Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity
A dysregulated immune response is emerging as a key feature of critical illness in COVID-19. Neutrophils are key components of early innate immunity that, if not tightly regulated, contribute to uncontrolled s... (Source: Critical Care)
Source: Critical Care - May 30, 2022 Category: Intensive Care Authors: Chlo é Loyer, Arnaud Lapostolle, Tomas Urbina, Alexandre Elabbadi, Jean-Rémi Lavillegrand, Thomas Chaigneau, Coraly Simoes, Julien Dessajan, Cyrielle Desnos, Mélanie Morin-Brureau, Yannick Chantran, Pierre Aucouturier, Bertrand Guidet, Guillaume Voirio Tags: Research Source Type: research

Prone positioning improves ventilation –perfusion matching assessed by electrical impedance tomography in patients with ARDS: a prospective physiological study
The physiological effects of prone ventilation in ARDS patients have been discussed for a long time but have not been fully elucidated. Electrical impedance tomography (EIT) has emerged as a tool for bedside m... (Source: Critical Care)
Source: Critical Care - May 27, 2022 Category: Intensive Care Authors: Yu-xian Wang, Ming Zhong, Min-hui Dong, Jie-qiong Song, Yi-jun Zheng, Wei Wu, Jia-le Tao, Ling Zhu and Xin Zheng Tags: Research Source Type: research

Effect of abdominal weight training with and without cough machine assistance on lung function in the patients with prolonged mechanical ventilation: a randomized trial
This study aimed to explore the effect of abdominal weight training (AWT)... (Source: Critical Care)
Source: Critical Care - May 25, 2022 Category: Intensive Care Authors: Tsai-Yi Hung, Wen-Lan Wu, Ho-Chang Kuo, Shih-Feng Liu, Chia-Ling Chang, Hui-Chuan Chang, Yuh-Chyn Tsai and Jui-Fang Liu Tags: Research Source Type: research

Venous return and mean systemic filling pressure: physiology and clinical applications
Venous return is the flow of blood from the systemic venous network towards the right heart. At steady state, venous return equals cardiac output, as the venous and arterial systems operate in series. However,... (Source: Critical Care)
Source: Critical Care - May 24, 2022 Category: Intensive Care Authors: Romain Persichini, Christopher Lai, Jean-Louis Teboul, Imane Adda, Laurent Gu érin and Xavier Monnet Tags: Review Source Type: research

Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation
Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin —a macrolide antibioti... (Source: Critical Care)
Source: Critical Care - May 24, 2022 Category: Intensive Care Authors: Tom D. Y. Reijnders, Hessel Peters-Sengers, Lonneke A. van Vught, Fabrice Uhel, Marc J. M. Bonten, Olaf L. Cremer, Marcus J. Schultz, Martijn M. Stuiver and Tom van der Poll Tags: Research Source Type: research

A multicentre evaluation exploring the impact of an integrated health and social care intervention for the caregivers of ICU survivors
Caregivers and family members of Intensive Care Unit (ICU) survivors can face emotional problems following patient discharge from hospital. We aimed to evaluate the impact of a multi-centre integrated health a... (Source: Critical Care)
Source: Critical Care - May 24, 2022 Category: Intensive Care Authors: Joanne McPeake, Philip Henderson, Pamela MacTavish, Helen Devine, Malcolm Daniel, Phil Lucie, Lynn Bollan, Lucy Hogg, Mike MacMahon, Sharon Mulhern, Pauline Murray, Laura O ’Neill, Laura Strachan, Theodore J. Iwashyna, Martin Shaw and Tara Quasim Tags: Research Source Type: research

Difference of 11 years between two periods of VV-ECMO does not impact mortality in large centres: we are not sure
(Source: Critical Care)
Source: Critical Care - May 23, 2022 Category: Intensive Care Authors: Patrick M. Honore, Sebastien Redant, Pharan Djimafo, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Andrea Gallerani and Rachid Attou Tags: Correspondence Source Type: research

Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis
Extracorporeal membrane oxygenation (ECMO) has been used extensively for coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). Reports early in the pandemic suggested that mor... (Source: Critical Care)
Source: Critical Care - May 23, 2022 Category: Intensive Care Authors: Ryan Ruiyang Ling, Kollengode Ramanathan, Jackie Jia Lin Sim, Suei Nee Wong, Ying Chen, Faizan Amin, Shannon M. Fernando, Bram Rochwerg, Eddy Fan, Ryan P. Barbaro, Graeme MacLaren, Kiran Shekar and Daniel Brodie Tags: Research Source Type: research

Hidden Harlequin syndrome in neonatal and pediatric VA-ECMO
(Source: Critical Care)
Source: Critical Care - May 20, 2022 Category: Intensive Care Authors: Yael Levy, Julie Starck, Anne-Lise Mary, Yohan Soreze, Sandrine Jean, Bernard Kreitmann, Pierre-Louis L éger and Jerome Rambaud Tags: Correspondence Source Type: research

Web-based application for predicting the potential target phenotype for recombinant human thrombomodulin therapy in patients with sepsis: analysis of three multicentre registries
A recent randomised controlled trial failed to demonstrate a beneficial effect of recombinant human thrombomodulin (rhTM) on sepsis. However, there is still controversy in the effects of rhTM for sepsis due to... (Source: Critical Care)
Source: Critical Care - May 19, 2022 Category: Intensive Care Authors: Tadahiro Goto, Daisuke Kudo, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi and Shigeki Kushimoto Tags: Brief Report Source Type: research

Pulmonary consolidation alters the ultrasound estimate of pleural fluid volume when considering chest drainage in patients on ECMO
(Source: Critical Care)
Source: Critical Care - May 18, 2022 Category: Intensive Care Authors: Martin Balik, Masego Candy Mokotedi, Michal Maly, Michal Otahal, Zdenek Stach, Eva Svobodova, Marek Flaksa, Jan Rulisek, Tomas Brozek and Michal Porizka Tags: Correspondence Source Type: research

Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN)
Medical nutrition therapy may be associated with clinical outcomes in critically ill patients with prolonged intensive care unit (ICU) stay. We wanted to assess nutrition practices in European intensive care u... (Source: Critical Care)
Source: Critical Care - May 18, 2022 Category: Intensive Care Authors: Martin Matejovic, Olivier Huet, Karolien Dams, Gunnar Elke, Clara Vaquerizo Alonso, Akos Csomos, Łukasz J. Krzych, Romano Tetamo, Zudin Puthucheary, Olav Rooyackers, Inga Tjäder, Helmut Kuechenhoff, Wolfgang H. Hartl and Michael Hiesmayr Tags: Research Source Type: research

TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trial
Critically ill COVID-19 patients may develop acute respiratory distress syndrome and the need for respiratory support, including mechanical ventilation in the intensive care unit. Previous observational studie... (Source: Critical Care)
Source: Critical Care - May 18, 2022 Category: Intensive Care Authors: M åns Eeg-Olofsson, Nina Pauli, Louise Hafsten, Josephine Jacobsson, Christopher Lundborg, Magnus Brink, Helen Larsson, Ellen Lindell, Karin Löwhagen, Magnus Gisslén and Henrik Bergquist Tags: Research Source Type: research

Higher serum haptoglobin levels were associated with improved outcomes of patients with septic shock
(Source: Critical Care)
Source: Critical Care - May 17, 2022 Category: Intensive Care Authors: Peng Lan, Peihao Yu, Jun Ni and Jiancang Zhou Tags: Correspondence Source Type: research

Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis
The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patie... (Source: Critical Care)
Source: Critical Care - May 17, 2022 Category: Intensive Care Authors: Gianluigi Li Bassi, Kristen Gibbons, Jacky Y. Suen, Heidi J. Dalton, Nicole White, Amanda Corley, Sally Shrapnel, Samuel Hinton, Simon Forsyth, John G. Laffey, Eddy Fan, Jonathon P. Fanning, Mauro Panigada, Robert Bartlett, Daniel Brodie, Aidan Burrell & Tags: Research Source Type: research