Advanced interventions in the pre-hospital resuscitation of patients with non-compressible haemorrhage after penetrating injuries
Early haemorrhage control and minimizing the time to definitive care have long been the cornerstones of therapy for patients exsanguinating from non-compressible haemorrhage (NCH) after penetrating injuries, a... (Source: Critical Care)
Source: Critical Care - June 20, 2022 Category: Intensive Care Authors: E. ter Avest, L. Carenzo, R. A. Lendrum, M. D. Christian, R. M. Lyon, C. Coniglio, M. Rehn, D. J. Lockey and Z. B. Perkins Tags: Review Source Type: research

Driving pressure-guided ventilation decreases the mechanical power compared to predicted body weight-guided ventilation in the Acute Respiratory Distress Syndrome
Whether targeting the driving pressure ( ∆P) when adjusting the tidal volume in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS) may decrease the risk of ventilator-induced l... (Source: Critical Care)
Source: Critical Care - June 20, 2022 Category: Intensive Care Authors: Anne-Fleur Haudebourg, Samuel Tuffet, Fran çois Perier, Keyvan Razazi, Nicolas de Prost, Armand Mekontso Dessap and Guillaume Carteaux Tags: Research Source Type: research

Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial
Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves... (Source: Critical Care)
Source: Critical Care - June 18, 2022 Category: Intensive Care Authors: Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T. Schrijver, Frantzeska Frantzeskaki, Ma Tags: Research Source Type: research

Safety and efficacy of the Seraph ® 100 Microbind® Affinity Blood Filter to remove bacteria from the blood stream: results of the first in human study
Bacterial burden as well as duration of bacteremia influence the outcome of patients with bloodstream infections. Promptly decreasing bacterial load in the blood by using extracorporeal devices in addition to ... (Source: Critical Care)
Source: Critical Care - June 17, 2022 Category: Intensive Care Authors: Gabriele Eden, Julius J. Schmidt, Stefan B üttner, Philipp Kümpers, Carsten Hafer, Alexandros Rovas, Benjamin Florian Koch, Bernhard M. W. Schmidt and Jan T. Kielstein Tags: Research Source Type: research

Mechanisms of lung and diaphragmatic protection by high PEEP in obese COVID-19 ARDS: role of the body mass index
(Source: Critical Care)
Source: Critical Care - June 17, 2022 Category: Intensive Care Authors: Joaquin P érez, Javier Hernan Dorado, Emiliano Navarro, Caio C. A. Morais and Matías Accoce Tags: Correspondence Source Type: research

Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhage: a propensity score-overlap weighted analysis
Andexanet alfa is approved (FDA “accelerated approval”; EMA “conditional approval”) as the first specific reversal agent for factor Xa (FXa) inhibitor-associated uncontrolled or life-threatening bleeding. Four... (Source: Critical Care)
Source: Critical Care - June 16, 2022 Category: Intensive Care Authors: Olivia S. Costa, Stuart J. Connolly, Mukul Sharma, Jan Beyer-Westendorf, Mary J. Christoph, Belinda Lovelace and Craig I. Coleman Tags: Research Source Type: research

A dual-center cohort study on the association between early deep sedation and clinical outcomes in mechanically ventilated patients during the COVID-19 pandemic: The COVID-SED study
Mechanically ventilated patients have experienced greater periods of prolonged deep sedation during the coronavirus disease (COVID-19) pandemic. Multiple studies from the pre-COVID era demonstrate that early d... (Source: Critical Care)
Source: Critical Care - June 15, 2022 Category: Intensive Care Authors: Robert J. Stephens, Erin M. Evans, Michael J. Pajor, Ryan D. Pappal, Haley M. Egan, Max Wei, Hunter Hayes, Jason A. Morris, Nicholas Becker, Brian W. Roberts, Marin H. Kollef, Nicholas M. Mohr and Brian M. Fuller Tags: Research Source Type: research

Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically ill patients
Therapeutic drug monitoring (TDM) may represent an invaluable tool for optimizing antimicrobial therapy in septic patients, but extensive use is burdened by barriers. The aim of this study was to assess the im... (Source: Critical Care)
Source: Critical Care - June 14, 2022 Category: Intensive Care Authors: Milo Gatti, Pier Giorgio Cojutti, Michele Bartoletti, Tommaso Tonetti, Amedeo Bianchini, Stefania Ramirez, Giacinto Pizzilli, Simone Ambretti, Maddalena Giannella, Rita Mancini, Antonio Siniscalchi, Pierluigi Viale and Federico Pea Tags: Research Source Type: research

Comparison of 6-month outcomes of sepsis versus non-sepsis critically ill patients receiving mechanical ventilation
Data on long-term outcomes after sepsis-associated critical illness have mostly come from small cohort studies, with no information about the incidence of new disability. We investigated whether sepsis-associa... (Source: Critical Care)
Source: Critical Care - June 13, 2022 Category: Intensive Care Authors: Carol L. Hodgson, Alisa M. Higgins, Michael Bailey, Jonathon Barrett, Rinaldo Bellomo, D. James Cooper, Belinda J. Gabbe, Theodore Iwashyna, Natalie Linke, Paul S. Myles, Michelle Paton, Steve Philpot, Mark Shulman, Meredith Young and Ary Serpa Neto Tags: Research Source Type: research

The sit-to-stand test as a patient-centered functional outcome for critical care research: a pooled analysis of five international rehabilitation studies
With ICU mortality rates decreasing, it is increasingly important to identify interventions to minimize functional impairments and improve outcomes for survivors. Simultaneously, we must identify robust patien... (Source: Critical Care)
Source: Critical Care - June 13, 2022 Category: Intensive Care Authors: Heather K. O ’Grady, Lara Edbrooke, Christopher Farley, Sue Berney, Linda Denehy, Zudin Puthucheary and Michelle E. Kho Tags: Research Source Type: research

Impact of dexamethasone on the incidence of ventilator-associated pneumonia in mechanically ventilated COVID-19 patients: a propensity-matched cohort study
To assess the impact of treatment with steroids on the incidence and outcome of ventilator-associated pneumonia (VAP) in mechanically ventilated COVID-19 patients. (Source: Critical Care)
Source: Critical Care - June 13, 2022 Category: Intensive Care Authors: Vittorio Scaravilli, Amedeo Guzzardella, Fabiana Madotto, Virginia Beltrama, Antonio Muscatello, Giacomo Bellani, Gianpaola Monti, Massimiliano Greco, Antonio Pesenti, Alessandra Bandera and Giacomo Grasselli Tags: Brief Report Source Type: research

Reply to “Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality”
(Source: Critical Care)
Source: Critical Care - June 13, 2022 Category: Intensive Care Authors: Marta Mart ín-Fernández, María Heredia-Rodríguez and Eduardo Tamayo Tags: Correspondence Source Type: research

Early versus delayed enteral nutrition in mechanically ventilated patients with circulatory shock: a nested cohort analysis of an international multicenter, pragmatic clinical trial
Real-world evidence on the timing and efficacy of enteral nutrition (EN) practices in intensive care unit (ICU) patients with circulatory shock is limited. We hypothesized early EN (EEN), as compared to delaye... (Source: Critical Care)
Source: Critical Care - June 9, 2022 Category: Intensive Care Authors: Luis Ortiz-Reyes, Jayshil J. Patel, Xuran Jiang, Angel Coz Yataco, Andrew G. Day, Faraaz Shah, James Zelten, Maximiliano Tamae-Kakazu, Todd Rice and Daren K. Heyland Tags: Research Source Type: research

Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein
SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin –angiotensin system (RAS) is involved in th... (Source: Critical Care)
Source: Critical Care - June 9, 2022 Category: Intensive Care Authors: Lingbing Zhang, Yandan Zhang, Xia Qin, Xuejun Jiang, Jun Zhang, Lejiao Mao, Ziqi Jiang, Yu Jiang, Gang Liu, Jingfu Qiu, Chengzhi Chen, Feng Qiu and Zhen Zou Tags: Research Source Type: research

Reply to: “Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality”
(Source: Critical Care)
Source: Critical Care - June 9, 2022 Category: Intensive Care Authors: Alessandro N. Franciosi, Cormac McCarthy and Ruth MacRedmond Tags: Correspondence Source Type: research