Identifying patients ’ support needs following critical illness: a scoping review of the qualitative literature
Intensive care survivors suffer chronic and potentially life-changing physical, psychosocial and cognitive sequelae, and supporting recovery is an international priority. As survivors ’ transition from the inte... (Source: Critical Care)
Source: Critical Care - May 24, 2019 Category: Intensive Care Authors: J. King, B. O ’Neill, P. Ramsay, M. A. Linden, A. Darweish Medniuk, J. Outtrim and B. Blackwood Tags: Research Source Type: research

Letter on “Sigh maneuver to enhance assessment of fluid responsiveness during pressure support ventilation”
(Source: Critical Care)
Source: Critical Care - May 24, 2019 Category: Intensive Care Authors: Khaoula Meddeb and Mohamed Boussarsar Tags: Letter Source Type: research

Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients
Multiple organ dysfunction is a common cause of morbidity and mortality in intensive care units (ICUs). Original development of the Sequential Organ Failure Assessment (SOFA) score was not to predict outcome, ... (Source: Critical Care)
Source: Critical Care - May 23, 2019 Category: Intensive Care Authors: Andrea Soo, Danny J. Zuege, Gordon H. Fick, Daniel J. Niven, Luc R. Berthiaume, Henry T. Stelfox and Christopher J. Doig Tags: Research Source Type: research

Endocan removal during continuous renal replacement therapy: does it affect the reliability of this biomarker?
(Source: Critical Care)
Source: Critical Care - May 22, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

Clinically relevant pharmacokinetic knowledge on antibiotic dosing among intensive care professionals is insufficient: a cross-sectional study
Antibiotic exposure in intensive care patients with sepsis is frequently inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the intensive care, as critically ill patients ha... (Source: Critical Care)
Source: Critical Care - May 22, 2019 Category: Intensive Care Authors: Lucas M. Fleuren, Luca F. Roggeveen, Tingjie Guo, Petr Waldauf, Peter H. J. van der Voort, Rob J. Bosman, Eleonora L. Swart, Armand R. J. Girbes and Paul W. G. Elbers Tags: Research Source Type: research

An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial
Sepsis remains one of the most important causes of morbidity and mortality worldwide. In approximately 30 –50% of cases of suspected sepsis, no pathogen is isolated, disabling the clinician to treat the patient... (Source: Critical Care)
Source: Critical Care - May 21, 2019 Category: Intensive Care Authors: Rishi S. Nannan Panday, Eline M. J. Lammers, Nadia Alam and Prabath W. B. Nanayakkara Tags: Research Source Type: research

How to treat combined respiratory and metabolic acidosis after extracorporeal cardiopulmonary resuscitation?
(Source: Critical Care)
Source: Critical Care - May 21, 2019 Category: Intensive Care Authors: Xavier Bemtgen, Florentine Schroth, Tobias Wengenmayer, Paul M. Biever, Daniel Duerschmied, Christoph Benk, Christoph Bode and Dawid L. Staudacher Tags: Letter Source Type: research

Response
(Source: Critical Care)
Source: Critical Care - May 20, 2019 Category: Intensive Care Authors: Huoyan Liang, Xianfei Ding and Tongwen Sun Tags: Letter Source Type: research

High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation: a systematic review and meta-analysis
The effect of high-flow nasal cannula (HFNC) therapy in patients after planned extubation remains inconclusive. We aimed to perform a rigorous and comprehensive systematic meta-analysis to robustly quantify th... (Source: Critical Care)
Source: Critical Care - May 17, 2019 Category: Intensive Care Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang, Xiaoling Ye and Jianrui Wei Tags: Research Source Type: research

Should ECMO be used in cardiogenic shock?
(Source: Critical Care)
Source: Critical Care - May 16, 2019 Category: Intensive Care Authors: Orhan Gokalp, Koksal Donmez, Hasan Iner, Gamze Gokalp, Yuksel Besir, Nihan Karakas Yesilkaya, Levent Yilik and Ali Gurbuz Tags: Letter Source Type: research

Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample
Timely initiation of physical, occupational, and speech therapy in critically ill patients is crucial to reduce morbidity and improve outcomes. Over a 5-year time interval, we sought to determine the utilizati... (Source: Critical Care)
Source: Critical Care - May 16, 2019 Category: Intensive Care Authors: Clare C. Prohaska, Peter D. Sottile, Amy Nordon-Craft, Matt D. Gallagher, Ellen L. Burnham, Brendan J. Clark, Michael Ho, Tyree H. Kiser, R. William Vandivier, Wenhui Liu, Margaret Schenkman and Marc Moss Tags: Research Source Type: research

How I ventilate an obese patient
(Source: Critical Care)
Source: Critical Care - May 16, 2019 Category: Intensive Care Authors: Lorenzo Ball and Paolo Pelosi Tags: Editorial Source Type: research

How I manage a difficult intubation
(Source: Critical Care)
Source: Critical Care - May 16, 2019 Category: Intensive Care Authors: Jonathan D. Casey, Matthew W. Semler, Kevin High and Wesley H. Self Tags: Editorial Source Type: research

Are we really preventing lung collapse with APRV?
(Source: Critical Care)
Source: Critical Care - May 16, 2019 Category: Intensive Care Authors: Ryota Sato, Natsumi Hamahata and Ehab G. Daoud Tags: Letter Source Type: research

Temporal change in characteristics and outcomes of acute kidney injury on renal replacement therapy in intensive care units: analysis of a nationwide administrative database in Japan, 2007 –2016
We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent... (Source: Critical Care)
Source: Critical Care - May 15, 2019 Category: Intensive Care Authors: Yoshihisa Miyamoto, Masao Iwagami, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Yoshifumi Hamasaki, Masaomi Nangaku and Kent Doi Tags: Research Source Type: research

The challenge of removal of sepsis markers by continuous hemofiltration
(Source: Critical Care)
Source: Critical Care - May 15, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant and Kianoush Kashani Tags: Letter Source Type: research

Inducible metabolic pathway for citrate metabolism in case of major liver dysfunction: fact or fiction?
(Source: Critical Care)
Source: Critical Care - May 14, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Sebastien Redant, Rachid Attou, Luc Kugener and Willem Boer Tags: Letter Source Type: research

Letter in response to “Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury”
(Source: Critical Care)
Source: Critical Care - May 14, 2019 Category: Intensive Care Authors: Richard W Pierce Tags: Letter Source Type: research

Comparative efficacy of vasoactive medications in patients with septic shock: a network meta-analysis of randomized controlled trials
Catecholamines, especially norepinephrine, are the most frequently used vasopressors for treating patients with septic shock. During the recent decades, terlipressin, vasopressin V1A agonist, and even Ca2+ sensit... (Source: Critical Care)
Source: Critical Care - May 14, 2019 Category: Intensive Care Authors: Lu Cheng, Jing Yan, Shutang Han, Qiuhua Chen, Mingqi Chen, Hua Jiang and Jun Lu Tags: Research Source Type: research

Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review
Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are disseminating worldwide leading to increased hospital length of stay and mortality in intensive care units (ICU). ESBL-E dissemination wa... (Source: Critical Care)
Source: Critical Care - May 14, 2019 Category: Intensive Care Authors: Renaud Prevel, Alexandre Boyer, Fatima M ’Zali, Agnès Lasheras, Jean-Ralph Zahar, Anne-Marie Rogues and Didier Gruson Tags: Research Source Type: research

Near-infrared spectroscopy after out-of-hospital cardiac arrest
Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is... (Source: Critical Care)
Source: Critical Care - May 14, 2019 Category: Intensive Care Authors: Pekka Jakkula, Johanna H ästbacka, Matti Reinikainen, Ville Pettilä, Pekka Loisa, Marjaana Tiainen, Erika Wilkman, Stepani Bendel, Thomas Birkelund, Anni Pulkkinen, Minna Bäcklund, Sirkku Heino, Sari Karlsson, Hiski Kopponen and Markus B. Skrifvars Tags: Research Source Type: research

Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders
At least a third of the world ’s population consumes alcohol regularly. Patients with alcohol use disorders (AUDs) are frequently hospitalized for both alcohol-related and unrelated medical conditions. It is we... (Source: Critical Care)
Source: Critical Care - May 10, 2019 Category: Intensive Care Authors: Paul E. Marik and Amanda Liggett Tags: Research Source Type: research

Hypothermia after decompressive hemicraniectomy in treatment of malignant middle cerebral artery stroke: comment on the randomized clinical trial
(Source: Critical Care)
Source: Critical Care - May 9, 2019 Category: Intensive Care Authors: N. Engrand, M. Mazighi and V. Dinkelacker Tags: Letter Source Type: research

Renal function after out-of-hospital cardiac arrest; the influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial
To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal func... (Source: Critical Care)
Source: Critical Care - May 8, 2019 Category: Intensive Care Authors: Malin Rundgren, Susann Ull én, Matt P. G. Morgan, Guy Glover, Julius Cranshaw, Nawaf Al-Subaie, Andrew Walden, Michael Joannidis, Marlies Ostermann, Josef Dankiewicz, Niklas Nielsen and Matthew P. Wise Tags: Research Source Type: research

How I monitor cerebral autoregulation
(Source: Critical Care)
Source: Critical Care - May 7, 2019 Category: Intensive Care Authors: Samuel P. Klein, Bart Depreitere and Geert Meyfroidt Tags: Editorial Source Type: research

The effect of adhesive tape versus endotracheal tube fastener in critically ill adults: the endotracheal tube securement (ETTS) randomized controlled trial
The optimal securement method of endotracheal tubes is unknown but should prevent dislodgement while minimizing complications. The use of an endotracheal tube fastener might reduce complications among critical... (Source: Critical Care)
Source: Critical Care - May 7, 2019 Category: Intensive Care Authors: Janna S. Landsperger, Jesse M. Byram, Bradley D. Lloyd and Todd W. Rice Tags: Research Source Type: research

Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock
The aim of this study was to evaluate oxidative stress from glutathione depletion in critically ill patients with a septic shock through the abnormal presence of pyroglutamic acid (PyroGlu) in the urine (indir... (Source: Critical Care)
Source: Critical Care - May 7, 2019 Category: Intensive Care Authors: Yenifer Gamarra, Felipe C. Santiago, Jorge Molina-L ópez, José Castaño, Lourdes Herrera-Quintana, Álvaro Domínguez and Elena Planells Tags: Research Source Type: research

Does training level affect the accuracy of visual assessment of capillary refill time?
(Source: Critical Care)
Source: Critical Care - May 6, 2019 Category: Intensive Care Authors: Koichiro Shinozaki, Lee S. Jacobson, Kota Saeki, Naoki Kobayashi, Steve Weisner, Julianne M. Falotico, Timmy Li, Junhwan Kim, Joshua W. Lampe and Lance B. Becker Tags: Letter Source Type: research

Retrospective cohort study of hospital variation in airway management during in-hospital cardiac arrest and the association with patient survival: insights from Get With The Guidelines-Resuscitation
The optimal approach to airway management during in-hospital cardiac arrest is unknown. (Source: Critical Care)
Source: Critical Care - May 6, 2019 Category: Intensive Care Authors: Steven M. Bradley, Yunshu Zhou, Satya Krishna Ramachandran, Milo Engoren, Michael Donnino and Saket Girotra Tags: Research Source Type: research

Fluid management in patients undergoing cardiac surgery: effects of an acetate- versus lactate-buffered balanced infusion solution on hemodynamic stability (HEMACETAT)
Recent evidence suggests that acetate-buffered infusions result in better hemodynamic stabilization than 0.9% saline in patients undergoing major surgery. The choice of buffer in balanced crystalloid solutions... (Source: Critical Care)
Source: Critical Care - May 6, 2019 Category: Intensive Care Authors: Carmen A. Pfortmueller, Livia Faeh, Martin M üller, Balthasar Eberle, Hansjörg Jenni, Björn Zante, Josef Prazak, Lars Englberger, Jukka Takala and Stephan M. Jakob Tags: Research Source Type: research

Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials
Randomised controlled trials (RCTs) enrolling patients with sepsis or acute respiratory distress syndrome (ARDS) generate heterogeneous trial populations. Non-random variation in the treatment effect of an int... (Source: Critical Care)
Source: Critical Care - May 3, 2019 Category: Intensive Care Authors: Shalini Santhakumaran, Anthony Gordon, A. Toby Prevost, Cecilia O ’Kane, Daniel F. McAuley and Manu Shankar-Hari Tags: Research Source Type: research

Social and economic problems of ICU survivors identified by a structured social welfare consultation
(Source: Critical Care)
Source: Critical Care - May 2, 2019 Category: Intensive Care Authors: J. M. McPeake, P. Henderson, G. Darroch, T. J. Iwashyna, P. MacTavish, C. Robinson and T. Quasim Tags: Letter Source Type: research

When circulatory death does not come in time in potential organ donors
(Source: Critical Care)
Source: Critical Care - May 2, 2019 Category: Intensive Care Authors: Angela Kotsopoulos, Nichon Jansen and Wilson Farid Abdo Tags: Letter Source Type: research

Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury
Elevated intracranial pressure (ICP) is frequent after traumatic brain injury (TBI) and may cause abnormal pupillary reactivity, which in turn is associated with a worse prognosis. Using automated infrared pup... (Source: Critical Care)
Source: Critical Care - May 2, 2019 Category: Intensive Care Authors: Fritz-Patrick Jahns, John Paul Miroz, Mahmoud Messerer, Roy T. Daniel, Fabio Silvio Taccone, Philippe Eckert and Mauro Oddo Tags: Research Source Type: research

The global challenge of Candida auris in the intensive care unit
(Source: Critical Care)
Source: Critical Care - May 2, 2019 Category: Intensive Care Authors: Andrea Cortegiani, Giovanni Misseri, Antonino Giarratano, Matteo Bassetti and David Eyre Tags: Editorial Source Type: research

Procalcitonin is an essential biomarker for hydrocortisone, ascorbic acid, and thiamine (HAT) therapy in patients with sepsis
(Source: Critical Care)
Source: Critical Care - May 2, 2019 Category: Intensive Care Authors: Paul E. Marik Tags: Letter Source Type: research

Quality and quantity of sample size is crucial in clinical studies to exclude association: antimicrobial exposure and the risk of delirium in critically ill patients
(Source: Critical Care)
Source: Critical Care - April 29, 2019 Category: Intensive Care Authors: Rashid Nadeem, Zainab Ameer Obeida, Sahish Kamat and Ahmed Nazir Elsousi Tags: Letter Source Type: research

Renin-angiotensin-aldosterone system blockers after KDIGO stage 3 acute kidney injury: use and impact on 2-year mortality in the AKIKI trial
(Source: Critical Care)
Source: Critical Care - April 29, 2019 Category: Intensive Care Authors: Mathilde Scarton, Anne Oppenheimer, Khalil Cha ïbi, Didier Dreyfuss and Stéphane Gaudry Tags: Letter Source Type: research

Angiotensin II in ECMO patients: a word of caution
(Source: Critical Care)
Source: Critical Care - April 26, 2019 Category: Intensive Care Authors: Elio Antonucci and Fabio Silvio Taccone Tags: Letter Source Type: research

Optimizing ceftolozane-tazobactam dosage in critically ill patients during continuous venovenous hemodiafiltration
(Source: Critical Care)
Source: Critical Care - April 26, 2019 Category: Intensive Care Authors: Gerardo Aguilar, Rafael Ferriols, Sara Mart ínez-Castro, Carlos Ezquer, Ernesto Pastor, José A. Carbonell, Manuel Alós and David Navarro Tags: Letter Source Type: research

Epidemiology of infective endocarditis in French intensive care units over the 1997 –2014 period—from CUB-Réa Network
This study aimed to describe demographical, comorbidities, organ fa... (Source: Critical Care)
Source: Critical Care - April 25, 2019 Category: Intensive Care Authors: J érémie Joffre, Guillaume Dumas, Philippe Aegerter, Vincent Dubée, Naike Bigé, Gabriel Preda, Jean-Luc Baudel, Eric Maury, Bertrand Guidet and Hafid Ait-Oufella Tags: Research Source Type: research

Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department
(Source: Critical Care)
Source: Critical Care - April 25, 2019 Category: Intensive Care Authors: Mari Rosenqvist, Darius Cameron Wilson, Lena Tegn ér, Maria Bengtsson-Toni, Marjaneh Peyman, Juan Gonzalez del Castillo, Kordo Saeed and Olle Melander Tags: Letter Source Type: research

Correction to: Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis
After publication of this article [1], it was noticed that the affiliations of Honghong Zhou were incorrect. The sole affiliation should be, “Department of Nephrology, the Second Affiliated Hospital of Nanchan... (Source: Critical Care)
Source: Critical Care - April 25, 2019 Category: Intensive Care Authors: Honghong Zou, Qianwen Hong and Gaosi XU Tags: Correction Source Type: research

Composed endotypes to guide antibiotic discontinuation in sepsis
Overuse of empiric antibiotic therapy in the ICU is responsible for promoting the dissemination of multidrug-resistant (MDR) bacteria. Shortened antibiotic treatment duration could contribute to palliating the... (Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Jesus F. Bermejo-Martin, David Andaluz-Ojeda, Marta Martin-Fernandez, Cesar Aldecoa and Raquel Almansa Tags: Editorial Source Type: research

Intelligently learning from data
(Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Edward Palmer, Roman Klapaukh, Steve Harris and Mervyn Singer Tags: Editorial Source Type: research

Response to “Incidence of hypotension according to the discontinuation order of vasopressors: a matter of pharmacokinetics”
(Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Kyeongman Jeon, Jae-Uk Song and Gee Young Suh Tags: Letter Source Type: research

Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis
(Source: Critical Care)
Source: Critical Care - April 24, 2019 Category: Intensive Care Authors: Meng-Si Luo, Hui-Zi Li, Guan-Jiang Huang and Lun Wu Tags: Letter Source Type: research

Control of respiratory drive by extracorporeal CO2 removal in acute exacerbation of COPD breathing on non-invasive NAVA
Veno-venous extracorporeal CO2 removal (vv-ECCO2R) and non-invasive neurally adjusted ventilator assist (NIV-NAVA) are two promising techniques which may prevent complications related to prolonged invasive mechan... (Source: Critical Care)
Source: Critical Care - April 23, 2019 Category: Intensive Care Authors: Christian Karagiannidis, Stephan Strassmann, Sarah Schwarz, Michaela Merten, Eddy Fan, Jennifer Beck, Christer Sinderby and Wolfram Windisch Tags: Research Source Type: research

vvECMO can be avoided by a transpulmonary pressure guided open lung concept in patients with severe ARDS
(Source: Critical Care)
Source: Critical Care - April 23, 2019 Category: Intensive Care Authors: Philip van der Zee, Dinis Dos Reis Miranda, Han Meeder, Henrik Endeman and Diederik Gommers Tags: Letter Source Type: research

Liberal versus conservative oxygen therapy in critically ill patients: using the fragility index to determine robust results
(Source: Critical Care)
Source: Critical Care - April 18, 2019 Category: Intensive Care Authors: Maria Vargas and Giuseppe Servillo Tags: Commentary Source Type: research