Adsorption and caspofungin dosing during continuous renal replacement therapy
(Source: Critical Care)
Source: Critical Care - July 2, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle... (Source: Critical Care)
Source: Critical Care - July 1, 2019 Category: Intensive Care Authors: Chlo ë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe and Lies Langouche Tags: Research Source Type: research

Pre-hospital plasma transfusion: a valuable coagulation support or an expensive fluid therapy?
(Source: Critical Care)
Source: Critical Care - July 1, 2019 Category: Intensive Care Authors: Christian Fenger-Eriksen, Dietmar Fries, Jean-Stephane David, Pierre Bouzat, Marcus Daniel Lance, Oliver Grottke, Donat R. Spahn, Herbert Schoechl and Marc Maegele Tags: Editorial Source Type: research

Alterations of the iNKT cell compartment in brain-injured patients
Brain injury (BI) induces a state of immunodepression leading to pneumonia. We investigated the invariant natural killer T (iNKT) cell compartment. (Source: Critical Care)
Source: Critical Care - June 28, 2019 Category: Intensive Care Authors: Allan Patinec, J ézabel Rocher, Mickael Vourc’h, Antoine Roquilly, Karim Asehnoune and Jacques Le Pendu Tags: Research Source Type: research

Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study
Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothe... (Source: Critical Care)
Source: Critical Care - June 28, 2019 Category: Intensive Care Authors: Michael G. S. Shashaty, John P. Reilly, Hilary E. Faust, Caitlin M. Forker, Caroline A. G. Ittner, Peggy X. Zhang, Meghan J. Hotz, David Fitzgerald, Wei Yang, Brian J. Anderson, Daniel N. Holena, Paul N. Lanken, Jason D. Christie, Nuala J. Meyer and Nilam Tags: Research Source Type: research

Is interleukin-8 a true predictor of pediatric acute respiratory distress syndrome outcomes? Beware of potential confounders
(Source: Critical Care)
Source: Critical Care - June 27, 2019 Category: Intensive Care Authors: S ébastien Redant, François Angoulvant, Oceane Barbance, David De Bels, Andrea Gallerani, Rachid Attou, Kianoush Kashani and Patrick M. Honore Tags: Letter Source Type: research

Hemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis
Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther... (Source: Critical Care)
Source: Critical Care - June 26, 2019 Category: Intensive Care Authors: Mariateresa Giglio, Lidia Dalfino, Filomena Puntillo and Nicola Brienza Tags: Research Source Type: research

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors
Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, and catabolism syndrome predisposing them to long-term functional limitations and h... (Source: Critical Care)
Source: Critical Care - June 24, 2019 Category: Intensive Care Authors: Carlo Custodero, Quran Wu, Gabriela L. Ghita, Stephen D. Anton, Scott C. Brakenridge, Babette A. Brumback, Philip A. Efron, Anna K. Gardner, Christiaan Leeuwenburgh, Lyle L. Moldawer, John W. Petersen, Frederick A. Moore and Robert T. Mankowski Tags: Research Source Type: research

Individualized recombinant human thrombomodulin (ART-123) administration in sepsis patients based on predicted phenotypes
(Source: Critical Care)
Source: Critical Care - June 24, 2019 Category: Intensive Care Authors: Daisuke Hasegawa and Osamu Nishida Tags: Letter Source Type: research

Attainment of therapeutic vancomycin level within the first 24  h
(Source: Critical Care)
Source: Critical Care - June 21, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

New-onset QT prolongation is a novel predictor of mortality in critically ill patients
(Source: Critical Care)
Source: Critical Care - June 21, 2019 Category: Intensive Care Authors: Yonghe Ding, Ryounghoon Jeon, Linyu Ran, Wenzhi Pan, Feilong Wang and Qiang Li Tags: Letter Source Type: research

Clinical use of [TIMP-2] •[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel
The first FDA-approved test to assess risk for acute kidney injury (AKI), [TIMP-2] •[IGFBP7], is clinically available in many parts of the world, including the USA and Europe. We sought to understand how the te... (Source: Critical Care)
Source: Critical Care - June 20, 2019 Category: Intensive Care Authors: Louis M. Guzzi, Tobias Bergler, Brian Binnall, Daniel T. Engelman, Lui Forni, Michael J. Germain, Eric Gluck, Ivan G öcze, Michael Joannidis, Jay L. Koyner, V. Seenu Reddy, Thomas Rimmelé, Claudio Ronco, Julien Textoris, Alexander Zarbock and John A. Ke Tags: Research Source Type: research

Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?
(Source: Critical Care)
Source: Critical Care - June 20, 2019 Category: Intensive Care Authors: Fabrice Uhel, Brendon P. Scicluna, Lonneke A. van Vught, Olaf L. Cremer, Marc J. Bonten, Marcus J. Schultz and Tom van der Poll Tags: Letter Source Type: research

Interventions aimed at healthcare professionals to increase the number of organ donors: a systematic review
The last decade, there have been many initiatives worldwide to increase the number of organ donors. However, it is not clear which initiatives are most effective. The aim of this study is to provide an overvie... (Source: Critical Care)
Source: Critical Care - June 20, 2019 Category: Intensive Care Authors: Marloes Witjes, Nichon E. Jansen, Johannes G. van der Hoeven and Wilson F. Abdo Tags: Research Source Type: research

The association between nutritional adequacy and 28-day mortality in the critically ill is not modified by their baseline nutritional status and disease severity
During the initial phase of critical illness, the association between the dose of nutrition support and mortality risk may vary among patients in the intensive care unit (ICU) because the prevalence of malnutr... (Source: Critical Care)
Source: Critical Care - June 18, 2019 Category: Intensive Care Authors: Charles Chin Han Lew, Gabriel Jun Yung Wong, Ka Po Cheung, Robert J. L. Fraser, Ai Ping Chua, Mary Foong Fong Chong and Michelle Miller Tags: Research Source Type: research

Adopting a smart toothbrush with artificial intelligence may improve oral care in patients admitted to the intensive care unit
(Source: Critical Care)
Source: Critical Care - June 18, 2019 Category: Intensive Care Authors: Tommaso Scquizzato and Arianna Gazzato Tags: Letter Source Type: research

Beyond dichotomy: patterns and amplitudes of SSEPs and neurological outcomes after cardiac arrest
We hypothesized that the absence of P25 and the N20 –P25 amplitude in somatosensory evoked potentials (SSEPs) have higher sensitivity than the absence of N20 for poor neurological outcomes, and we evaluated the... (Source: Critical Care)
Source: Critical Care - June 18, 2019 Category: Intensive Care Authors: Sang Hoon Oh, Kyu Nam Park, Seung Pill Choi, Joo Suk Oh, Han Joon Kim, Chun Song Youn, Soo Hyun Kim, Kiyuk Chang and Seong Hoon Kim Tags: Research Source Type: research

Videolaryngoscopy in critically ill patients
Intubation is frequently required for patients in the intensive care unit (ICU) but is associated with high morbidity and mortality mainly in emergency procedures and in the presence of severe organ failures. ... (Source: Critical Care)
Source: Critical Care - June 17, 2019 Category: Intensive Care Authors: Samir Jaber, Audrey De Jong, Paolo Pelosi, Luca Cabrini, Jean Reignier and Jean Baptiste Lascarrou Tags: Viewpoint Source Type: research

Sepsis: personalization v protocolization?
The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined ‘Without clinical expertise, practice risks becoming tyrannised by evidence’. Rigid pr... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Mervyn Singer Tags: Review Source Type: research

Preserving the quality of life: nutrition in the ICU
Critically ill patients require adequate nutritional support to meet energy requirements both during and after intensive care unit (ICU) stay to protect against severe catabolism and prevent significant decond... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Pierre Singer Tags: Review Source Type: research

NIV through the helmet can be used as first-line intervention for early mild and moderate ARDS: an unproven idea thinking out of the box
(Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Massimo Antonelli Tags: Review Source Type: research

Minimizing catecholamines and optimizing perfusion
Catecholamines are used to increase cardiac output and blood pressure, aiming ultimately at restoring/improving tissue perfusion. While intuitive in its concept, this approach nevertheless implies to be effect... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Daniel De Backer and Pierre Foulon Tags: Review Source Type: research

Impact of weekly case-based tele-education on quality of care in a limited resource medical intensive care unit
Limited critical care subspecialty training and experience is available in many low- and middle-income countries, creating barriers to the delivery of evidence-based critical care. We hypothesized that a struc... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Pedja Kovacevic, Sasa Dragic, Tijana Kovacevic, Danica Momcicevic, Emir Festic, Rahul Kashyap, Alexander S. Niven, Yue Dong and Ognjen Gajic Tags: Research Source Type: research

Influence of pathogen and focus of infection on procalcitonin values in sepsis: are there additional confounding factors?
(Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

How to achieve nutrition goals by actual nutrition guidelines
(Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Christian Stoppe, Jean-Charles Preiser and Daren Heyland Tags: Editorial Source Type: research

Detailed measurements of oesophageal pressure during mechanical ventilation with an advanced high-resolution manometry catheter
Oesophageal pressure (PES) is used for calculation of lung and chest wall mechanics and transpulmonary pressure during mechanical ventilation. Measurements performed with a balloon catheter are suggested as a ... (Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Per Persson, Rebecca Ahlstrand, Magni Gudmundsson, Alex de Leon and Stefan Lundin Tags: Research Source Type: research

Benefits of red blood cell transfusion in patients with traumatic brain injury
(Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Weimin Zhang, Kailei Du and Xuping Chen Tags: Letter Source Type: research

Influenza virus-related critical illness: prevention, diagnosis, treatment
Annual seasonal influenza epidemics of variable severity result in significant morbidity and mortality in the United States (U.S.) and worldwide. In temperate climate countries, including the U.S., influenza a... (Source: Critical Care)
Source: Critical Care - June 12, 2019 Category: Intensive Care Authors: Eric J. Chow, Joshua D. Doyle and Timothy M. Uyeki Tags: Review Source Type: research

Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis
Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly described; we performed a systematic review and meta-analysis to summarise the available data. (Source: Critical Care)
Source: Critical Care - June 11, 2019 Category: Intensive Care Authors: Joseph M. Lewis, Nicholas A. Feasey and Jamie Rylance Tags: Research Source Type: research

Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis
As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the qualit... (Source: Critical Care)
Source: Critical Care - June 11, 2019 Category: Intensive Care Authors: C ássia Righy, Regis Goulart Rosa, Rodrigo Teixeira Amancio da Silva, Renata Kochhann, Celina Borges Migliavaca, Caroline Cabral Robinson, Stefania Pigatto Teche, Cassiano Teixeira, Fernando Augusto Bozza and Maicon Falavigna Tags: Research Source Type: research

Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters
Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and oth... (Source: Critical Care)
Source: Critical Care - June 10, 2019 Category: Intensive Care Authors: Guillaume Dumas, Jean-R émi Lavillegrand, Jérémie Joffre, Naïke Bigé, Edmilson Bastos de-Moura, Jean-Luc Baudel, Sylvie Chevret, Bertrand Guidet, Eric Maury, Fabio Amorim and Hafid Ait-Oufella Tags: Research Source Type: research

The ecological effects of selective decontamination of the digestive tract (SDD) on antimicrobial resistance: a 21-year longitudinal single-centre study
The long-term ecological effects on the emergence of antimicrobial resistance at the ICU level during selective decontamination of the digestive tract (SDD) are unknown. We determined the incidence of newly ac... (Source: Critical Care)
Source: Critical Care - June 7, 2019 Category: Intensive Care Authors: Sophie Buitinck, Rogier Jansen, Saskia Rijkenberg, Jos P. J. Wester, Rob J. Bosman, Nardo J. M. van der Meer and Peter H. J. van der Voort Tags: Research Source Type: research

Decompressive craniectomy for acute ischemic stroke
Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cere... (Source: Critical Care)
Source: Critical Care - June 7, 2019 Category: Intensive Care Authors: Thomas Beez, Christopher Munoz-Bendix, Hans-Jakob Steiger and Kerim Beseoglu Tags: Review Source Type: research

Interventions to improve cardiopulmonary resuscitation: a review of meta-analyses and future agenda
(Source: Critical Care)
Source: Critical Care - June 7, 2019 Category: Intensive Care Authors: Athanasios Chalkias and John P. A. Ioannidis Tags: Editorial Source Type: research

In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission
Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aime... (Source: Critical Care)
Source: Critical Care - June 6, 2019 Category: Intensive Care Authors: Toshikazu Abe, Yasuharu Tokuda, Atsushi Shiraishi, Seitaro Fujishima, Toshihiko Mayumi, Takehiro Sugiyama, Gautam A. Deshpande, Yasukazu Shiino, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shirai Tags: Research Source Type: research

ELS (Ethical Life Support): a new teaching tool for medical ethics
(Source: Critical Care)
Source: Critical Care - June 6, 2019 Category: Intensive Care Authors: Marco Vergano, Giuseppe Naretto, Fabrizio Elia, Enrico Gandolfo, Chiara Nebris Calliera and Giuseppe R. Gristina Tags: Editorial Source Type: research

Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients
The population pharmacokinetics of total and unbound posaconazole following intravenous administration has not yet been described for the critically ill patient population. The aim of this work was, therefore,... (Source: Critical Care)
Source: Critical Care - June 6, 2019 Category: Intensive Care Authors: Fekade B. Sime, Catherine J. Byrne, Suzanne Parker, Janine Stuart, Jenie Butler, Therese Starr, Saurabh Pandey, Steven C. Wallis, Jeffrey Lipman and Jason A. Roberts Tags: Research Source Type: research

Reversal of oral anticoagulation in patients with acute intracerebral hemorrhage
In light of an aging population with increased cardiovascular comorbidity, the use of oral anticoagulation (OAC) is steadily expanding. A variety of pharmacological alternatives to vitamin K antagonists (VKA) ... (Source: Critical Care)
Source: Critical Care - June 6, 2019 Category: Intensive Care Authors: Joji B. Kuramatsu, Jochen A. Sembill and Hagen B. Huttner Tags: Review Source Type: research

Examining the weekend effect across ICU performance metrics
Known colloquially as the “weekend effect,” the association between weekend admissions and increased mortality within hospital settings has become a highly contested topic over the last two decades. Drawing in... (Source: Critical Care)
Source: Critical Care - June 6, 2019 Category: Intensive Care Authors: Louis Faust, Keith Feldman and Nitesh V. Chawla Tags: Research Source Type: research

Trying to identify who may benefit most from future vitamin D intervention trials: a post hoc analysis from the VITDAL-ICU study excluding the early deaths
Vitamin D supplementation has shown promise for reducing mortality in the intensive care setting. As a steroid prohormone with pleiotropic effects, there may be a lag between administration and observing clini... (Source: Critical Care)
Source: Critical Care - June 4, 2019 Category: Intensive Care Authors: Gennaro Martucci, Dayre McNally, Dhruv Parekh, Paul Zajic, Fabio Tuzzolino, Antonio Arcadipane, Kenneth B. Christopher, Harald Dobnig and Karin Amrein Tags: Research Source Type: research

Post-stroke treatment with argon attenuated brain injury, reduced brain inflammation and enhanced M2 microglia/macrophage polarization: a randomized controlled animal study
In recent years, argon has been shown to exert neuroprotective effects in an array of models. However, the mechanisms by which argon exerts its neuroprotective characteristics remain unclear. Accumulating evid... (Source: Critical Care)
Source: Critical Care - June 3, 2019 Category: Intensive Care Authors: Jingjin Liu, Kay Nolte, Gary Brook, Lisa Liebenstund, Agnieszka Weinandy, Anke H öllig, Michael Veldeman, Antje Willuweit, Karl-Josef Langen, Rolf Rossaint and Mark Coburn Tags: Research Source Type: research

Short-term assist devices in postcardiotomy cardiogenic shock
(Source: Critical Care)
Source: Critical Care - June 3, 2019 Category: Intensive Care Authors: Hasan Iner, Nihan Karakas Yesilkaya, Yuksel Besir, Gamze Gokalp, Orhan Gokalp, Levent Yilik and Ali Gurbuz Tags: Letter Source Type: research

Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death
Despite the essential functions of the intestinal microbiota in human physiology, little has been reported about the microbiome in neurocritically ill patients. This investigation aimed to evaluate the charact... (Source: Critical Care)
Source: Critical Care - May 31, 2019 Category: Intensive Care Authors: Ruoting Xu, Chuhong Tan, Jiajia Zhu, Xiuli Zeng, Xuxuan Gao, Qiheng Wu, Qiong Chen, Huidi Wang, Hongwei Zhou, Yan He, Suyue Pan and Jia Yin Tags: Research Source Type: research

Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis
Septic shock is the most severe form of sepsis, in which profound underlying abnormalities in circulatory and cellular/metabolic parameters lead to substantially increased mortality. A clear understanding and ... (Source: Critical Care)
Source: Critical Care - May 31, 2019 Category: Intensive Care Authors: Jean-Louis Vincent, Gabriel Jones, Sholto David, Elena Olariu and Kevin K. Cadwell Tags: Research Source Type: research

Acute kidney injury after cardiac arrest: the role of coronary angiography and temperature management
(Source: Critical Care)
Source: Critical Care - May 30, 2019 Category: Intensive Care Authors: Ang élique M. E. Spoelstra-de Man and Heleen M. Oudemans-van Straaten Tags: Editorial Source Type: research

Automated continuous noninvasive ward monitoring: future directions and challenges
Automated continuous noninvasive ward monitoring may enable subtle changes in vital signs to be recognized. There is already some evidence that automated ward monitoring can improve patient outcome. Before aut... (Source: Critical Care)
Source: Critical Care - May 30, 2019 Category: Intensive Care Authors: Ashish K. Khanna, Phillip Hoppe and Bernd Saugel Tags: Viewpoint Source Type: research

Continuous monitoring of intrinsic PEEP based on expired CO2 kinetics: an experimental validation study
Quantification of intrinsic PEEP (PEEPi) has important implications for patients subjected to invasive mechanical ventilation. A new non-invasive breath-by-breath method (etCO2D) for determination of PEEPi is eva... (Source: Critical Care)
Source: Critical Care - May 29, 2019 Category: Intensive Care Authors: Sarah Heili-Frades, Fernando Suarez-Sipmann, Arnoldo Santos, Maria Pilar Carballosa, Alba Naya-Prieto, Carlos Castilla-Reparaz, Maria Jes ús Rodriguez-Nieto, Nicolás González-Mangado and German Peces -Barba Tags: Research Source Type: research

Procalcitonin levels in candidemia versus bacteremia: a systematic review
Procalcitonin (PCT) is a biomarker used to assess systemic inflammation, infection, and sepsis and to optimize antimicrobial therapies. Its role in the in the differential diagnosis between candidemia and bact... (Source: Critical Care)
Source: Critical Care - May 28, 2019 Category: Intensive Care Authors: Andrea Cortegiani, Giovanni Misseri, Mariachiara Ippolito, Matteo Bassetti, Antonino Giarratano, Ignacio Martin-Loeches and Sharon Einav Tags: Research Source Type: research

Albumin infusion rate and plasma volume expansion: a randomized clinical trial in postoperative patients after major surgery
Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is a... (Source: Critical Care)
Source: Critical Care - May 28, 2019 Category: Intensive Care Authors: Svajunas Statkevicius, Johan Bonnevier, Jane Fisher, Bj örn P. Bark, Erik Larsson, Carl M. Öberg, Päivi Kannisto, Bobby Tingstedt and Peter Bentzer Tags: Research Source Type: research

Red blood cell transfusion may be more detrimental than anemia for the clinical outcome of patients with severe traumatic brain injury
(Source: Critical Care)
Source: Critical Care - May 27, 2019 Category: Intensive Care Authors: Santiago R. Leal-Noval, Mar ía D. Rincón-Ferrari and Manuel Múñoz-Gómez Tags: Letter Source Type: research