Control of respiratory drive by extracorporeal CO2 removal in acute exacerbation of COPD breathing on non-invasive NAVA
Veno-venous extracorporeal CO2 removal (vv-ECCO2R) and non-invasive neurally adjusted ventilator assist (NIV-NAVA) are two promising techniques which may prevent complications related to prolonged invasive mechan... (Source: Critical Care)
Source: Critical Care - April 23, 2019 Category: Intensive Care Authors: Christian Karagiannidis, Stephan Strassmann, Sarah Schwarz, Michaela Merten, Eddy Fan, Jennifer Beck, Christer Sinderby and Wolfram Windisch Tags: Research Source Type: research

vvECMO can be avoided by a transpulmonary pressure guided open lung concept in patients with severe ARDS
(Source: Critical Care)
Source: Critical Care - April 23, 2019 Category: Intensive Care Authors: Philip van der Zee, Dinis Dos Reis Miranda, Han Meeder, Henrik Endeman and Diederik Gommers Tags: Letter Source Type: research

Liberal versus conservative oxygen therapy in critically ill patients: using the fragility index to determine robust results
(Source: Critical Care)
Source: Critical Care - April 18, 2019 Category: Intensive Care Authors: Maria Vargas and Giuseppe Servillo Tags: Commentary Source Type: research

Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort
We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a resource-limited setting. (Source: Critical Care)
Source: Critical Care - April 17, 2019 Category: Intensive Care Authors: Romina E. Arag ón, Alvaro Proaño, Nicole Mongilardi, Aldo de Ferrari, Phabiola Herrera, Rollin Roldan, Enrique Paz, Amador A. Jaymez, Eduardo Chirinos, Jose Portugal, Rocio Quispe, Roy G. Brower and William Checkley Tags: Research Source Type: research

TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients
Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7... (Source: Critical Care)
Source: Critical Care - April 17, 2019 Category: Intensive Care Authors: Julie Mouillaux, Camille Allam, Morgane Gossez, Thomas Uberti, Benjamin Delwarde, Jack Hayman, Thomas Rimmel é, Julien Textoris, Guillaume Monneret, Estelle Peronnet and Fabienne Venet Tags: Research Source Type: research

A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome
The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure at risk for PARDS has not been ex... (Source: Critical Care)
Source: Critical Care - April 17, 2019 Category: Intensive Care Authors: Heidi Flori, Anil Sapru, Michael W. Quasney, Ginny Gildengorin, Martha A. Q. Curley, Michael A. Matthay and Mary K. Dahmer Tags: Research Source Type: research

Application of MR-ProADM to predict prevention of hospitalisation, derived from a multi-centre study
(Source: Critical Care)
Source: Critical Care - April 17, 2019 Category: Intensive Care Authors: Milo Cullinan, Sara Graziadio and David Ashley Price Tags: Letter Source Type: research

Broad spectrum vasopressors: a new approach to the initial management of septic shock?
The mainstay of hemodynamic treatment of septic shock is fluid resuscitation followed by vasopressors where fluids alone are insufficient to achieve target blood pressure. Norepinephrine, a catecholamine, is t... (Source: Critical Care)
Source: Critical Care - April 16, 2019 Category: Intensive Care Authors: Lakhmir S. Chawla, Marlies Ostermann, Lui Forni and George F. Tidmarsh Tags: Commentary Source Type: research

Heterogeneity of regional inflection points from pressure-volume curves assessed by electrical impedance tomography
The pressure-volume (P-V) curve has been suggested as a bedside tool to set mechanical ventilation; however, it reflects a global behavior of the lung without giving information on the regional mechanical propert... (Source: Critical Care)
Source: Critical Care - April 16, 2019 Category: Intensive Care Authors: Gaetano Scaramuzzo, Savino Spadaro, Andreas D. Waldmann, Stephan H. B öhm, Riccardo Ragazzi, Elisabetta Marangoni, Valentina Alvisi, Elena Spinelli, Tommaso Mauri and Carlo Alberto Volta Tags: Research Source Type: research

Neurally adjusted ventilatory assist decreases work of breathing during non-invasive ventilation in infants with severe bronchiolitis
(Source: Critical Care)
Source: Critical Care - April 16, 2019 Category: Intensive Care Authors: Florent Baudin, Guillaume Emeriaud, Sandrine Essouri, Jennifer Beck, Etienne Javouhey and Claude Guerin Tags: Letter Source Type: research

Comment on the article: “Microvascular effects of intravenous esmolol in patients with normal cardiac function undergoing postoperative atrial fibrillation: a prospective pilot study in cardiothoracic surgery”
(Source: Critical Care)
Source: Critical Care - April 16, 2019 Category: Intensive Care Authors: Ye Ying Zheng, Fei Guo, Bin Lu and Qiang Li Tags: Letter Source Type: research

Cardiovascular determinants of resuscitation from sepsis and septic shock
We hypothesized that the cardiovascular responses to Surviving Sepsis Guidelines (SSG)-defined resuscitation are predictable based on the cardiovascular state. (Source: Critical Care)
Source: Critical Care - April 15, 2019 Category: Intensive Care Authors: Fabio Guarracino, Pietro Bertini and Michael R. Pinsky Tags: Research Source Type: research

Lack of relationship between fasting plasma citrulline and glucose absorption: do not underestimate the role of the failing kidney!
(Source: Critical Care)
Source: Critical Care - April 11, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Andrea Gallerani, Rachid Attou and Willem Boer Tags: Letter Source Type: research

What is the lowest change in cardiac output that transthoracic echocardiography can detect?
In critically ill patients, changes in the velocity-time integral (VTI) of the left ventricular outflow tract, measured by transthoracic echocardiography (TTE), are often used to non-invasively assess the resp... (Source: Critical Care)
Source: Critical Care - April 11, 2019 Category: Intensive Care Authors: Mathieu Jozwiak, Pablo Mercado, Jean-Louis Teboul, Anouar Benmalek, Julia Gimenez, Fran çois Dépret, Christian Richard and Xavier Monnet Tags: Research Source Type: research

Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels
Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperat... (Source: Critical Care)
Source: Critical Care - April 11, 2019 Category: Intensive Care Authors: Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Willem W. J. van Strien, Jisca Majol ée, Robert Szulcek, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer and Charissa E. van den Brom Tags: Research Source Type: research

Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. (Source: Critical Care)
Source: Critical Care - April 8, 2019 Category: Intensive Care Authors: David F. Col ón, Carlos W. Wanderley, Marcelo Franchin, Camila M. Silva, Carlos H. Hiroki, Fernanda V. S. Castanheira, Paula B. Donate, Alexandre H. Lopes, Leila C. Volpon, Silvia K. Kavaguti, Vanessa F. Borges, Cesar A. Speck-Hernandez, Fernando Ramalho Tags: Research Source Type: research

Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care
This study aimed to develop a prediction model that can be used to differentiate... (Source: Critical Care)
Source: Critical Care - April 8, 2019 Category: Intensive Care Authors: Zhongheng Zhang, Kwok M. Ho and Yucai Hong Tags: Research Source Type: research

Impact of nutrition route on microaspiration in critically ill patients with shock: a planned ancillary study of the NUTRIREA-2 trial
Microaspiration of gastric and oropharyngeal secretions is the main mechanism of entry of bacteria into the lower respiratory tract in intubated critically ill patients. The aim of this study is to determine t... (Source: Critical Care)
Source: Critical Care - April 5, 2019 Category: Intensive Care Authors: Saad Nseir, Am élie Le Gouge, Jean-Baptiste Lascarrou, Jean-Claude Lacherade, Emmanuelle Jaillette, Jean-Paul Mira, Emmanuelle Mercier, Pierre-Louis Declercq, Michel Sirodot, Gaël Piton, François Tinturier, Elisabeth Coupez, Stéphane Gaudry, Michel Dj Tags: Research Source Type: research

Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study
CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research r... (Source: Critical Care)
Source: Critical Care - April 4, 2019 Category: Intensive Care Authors: Peter Ahnert, Petra Creutz, Katrin Horn, Fabian Schwarzenberger, Michael Kiehntopf, Hamid Hossain, Michael Bauer, Frank Martin Brunkhorst, Konrad Reinhart, Uwe V ölker, Trinad Chakraborty, Martin Witzenrath, Markus Löffler, Norbert Suttorp and Markus Sc Tags: Research Source Type: research

Flagellin attenuates experimental sepsis in a macrophage-dependent manner
Sepsis is the leading cause of death among critically ill patients, and no specific therapeutic agent is currently approved for the treatment of sepsis. (Source: Critical Care)
Source: Critical Care - April 3, 2019 Category: Intensive Care Authors: Xiaoliang Yang, Yibing Yin, Xingxing Yan, Zebo Yu, Yi Liu and Ju Cao Tags: Research Source Type: research

Death after awakening from post-anoxic coma: the “Best CPC” project
In patients who recover consciousness after cardiac arrest (CA), a subsequent death from non-neurological causes may confound the assessment of long-term neurological outcome. We investigated the prevalence an... (Source: Critical Care)
Source: Critical Care - April 3, 2019 Category: Intensive Care Authors: Fabio Silvio Taccone, Janneke Horn, Christian Storm, Alain Cariou, Claudio Sandroni, Hans Friberg, Cornelia Astrid Hoedemaekers and Mauro Oddo Tags: Research Source Type: research

Cytokine clearance with CytoSorb ® during cardiac surgery: a pilot randomized controlled trial
Cardiopulmonary bypass (CPB) is often associated with degrees of complex inflammatory response mediated by various cytokines. This response can, in severe cases, lead to systemic hypotension and organ dysfunct... (Source: Critical Care)
Source: Critical Care - April 3, 2019 Category: Intensive Care Authors: Elettra C Poli, Lorenzo Alberio, Anna Bauer-Doerries, Carlo Marcucci, Aur élien Roumy, Matthias Kirsch, Eleonora De Stefano, Lucas Liaudet and Antoine G Schneider Tags: Research Source Type: research

Is intravenous vitamin C contraindicated in patients with G6PD deficiency?
(Source: Critical Care)
Source: Critical Care - April 3, 2019 Category: Intensive Care Authors: Paul E. Marik Tags: Editorial Source Type: research

Safety and efficacy of volume-based feeding in critically ill, mechanically ventilated adults using the ‘Protein & Energy Requirements Fed for Every Critically ill patient every Time ’ (PERFECT) protocol: a before-and-after study
Underfeeding in critical illness is common and associated with poor outcomes. According to large prospective hospital studies, volume-based feeding (VBF) safely and effectively improves energy and protein deli... (Source: Critical Care)
Source: Critical Care - April 2, 2019 Category: Intensive Care Authors: Sue Brierley-Hobson, Graham Clarke and Vincent O ’Keeffe Tags: Research Source Type: research

Optimization of the treatment with beta-lactam antibiotics in critically ill patients —guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR)
Beta-lactam antibiotics ( βLA) are the most commonly used antibiotics in the intensive care unit (ICU). ICU patients present many pathophysiological features that cause pharmacokinetic (PK) and pharmacodynamic ... (Source: Critical Care)
Source: Critical Care - March 29, 2019 Category: Intensive Care Authors: Romain Guilhaumou, Sihem Benaboud, Youssef Bennis, Claire Dahyot-Fizelier, Eric Dailly, Peggy Gandia, Sylvain Goutelle, Sandrine Lefeuvre, Nicolas Mongardon, Claire Roger, Julien Scala-Bertola, Florian Lemaitre and Marc Garnier Tags: Review Source Type: research

Dysphagia in the intensive care unit: epidemiology, mechanisms, and clinical management
Dysphagia may present in all critically ill patients and large-scale clinical data show that e.g. post-extubation dysphagia (PED) is commonly observed in intensive care unit (ICU) patients. Recent data demonst... (Source: Critical Care)
Source: Critical Care - March 28, 2019 Category: Intensive Care Authors: Patrick Zuercher, C éline S. Moret, Rainer Dziewas and Joerg C. Schefold Tags: Review Source Type: research

The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis
The effect of corticosteroids on clinical outcomes in patients with influenza pneumonia remains controversial. We aimed to further evaluate the influence of corticosteroids on mortality in adult patients with ... (Source: Critical Care)
Source: Critical Care - March 27, 2019 Category: Intensive Care Authors: Yue-Nan Ni, Guo Chen, Jiankui Sun, Bin-Miao Liang and Zong-An Liang Tags: Research Source Type: research

A meta-analysis of the resuscitative effects of mechanical and manual chest compression in out-of-hospital cardiac arrest patients
To evaluate the resuscitative effects of mechanical and manual chest compression in patients with out-of-hospital cardiac arrest (OHCA). (Source: Critical Care)
Source: Critical Care - March 27, 2019 Category: Intensive Care Authors: Ni Zhu, Qi Chen, Zhixia Jiang, Futuan Liao, Bujin Kou, Hui Tang and Manhong Zhou Tags: Research Source Type: research

Time to epinephrine treatment is associated with the risk of mortality in children who achieve sustained ROSC after traumatic out-of-hospital cardiac arrest
The benefits of early epinephrine administration in pediatric with nontraumatic out-of-hospital cardiac arrest (OHCA) have been reported; however, the effects in pediatric cases of traumatic OHCA are unclear. ... (Source: Critical Care)
Source: Critical Care - March 27, 2019 Category: Intensive Care Authors: Yan-Ren Lin, Meng-Huan Wu, Tren-Yi Chen, Yuan-Jhen Syue, Mei-Chueh Yang, Tsung-Han Lee, Chih-Ming Lin, Chu-Chung Chou, Chin-Fu Chang and Chao-Jui Li Tags: Research Source Type: research

The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition
Severe traumatic injury continues to present challenges to healthcare systems around the world, and post-traumatic bleeding remains a leading cause of potentially preventable death among injured patients. Now ... (Source: Critical Care)
Source: Critical Care - March 27, 2019 Category: Intensive Care Authors: Donat R. Spahn, Bertil Bouillon, Vladimir Cerny, Jacques Duranteau, Daniela Filipescu, Beverley J. Hunt, Radko Komadina, Marc Maegele, Giuseppe Nardi, Louis Riddez, Charles-Marc Samama, Jean-Louis Vincent and Rolf Rossaint Tags: Research Source Type: research

Pediatric ARDS biomarkers: missing the random forest for the trees
(Source: Critical Care)
Source: Critical Care - March 25, 2019 Category: Intensive Care Authors: Nadir Yehya Tags: Editorial Source Type: research

Some questions about preadmission metformin use and mortality in patients with sepsis and diabetes mellitus
(Source: Critical Care)
Source: Critical Care - March 25, 2019 Category: Intensive Care Authors: Jiarong Ye, Qianrong Liang and Xiaotu Xi Tags: Letter Source Type: research

Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury
We aimed to develop a set of quality indicators for patients with traumatic brain injury (TBI) in intensive care units (ICUs) across Europe and to explore barriers and facilitators for implementation of these ... (Source: Critical Care)
Source: Critical Care - March 22, 2019 Category: Intensive Care Authors: Jilske A. Huijben, Eveline J. A. Wiegers, Nicolette F. de Keizer, Andrew I. R. Maas, David Menon, Ari Ercole, Giuseppe Citerio, Fiona Lecky, Lindsay Wilson, Maryse C. Cnossen, Suzanne Polinder, Ewout W. Steyerberg, Mathieu van der Jagt and Hester F. Lings Tags: Research Source Type: research

Is cortical perfusion a reliable marker for predicting septic acute kidney injury?
(Source: Critical Care)
Source: Critical Care - March 22, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Andrea Gallerani, Rachid Attou, Sebastien Redant, Leonel Barreto Gutierrez and Willem Boer Tags: Letter Source Type: research

39th International Symposium on Intensive Care and Emergency Medicine
(Source: Critical Care)
Source: Critical Care - March 19, 2019 Category: Intensive Care Tags: Meeting abstracts Source Type: research

The association between autoimmune disease and 30-day mortality among sepsis ICU patients: a cohort study
Sepsis results from a dysregulated host response to an infection that is associated with an imbalance between pro- and anti-inflammatory cytokines. This imbalance is hypothesized to be a driver of patient mort... (Source: Critical Care)
Source: Critical Care - March 18, 2019 Category: Intensive Care Authors: Mallory Sheth, Corey M. Benedum, Leo Anthony Celi, Roger G. Mark and Natasha Markuzon Tags: Research Source Type: research

State-level hospital compliance with and performance in the Centers for Medicaid & Medicare Services ’ Early Management Severe Sepsis and Septic Shock Bundle
(Source: Critical Care)
Source: Critical Care - March 18, 2019 Category: Intensive Care Authors: Jordan A. Kempker, Michael R. Kramer, Lance A. Waller, Henry E. Wang and Greg S. Martin Tags: Letter Source Type: research

The effects and safety of vasopressin receptor agonists in patients with septic shock: a meta-analysis and trial sequential analysis
The aim of this study was to evaluate the effects and safety of vasopressin receptor agonists in patients with septic shock. (Source: Critical Care)
Source: Critical Care - March 14, 2019 Category: Intensive Care Authors: Libing Jiang, Yi Sheng, Xia Feng and Jing Wu Tags: Research Source Type: research

Weaning order of vasoactive drugs
(Source: Critical Care)
Source: Critical Care - March 13, 2019 Category: Intensive Care Authors: Vilto Michels Jr and Daisson Jos é Trevisol Tags: Letter Source Type: research

Validity of the relationship between mobility group box-1 protein and poor post –cardiac arrest neurological outcome during renal replacement therapy
(Source: Critical Care)
Source: Critical Care - March 12, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and Herbert D. Spapen Tags: Letter Source Type: research

Incidence of hypotension according to the discontinuation order of vasopressors: a matter of pharmacokinetics
(Source: Critical Care)
Source: Critical Care - March 12, 2019 Category: Intensive Care Authors: Ross Freebairn and Brigitte Hollander Tags: Letter Source Type: research

Response to “Weaning order of vasoactive drugs”
(Source: Critical Care)
Source: Critical Care - March 12, 2019 Category: Intensive Care Authors: Kyeongman Jeon, Jae-Uk Song and Gee Young Suh Tags: Letter Source Type: research

Organ system network analysis and biological stability in critically ill patients
Continuous coordination among organ systems is necessary to maintain biological stability in humans. Organ system network analysis in addition to organ-oriented medicine is expected to improve patient outcomes... (Source: Critical Care)
Source: Critical Care - March 12, 2019 Category: Intensive Care Authors: Toshifumi Asada, Kent Doi, Ryota Inokuchi, Naoki Hayase, Miyuki Yamamoto and Naoto Morimura Tags: Research Source Type: research

The complex kinetics of blood endocan during the time course of sepsis and acute respiratory distress syndrome
(Source: Critical Care)
Source: Critical Care - March 12, 2019 Category: Intensive Care Authors: Alexandre Gaudet, Erika Parmentier, Sylvain Dubucquoi, Julien Poissy, Thibault Duburcq, Lucie Portier, Philippe Lassalle, Nathalie De Freitas Caires and Daniel Mathieu Tags: Letter Source Type: research

The pharmacokinetic challenge of voriconazole therapy for cerebral aspergillosis in patients treated with ibrutinib
(Source: Critical Care)
Source: Critical Care - March 12, 2019 Category: Intensive Care Authors: R émy Nyga, Laura Simon, Taieb Chouaki, Caroline Delette, Youssef Bennis, Cedric Joseph, Jean-Pierre Marolleau, Michel Slama, Elie Zogheib and Julien Maizel Tags: Letter Source Type: research

Recruitment Maneuvers and Higher PEEP, the So-Called Open Lung Concept, in Patients with ARDS
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 9, 2019 Category: Intensive Care Authors: Philip van der Zee and Diederik Gommers Tags: Review Source Type: research

ARDS in Obese Patients: Specificities and Management
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 9, 2019 Category: Intensive Care Authors: Audrey De Jong, Daniel Verzilli and Samir Jaber Tags: Review Source Type: research

Physiological and Technical Considerations of Extracorporeal CO2 Removal
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 9, 2019 Category: Intensive Care Authors: Christian Karagiannidis, Felix Hesselmann and Eddy Fan Tags: Review Source Type: research

Heterogeneity in sepsis: new biological evidence with clinical applications
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 9, 2019 Category: Intensive Care Authors: Aleksandra Leligdowicz and Michael A. Matthay Tags: Review Source Type: research

Iron Metabolism: An Emerging Therapeutic Target in Critical Illness
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 9, 2019 Category: Intensive Care Authors: Edward Litton and Jolene Lim Tags: Review Source Type: research