Corticosteroids in severe COVID-19: a critical view of the evidence
(Source: Critical Care)
Source: Critical Care - October 29, 2020 Category: Intensive Care Authors: Daniel De Backer, Elie Azoulay and Jean-Louis Vincent Tags: Editorial Source Type: research

Inpatient hospital performance is associated with post-discharge sepsis mortality
The objective of this study was to test the hypothesis that hospitals with high risk-... (Source: Critical Care)
Source: Critical Care - October 27, 2020 Category: Intensive Care Authors: Nicholas M. Mohr, Alexis M. Zebrowski, David F. Gaieski, David G. Buckler and Brendan G. Carr Tags: Research Source Type: research

Central venous pressure monitoring and mortality: What was neglected?
(Source: Critical Care)
Source: Critical Care - October 23, 2020 Category: Intensive Care Authors: Shaowei Gao, Zhanxin Du, Lu Yang and Zhongxing Wang Tags: Letter Source Type: research

Is there still a place for transcranial Doppler in patients with IABP?
(Source: Critical Care)
Source: Critical Care - October 23, 2020 Category: Intensive Care Authors: Juliana R. Caldas, Ronney B. Panerai, Rog ério Passos and Ludhmila A. Hajjar Tags: Research Letter Source Type: research

SARS-CoV-2 infection as a risk factor for herpesviridae reactivation: consider the potential influence of corticosteroid therapy
(Source: Critical Care)
Source: Critical Care - October 22, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Recommendations for hemodynamic monitoring for critically ill children —expert consensus statement issued by the cardiovascular dynamics section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)
Cardiovascular instability is common in critically ill children. There is a scarcity of published high-quality studies to develop meaningful evidence-based hemodynamic monitoring guidelines and hence, with the... (Source: Critical Care)
Source: Critical Care - October 22, 2020 Category: Intensive Care Authors: Yogen Singh, Javier Urbano Villaescusa, Eduardo M. da Cruz, Shane M. Tibby, Gabriella Bottari, Rohit Saxena, Marga Guill én, Jesus Lopez Herce, Matteo Di Nardo, Corrado Cecchetti, Joe Brierley, Willem de Boode and Joris Lemson Tags: Research Source Type: research

A call for collaboration and consensus on training for endotracheal intubation in the medical intensive care unit
Endotracheal intubation (EI) is a potentially lifesaving but high-risk procedure in critically ill patients. While the ACGME mandates that trainees in pulmonary and critical care medicine (PCCM) achieve compet... (Source: Critical Care)
Source: Critical Care - October 22, 2020 Category: Intensive Care Authors: Wade Brown, Lekshmi Santhosh, Anna K. Brady, Joshua L. Denson, Abesh Niroula, Meredith E. Pugh, Wesley H. Self, Aaron M. Joffe, P. O ’Neal Maynord and W. Graham Carlos Tags: Viewpoint Source Type: research

Gravitational distribution of regional opening and closing pressures, hysteresis and atelectrauma in ARDS evaluated by electrical impedance tomography
The physiological behavior of lungs affected by the acute respiratory distress syndrome (ARDS) differs between inspiration and expiration and presents heterogeneous gravity-dependent distribution. This phenome... (Source: Critical Care)
Source: Critical Care - October 22, 2020 Category: Intensive Care Authors: Gaetano Scaramuzzo, Elena Spinelli, Savino Spadaro, Alessandro Santini, Donatella Tortolani, Francesca Dalla Corte, Antonio Pesenti, Carlo Alberto Volta, Giacomo Grasselli and Tommaso Mauri Tags: Research Source Type: research

Cognitive phenotypes 1 month after ICU discharge in mechanically ventilated patients: a prospective observational cohort study
ICU patients undergoing invasive mechanical ventilation experience cognitive decline associated with their critical illness and its management. The early detection of different cognitive phenotypes might revea... (Source: Critical Care)
Source: Critical Care - October 21, 2020 Category: Intensive Care Authors: Sol Fern ández-Gonzalo, Guillem Navarra-Ventura, Neus Bacardit, Gemma Gomà Fernández, Candelaria de Haro, Carles Subirà, Josefina López-Aguilar, Rudys Magrans, Leonardo Sarlabous, Jose Aquino Esperanza, Mercè Jodar, Montse Rué, Ana Ochagavía, Dieg Tags: Research Source Type: research

COVID-19: What Iodine Maps From Perfusion CT can reveal —A Prospective Cohort Study
Subtraction CT angiography (sCTA) is a technique used to evaluate pulmonary perfusion based on iodine distribution maps. The aim of this study is to assess lung perfusion changes with sCTA seen in patients wit... (Source: Critical Care)
Source: Critical Care - October 21, 2020 Category: Intensive Care Authors: Mario G. Santamarina, Dominique Boisier Riscal, Ignacio Beddings, Roberto Contreras, Martiniano Baque, Mariano Volpacchio and Felipe Martinez Lomakin Tags: Research Source Type: research

Sex differences in survival after out-of-hospital cardiac arrest: a meta-analysis
Out-of-hospital cardiac arrest (OHCA) is a leading cause of sudden cardiac death worldwide. Researchers have found significant pathophysiological differences between females and males and clinically significan... (Source: Critical Care)
Source: Critical Care - October 19, 2020 Category: Intensive Care Authors: Hao Lei, Jiahui Hu, Leiling Liu and Danyan Xu Tags: Research Source Type: research

Gut-liver crosstalk in sepsis-induced liver injury
Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality ... (Source: Critical Care)
Source: Critical Care - October 19, 2020 Category: Intensive Care Authors: Jian Sun, Jingxiao Zhang, Xiangfeng Wang, Fuxi Ji, Claudio Ronco, Jiakun Tian and Yongjie Yin Tags: Review Source Type: research

The use of venous Doppler to predict adverse kidney events in a general ICU cohort
Changes in Doppler flow patterns of hepatic veins (HV), portal vein (PV) and intra-renal veins (RV) reflect right atrial pressure and venous congestion; the feasibility of obtaining these assessments and the c... (Source: Critical Care)
Source: Critical Care - October 19, 2020 Category: Intensive Care Authors: Rory Spiegel, William Teeter, Scott Sullivan, Keegan Tupchong, Nabeel Mohammed, Mark Sutherland, Evan Leibner, Philippe Rola, Samuel M. Galvagno Jr. and Sarah B. Murthi Tags: Research Source Type: research

Clearance of micronutrients during continuous renal replacement therapy
(Source: Critical Care)
Source: Critical Care - October 19, 2020 Category: Intensive Care Authors: Nuttha Lumlertgul, Danielle E. Bear and Marlies Ostermann Tags: Research Letter Source Type: research

Increased percentage of PD-L1+ natural killer cells predicts poor prognosis in sepsis patients: a prospective observational cohort study
Natural killer (NK) cells play a major role in immune tolerance after sepsis, and the programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) system mediates evasion of host immunity. The cor... (Source: Critical Care)
Source: Critical Care - October 19, 2020 Category: Intensive Care Authors: Wenqiang Jiang, Xusheng Li, Miaoyun Wen, Xiaoyu Liu, Kangrong Wang, Qiaosheng Wang, Ya Li, Maohua Zhou, Mengting Liu, Bei Hu and Hongke Zeng Tags: Research Source Type: research

Rethinking brain injury after subarachnoid hemorrhage
(Source: Critical Care)
Source: Critical Care - October 17, 2020 Category: Intensive Care Authors: Sara Amodio, Pierre Bouzat, Chiara Robba and Fabio Silvio Taccone Tags: Editorial Source Type: research

SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients
Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically... (Source: Critical Care)
Source: Critical Care - October 16, 2020 Category: Intensive Care Authors: Niccol ò Buetti, Paul-Henri Wicky, Quentin Le Hingrat, Stéphane Ruckly, Timothy Mazzuchelli, Ambre Loiodice, Pierpaolo Trimboli, Valentina Forni Ogna, Etienne de Montmollin, Enos Bernasconi, Benoit Visseaux and Jean-François Timsit Tags: Research Source Type: research

Establishing a critical care network in Asia to improve care for critically ill patients in low- and middle-income countries
(Source: Critical Care)
Source: Critical Care - October 15, 2020 Category: Intensive Care Tags: Editorial Source Type: research

Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study
Clinical frailty among older adults admitted to intensive care has been proposed as an important determinant of patient outcomes. Among this group of patients, an acute episode of delirium is also common, but ... (Source: Critical Care)
Source: Critical Care - October 15, 2020 Category: Intensive Care Authors: David Sanchez, Kathleen Brennan, Masar Al Sayfe, Sharon-Ann Shunker, Tony Bogdanoski, Sonja Hedges, Yu Chin Hou, Joan Lynch, Leanne Hunt, Evan Alexandrou, Manoj Saxena, Simon Abel, Ramanathan Lakshmanan, Deepak Bhonagiri, Michael J. Parr, Anders Aneman & Tags: Research Source Type: research

Dynamic trajectory of platelet-related indicators and survival of severe COVID-19 patients
(Source: Critical Care)
Source: Critical Care - October 14, 2020 Category: Intensive Care Authors: Jieyu He, Yongyue Wei, Jiao Chen, Feng Chen, Wei Gao and Xiang Lu Tags: Research Letter Source Type: research

Mortality in non-elderly septic patients was increased with hypothermia and decreased with fever while mortality in elderly patients was not associated with body temperature: beware of some confounders!
(Source: Critical Care)
Source: Critical Care - October 13, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry
The objective of this study was to assess the association between e... (Source: Critical Care)
Source: Critical Care - October 12, 2020 Category: Intensive Care Authors: Josefine S. Baekgaard, Paer-Selim Abback, Marouane Boubaya, Jean-Denis Moyer, Delphine Garrigue, Mathieu Raux, Benoit Champigneulle, Guillaume Dubreuil, Julien Pottecher, Philippe Laitselart, Fleur Laloum, Coralie Bloch-Queyrat, Fr édéric Adnet and Cath Tags: Research Source Type: research

Blood purification therapy with a hemodiafilter featuring enhanced adsorptive properties for cytokine removal in patients presenting COVID-19: a pilot study
Systemic inflammation in COVID-19 often leads to multiple organ failure, including acute kidney injury (AKI). Renal replacement therapy (RRT) in combination with sequential extracorporeal blood purification th... (Source: Critical Care)
Source: Critical Care - October 12, 2020 Category: Intensive Care Authors: Gianluca Villa, Stefano Romagnoli, Silvia De Rosa, Massimiliano Greco, Marco Resta, Diego Pomar è Montin, Federico Prato, Francesco Patera, Fiorenza Ferrari, Giuseppe Rotondo and Claudio Ronco Tags: Research Source Type: research

Infliximab can reduce mortality from 35 to 14% in critically ill patients with COVID-19: perhaps some potential confounders to consider
(Source: Critical Care)
Source: Critical Care - October 9, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

A retrospective study in adult patients with septic shock and multiple organ failure demonstrated improved 28-day survival with adjunct TPE compared to standard care alone: true effect or mediated by a negative fluid balance achieved by RRT?
(Source: Critical Care)
Source: Critical Care - October 8, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Energy transmission in mechanically ventilated children: a translational study
Recurrent delivery of tidal mechanical energy (ME) inflicts ventilator-induced lung injury (VILI) when stress and strain exceed the limits of tissue tolerance. Mechanical power (MP) is the mathematical descrip... (Source: Critical Care)
Source: Critical Care - October 7, 2020 Category: Intensive Care Authors: Martin C. J. Kneyber, Stavroula Ilia, Alette A. Koopman, Patrick van Schelven, Jefta van Dijk, Johannes G. M. Burgerhof, Dick G. Markhorst and Robert G. T. Blokpoel Tags: Research Source Type: research

Effect of PEEP decremental on respiratory mechanics, gasses exchanges, pulmonary regional ventilation, and hemodynamics in patients with SARS-Cov-2-associated acute respiratory distress syndrome
(Source: Critical Care)
Source: Critical Care - October 6, 2020 Category: Intensive Care Authors: Vincent Bonny, Vincent Janiak, Savino Spadaro, Andrea Pinna, Alexandre Demoule and Martin Dres Tags: Research Letter Source Type: research

Anakinra: a silver lining in COVID-19?
(Source: Critical Care)
Source: Critical Care - October 6, 2020 Category: Intensive Care Authors: Rahul Gupta Tags: Letter Source Type: research

TPE seems to be a treatment that may improve outcomes by effectively removing fibrin degradation products and restoring coagulation status: fact or fiction?
(Source: Critical Care)
Source: Critical Care - October 6, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?
(Source: Critical Care)
Source: Critical Care - October 6, 2020 Category: Intensive Care Authors: Miranda van Berkel, Matthijs Kox, Tim Frenzel, Peter Pickkers and Jeroen Schouten Tags: Research Letter Source Type: research

Ultrasound-guided peripheral vascular catheterization in pediatric patients: a narrative review
Peripheral vascular catheterization (PVC) in pediatric patients is technically challenging. Ultrasound guidance has gained the most interest in perioperative and intensive care fields because it visualizes the... (Source: Critical Care)
Source: Critical Care - September 30, 2020 Category: Intensive Care Authors: Yoshinobu Nakayama, Jun Takeshita, Yasufumi Nakajima and Nobuaki Shime Tags: Review Source Type: research

Challenges for the care delivery for critically ill COVID-19 patients in developing countries: the Brazilian perspective
(Source: Critical Care)
Source: Critical Care - September 30, 2020 Category: Intensive Care Authors: Jorge I. F. Salluh, Thiago Lisboa and Fernando A. Bozza Tags: Commentary Source Type: research

COVID-19: instruments for the allocation of mechanical ventilators —a narrative review
After the World Health Organization declared COVID-19 to be a pandemic, the elaboration of comprehensive and preventive public policies became important in order to stop the spread of the disease. However, ins... (Source: Critical Care)
Source: Critical Care - September 29, 2020 Category: Intensive Care Authors: Marcelo Jos é dos Santos, Maristela Santini Martins, Fabiana Lopes Pereira Santana, Maria Carolina Silvano Pacheco Corrêa Furtado, Fabiana Cristina Bazana Remédio Miname, Rafael Rodrigo da Silva Pimentel, Ágata Nunes Brito, Patrick Schneider, Edson Si Tags: Review Source Type: research

Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis
Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is as... (Source: Critical Care)
Source: Critical Care - September 29, 2020 Category: Intensive Care Authors: Stefan Hagel, Andr é Scherag, Lukas Schuierer, Reinhard Hoffmann, Charles-Edouard Luyt, Mathias W. Pletz, Miriam Kesselmeier and Sebastian Weis Tags: Research Source Type: research

Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment
(Source: Critical Care)
Source: Critical Care - September 29, 2020 Category: Intensive Care Authors: Rene A. Posma, Adam Hulman, Reimar W. Thomsen, Bente Jespersen, Maarten W. Nijsten and Christian F. Christiansen Tags: Research Letter Source Type: research

Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients
(Source: Critical Care)
Source: Critical Care - September 29, 2020 Category: Intensive Care Authors: Robert Frithiof, Anders Bergqvist, Josef D. J ärhult, Miklos Lipcsey and Michael Hultström Tags: Research Letter Source Type: research

No time for pending confirmation of invasive fungal disease in critically ill COVID-19 patients —think empirical treatment
(Source: Critical Care)
Source: Critical Care - September 29, 2020 Category: Intensive Care Authors: Anne-Lise Bienvenu, Nathalie Bleyzac, Jean-Christophe Richard and Gilles Leboucher Tags: Letter Source Type: research

Cost-effectiveness of adrenaline for out-of-hospital cardiac arrest
The ‘Prehospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration In Cardiac Arrest’ (PARAMEDIC2) trial showed that adrenaline improves overall survival, but not neurolo... (Source: Critical Care)
Source: Critical Care - September 27, 2020 Category: Intensive Care Authors: Felix Achana, Stavros Petrou, Jason Madan, Kamran Khan, Chen Ji, Anower Hossain, Ranjit Lall, Anne-Marie Slowther, Charles D. Deakin, Tom Quinn, Jerry P. Nolan, Helen Pocock, Nigel Rees, Michael Smyth, Simon Gates, Dale Gardiner & hellip; Tags: Research Source Type: research

Lessons from an ICU recovery clinic: two cases of meralgia paresthetica after prone positioning to treat COVID-19-associated ARDS and modification of unit practices
(Source: Critical Care)
Source: Critical Care - September 27, 2020 Category: Intensive Care Authors: Amy L. Bellinghausen, Jamie N. LaBuzetta, Frank Chu, Francesca Novelli, Anthony R. Rodelo and Robert L. Owens Tags: Research Letter Source Type: research

Oral favipiravir for patients with delayed SARS-CoV-2 viral RNA clearance: a case series
(Source: Critical Care)
Source: Critical Care - September 25, 2020 Category: Intensive Care Authors: Dian Fu, Ruiyuan Cao, Lei Zhao, Wei Li, Wu Zhong and Jiqiu Wen Tags: Research Letter Source Type: research

SuPAR levels in BAL fluid from patients with acute respiratory distress syndrome —a pilot study
(Source: Critical Care)
Source: Critical Care - September 25, 2020 Category: Intensive Care Authors: Alexander C. Reisinger, Gerald Hackl, Tobias Niedrist, Martin Hoenigl, Philipp Eller and Juergen Prattes Tags: Research Letter Source Type: research

Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors
Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cit... (Source: Critical Care)
Source: Critical Care - September 25, 2020 Category: Intensive Care Authors: Zudin A. Puthucheary, Jochen S. Gensichen, Aylin S. Cakiroglu, Richard Cashmore, Lara Edbrooke, Christoph Heintze, Konrad Neumann, Tobias Wollersheim, Linda Denehy and Konrad F. R. Schmidt Tags: Research Source Type: research

Sensitivity of point-of-care IgM and IgG test in critically ill patients with SARS-Cov-2
(Source: Critical Care)
Source: Critical Care - September 24, 2020 Category: Intensive Care Authors: Lee S. Nguyen, Driss Laghlam, Emmanuelle De Gonfreville, Fr édéric Pène, Flore Rozenberg and Jean-Paul Mira Tags: Research Letter Source Type: research

Fibrin-derived peptide B β15-42 (FX06) as salvage treatment in critically ill patients with COVID-19-associated acute respiratory distress syndrome
(Source: Critical Care)
Source: Critical Care - September 24, 2020 Category: Intensive Care Authors: Elisabeth H. Adam, Benedikt Schmid, Michael Sonntagbauer, Peter Kranke, Kai Zacharowski and Patrick Meybohm Tags: Research Letter Source Type: research

Mechanical ventilation in aneurysmal subarachnoid hemorrhage: systematic review and recommendations
Mechanical ventilation (MV) has a complex interplay with the pathophysiology of aneurysmal subarachnoid hemorrhage (aSAH). We aim to provide a review of the physiology of MV in patients with aSAH, give recomme... (Source: Critical Care)
Source: Critical Care - September 24, 2020 Category: Intensive Care Authors: James E. Towner, Redi Rahmani, Christopher G. Zammit, Imad R. Khan, David A. Paul, Tarun Bhalla and Debra E. Roberts Tags: Review Source Type: research

Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19
Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute... (Source: Critical Care)
Source: Critical Care - September 23, 2020 Category: Intensive Care Authors: Ramandeep Kaur, Tyler T. Weiss, Andrew Perez, James B. Fink, Rongchang Chen, Fengming Luo, Zongan Liang, Sara Mirza and Jie Li Tags: Review Source Type: research

Rapid positioning of nasogastric tube by ultrasound in COVID-19 patients
(Source: Critical Care)
Source: Critical Care - September 22, 2020 Category: Intensive Care Authors: Anyu Qian, Shanxiang Xu, Xiao Lu, Luping Tang, Mao Zhang and Xiao Chen Tags: Research Letter Source Type: research

Pulse pressure and end-tidal carbon dioxide for monitoring low native cardiac output during veno-arterial ECLS: a prospective observational study
Veno-arterial extracorporeal life support (VA-ECLS) results in cardiopulmonary shunting with reduced native cardiac output (NCO). Low NCO occurrence is common and associated with risk of thromboembolic and pul... (Source: Critical Care)
Source: Critical Care - September 22, 2020 Category: Intensive Care Authors: Marc Mourad, Jacob Eliet, Norddine Zeroual, Marine Saour, Pierre Sentenac, Federico Manna, Nicolas Molinari, Thomas Gandet, Pascal H. Colson and Philippe Gaudard Tags: Research Source Type: research

Hepcidin is described as the master regulator of iron: could its removal by CRRT lead to iron dysmetabolism in the critically ill?
(Source: Critical Care)
Source: Critical Care - September 22, 2020 Category: Intensive Care Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels Tags: Letter Source Type: research

Chlorhexidine still has skin in the game
(Source: Critical Care)
Source: Critical Care - September 21, 2020 Category: Intensive Care Authors: Alexandra Lackey, Brandon Kalivoda and Amay Parikh Tags: Letter Source Type: research