Severe necrotizing soft-tissue infection-associated mortality: Have a look at the computed tomography!
(Source: Critical Care)
Source: Critical Care - January 25, 2022 Category: Intensive Care Authors: S ébastien Tanaka, Michael Thy, Ralph Khoury, Alexy Tran-Dinh, Antoine Khalil and Philippe Montravers Tags: Research Letter Source Type: research

Effects of prone and lateral positioning alternate in high-flow nasal cannula patients with severe COVID-19
(Source: Critical Care)
Source: Critical Care - January 25, 2022 Category: Intensive Care Authors: Yang Chong, Chuanchuan Nan, Wenjing Mu, Changsong Wang, Mingyan Zhao and Kaijiang Yu Tags: Research Letter Source Type: research

Association between hospital and ICU structural factors and patient outcomes in China: a secondary analysis of the National Clinical Improvement System Data in 2019
This study was designed to investigate how difference... (Source: Critical Care)
Source: Critical Care - January 21, 2022 Category: Intensive Care Authors: Zhen Li, Xudong Ma, Sifa Gao, Qi Li, Hongbo Luo, Jianhua Sun, Wei Du, Longxiang Su, Lu Wang, Qing Zhang, Zunzhu Li, Xiang Zhou and Dawei Liu Tags: Research Source Type: research

Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients
Vitamin C has potential protective effects through antioxidant and anti-inflammatory properties. However, the effect of vitamin C supplementation on microvascular function and peripheral tissue perfusion in hu... (Source: Critical Care)
Source: Critical Care - January 21, 2022 Category: Intensive Care Authors: Jean-R émi Lavillegrand, Lisa Raia, Tomas Urbina, Geoffroy Hariri, Paul Gabarre, Vincent Bonny, Naïke Bigé, Jean-Luc Baudel, Arnaud Bruneel, Thierry Dupre, Bertrand Guidet, Eric Maury and Hafid Ait-Oufella Tags: Research Source Type: research

Omega-6 sparing effects of parenteral lipid emulsions —an updated systematic review and meta-analysis on clinical outcomes in critically ill patients
Parenteral lipid emulsions in critical care are traditionally based on soybean oil (SO) and rich in pro-inflammatory omega-6 fatty acids (FAs). Parenteral nutrition (PN) strategies with the aim of reducing ome... (Source: Critical Care)
Source: Critical Care - January 19, 2022 Category: Intensive Care Authors: Quirin Notz, Zheng-Yii Lee, Johannes Menger, Gunnar Elke, Aileen Hill, Peter Kranke, Daniel Roeder, Christopher Lotz, Patrick Meybohm, Daren K. Heyland and Christian Stoppe Tags: Research Source Type: research

Correction to: Vital-sign circadian rhythms in patients prior to discharge from an ICU: a retrospective observational analysis of routinely recorded physiological data
(Source: Critical Care)
Source: Critical Care - January 17, 2022 Category: Intensive Care Authors: Shaun Davidson, Mauricio Villarroel, Mirae Harford, Eoin Finnegan, Joao Jorge, Duncan Young, Peter Watkinson and Lionel Tarassenko Tags: Correction Source Type: research

Value of variation of end-tidal carbon dioxide for predicting fluid responsiveness during the passive leg raising test in patients with mechanical ventilation: a systematic review and meta-analysis
The ability of end-tidal carbon dioxide ( ΔEtCO2) for predicting fluid responsiveness has been extensively studied with conflicting results. This meta-analysis aimed to explore the value of ΔEtCO2 for predictin... (Source: Critical Care)
Source: Critical Care - January 14, 2022 Category: Intensive Care Authors: Haijun Huang, Chenxia Wu, Qinkang Shen, Yixin Fang and Hua Xu Tags: Research Source Type: research

The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis
Sepsis, the dysregulated host response to infection, triggers abnormal pro-coagulant and pro-inflammatory host responses. Limitations in early disease intervention highlight the need for effective diagnostic a... (Source: Critical Care)
Source: Critical Care - January 14, 2022 Category: Intensive Care Authors: Vanessa Catenacci, Fatima Sheikh, Kush Patel and Alison E. Fox-Robichaud Tags: Research Source Type: research

Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study
Timely administration of antibiotics is one of the most important interventions in reducing mortality in sepsis. However, administering antibiotics within a strict time threshold in all patients suspected with... (Source: Critical Care)
Source: Critical Care - January 13, 2022 Category: Intensive Care Authors: Yunjoo Im, Danbee Kang, Ryoung-Eun Ko, Yeon Joo Lee, Sung Yoon Lim, Sunghoon Park, Soo Jin Na, Chi Ryang Chung, Mi Hyeon Park, Dong Kyu Oh, Chae-Man Lim and Gee Young Suh Tags: Research Source Type: research

Protein intake and outcome of critically ill patients: analysis of a large international database using piece-wise exponential additive mixed models
Proteins are an essential part of medical nutrition therapy in critically ill patients. Guidelines almost universally recommend a high protein intake without robust evidence supporting its use. (Source: Critical Care)
Source: Critical Care - January 11, 2022 Category: Intensive Care Authors: Wolfgang H. Hartl, Philipp Kopper, Andreas Bender, Fabian Scheipl, Andrew G. Day, Gunnar Elke and Helmut K üchenhoff Tags: Research Source Type: research

Choosing the right reference cohort for assessing outcome of venovenous ECMO
(Source: Critical Care)
Source: Critical Care - January 10, 2022 Category: Intensive Care Authors: Alexander Supady, Paul M. Biever, Dawid L. Staudacher and Tobias Wengenmayer Tags: Letter Source Type: research

Awake prone positioning on diaphragmatic function: Really bad or maybe good?
(Source: Critical Care)
Source: Critical Care - December 29, 2021 Category: Intensive Care Authors: Basang Xiao, Yuntao Zhang, Zhuoga Ci, Dandan Shi and Hangyong He Tags: Letter Source Type: research

Predictors for extubation failure in COVID-19 patients using a machine learning approach
In this study, we aim to identify predictors for extubation failure in critically ill patients with COVID-19. (Source: Critical Care)
Source: Critical Care - December 27, 2021 Category: Intensive Care Authors: Lucas M. Fleuren, Tariq A. Dam, Michele Tonutti, Daan P. de Bruin, Robbert C. A. Lalisang, Diederik Gommers, Olaf L. Cremer, Rob J. Bosman, Sander Rigter, Evert-Jan Wils, Tim Frenzel, Dave A. Dongelmans, Remko de Jong, Marco Peters, Marlijn J. A. Kamps, D Tags: Research Source Type: research

Demystifying machine learning for mortality prediction
(Source: Critical Care)
Source: Critical Care - December 23, 2021 Category: Intensive Care Authors: J. M. Smit, M. E. van Genderen, M. J. T. Reinders, D. A. M. P. J. Gommers, J. H. Krijthe and J. Van Bommel Tags: Letter Source Type: research

Surface EMG-based quantification of inspiratory effort: a quantitative comparison with Pes
Inspiratory patient effort under assisted mechanical ventilation is an important quantity for assessing patient –ventilator interaction and recognizing over and under assistance. An established clinical standar... (Source: Critical Care)
Source: Critical Care - December 20, 2021 Category: Intensive Care Authors: Jan Gra ßhoff, Eike Petersen, Franziska Farquharson, Max Kustermann, Hans-Joachim Kabitz, Philipp Rostalski and Stephan Walterspacher Tags: Research Source Type: research