, breast, and prostate cancers, and its 5-year survival rate is only 18%. Lung cancer has no specific clinical symptoms in its early stages and lacks effective detection, making early detection difficult. The survival rate for advanced lung cancer is meager, with a median survival of only 12 months for stage IIIB/IV non-small cell lung cancer treated with platinumbased chemotherapy. Exosomes could provide vita...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Huiqing Shen Dawei Cao Xinri Zhang Source Type: research

The applications of CRISPR/Cas9 System for Urinary System Tumor
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504100706. Online ahead of print.ABSTRACTTumors of the urinary system include those in the urinary and reproductive systems, of which tumors of the prostate, bladder, and kidney have the highest incidence. In recent years, due to changes in dietary structure, prostate cancer has become the most common type of male genitourinary system cancer. Furthermore, due to tobacco consumption, increases in industrialization, and the age of the population, the incidence of bladder cancer in both males and females in both urban and rural areas, has shown an increasing trend. T...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Shulin Li Xiangwei Wang Yuqi Wu Source Type: research

Cocrystallizing and Codelivering Complementary Drugs to MultidrugResistant Tuberculosis Bacteria in Perfecting Multidrug Therapy
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504094521. Online ahead of print.ABSTRACTBacteria cells exhibit multidrug resistance in one of two ways: by raising the genetic expression of multidrug efflux pumps or by accumulating several drug-resistant components in many genes. Multidrug-resistive tuberculosis bacteria are treated by multidrug therapy, where a few certain antibacterial drugs are administered together to kill a bacterium jointly. A major drawback of conventional multidrug therapy is that the administration never ensures the reaching of different drug molecules to a particular bacterium cell at...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Pathik Sahoo Source Type: research

AmpC inhibition: An Explicit Approach against Multi-Drug Resistance (MDR)
Curr Top Med Chem. 2023 May 4. doi: 10.2174/1568026623666230504095005. Online ahead of print.ABSTRACTMulti-drug resistance and its transmission is a ubiquitous health issue worldwide. The beta-lactamase AmpC resistance is a major concern among all health settings like hospitals and child care centers, etc. The clinical pipeline of the new antibiotics remains dry due to the production of AmpC beta-lactamases by the bacteria to develop resistance against antibiotics. According to the global antimicrobial resistance and use surveillance system, the rate of resistance to ciprofloxacin an antibiotic commonly used to treat urina...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Manish Kaushik Aditi Kaushik Akash Jain Jasmine Chaudhary Vrinda Gupta Source Type: research

Anti-tumoral Titanium(IV) Complexes Stabilized with Phenolato Ligands and Structure-Activity Relationship
Curr Top Med Chem. 2023 May 5. doi: 10.2174/1568026623666230505104626. Online ahead of print.ABSTRACTTitanocene dichloride and budotitane have opened a new chapter in medicinal chemistry of titanium(IV) complexes being novel non-platinum antitumor metallic agents. Numerous efforts have led to the discovery of the diamino bis-phenolato titanium(IV) complexes. Among which, the [ONNO] and [ONON] type ligands namely Salan, Salen and Salalen coordinated titanium(IV) alkoxyl complexes have demonstrated significantly enhanced aqueous stability, their in vitro and in vivo antitumor efficacy, mechanism of action, structure-activity...
Source: Current Topics in Medicinal Chemistry - May 8, 2023 Category: Chemistry Authors: Tiankun Zhao Peng Wang Xupeng Zhang Nan Liu Wenzhuo Zhao Yong Zhang Pengpeng Yuan Shanjia Li Mingjun Yang Zhongduo Yang Thomas Huhn Source Type: research