A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques

Curr Top Med Chem. 2024 Feb 15:e150224227031. doi: 10.2174/0115680266281358240206112605. Online ahead of print.ABSTRACTPeptides acquire target affinity based on the combination of residues in their sequences and the conformation formed by their flexible folding, an ability that makes them very attractive biomaterials in therapeutic, diagnostic, and assay fields. With the development of computer technology, computer-aided design and screening of affinity peptides has become a more efficient and faster method. This review summarizes successful cases of computer-aided design and screening of affinity peptide ligands in recent years and lists the computer programs and online servers used in the process. In particular, the characteristics of different design and screening methods are summarized and categorized to help researchers choose between different methods. In addition, experimentally validated sequences are listed, and their applications are described, providing directions for the future development and application of computational peptide screening and design.PMID:38549525 | DOI:10.2174/0115680266281358240206112605

Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Zheng Wei Meilun Chen Xiaoling Lu Yijie Liu Guangnan Peng Jie Yang Chunhua Tang Peng Yu Source Type: research