Decrease of the plasmatic endocan cleavage ratio is associated with the hyperinflammatory phenotype of acute respiratory distress syndrome
(Source: Critical Care)
Source: Critical Care - July 11, 2019 Category: Intensive Care Authors: Alexandre Gaudet, Erika Parmentier, Nathalie De Freitas Caires, Lucie Portier, Sylvain Dubucquoi, Julien Poissy, Thibault Duburcq, Maxence Hureau, Philippe Lassalle and Daniel Mathieu Tags: Letter Source Type: research

Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients
To compare the efficacy of systemic treatment with linezolid (LNZ) versus vancomycin (VAN) on methicillin-resistant Staphylococcus aureus (MRSA) burden and eradication in endotracheal tube (ETT) biofilm and ETT c... (Source: Critical Care)
Source: Critical Care - July 10, 2019 Category: Intensive Care Authors: Laia Fern ández-Barat, Ana Motos, Mauro Panigada, Francisco Álvarez-Lerma, Lucía Viña, Ruben Lopez-Aladid, Adrian Ceccato, Gianluigi Li Bassi, David P. Nicolau, Yuli Lopez, Laura Muñoz, Laura Guerrero, Dolors Soy, Trinidad Israel, Pedro Castro and An Tags: Research Source Type: research

Population pharmacokinetics of intravenous sufentanil in critically ill patients supported with extracorporeal membrane oxygenation therapy
Sufentanil is commonly used for analgesia and sedation during extracorporeal membrane oxygenation (ECMO). Both ECMO and the pathophysiological changes derived from critical illness have significant effects on ... (Source: Critical Care)
Source: Critical Care - July 9, 2019 Category: Intensive Care Authors: Jongsung Hahn, Seungwon Yang, Kyoung Lok Min, Dasohm Kim, Byung Hak Jin, Changhun Park, Min Soo Park, Jin Wi and Min Jung Chang Tags: Research Source Type: research

Influence of contrast media on renal function and outcomes in patients with sepsis-associated acute kidney injury: a propensity-matched cohort study
Recent studies have suggested a low potential risk for contrast medium-induced kidney injury in patients with relatively normal renal function. However, whether contrast media cause additional deterioration of... (Source: Critical Care)
Source: Critical Care - July 9, 2019 Category: Intensive Care Authors: Yuya Goto, Kansuke Koyama, Shinshu Katayama, Ken Tonai, Jun Shima, Toshitaka Koinuma and Shin Nunomiya Tags: Research Source Type: research

Health inequities in the diagnosis and outcome of sepsis in Argentina: a prospective cohort study
Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis and also have significant health inequities... (Source: Critical Care)
Source: Critical Care - July 9, 2019 Category: Intensive Care Authors: Elisa Estenssoro, Cecilia I. Loudet, Vanina S. K. Edul, Javier Osatnik, Fernando G. R íos, Daniela N. Vásquez, Mario O. Pozo, Bernardo Lattanzio, Fernando Pálizas, Francisco Klein, Damián Piezny, Paolo N. Rubatto Birri, Graciela Tuhay, Anatilde Díaz, Tags: Research Source Type: research

Tenth International Symposium on Intensive Care and Emergency Medicine for Latin America
(Source: Critical Care)
Source: Critical Care - July 8, 2019 Category: Intensive Care Tags: Meeting abstracts Source Type: research

Multimorbidity states associated with higher mortality rates in organ dysfunction and sepsis: a data-driven analysis in critical care
Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients ’ medical back... (Source: Critical Care)
Source: Critical Care - July 8, 2019 Category: Intensive Care Authors: Zsolt Zador, Alexander Landry, Michael D. Cusimano and Nophar Geifman Tags: Research Source Type: research

ECCCOing the call for emergency and critical care training in low middle-income countries
(Source: Critical Care)
Source: Critical Care - July 5, 2019 Category: Intensive Care Authors: B. Jason Brotherton, Pete Halestrap, Evelyn Mbugua, Hannah Gitura, David Aliba, Jonathan E. Matson and Burton W. Lee Tags: Letter Source Type: research

Effects of sedatives and opioids on trigger and cycling asynchronies throughout mechanical ventilation: an observational study in a large dataset from critically ill patients
In critically ill patients, poor patient-ventilator interaction may worsen outcomes. Although sedatives are often administered to improve comfort and facilitate ventilation, they can be deleterious. Whether op... (Source: Critical Care)
Source: Critical Care - July 5, 2019 Category: Intensive Care Authors: Candelaria de Haro, Rudys Magrans, Josefina L ópez-Aguilar, Jaume Montanyà, Enrico Lena, Carles Subirà, Sol Fernandez-Gonzalo, Gemma Gomà, Rafael Fernández, Guillermo M. Albaiceta, Yoanna Skrobik, Umberto Lucangelo, Gastón Murias, Ana Ochagavia, Rob Tags: Research Source Type: research

Neurological prognostication after cardiac arrest: how the “Best CPC” project would overcome selection biases
(Source: Critical Care)
Source: Critical Care - July 5, 2019 Category: Intensive Care Authors: Marine Paul and St éphane Legriel Tags: Commentary Source Type: research

Need for expanded Candida Score for empiric antifungal use in medically critically ill patients?
(Source: Critical Care)
Source: Critical Care - July 4, 2019 Category: Intensive Care Authors: Melanie E. Laine, Alexander H. Flannery, Breanna Moody and Melissa L. Thompson Bastin Tags: Letter Source Type: research

How I manage intracranial hypertension
(Source: Critical Care)
Source: Critical Care - July 4, 2019 Category: Intensive Care Authors: Chiara Robba and Giuseppe Citerio Tags: Editorial Source Type: research

Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002 –2016
Epidemiologic data have shown an increasing incidence and declining mortality rate in sepsis. However, confounding effects due to differences in disease classification might have contributed to these trends. (Source: Critical Care)
Source: Critical Care - July 3, 2019 Category: Intensive Care Authors: Robert Luhr, Yang Cao, Bo S öderquist and Sara Cajander Tags: Research Source Type: research

The hospital frailty risk score is of limited value in intensive care unit patients
(Source: Critical Care)
Source: Critical Care - July 2, 2019 Category: Intensive Care Authors: Raphael Romano Bruno, Bernhard Wernly, Hans Flaatten, Fabian Sch ölzel, Malte Kelm and Christian Jung Tags: Letter Source Type: research

Adsorption and caspofungin dosing during continuous renal replacement therapy
(Source: Critical Care)
Source: Critical Care - July 2, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones
ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle... (Source: Critical Care)
Source: Critical Care - July 1, 2019 Category: Intensive Care Authors: Chlo ë Goossens, Ruben Weckx, Sarah Derde, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Steven E. Thiessen, Paul P. Van Veldhoven, Greet Van den Berghe and Lies Langouche Tags: Research Source Type: research

Pre-hospital plasma transfusion: a valuable coagulation support or an expensive fluid therapy?
(Source: Critical Care)
Source: Critical Care - July 1, 2019 Category: Intensive Care Authors: Christian Fenger-Eriksen, Dietmar Fries, Jean-Stephane David, Pierre Bouzat, Marcus Daniel Lance, Oliver Grottke, Donat R. Spahn, Herbert Schoechl and Marc Maegele Tags: Editorial Source Type: research

Alterations of the iNKT cell compartment in brain-injured patients
Brain injury (BI) induces a state of immunodepression leading to pneumonia. We investigated the invariant natural killer T (iNKT) cell compartment. (Source: Critical Care)
Source: Critical Care - June 28, 2019 Category: Intensive Care Authors: Allan Patinec, J ézabel Rocher, Mickael Vourc’h, Antoine Roquilly, Karim Asehnoune and Jacques Le Pendu Tags: Research Source Type: research

Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study
Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothe... (Source: Critical Care)
Source: Critical Care - June 28, 2019 Category: Intensive Care Authors: Michael G. S. Shashaty, John P. Reilly, Hilary E. Faust, Caitlin M. Forker, Caroline A. G. Ittner, Peggy X. Zhang, Meghan J. Hotz, David Fitzgerald, Wei Yang, Brian J. Anderson, Daniel N. Holena, Paul N. Lanken, Jason D. Christie, Nuala J. Meyer and Nilam Tags: Research Source Type: research

Is interleukin-8 a true predictor of pediatric acute respiratory distress syndrome outcomes? Beware of potential confounders
(Source: Critical Care)
Source: Critical Care - June 27, 2019 Category: Intensive Care Authors: S ébastien Redant, François Angoulvant, Oceane Barbance, David De Bels, Andrea Gallerani, Rachid Attou, Kianoush Kashani and Patrick M. Honore Tags: Letter Source Type: research

Hemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis
Perioperative goal-directed therapy (GDT) reduces the risk of renal injury. However, several questions remain unanswered, such as target, kind of patients and surgery, and role of fluids and inotropes. We ther... (Source: Critical Care)
Source: Critical Care - June 26, 2019 Category: Intensive Care Authors: Mariateresa Giglio, Lidia Dalfino, Filomena Puntillo and Nicola Brienza Tags: Research Source Type: research

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors
Sepsis survivors often develop chronic critical illness (CCI) and demonstrate the persistent inflammation, immunosuppression, and catabolism syndrome predisposing them to long-term functional limitations and h... (Source: Critical Care)
Source: Critical Care - June 24, 2019 Category: Intensive Care Authors: Carlo Custodero, Quran Wu, Gabriela L. Ghita, Stephen D. Anton, Scott C. Brakenridge, Babette A. Brumback, Philip A. Efron, Anna K. Gardner, Christiaan Leeuwenburgh, Lyle L. Moldawer, John W. Petersen, Frederick A. Moore and Robert T. Mankowski Tags: Research Source Type: research

Individualized recombinant human thrombomodulin (ART-123) administration in sepsis patients based on predicted phenotypes
(Source: Critical Care)
Source: Critical Care - June 24, 2019 Category: Intensive Care Authors: Daisuke Hasegawa and Osamu Nishida Tags: Letter Source Type: research

Attainment of therapeutic vancomycin level within the first 24  h
(Source: Critical Care)
Source: Critical Care - June 21, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

New-onset QT prolongation is a novel predictor of mortality in critically ill patients
(Source: Critical Care)
Source: Critical Care - June 21, 2019 Category: Intensive Care Authors: Yonghe Ding, Ryounghoon Jeon, Linyu Ran, Wenzhi Pan, Feilong Wang and Qiang Li Tags: Letter Source Type: research

Clinical use of [TIMP-2] •[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel
The first FDA-approved test to assess risk for acute kidney injury (AKI), [TIMP-2] •[IGFBP7], is clinically available in many parts of the world, including the USA and Europe. We sought to understand how the te... (Source: Critical Care)
Source: Critical Care - June 20, 2019 Category: Intensive Care Authors: Louis M. Guzzi, Tobias Bergler, Brian Binnall, Daniel T. Engelman, Lui Forni, Michael J. Germain, Eric Gluck, Ivan G öcze, Michael Joannidis, Jay L. Koyner, V. Seenu Reddy, Thomas Rimmelé, Claudio Ronco, Julien Textoris, Alexander Zarbock and John A. Ke Tags: Research Source Type: research

Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?
(Source: Critical Care)
Source: Critical Care - June 20, 2019 Category: Intensive Care Authors: Fabrice Uhel, Brendon P. Scicluna, Lonneke A. van Vught, Olaf L. Cremer, Marc J. Bonten, Marcus J. Schultz and Tom van der Poll Tags: Letter Source Type: research

Interventions aimed at healthcare professionals to increase the number of organ donors: a systematic review
The last decade, there have been many initiatives worldwide to increase the number of organ donors. However, it is not clear which initiatives are most effective. The aim of this study is to provide an overvie... (Source: Critical Care)
Source: Critical Care - June 20, 2019 Category: Intensive Care Authors: Marloes Witjes, Nichon E. Jansen, Johannes G. van der Hoeven and Wilson F. Abdo Tags: Research Source Type: research

The association between nutritional adequacy and 28-day mortality in the critically ill is not modified by their baseline nutritional status and disease severity
During the initial phase of critical illness, the association between the dose of nutrition support and mortality risk may vary among patients in the intensive care unit (ICU) because the prevalence of malnutr... (Source: Critical Care)
Source: Critical Care - June 18, 2019 Category: Intensive Care Authors: Charles Chin Han Lew, Gabriel Jun Yung Wong, Ka Po Cheung, Robert J. L. Fraser, Ai Ping Chua, Mary Foong Fong Chong and Michelle Miller Tags: Research Source Type: research

Adopting a smart toothbrush with artificial intelligence may improve oral care in patients admitted to the intensive care unit
(Source: Critical Care)
Source: Critical Care - June 18, 2019 Category: Intensive Care Authors: Tommaso Scquizzato and Arianna Gazzato Tags: Letter Source Type: research

Beyond dichotomy: patterns and amplitudes of SSEPs and neurological outcomes after cardiac arrest
We hypothesized that the absence of P25 and the N20 –P25 amplitude in somatosensory evoked potentials (SSEPs) have higher sensitivity than the absence of N20 for poor neurological outcomes, and we evaluated the... (Source: Critical Care)
Source: Critical Care - June 18, 2019 Category: Intensive Care Authors: Sang Hoon Oh, Kyu Nam Park, Seung Pill Choi, Joo Suk Oh, Han Joon Kim, Chun Song Youn, Soo Hyun Kim, Kiyuk Chang and Seong Hoon Kim Tags: Research Source Type: research

Videolaryngoscopy in critically ill patients
Intubation is frequently required for patients in the intensive care unit (ICU) but is associated with high morbidity and mortality mainly in emergency procedures and in the presence of severe organ failures. ... (Source: Critical Care)
Source: Critical Care - June 17, 2019 Category: Intensive Care Authors: Samir Jaber, Audrey De Jong, Paolo Pelosi, Luca Cabrini, Jean Reignier and Jean Baptiste Lascarrou Tags: Viewpoint Source Type: research

Sepsis: personalization v protocolization?
The founding tenet of evidence-based medicine is to combine best evidence with clinical expertise. As David Sackett opined ‘Without clinical expertise, practice risks becoming tyrannised by evidence’. Rigid pr... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Mervyn Singer Tags: Review Source Type: research

Preserving the quality of life: nutrition in the ICU
Critically ill patients require adequate nutritional support to meet energy requirements both during and after intensive care unit (ICU) stay to protect against severe catabolism and prevent significant decond... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Pierre Singer Tags: Review Source Type: research

NIV through the helmet can be used as first-line intervention for early mild and moderate ARDS: an unproven idea thinking out of the box
(Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Massimo Antonelli Tags: Review Source Type: research

Minimizing catecholamines and optimizing perfusion
Catecholamines are used to increase cardiac output and blood pressure, aiming ultimately at restoring/improving tissue perfusion. While intuitive in its concept, this approach nevertheless implies to be effect... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Daniel De Backer and Pierre Foulon Tags: Review Source Type: research

Impact of weekly case-based tele-education on quality of care in a limited resource medical intensive care unit
Limited critical care subspecialty training and experience is available in many low- and middle-income countries, creating barriers to the delivery of evidence-based critical care. We hypothesized that a struc... (Source: Critical Care)
Source: Critical Care - June 14, 2019 Category: Intensive Care Authors: Pedja Kovacevic, Sasa Dragic, Tijana Kovacevic, Danica Momcicevic, Emir Festic, Rahul Kashyap, Alexander S. Niven, Yue Dong and Ognjen Gajic Tags: Research Source Type: research

Influence of pathogen and focus of infection on procalcitonin values in sepsis: are there additional confounding factors?
(Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani and Kianoush Kashani Tags: Letter Source Type: research

How to achieve nutrition goals by actual nutrition guidelines
(Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Christian Stoppe, Jean-Charles Preiser and Daren Heyland Tags: Editorial Source Type: research

Detailed measurements of oesophageal pressure during mechanical ventilation with an advanced high-resolution manometry catheter
Oesophageal pressure (PES) is used for calculation of lung and chest wall mechanics and transpulmonary pressure during mechanical ventilation. Measurements performed with a balloon catheter are suggested as a ... (Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Per Persson, Rebecca Ahlstrand, Magni Gudmundsson, Alex de Leon and Stefan Lundin Tags: Research Source Type: research

Benefits of red blood cell transfusion in patients with traumatic brain injury
(Source: Critical Care)
Source: Critical Care - June 13, 2019 Category: Intensive Care Authors: Weimin Zhang, Kailei Du and Xuping Chen Tags: Letter Source Type: research

Influenza virus-related critical illness: prevention, diagnosis, treatment
Annual seasonal influenza epidemics of variable severity result in significant morbidity and mortality in the United States (U.S.) and worldwide. In temperate climate countries, including the U.S., influenza a... (Source: Critical Care)
Source: Critical Care - June 12, 2019 Category: Intensive Care Authors: Eric J. Chow, Joshua D. Doyle and Timothy M. Uyeki Tags: Review Source Type: research

Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis
Aetiology and outcomes of sepsis in sub-Saharan Africa (sSA) are poorly described; we performed a systematic review and meta-analysis to summarise the available data. (Source: Critical Care)
Source: Critical Care - June 11, 2019 Category: Intensive Care Authors: Joseph M. Lewis, Nicholas A. Feasey and Jamie Rylance Tags: Research Source Type: research

Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis
As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the qualit... (Source: Critical Care)
Source: Critical Care - June 11, 2019 Category: Intensive Care Authors: C ássia Righy, Regis Goulart Rosa, Rodrigo Teixeira Amancio da Silva, Renata Kochhann, Celina Borges Migliavaca, Caroline Cabral Robinson, Stefania Pigatto Teche, Cassiano Teixeira, Fernando Augusto Bozza and Maicon Falavigna Tags: Research Source Type: research

Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters
Mottling score, a tissue perfusion parameter, is correlated with outcome in septic shock patients. However, its predictive value on mortality according to prognostic covariates such as vasopressor dose and oth... (Source: Critical Care)
Source: Critical Care - June 10, 2019 Category: Intensive Care Authors: Guillaume Dumas, Jean-R émi Lavillegrand, Jérémie Joffre, Naïke Bigé, Edmilson Bastos de-Moura, Jean-Luc Baudel, Sylvie Chevret, Bertrand Guidet, Eric Maury, Fabio Amorim and Hafid Ait-Oufella Tags: Research Source Type: research

The ecological effects of selective decontamination of the digestive tract (SDD) on antimicrobial resistance: a 21-year longitudinal single-centre study
The long-term ecological effects on the emergence of antimicrobial resistance at the ICU level during selective decontamination of the digestive tract (SDD) are unknown. We determined the incidence of newly ac... (Source: Critical Care)
Source: Critical Care - June 7, 2019 Category: Intensive Care Authors: Sophie Buitinck, Rogier Jansen, Saskia Rijkenberg, Jos P. J. Wester, Rob J. Bosman, Nardo J. M. van der Meer and Peter H. J. van der Voort Tags: Research Source Type: research

Decompressive craniectomy for acute ischemic stroke
Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cere... (Source: Critical Care)
Source: Critical Care - June 7, 2019 Category: Intensive Care Authors: Thomas Beez, Christopher Munoz-Bendix, Hans-Jakob Steiger and Kerim Beseoglu Tags: Review Source Type: research

Interventions to improve cardiopulmonary resuscitation: a review of meta-analyses and future agenda
(Source: Critical Care)
Source: Critical Care - June 7, 2019 Category: Intensive Care Authors: Athanasios Chalkias and John P. A. Ioannidis Tags: Editorial Source Type: research

In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission
Rapid detection, early resuscitation, and appropriate antibiotic use are crucial for sepsis care. Accurate identification of the site of infection may facilitate a timely provision of appropriate care. We aime... (Source: Critical Care)
Source: Critical Care - June 6, 2019 Category: Intensive Care Authors: Toshikazu Abe, Yasuharu Tokuda, Atsushi Shiraishi, Seitaro Fujishima, Toshihiko Mayumi, Takehiro Sugiyama, Gautam A. Deshpande, Yasukazu Shiino, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shirai Tags: Research Source Type: research

ELS (Ethical Life Support): a new teaching tool for medical ethics
(Source: Critical Care)
Source: Critical Care - June 6, 2019 Category: Intensive Care Authors: Marco Vergano, Giuseppe Naretto, Fabrizio Elia, Enrico Gandolfo, Chiara Nebris Calliera and Giuseppe R. Gristina Tags: Editorial Source Type: research