How I manage ICP-CPP: a visual, yet individualized approach
(Source: Critical Care)
Source: Critical Care - August 27, 2019 Category: Intensive Care Authors: William D. Freeman Tags: Letter Source Type: research

Effect of different methods of cooling for targeted temperature management on outcome after cardiac arrest: a systematic review and meta-analysis
Although targeted temperature management (TTM) is recommended in comatose survivors after cardiac arrest (CA), the optimal method to deliver TTM remains unknown. We performed a meta-analysis to evaluate the ef... (Source: Critical Care)
Source: Critical Care - August 23, 2019 Category: Intensive Care Authors: Lorenzo Calabr ó, Wulfran Bougouin, Alain Cariou, Chiara De Fazio, Markus Skrifvars, Eldar Soreide, Jacques Creteur, Hans Kirkegaard, Stéphane Legriel, Jean-Baptiste Lascarrou, Bruno Megarbane, Nicolas Deye and Fabio Silvio Taccone Tags: Research Source Type: research

Use of machine learning to analyse routinely collected intensive care unit data: a systematic review
Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients ’ journeys into and through intensive care are now collected and stored in el... (Source: Critical Care)
Source: Critical Care - August 22, 2019 Category: Intensive Care Authors: Duncan Shillan, Jonathan A. C. Sterne, Alan Champneys and Ben Gibbison Tags: Research Source Type: research

Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors
Altered coagulation and alveolar injury are the hallmarks of acute respiratory distress syndrome (ARDS). However, whether the biomarkers that reflect pathophysiology differ depending on the etiology of ARDS ha... (Source: Critical Care)
Source: Critical Care - August 19, 2019 Category: Intensive Care Authors: Kansuke Koyama, Shinshu Katayama, Ken Tonai, Jun Shima, Toshitaka Koinuma and Shin Nunomiya Tags: Research Source Type: research

Capillary refill time variation induced by passive leg raising predicts capillary refill time response to volume expansion
A peripheral perfusion-targeted resuscitation during early septic shock has shown encouraging results. Capillary refill time, which has a prognostic value, was used. Adding accuracy and predictability on capil... (Source: Critical Care)
Source: Critical Care - August 16, 2019 Category: Intensive Care Authors: Matthias Jacquet-Lagr èze, Nourredine Bouhamri, Philippe Portran, Rémi Schweizer, Florent Baudin, Marc Lilot, William Fornier and Jean-Luc Fellahi Tags: Research Source Type: research

Machine learning versus physicians ’ prediction of acute kidney injury in critically ill adults: a prospective evaluation of the AKIpredictor
Early diagnosis of acute kidney injury (AKI) is a major challenge in the intensive care unit (ICU). The AKIpredictor is a set of machine-learning-based prediction models for AKI using routinely collected patie... (Source: Critical Care)
Source: Critical Care - August 16, 2019 Category: Intensive Care Authors: Marine Flechet, Stefano Falini, Claudia Bonetti, Fabian G üiza, Miet Schetz, Greet Van den Berghe and Geert Meyfroidt Tags: Research Source Type: research

Thrombomodulin in disseminated intravascular coagulation and other critical conditions —a multi-faceted anticoagulant protein with therapeutic potential
Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and syste... (Source: Critical Care)
Source: Critical Care - August 15, 2019 Category: Intensive Care Authors: Takashi Ito, Jecko Thachil, Hidesaku Asakura, Jerrold H. Levy and Toshiaki Iba Tags: Review Source Type: research

A deep learning model for real-time mortality prediction in critically ill children
The rapid development in big data analytics and the data-rich environment of intensive care units together provide unprecedented opportunities for medical breakthroughs in the field of critical care. We develo... (Source: Critical Care)
Source: Critical Care - August 14, 2019 Category: Intensive Care Authors: Soo Yeon Kim, Saehoon Kim, Joongbum Cho, Young Suh Kim, In Suk Sol, Youngchul Sung, Inhyeok Cho, Minseop Park, Haerin Jang, Yoon Hee Kim, Kyung Won Kim and Myung Hyun Sohn Tags: Research Source Type: research

Interventions to prevent iatrogenic anemia: a Laboratory Medicine Best Practices systematic review
As many as 90% of patients develop anemia by their third day in an intensive care unit (ICU). We evaluated the efficacy of interventions to reduce phlebotomy-related blood loss on the volume of blood lost, hem... (Source: Critical Care)
Source: Critical Care - August 9, 2019 Category: Intensive Care Authors: Nedra S. Whitehead, Laurina O. Williams, Sreelatha Meleth, Sara M. Kennedy, Nneka Ubaka-Blackmoore, Sharon M. Geaghan, James H. Nichols, Patrick Carroll, Michael T. McEvoy, Julie Gayken, Dennis J. Ernst, Christine Litwin, Paul Epner, Jennifer Taylor and M Tags: Research Source Type: research

Obituary Brian P. Kavanagh, MD
(Source: Critical Care)
Source: Critical Care - August 8, 2019 Category: Intensive Care Authors: John C. Marshall and Arthur S. Slutsky Tags: Editorial Source Type: research

The end-expiratory occlusion test: please, let me hold your breath!
(Source: Critical Care)
Source: Critical Care - August 7, 2019 Category: Intensive Care Authors: Francesco Gavelli, Jean-Louis Teboul and Xavier Monnet Tags: Editorial Source Type: research

Veno-venous ECMO indications: more than respiratory support
(Source: Critical Care)
Source: Critical Care - August 7, 2019 Category: Intensive Care Authors: Aaron Blandino Ortiz, David Cabestrero Alonso and Ra úl De Pablo Sánchez Tags: Letter Source Type: research

Screening for posttraumatic stress disorder in ARDS survivors: validation of the Impact of Event Scale-6 (IES-6)
Posttraumatic stress disorder (PTSD) symptoms are common in acute respiratory distress syndrome (ARDS) survivors. Brief screening instruments are needed for clinical and research purposes. We evaluated interna... (Source: Critical Care)
Source: Critical Care - August 7, 2019 Category: Intensive Care Authors: Megan M. Hosey, Jeannie-Marie S. Leoutsakos, Ximin Li, Victor D. Dinglas, O. Joseph Bienvenu, Ann M. Parker, Ramona O. Hopkins, Dale M. Needham and Karin J. Neufeld Tags: Research Source Type: research

Is this patient really “(un)stable”? How to describe cardiovascular dynamics in critically ill patients
(Source: Critical Care)
Source: Critical Care - August 6, 2019 Category: Intensive Care Authors: Jean-Louis Vincent, Maurizio Cecconi and Bernd Saugel Tags: Editorial Source Type: research

Harmful effects of mechanical ventilation on neurocognitive functions
(Source: Critical Care)
Source: Critical Care - August 6, 2019 Category: Intensive Care Authors: Federico Bilotta, Giovanni Giordano, Paola Giuseppina Sergi and Francesco Pugliese Tags: Editorial Source Type: research

Combined assessment of ΔPCT and ΔCRP could increase the ability to differentiate candidemia from bacteremia
(Source: Critical Care)
Source: Critical Care - August 5, 2019 Category: Intensive Care Authors: Qin Wu, Hao Yang and Yan Kang Tags: Letter Source Type: research

Mottling reduction in the early phases of profound septic shock
(Source: Critical Care)
Source: Critical Care - August 2, 2019 Category: Intensive Care Authors: Daniel Taylor and Duncan Wyncoll Tags: Letter Source Type: research

Functions and regulation of lipocalin-2 in gut-origin sepsis: a narrative review
Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on... (Source: Critical Care)
Source: Critical Care - August 2, 2019 Category: Intensive Care Authors: Fanglin Lu, Kei Inoue, Jungo Kato, Shizuka Minamishima and Hiroshi Morisaki Tags: Review Source Type: research

The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation: a secondary analysis of the EPaNIC RCT
Invasive fungal infections (IFI) are difficult to diagnose, especially in critically ill patients. As the mannose receptor (MR) is shed from macrophage cell surfaces after exposure to fungi, we investigate whe... (Source: Critical Care)
Source: Critical Care - August 2, 2019 Category: Intensive Care Authors: Greet De Vlieger, Ilse Vanhorebeek, Pieter J. Wouters, Inge Derese, Michael P. Casaer, Yves Debaveye, Greet Hermans, Philippe Meersseman, Holger J. M øller, Greet Van den Berghe and Catherine Ingels Tags: Research Source Type: research

Vitamin A deficiency in critically ill children with sepsis
Data that indicate vitamin A status in critically ill children with sepsis are sparse. The association between serum vitamin A levels and the clinical outcomes of sepsis has not been well assessed. The aim of ... (Source: Critical Care)
Source: Critical Care - August 1, 2019 Category: Intensive Care Authors: Xuepeng Zhang, Kaiying Yang, Linwen Chen, Xuelian Liao, Liping Deng, Siyuan Chen and Yi Ji Tags: Research Source Type: research

Vitamin C administration in the critically ill: a summary of recent meta-analyses
(Source: Critical Care)
Source: Critical Care - July 30, 2019 Category: Intensive Care Authors: Anitra C. Carr Tags: Letter Source Type: research

Limb ischemia in peripheral veno-arterial extracorporeal membrane oxygenation: a narrative review of incidence, prevention, monitoring, and treatment
Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly adopted life-saving mechanical circulatory support for a number of potentially reversible or treatable cardiac diseases. It is al... (Source: Critical Care)
Source: Critical Care - July 30, 2019 Category: Intensive Care Authors: Eleonora Bonicolini, Gennaro Martucci, Jorik Simons, Giuseppe M. Raffa, Cristina Spina, Valeria Lo Coco, Antonio Arcadipane, Michele Pilato and Roberto Lorusso Tags: Review Source Type: research

Functional hemodynamic tests: a systematic review and a metanalysis on the reliability of the end-expiratory occlusion test and of the mini-fluid challenge in predicting fluid responsiveness
Bedside functional hemodynamic assessment has gained in popularity in the last years to overcome the limitations of static or dynamic indexes in predicting fluid responsiveness. The aim of this systematic revi... (Source: Critical Care)
Source: Critical Care - July 29, 2019 Category: Intensive Care Authors: Antonio Messina, Antonio Dell ’Anna, Marta Baggiani, Flavia Torrini, Gian Marco Maresca, Victoria Bennett, Laura Saderi, Giovanni Sotgiu, Massimo Antonelli and Maurizio Cecconi Tags: Research Source Type: research

Liberal versus restrictive red blood cell transfusion strategy in sepsis or septic shock: a systematic review and meta-analysis of randomized trials
We assessed the effect of liberal versus restrictive red blood cell transfusion strategy on survival outcome in sepsis or septic shock by systematically reviewing the literature and synthesizing evidence from ... (Source: Critical Care)
Source: Critical Care - July 25, 2019 Category: Intensive Care Authors: Yohei Hirano, Yukari Miyoshi, Yutaka Kondo, Ken Okamoto and Hiroshi Tanaka Tags: Research Source Type: research

Sex-specific differences in survival after out-of-hospital cardiac arrest: a nationwide, population-based observational study
It remains unclear whether men have more favorable survival outcomes after out-of-hospital cardiac arrest (OHCA) than women. (Source: Critical Care)
Source: Critical Care - July 25, 2019 Category: Intensive Care Authors: Yoshikazu Goto, Akira Funada, Tetsuo Maeda, Hirofumi Okada and Yumiko Goto Tags: Research Source Type: research

Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to... (Source: Critical Care)
Source: Critical Care - July 24, 2019 Category: Intensive Care Authors: Alexandros Rovas, Laura Mareen Seidel, Hans Vink, Timo Pohlk ötter, Hermann Pavenstädt, Christian Ertmer, Michael Hessler and Philipp Kümpers Tags: Research Source Type: research

Abdominal functional electrical stimulation to assist ventilator weaning in critical illness: a double-blinded, randomised, sham-controlled pilot study
For every day a person is dependent on mechanical ventilation, respiratory and cardiac complications increase, quality of life decreases and costs increase by> $USD 1500. Interventions that improve respirator... (Source: Critical Care)
Source: Critical Care - July 24, 2019 Category: Intensive Care Authors: Euan J. McCaughey, Annemijn H. Jonkman, Claire L. Boswell-Ruys, Rachel A. McBain, Elizabeth A. Bye, Anna L. Hudson, David W. Collins, Leo M. A. Heunks, Angus J. McLachlan, Simon C. Gandevia and Jane E. Butler Tags: Research Source Type: research

Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation
Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the endoth... (Source: Critical Care)
Source: Critical Care - July 23, 2019 Category: Intensive Care Authors: Joseph A. Hippensteel, Ryo Uchimido, Patrick D. Tyler, Ryan C. Burke, Xiaorui Han, Fuming Zhang, Sarah A. McMurtry, James F. Colbert, Christopher J. Lindsell, Derek C. Angus, John A. Kellum, Donald M. Yealy, Robert J. Linhardt, Nathan I. Shapiro and Eric Tags: Research Source Type: research

Influenza virus-related critical illness: pathophysiology and epidemiology
Influenza virus affects the respiratory tract by direct viral infection or by damage from the immune system response. In humans, the respiratory epithelium is the only site where the hemagglutinin (HA) molecul... (Source: Critical Care)
Source: Critical Care - July 19, 2019 Category: Intensive Care Authors: Andre C. Kalil and Paul G. Thomas Tags: Review Source Type: research

Feasibility of myocardial perfusion assessment with contrast echocardiography: can it improve recognition of significant coronary artery disease in the ICU?
Diagnosis of significant coronary artery disease (CAD) and acute coronary artery occlusion in ICU can be difficult, and an inappropriate intervention is potentially harmful. Myocardial contrast perfusion echo ... (Source: Critical Care)
Source: Critical Care - July 17, 2019 Category: Intensive Care Authors: Sam Orde, Michel Slama, Faraz Pathan, Stephen Huang and Anthony Mclean Tags: Research Source Type: research

Correction to: The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study
In the publication of this article [1], there are two errors in contributing author affiliations. This has now been included in this correction article. (Source: Critical Care)
Source: Critical Care - July 15, 2019 Category: Intensive Care Authors: Kordo Saeed, Darius Cameron Wilson, Frank Bloos, Philipp Schuetz, Yuri van der Does, Olle Melander, Pierre Hausfater, Jacopo M. Legramante, Yann-Erick Claessens, Deveendra Amin, Mari Rosenqvist, Graham White, Beat Mueller, Maarten Limper, Carlota Clemente Tags: Correction Source Type: research

Recovery from acute kidney injury as a potent predictor of survival and good neurological outcome at discharge after out-of-hospital cardiac arrest
This study inv... (Source: Critical Care)
Source: Critical Care - July 15, 2019 Category: Intensive Care Authors: Yoo Seok Park, Yoon Hee Choi, Je Hyeok Oh, In Soo Cho, Kyoung-Chul Cha, Byung-Sun Choi and Je Sung You Tags: Research Source Type: research

Lack of clinically relevant correlation between subjective and objective cognitive function in ICU survivors: a prospective 12-month follow-up study
Cognitive impairment and psychological distress are common in intensive care unit (ICU) survivors. Early identification of affected individuals is important, so intervention and treatment can be utilized at an... (Source: Critical Care)
Source: Critical Care - July 12, 2019 Category: Intensive Care Authors: Emily Br ück, Jacob W. Larsson, Julie Lasselin, Matteo Bottai, Tatja Hirvikoski, Eva Sundman, Michael Eberhardson, Peter Sackey and Peder S. Olofsson Tags: Research Source Type: research

Interaction between low tidal volume ventilation strategy and severity of acute respiratory distress syndrome: a retrospective cohort study
This study aimed to invest... (Source: Critical Care)
Source: Critical Care - July 12, 2019 Category: Intensive Care Authors: Yanfei Shen, Guolong Cai, Shijin Gong, Lei Dong, Jing Yan and Wanru Cai Tags: Research Source Type: research

Decrease of the plasmatic endocan cleavage ratio is associated with the hyperinflammatory phenotype of acute respiratory distress syndrome
(Source: Critical Care)
Source: Critical Care - July 11, 2019 Category: Intensive Care Authors: Alexandre Gaudet, Erika Parmentier, Nathalie De Freitas Caires, Lucie Portier, Sylvain Dubucquoi, Julien Poissy, Thibault Duburcq, Maxence Hureau, Philippe Lassalle and Daniel Mathieu Tags: Letter Source Type: research

Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients
To compare the efficacy of systemic treatment with linezolid (LNZ) versus vancomycin (VAN) on methicillin-resistant Staphylococcus aureus (MRSA) burden and eradication in endotracheal tube (ETT) biofilm and ETT c... (Source: Critical Care)
Source: Critical Care - July 10, 2019 Category: Intensive Care Authors: Laia Fern ández-Barat, Ana Motos, Mauro Panigada, Francisco Álvarez-Lerma, Lucía Viña, Ruben Lopez-Aladid, Adrian Ceccato, Gianluigi Li Bassi, David P. Nicolau, Yuli Lopez, Laura Muñoz, Laura Guerrero, Dolors Soy, Trinidad Israel, Pedro Castro and An Tags: Research Source Type: research

Population pharmacokinetics of intravenous sufentanil in critically ill patients supported with extracorporeal membrane oxygenation therapy
Sufentanil is commonly used for analgesia and sedation during extracorporeal membrane oxygenation (ECMO). Both ECMO and the pathophysiological changes derived from critical illness have significant effects on ... (Source: Critical Care)
Source: Critical Care - July 9, 2019 Category: Intensive Care Authors: Jongsung Hahn, Seungwon Yang, Kyoung Lok Min, Dasohm Kim, Byung Hak Jin, Changhun Park, Min Soo Park, Jin Wi and Min Jung Chang Tags: Research Source Type: research

Influence of contrast media on renal function and outcomes in patients with sepsis-associated acute kidney injury: a propensity-matched cohort study
Recent studies have suggested a low potential risk for contrast medium-induced kidney injury in patients with relatively normal renal function. However, whether contrast media cause additional deterioration of... (Source: Critical Care)
Source: Critical Care - July 9, 2019 Category: Intensive Care Authors: Yuya Goto, Kansuke Koyama, Shinshu Katayama, Ken Tonai, Jun Shima, Toshitaka Koinuma and Shin Nunomiya Tags: Research Source Type: research

Health inequities in the diagnosis and outcome of sepsis in Argentina: a prospective cohort study
Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis and also have significant health inequities... (Source: Critical Care)
Source: Critical Care - July 9, 2019 Category: Intensive Care Authors: Elisa Estenssoro, Cecilia I. Loudet, Vanina S. K. Edul, Javier Osatnik, Fernando G. R íos, Daniela N. Vásquez, Mario O. Pozo, Bernardo Lattanzio, Fernando Pálizas, Francisco Klein, Damián Piezny, Paolo N. Rubatto Birri, Graciela Tuhay, Anatilde Díaz, Tags: Research Source Type: research

Tenth International Symposium on Intensive Care and Emergency Medicine for Latin America
(Source: Critical Care)
Source: Critical Care - July 8, 2019 Category: Intensive Care Tags: Meeting abstracts Source Type: research

Multimorbidity states associated with higher mortality rates in organ dysfunction and sepsis: a data-driven analysis in critical care
Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients ’ medical back... (Source: Critical Care)
Source: Critical Care - July 8, 2019 Category: Intensive Care Authors: Zsolt Zador, Alexander Landry, Michael D. Cusimano and Nophar Geifman Tags: Research Source Type: research

ECCCOing the call for emergency and critical care training in low middle-income countries
(Source: Critical Care)
Source: Critical Care - July 5, 2019 Category: Intensive Care Authors: B. Jason Brotherton, Pete Halestrap, Evelyn Mbugua, Hannah Gitura, David Aliba, Jonathan E. Matson and Burton W. Lee Tags: Letter Source Type: research

Effects of sedatives and opioids on trigger and cycling asynchronies throughout mechanical ventilation: an observational study in a large dataset from critically ill patients
In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be deleterious. Whether op... (Source: Critical Care)
Source: Critical Care - July 5, 2019 Category: Intensive Care Authors: Candelaria de Haro, Rudys Magrans, Josefina L ópez-Aguilar, Jaume Montanyà, Enrico Lena, Carles Subirà, Sol Fernandez-Gonzalo, Gemma Gomà, Rafael Fernández, Guillermo M. Albaiceta, Yoanna Skrobik, Umberto Lucangelo, Gastón Murias, Ana Ochagavia, Rob Tags: Research Source Type: research

Neurological prognostication after cardiac arrest: how the “Best CPC” project would overcome selection biases
(Source: Critical Care)
Source: Critical Care - July 5, 2019 Category: Intensive Care Authors: Marine Paul and St éphane Legriel Tags: Commentary Source Type: research

Need for expanded Candida Score for empiric antifungal use in medically critically ill patients?
(Source: Critical Care)
Source: Critical Care - July 4, 2019 Category: Intensive Care Authors: Melanie E. Laine, Alexander H. Flannery, Breanna Moody and Melissa L. Thompson Bastin Tags: Letter Source Type: research

How I manage intracranial hypertension
(Source: Critical Care)
Source: Critical Care - July 4, 2019 Category: Intensive Care Authors: Chiara Robba and Giuseppe Citerio Tags: Editorial Source Type: research

Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002 –2016
Epidemiologic data have shown an increasing incidence and declining mortality rate in sepsis. However, confounding effects due to differences in disease classification might have contributed to these trends. (Source: Critical Care)
Source: Critical Care - July 3, 2019 Category: Intensive Care Authors: Robert Luhr, Yang Cao, Bo S öderquist and Sara Cajander Tags: Research Source Type: research

The hospital frailty risk score is of limited value in intensive care unit patients
(Source: Critical Care)
Source: Critical Care - July 2, 2019 Category: Intensive Care Authors: Raphael Romano Bruno, Bernhard Wernly, Hans Flaatten, Fabian Sch ölzel, Malte Kelm and Christian Jung Tags: Letter Source Type: research

Adsorption and caspofungin dosing during continuous renal replacement therapy
(Source: Critical Care)
Source: Critical Care - July 2, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle... (Source: Critical Care)
Source: Critical Care - July 1, 2019 Category: Intensive Care Authors: Chlo ë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe and Lies Langouche Tags: Research Source Type: research