Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions
Sugar-protein glycocalyx coats healthy endothelium, but its ultrastructure is not well described. Our aim was to determine the three-dimensional ultrastructure of capillary endothelial glycocalyx in the heart,... (Source: Critical Care)
Source: Critical Care - October 23, 2017 Category: Intensive Care Authors: Hideshi Okada, Genzou Takemura, Kodai Suzuki, Kazumasa Oda, Chihiro Takada, Yasuaki Hotta, Nagisa Miyazaki, Akiko Tsujimoto, Isamu Muraki, Yoshiaki Ando, Ryogen Zaikokuji, Atsumu Matsumoto, Hiroki Kitagaki, Yuto Tamaoki, Takahiro Usui, Tomoaki Doi & helli Tags: Research Source Type: research

Finding the precision to improve outcome in patients after cardiac arrest
(Source: Critical Care)
Source: Critical Care - October 22, 2017 Category: Intensive Care Authors: Gentle Sunder Shrestha Tags: Letter Source Type: research

Sleeping with the enemy: Clostridium difficile infection in the intensive care unit
Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI amon... (Source: Critical Care)
Source: Critical Care - October 22, 2017 Category: Intensive Care Authors: Florian Prechter, Katrin Katzer, Michael Bauer and Andreas Stallmach Tags: Review Source Type: research

Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study
Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has been associated with clinical success in critically... (Source: Critical Care)
Source: Critical Care - October 21, 2017 Category: Intensive Care Authors: Lisa Ehmann, Michael Zoller, Iris K. Minichmayr, Christina Scharf, Barbara Maier, Maximilian V. Schmitt, Niklas Hartung, Wilhelm Huisinga, Michael Vogeser, Lorenz Frey, Johannes Zander and Charlotte Kloft Tags: Research Source Type: research

Predictors of diffuse alveolar damage in patients with acute respiratory distress syndrome: a retrospective analysis of clinical autopsies
Although diffuse alveolar damage (DAD) is considered the typical histological pattern of acute respiratory distress syndrome (ARDS), only half of patients exhibit this morphological hallmark. Patients with DAD... (Source: Critical Care)
Source: Critical Care - October 20, 2017 Category: Intensive Care Authors: Arnaud W. Thille, Oscar Pe ñuelas, José A. Lorente, Pilar Fernández-Segoviano, José-Maria Rodriguez, José-Antonio Aramburu, Julian Panizo, Andres Esteban and Fernando Frutos-Vivar Tags: Research Source Type: research

Association between kidney intracapsular pressure and ultrasound elastography
Kidney congestion is a common pathophysiologic pathway of acute kidney injury (AKI) in sepsis and heart failure. There is no noninvasive tool to measure kidney intracapsular pressure (KIP) directly. (Source: Critical Care)
Source: Critical Care - October 19, 2017 Category: Intensive Care Authors: Kianoush B. Kashani, Shennen A. Mao, Sami Safadi, Bruce P. Amiot, Jaime M. Glorioso, John C. Lieske, Scott L. Nyberg and Xiaoming Zhang Tags: Research Source Type: research

Levosimendan for patients with severely reduced left ventricular systolic function and/or low cardiac output syndrome undergoing cardiac surgery: a systematic review and meta-analysis
Previous studies have shown beneficial effects of levosimendan in high-risk patients undergoing cardiac surgery. Two large randomized controlled trials (RCTs), however, showed no advantages of levosimendan. (Source: Critical Care)
Source: Critical Care - October 19, 2017 Category: Intensive Care Authors: Filippo Sanfilippo, Joshua B. Knight, Sabino Scolletta, Cristina Santonocito, Federico Pastore, Ferdinando L. Lorini, Luigi Tritapepe, Andrea Morelli and Antonio Arcadipane Tags: Research Source Type: research

Erratum to: Immunomodulation after ischemic stroke: potential mechanisms and implications for therapy
(Source: Critical Care)
Source: Critical Care - October 18, 2017 Category: Intensive Care Authors: Cynthia Santos Samary, Paolo Pelosi, Pedro Leme Silva and Patricia Rieken Macedo Rocco Tags: Erratum Source Type: research

Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness
All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field of critic... (Source: Critical Care)
Source: Critical Care - October 18, 2017 Category: Intensive Care Authors: Christopher W. Seymour, Hernando Gomez, Chung-Chou H. Chang, Gilles Clermont, John A. Kellum, Jason Kennedy, Sachin Yende and Derek C. Angus Tags: Review Source Type: research

Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis
Mildly elevated lactate levels (i.e., 1 –2 mmol/L) are increasingly recognized as a prognostic finding in critically ill patients. One of several possible underlying mechanisms, microcirculatory dysfunction, ca... (Source: Critical Care)
Source: Critical Care - October 18, 2017 Category: Intensive Care Authors: Namkje A. R. Vellinga, E. Christiaan Boerma, Matty Koopmans, Abele Donati, Arnaldo Dubin, Nathan I. Shapiro, Rupert M. Pearse, Peter H. J. van der Voort, Arjen M. Dondorp, Tony Bafi, Michael Fries, Tulin Akarsu-Ayazoglu, Andrius Pranskunas, Steven Hollenb Tags: Research Source Type: research

Effect of levosimendan on prognosis in adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials
Small trials suggest that levosimendan is associated with a favorable outcome in patients undergoing cardiac surgery. However, recently published larger-scale trials did not provide evidence for a similar bene... (Source: Critical Care)
Source: Critical Care - October 17, 2017 Category: Intensive Care Authors: Qi-Hong Chen, Rui-Qiang Zheng, Hua Lin, Jun Shao, Jiang-quan Yu and Hua-Ling Wang Tags: Research Source Type: research

Simplified prognostic model for critically ill patients in resource limited settings in South Asia
Current critical care prognostic models are predominantly developed in high-income countries (HICs) and may not be feasible in intensive care units (ICUs) in lower- and middle-income countries (LMICs). Existin... (Source: Critical Care)
Source: Critical Care - October 17, 2017 Category: Intensive Care Authors: Rashan Haniffa, Mavuto Mukaka, Sithum Bandara Munasinghe, Ambepitiyawaduge Pubudu De Silva, Kosala Saroj Amarasiri Jayasinghe, Abi Beane, Nicolette de Keizer and Arjen M. Dondorp Tags: Research Source Type: research

Evaluating physical functioning in critical care: considerations for clinical practice and research
The evaluation of physical functioning is valuable in the intensive care unit (ICU) to help inform patient recovery after critical illness, to identify patients who may require rehabilitation interventions, an... (Source: Critical Care)
Source: Critical Care - October 4, 2017 Category: Intensive Care Authors: Selina M. Parry, Minxuan Huang and Dale M. Needham Tags: Viewpoint Source Type: research

Blind bedside postpyloric placement of spiral tube as rescue therapy in critically ill patients: a prospective, tricentric, observational study
Various special techniques for blind bedside transpyloric tube placement have been introduced into clinical practice. However, transpyloric spiral tube placement facilitated by a blind bedside method has not y... (Source: Critical Care)
Source: Critical Care - September 26, 2017 Category: Intensive Care Authors: Bo Lv, Linhui Hu, Lifang Chen, Bei Hu, Yanlin Zhang, Heng Ye, Cheng Sun, Xiunong Zhang, Huilan Lan and Chunbo Chen Tags: Research Source Type: research

Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein
Ischemia/reperfusion injury (I/R) is an important pathophysiology of post-cardiac arrest syndrome (PCAS) against multiple organ dysfunction and mortality. The inflammatory response in PCAS causes systemic I/R.... (Source: Critical Care)
Source: Critical Care - September 26, 2017 Category: Intensive Care Authors: Atsunori Sugita, Kosaku Kinoshita, Atsushi Sakurai, Nobutaka Chiba, Junko Yamaguchi, Tsukasa Kuwana, Nami Sawada and Satoshi Hori Tags: Research Source Type: research

Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients
Intravascular haemolysis has been associated with acute kidney injury (AKI) in different clinical settings (cardiac surgery, sickle cell disease). Haemolysis occurs frequently in critically ill burn patients. ... (Source: Critical Care)
Source: Critical Care - September 26, 2017 Category: Intensive Care Authors: Fran çois Dépret, Chloé Dunyach, Christian De Tymowski, Maïté Chaussard, Aurélien Bataille, Axelle Ferry, Nabila Moreno, Alexandru Cupaciu, Sabri Soussi, Mourad Benyamina, Alexandre Mebazaa, Kevin Serror, Marc Chaouat, Jean-Pierre Garnier, Romain Pi Tags: Research Source Type: research

Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis
(Source: Critical Care)
Source: Critical Care - September 26, 2017 Category: Intensive Care Authors: Carolina D. Garciarena, Tony M. McHale, Ignacio Martin-Loeches and Steve W. Kerrigan Tags: Letter Source Type: research

Limited evidence to recommend against open chest cardiopulmonary resuscitation in blunt trauma
(Source: Critical Care)
Source: Critical Care - September 20, 2017 Category: Intensive Care Authors: Stefano Malinverni and Pierre Mols Tags: Letter Source Type: research

Main limitations of transpulmonary thermodilution: set targets
(Source: Critical Care)
Source: Critical Care - September 18, 2017 Category: Intensive Care Authors: Manuel S ánchez-Sánchez, Eva Herrero, Lucia Cachafeiro, Eva Flores, Alexander Agrifoglio, Belén Civantos and Abelardo García-de-Lorenzo Tags: Letter Source Type: research

Effect of extended visiting hours on physician distractions in the ICU: a before-and-after study
(Source: Critical Care)
Source: Critical Care - September 18, 2017 Category: Intensive Care Authors: Kay Choong See, Xie Ying Song and Han Tun Aung Tags: Letter Source Type: research

Accounting for single center effects in systematic reviews cannot be overlooked
(Source: Critical Care)
Source: Critical Care - September 15, 2017 Category: Intensive Care Authors: Bruno Adler Maccagnan Pinheiro Besen, Marcelo Park and Antonio Paulo Nassar Jr Tags: Letter Source Type: research

Respiratory support in patients with acute respiratory distress syndrome: an expert opinion
Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30 –45% and considerable long-term morbidity. Respira... (Source: Critical Care)
Source: Critical Care - September 12, 2017 Category: Intensive Care Authors: Davide Chiumello, Laurent Brochard, John J. Marini, Arthur S. Slutsky, Jordi Mancebo, V. Marco Ranieri, B. Taylor Thompson, Laurent Papazian, Marcus J. Schultz, Marcelo Amato, Luciano Gattinoni, Alain Mercat, Antonio Pesenti, Daniel Talmor and Jean-Louis Tags: Review Source Type: research

Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury
Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemi... (Source: Critical Care)
Source: Critical Care - September 8, 2017 Category: Intensive Care Authors: Chen-Fei Zheng, Wen-Yue Liu, Fang-Fang Zeng, Ming-Hua Zheng, Hong-Ying Shi, Ying Zhou and Jing-Ye Pan Tags: Research Source Type: research

Targeted therapeutic mild hypercapnia after cardiac arrest: a part of the bundle of care for mitigating secondary injury after cardiac arrest
(Source: Critical Care)
Source: Critical Care - September 7, 2017 Category: Intensive Care Authors: Romain Jouffroy and Beno ît Vivien Tags: Letter Source Type: research

Traversing the valley of glycemic control despair
(Source: Critical Care)
Source: Critical Care - September 7, 2017 Category: Intensive Care Authors: J. Geoffrey Chase and Jennifer L. Dickson Tags: Editorial Source Type: research

Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care
In this study, we primarily investigated whether ICU admission or ICU stay at weekends (Saturday and Sunday) is associated with a different risk of ICU mortality or chance of ICU discharge than ICU admission o... (Source: Critical Care)
Source: Critical Care - September 7, 2017 Category: Intensive Care Authors: Paul Zajic, Peter Bauer, Andrew Rhodes, Rui Moreno, Tobias Fellinger, Barbara Metnitz, Faidra Stavropoulou, Martin Posch and Philipp G. H. Metnitz Tags: Research Source Type: research

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 usi... (Source: Critical Care)
Source: Critical Care - September 7, 2017 Category: Intensive Care Authors: Akram Khan, Cody Benthin, Brian Zeno, Timothy E. Albertson, John Boyd, Jason D. Christie, Richard Hall, Germain Poirier, Juan J. Ronco, Mark Tidswell, Kelly Hardes, William M. Powley, Tracey J. Wright, Sarah K. Siederer, David A. Fairman, David A. Lipson Tags: Research Source Type: research

Satisfaction with quality of ICU care for patients and families: the euroQ2 project
Families ’ perspectives are of great importance in evaluating quality of care in the intensive care unit (ICU). This Danish-Dutch study tested a European adaptation of the “Family Satisfaction in the ICU” (euro... (Source: Critical Care)
Source: Critical Care - September 7, 2017 Category: Intensive Care Authors: Hanne Irene Jensen, Rik T. Gerritsen, Matty Koopmans, Lois Downey, Ruth A. Engelberg, J. Randall Curtis, Peter E. Spronk, Jan G. Zijlstra and Helle Ørding Tags: Research Source Type: research

Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study
No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potent... (Source: Critical Care)
Source: Critical Care - September 6, 2017 Category: Intensive Care Authors: Maryse C. Cnossen, Jilske A. Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C. Peul, Andrew I. R. Maas, David Menon, Ewout W. Steyerberg and Hester F. Tags: Research Source Type: research

Loxapine to control agitation during weaning from mechanical ventilation
Weaning from mechanical ventilation (MV) may be impeded by the occurrence of agitation. Loxapine has the ability to control agitation without affecting spontaneous ventilation. The aim of this study was to est... (Source: Critical Care)
Source: Critical Care - September 6, 2017 Category: Intensive Care Authors: St éphane Gaudry, Benjamin Sztrymf, Romain Sonneville, Bruno Megarbane, Guillaume Van Der Meersch, Dominique Vodovar, Yves Cohen, Jean-Damien Ricard, David Hajage, Laurence Salomon and Didier Dreyfuss Tags: Research Source Type: research

Hydrolysed protein enteral nutrition is not superior to polymeric whole protein feeding with regard to gastrointestinal feeding tolerance and feeding adequacy
(Source: Critical Care)
Source: Critical Care - September 5, 2017 Category: Intensive Care Authors: Arthur R. H. van Zanten and Gunnar Elke Tags: Letter Source Type: research

Renal replacement therapy after cardiac surgery: do not ask “When”, ask “Why”
(Source: Critical Care)
Source: Critical Care - September 5, 2017 Category: Intensive Care Authors: St éphane Gaudry, David Hajage and Didier Dreyfuss Tags: Letter Source Type: research

Ultrasound-guided central venous catheter placement: a structured review and recommendations for clinical practice
The use of ultrasound (US) has been proposed to reduce the number of complications and to increase the safety and quality of central venous catheter (CVC) placement. In this review, we describe the rationale f... (Source: Critical Care)
Source: Critical Care - August 28, 2017 Category: Intensive Care Authors: Bernd Saugel, Thomas W. L. Scheeren and Jean-Louis Teboul Tags: Review Source Type: research

Immunosuppression and herpes viral reactivation in intensive care unit patients: one size does not fit all
(Source: Critical Care)
Source: Critical Care - August 26, 2017 Category: Intensive Care Authors: Julien Textoris and Fran çois Mallet Tags: Editorial Source Type: research

The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review
The lack of benefit from randomised controlled trials has resulted in significant controversy regarding the role of nutrition during critical illness in terms of long-term recovery and outcome. Although method... (Source: Critical Care)
Source: Critical Care - August 26, 2017 Category: Intensive Care Authors: Danielle E. Bear, Liesl Wandrag, Judith L. Merriweather, Bronwen Connolly, Nicholas Hart and Michael P. W. Grocott Tags: Review Source Type: research

Variability of response to the fluid bolus is again demonstrated
(Source: Critical Care)
Source: Critical Care - August 25, 2017 Category: Intensive Care Authors: Ellis R. Muggleton Tags: Letter Source Type: research

Current clinical nutrition practices in critically ill patients in Latin America: a multinational observational study
Malnutrition in critically ill adults in the intensive care unit (ICU) is associated with a significantly elevated risk of mortality. Adequate nutrition therapy is crucial to optimise outcomes. Currently, ther... (Source: Critical Care)
Source: Critical Care - August 25, 2017 Category: Intensive Care Authors: Karin Papapietro Vallejo, Carolina M éndez Martínez, Alfredo A. Matos Adames, Vanessa Fuchs-Tarlovsky, Guillermo Carlos Contreras Nogales, Roger Enrique Riofrio Paz, Mario Ignacio Perman, Maria Isabel Toulson Davisson Correia and Dan Linetzky Waitzberg Tags: Research Source Type: research

A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema
Discriminating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) from cardiogenic pulmonary edema (CPE) is often challenging. This systematic review examines studies using biomarkers or ima... (Source: Critical Care)
Source: Critical Care - August 25, 2017 Category: Intensive Care Authors: Kosaku Komiya, Tomohiro Akaba, Yuji Kozaki, Jun-ichi Kadota and Bruce K. Rubin Tags: Research Source Type: research

Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin
Endothelial activation and damage occur early during sepsis, with activated coagulopathy and playing a major role in the pathophysiology of sepsis-induced acute kidney injury (AKI). The aim of this study was t... (Source: Critical Care)
Source: Critical Care - August 25, 2017 Category: Intensive Care Authors: Shinshu Katayama, Shin Nunomiya, Kansuke Koyama, Masahiko Wada, Toshitaka Koinuma, Yuya Goto, Ken Tonai and Jun Shima Tags: Research Source Type: research

Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study
Hyperfibrinolysis is a critical complication in severe trauma. Hyperfibrinolysis is traditionally diagnosed via elevated D-dimer or fibrin/fibrinogen degradation product levels, and recently, using thromboelas... (Source: Critical Care)
Source: Critical Care - August 23, 2017 Category: Intensive Care Authors: Mineji Hayakawa, Kunihiko Maekawa, Shigeki Kushimoto, Hiroshi Kato, Junichi Sasaki, Hiroshi Ogura, Tetsuya Matsuoka, Toshifumi Uejima, Naoto Morimura, Hiroyasu Ishikura, Akiyoshi Hagiwara, Munekazu Takeda, Naoyuki Kaneko, Daizoh Saitoh, Daisuke Kudo, Taka Tags: Research Source Type: research

Recorded time periods of bispectral index values equal to zero predict neurological outcome after out-of-hospital cardiac arrest
Prognostication in out-of-hospital cardiac arrest (OHCA) survivors is often difficult. Recent studies have shown the predictive ability of bispectral index (BIS) monitoring to assist with early neuroprognostic... (Source: Critical Care)
Source: Critical Care - August 22, 2017 Category: Intensive Care Authors: Ward Eertmans, Cornelia Genbrugge, Gilles Haesevoets, Jo Dens, Willem Boer, Frank Jans and Cathy De Deyne Tags: Research Source Type: research

Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury
There is evidence to demonstrate that the coagulopathy which occurs in patients with traumatic brain injury coincides with disseminated intravascular coagulation (DIC). We hypothesized that DIC with increased ... (Source: Critical Care)
Source: Critical Care - August 22, 2017 Category: Intensive Care Authors: Takeshi Wada, Satoshi Gando, Kunihiko Maekaw, Kenichi Katabami, Hisako Sageshima, Mineji Hayakawa and Atsushi Sawamura Tags: Research Source Type: research

Costs and expected gain in lifetime health from intensive care versus general ward care of 30,712 individual patients: a distribution-weighted cost-effectiveness analysis
The objectives of this modelling st... (Source: Critical Care)
Source: Critical Care - August 21, 2017 Category: Intensive Care Authors: Frode Lindemark, Øystein A. Haaland, Reidar Kvåle, Hans Flaatten, Ole F. Norheim and Kjell A. Johansson Tags: Research Source Type: research

The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients
The development of renal and liver dysfunction may be accompanied by initially subtle derangements in the gluconeogenetic function. Discrepantly low glucose levels combined with high lactate levels might indic... (Source: Critical Care)
Source: Critical Care - August 21, 2017 Category: Intensive Care Authors: Pedro Freire Jorge, Nienke Wieringa, Eva de Felice, Iwan C. C. van der Horst, Annemieke Oude Lansink and Maarten W. Nijsten Tags: Research Source Type: research

Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype
Critically ill patients with acute kidney injury (AKI) can be divided into two subphenotypes, resolving or nonresolving, on the basis of the trajectory of serum creatinine. It is unknown if the biology underly... (Source: Critical Care)
Source: Critical Care - August 17, 2017 Category: Intensive Care Authors: Pavan K. Bhatraju, Cassianne Robinson-Cohen, Carmen Mikacenic, Susanna Harju-Baker, Victoria Dmyterko, Natalie S. J. Slivinski, W. Conrad Liles, Jonathan Himmelfarb, Susan R. Heckbert and Mark M. Wurfel Tags: Research Source Type: research

Point-of-care ultrasonography: a practical step in the path to precision in critical care
(Source: Critical Care)
Source: Critical Care - August 16, 2017 Category: Intensive Care Authors: Gentle Sunder Shrestha Tags: Letter Source Type: research

Early troponin I in critical illness and its association with hospital mortality: a cohort study
Troponin I (TnI) is frequently elevated in critical illness, but its interpretation is unclear. Our primary objectives in this study were to evaluate whether TnI is associated with hospital mortality and if th... (Source: Critical Care)
Source: Critical Care - August 16, 2017 Category: Intensive Care Authors: Annemarie B. Docherty, Malcolm Sim, Joao Oliveira, Michael Adlam, Marlies Ostermann, Timothy S. Walsh, John Kinsella and Nazir I. Lone Tags: Research Source Type: research

Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?
Cirrhotic patients are susceptible to sepsis and critical illness-related corticosteroid insufficiency (CIRCI). Dehydroepiandrosterone sulfate (DHEAS) is a corticotropin-dependent adrenal androgen, which has i... (Source: Critical Care)
Source: Critical Care - August 15, 2017 Category: Intensive Care Authors: Ming-Hung Tsai, Hui-Chun Huang, Yun-Shing Peng, Yung-Chang Chen, Ya-Chung Tian, Chih-Wei Yang, Jau-Min Lien, Ji-Tseng Fang, Cheng-Shyong Wu, Sen-Yung Hsieh and Fa-Yauh Lee Tags: Research Source Type: research

Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients
Vasopressin is widely used for vasopressor support in septic shock patients, but experimental evidence suggests that selective V1A agonists are superior. The initial pharmacodynamic effects, pharmacokinetics, and... (Source: Critical Care)
Source: Critical Care - August 15, 2017 Category: Intensive Care Authors: James A. Russell, Jean-Louis Vincent, Anne Louise Kj ølbye, Håkan Olsson, Allan Blemings, Herbert Spapen, Peder Carl, Pierre-Francois Laterre and Lars Grundemar Tags: Research Source Type: research

Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial
Blood glucose control in the intensive care unit (ICU) has the potential to save lives. However, maintaining blood glucose concentrations within a chosen target range is difficult in clinical practice and hold... (Source: Critical Care)
Source: Critical Care - August 14, 2017 Category: Intensive Care Authors: Dieter Mesotten, Jasperina Dubois, Tom Van Herpe, Roosmarijn T. van Hooijdonk, Ruben Wouters, Domien Coart, Pieter Wouters, Aim é Van Assche, Guy Veraghtert, Bart De Moor, Joost Wauters, Alexander Wilmer, Marcus J. Schultz and Greet Van den Berghe Tags: Research Source Type: research