Factors associated with recurrence and mortality in central line-associated bloodstream infections: a retrospective cohort study
Central line-associated bloodstream infections (CLABSIs) are associated with increased mortality, hospital length of stay, and cost. Antimicrobial treatment guidelines for CLABSIs are primarily based on expert... (Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Luis E Huerta, George E Nelson, Thomas G Stewart and Todd W Rice Tags: Research Source Type: research

Differences in attitudes towards end-of-life care among intensivists, oncologists and prosecutors in Brazil: a nationwide survey
(Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Jo ão Gabriel Rosa Ramos, Roberto D’Oliveira Vieira, Fernanda Correia Tourinho, Andre Ismael, Diaulas Costa Ribeiro, Humberto Jacques de Medeiro and Daniel Neves Forte Tags: Letter Source Type: research

Endocan, sepsis, pneumonia, and acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the facto... (Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Nathalie De Freitas Caires, Alexandre Gaudet, Lucie Portier, Anne Tsicopoulos, Daniel Mathieu and Philippe Lassalle Tags: Review Source Type: research

The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients
Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear whether the therapy could provide benefit for highly sele... (Source: Critical Care)
Source: Critical Care - October 26, 2018 Category: Intensive Care Authors: Nattachai Srisawat, Somkanya Tungsanga, Nuttha Lumlertgul, Chalermchai Komaenthammasophon, Sadudee Peerapornratana, Nicha Thamrongsat, Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Kriang Tungsanga and John A. Kellum Tags: Research Source Type: research

High protein intake during the early phase of critical illness: yes or no?
The rationale for the provision of nitrogen from proteins given via the enteral route or from intravenous amino acids is to boost the synthesis of muscle proteins, and thereby to limit the severity of intensiv... (Source: Critical Care)
Source: Critical Care - October 25, 2018 Category: Intensive Care Authors: Jean-Charles Preiser Tags: Viewpoint Source Type: research

Volutrauma and atelectrauma: which is worse?
(Source: Critical Care)
Source: Critical Care - October 25, 2018 Category: Intensive Care Authors: Luciano Gattinoni, Michael Quintel and John J. Marini Tags: Editorial Source Type: research

Electrical impedance tomography in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is a clinical entity that acutely affects the lung parenchyma, and is characterized by diffuse alveolar damage and increased pulmonary vascular permeability. Currentl... (Source: Critical Care)
Source: Critical Care - October 25, 2018 Category: Intensive Care Authors: M Consuelo Bachmann, Caio Morais, Guillermo Bugedo, Alejandro Bruhn, Arturo Morales, Jo ão B Borges, Eduardo Costa and Jaime Retamal Tags: Review Source Type: research

Extracorporeal techniques for the treatment of critically ill patients with sepsis beyond conventional blood purification therapy: the promises and the pitfalls
Sepsis is one of the leading causes of morbidity and mortality worldwide. It is characterized by a dysregulated immune response to infections that results in life-threatening organ dysfunction and even death. ... (Source: Critical Care)
Source: Critical Care - October 25, 2018 Category: Intensive Care Authors: Ghada Ankawi, Mauro Neri, Jingxiao Zhang, Andrea Breglia, Zaccaria Ricci and Claudio Ronco Tags: Review Source Type: research

Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis
Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary ext... (Source: Critical Care)
Source: Critical Care - October 11, 2018 Category: Intensive Care Authors: Jing Li Tags: Commentary Source Type: research

Epidemiology of subsequent bloodstream infections in the ICU
Subsequent bloodstream infections (sBSI) occur with a delay after removal of the intravascular catheter (IVC) whose tip revealed microbial growth. Here we describe the epidemiology of sBSI in the intensive car... (Source: Critical Care)
Source: Critical Care - October 11, 2018 Category: Intensive Care Authors: Niccol ò Buetti, Elia Lo Priore, Rami Sommerstein, Andrew Atkinson, Andreas Kronenberg and Jonas Marschall Tags: Letter Source Type: research

New perspectives on substituted relational autonomy for shared decision-making in critical care
In critical care when unconscious patients are assisted by machines, humanity is mainly ensured by respect for autonomy, realised through advance directives or, mostly, reconstructed by cooperation with relati... (Source: Critical Care)
Source: Critical Care - October 11, 2018 Category: Intensive Care Authors: Nicola Grignoli, Valentina Di Bernardo and Roberto Malacrida Tags: Viewpoint Source Type: research

The meaning of blood pressure
Measurement of arterial pressure is one of the most basic elements of patient management. Arterial pressure is determined by the volume ejected by the heart into the arteries, the elastance of the walls of the... (Source: Critical Care)
Source: Critical Care - October 11, 2018 Category: Intensive Care Authors: S. Magder Tags: Review Source Type: research

Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis and is defined by organ failure and high rates of short-term mortality. Patients with ACLF are managed with multiorgan support in the... (Source: Critical Care)
Source: Critical Care - October 10, 2018 Category: Intensive Care Authors: Cornelius Engelmann, Karen Louise Thomsen, Nekisa Zakeri, Mohammed Sheikh, Banwari Agarwal, Rajiv Jalan and Rajeshwar P. Mookerjee Tags: Research Source Type: research

Association between diuretics and successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury
Despite aggressive application of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), there is no consensus on diuretic therapy when discontinuation of CRRT i... (Source: Critical Care)
Source: Critical Care - October 10, 2018 Category: Intensive Care Authors: Junseok Jeon, Do Hee Kim, Song In Baeg, Eun Jeong Lee, Chi Ryang Chung, Kyeongman Jeon, Jung Eun Lee, Wooseong Huh, Gee Young Suh, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh and Hye Ryoun Jang Tags: Research Source Type: research

Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children
Research on acute kidney injury (AKI) has focused on identifying early biomarkers. However, whether AKI could be diagnosed in the absence of the classic signs of clinical AKI and whether the condition of subcl... (Source: Critical Care)
Source: Critical Care - October 10, 2018 Category: Intensive Care Authors: Fang Fang, Xiaohan Hu, Xiaomei Dai, Sanfeng Wang, Zhenjiang Bai, Jiao Chen, Jian Pan, Xiaozhong Li, Jian Wang and Yanhong Li Tags: Research Source Type: research

Bougie-in-channel intubation technique
(Source: Critical Care)
Source: Critical Care - October 6, 2018 Category: Intensive Care Authors: Kay Choong See, Melanie Estaras, Rolando Capistrano, Sui Hua Wong, Juliet Sahagun and Juvel Taculod Tags: Letter Source Type: research

Noise in the intensive care unit and its influence on sleep quality: a multicenter observational study in Dutch intensive care units
High noise levels in the intensive care unit (ICU) are a well-known problem. Little is known about the effect of noise on sleep quality in ICU patients. The study aim is to determine the effect of noise on sub... (Source: Critical Care)
Source: Critical Care - October 5, 2018 Category: Intensive Care Authors: Koen S. Simons, Eva Verweij, Paul M. C. Lemmens, Sam Jelfs, Munhum Park, Peter E. Spronk, Johannes P. C. Sonneveld, Hilde-Marieken Feijen, Marijke S. van der Steen, Armin G. Kohlrausch, Mark van den Boogaard and Cornelis P. C. de Jager Tags: Research Source Type: research

An early increase in endothelial protein C receptor is associated with excess mortality in pneumococcal pneumonia with septic shock in the ICU
This study investigated changes in plasma level of soluble endothelial protein C receptor (sEPCR) in association with outcome in patients with septic shock. We explored sEPCR for early sepsis prognosis assessm... (Source: Critical Care)
Source: Critical Care - October 5, 2018 Category: Intensive Care Authors: Agn ès Chapelet, Yohann Foucher, Nathalie Gérard, Christophe Rousseau, Olivier Zambon, Cédric Bretonnière, Jean-Paul Mira, Béatrice Charreau and Christophe Guitton Tags: Research Source Type: research

Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients
(Source: Critical Care)
Source: Critical Care - October 5, 2018 Category: Intensive Care Authors: Matteo Bassetti, Alessandro Russo, Elda Righi, Elisabetta Dolso, Maria Merelli, Nicola Cannarsa, Federica D ’Aurizio, Assunta Sartor and Francesco Curcio Tags: Letter Source Type: research

Focal ischemic stroke leads to lung injury and reduces alveolar macrophage phagocytic capability in rats
Ischemic stroke causes brain inflammation, which we postulate may result in lung damage. Several studies have focused on stroke-induced immunosuppression and lung infection; however, the possibility that strok... (Source: Critical Care)
Source: Critical Care - October 5, 2018 Category: Intensive Care Authors: Cynthia S. Samary, Alane B. Ramos, L ígia A. Maia, Nazareth N. Rocha, Cíntia L. Santos, Raquel F. Magalhães, Amanda L. Clevelario, Pedro M. Pimentel-Coelho, Rosália Mendez-Otero, Fernanda F. Cruz, Vera L. Capelozzi, Tatiana P. T. Ferreira, Thea Koch, Tags: Research Source Type: research

In vivo quantification of rolling and adhered leukocytes in human sepsis
The use of in vivo videomicroscopy at the bedside has demonstrated microcirculatory flow disturbances in sepsis. The ability of in vivo videomicroscopy to detect changes in the prevalence of rolling and adhere... (Source: Critical Care)
Source: Critical Care - September 30, 2018 Category: Intensive Care Authors: Bjorn K. Fabian-Jessing, Michael J. Massey, Michael R. Filbin, Peter C. Hou, Henry E. Wang, Hans Kirkegaard, Donald M. Yealy, William C. Aird, John A. Kellum, Derek C. Angus and Nathan I. Shapiro Tags: Research Source Type: research

Comparison of outcomes between vertical and transverse skin incisions in percutaneous tracheostomy for critically ill patients: a retrospective cohort study
Percutaneous tracheostomy (PT) is a common procedure in critical care medicine. No definite clinical practice guidelines recommended on the choice of the direction of skin incision, vertical or transverse for ... (Source: Critical Care)
Source: Critical Care - September 30, 2018 Category: Intensive Care Authors: Sung Yoon Lim, Won Gun Kwack, Youlim Kim, Yeon Joo Lee, Jong Sun Park, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee and Young-Jae Cho Tags: Research Source Type: research

The role of bile acids in nutritional support
Nutritional support continues to receive much attention as a possible intervention to prevent loss of lean tissue mass, promote recovery and re-establish proper immune function in critical care patients. Yet t... (Source: Critical Care)
Source: Critical Care - September 30, 2018 Category: Intensive Care Authors: Gustav van Niekerk, Tanja Davis, Willem de Villiers and Anna-Mart Engelbrecht Tags: Viewpoint Source Type: research

The interleukin-27 -964A > G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis
Previous studies have identified critical roles of IL-27 in the pathological mechanisms of sepsis, and blockade of IL-27 may be a promising alternative therapy for sepsis. The purpose of this study was to eval... (Source: Critical Care)
Source: Critical Care - September 30, 2018 Category: Intensive Care Authors: Junbing He, Quanfu Zhang, Wenying Zhang, Feng Chen, Tian Zhao, Yao Lin, Jia Li, Yansong Liu, Yuchun Liu and Yiming Shao Tags: Research Source Type: research

Can a simple chemical help to both prevent and treat sepsis
(Source: Critical Care)
Source: Critical Care - September 29, 2018 Category: Intensive Care Authors: Anitra C. Carr Tags: Letter Source Type: research

Is protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?
(Source: Critical Care)
Source: Critical Care - September 22, 2018 Category: Intensive Care Authors: Jan Gunst and Michael P. Casaer Tags: Letter Source Type: research

The path to great pediatric septic shock outcomes
(Source: Critical Care)
Source: Critical Care - September 22, 2018 Category: Intensive Care Authors: Stefanie G. Ames, Christopher M. Horvat, Arno Zaritsky and Joseph A. Carcillo Tags: Editorial Source Type: research

Endotracheal tube-mounted camera-assisted intubation versus conventional intubation in intensive care: a prospective, randomised trial (VivaITN)
For critically ill patients, effective airway management with a high first-attempt success rate for endotracheal intubation is essential to prevent hypoxic complications during securing of the airway. Video gu... (Source: Critical Care)
Source: Critical Care - September 22, 2018 Category: Intensive Care Authors: J örn Grensemann, Lars Eichler, Nuowei Wang, Dominik Jarczak, Marcel Simon and Stefan Kluge Tags: Research Source Type: research

Extracorporeal membrane oxygenation offers long-term survival in childhood leukemia and acute respiratory failure
(Source: Critical Care)
Source: Critical Care - September 22, 2018 Category: Intensive Care Authors: Gerard Cortina, Nikolaus Neu, Gabriele Kropshofer, Bernhard Meister, Uwe Klingkowski and Roman Crazzolara Tags: Letter Source Type: research

The association of clinical frailty with outcomes of patients reviewed by rapid response teams: an international prospective observational cohort study
Frailty is a state of vulnerability to poor resolution of homeostasis after a stressor event and is strongly associated with adverse outcomes. Therefore, the assessment of frailty may be an essential part of e... (Source: Critical Care)
Source: Critical Care - September 22, 2018 Category: Intensive Care Authors: Ralph K. L. So, Jonathan Bannard-Smith, Chris P. Subbe, Daryl A. Jones, Joost van Rosmalen and Geoffrey K. Lighthall Tags: Research Source Type: research

Studies should fully report on variables that determine the dynamics and the temperature gradients during hypothermia
(Source: Critical Care)
Source: Critical Care - September 21, 2018 Category: Intensive Care Authors: Horia-Nicolai Teodorescu Tags: Letter Source Type: research

Hyperoxia effects on intensive care unit mortality: a retrospective pragmatic cohort study
(Source: Critical Care)
Source: Critical Care - September 21, 2018 Category: Intensive Care Authors: Mathilde Ruggiu, Nadia Aissaoui, Julien Nael, Caroline Haw-Berlemont, Bertrand Herrmann, Jean-Loup Augy, Sofia Ortuno, Damien Vimp ère, Jean-Luc Diehl, Clotilde Bailleul and Emmanuel Guerot Tags: Letter Source Type: research

Gender differences in the use of atypical antipsychotic medications for ICU delirium
(Source: Critical Care)
Source: Critical Care - September 21, 2018 Category: Intensive Care Authors: Kunal Karamchandani, Robert S. Schoaps, Jillian Printz, Jeffrey M. Kowaleski and Zyad J. Carr Tags: Letter Source Type: research

Regional expiratory time constants in severe respiratory failure estimated by electrical impedance tomography: a feasibility study
Electrical impedance tomography (EIT) has been used to guide mechanical ventilation in ICU patients with lung collapse. Its use in patients with obstructive pulmonary diseases has been rare since obstructions ... (Source: Critical Care)
Source: Critical Care - September 21, 2018 Category: Intensive Care Authors: Christian Karagiannidis, Andreas D. Waldmann, P éter L. Róka, Tina Schreiber, Stephan Strassmann, Wolfram Windisch and Stephan H. Böhm Tags: Research Source Type: research

Categorization of post-cardiac arrest patients according to the pattern of amplitude-integrated electroencephalography after return of spontaneous circulation
Continuous electroencephalography (cEEG), interpreted by an experienced neurologist, has been reported to be useful in predicting neurological outcome in adult patients post cardiac arrest. Amplitude-integrate... (Source: Critical Care)
Source: Critical Care - September 20, 2018 Category: Intensive Care Authors: Kazuhiro Sugiyama, Kazuki Miyazaki, Takuto Ishida, Takahiro Tanabe and Yuichi Hamabe Tags: Research Source Type: research

The relationship between the decrease in haemoglobin concentration and the volume of fluids administered during resuscitation from septic shock may not be so “weak”
(Source: Critical Care)
Source: Critical Care - September 20, 2018 Category: Intensive Care Authors: Azriel Perel Tags: Letter Source Type: research

Costs, outcome and cost-effectiveness of neurocritical care: a multi-center observational study
Neurocritical illness is a growing healthcare problem with profound socioeconomic effects. We assessed differences in healthcare costs and long-term outcome for different forms of neurocritical illnesses treat... (Source: Critical Care)
Source: Critical Care - September 20, 2018 Category: Intensive Care Authors: R. Raj, S. Bendel, M. Reinikainen, S. Hoppu, R. Laitio, T. Ala-Kokko, S. Curtze and M. B. Skrifvars Tags: Research Source Type: research

When to initiate ECMO with low likelihood of success
(Source: Critical Care)
Source: Critical Care - September 19, 2018 Category: Intensive Care Authors: Graeme MacLaren Tags: Editorial Source Type: research

Refractory septic shock: our pragmatic approach
Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mort... (Source: Critical Care)
Source: Critical Care - September 19, 2018 Category: Intensive Care Authors: Prashanth Nandhabalan, Nicholas Ioannou, Christopher Meadows and Duncan Wyncoll Tags: Viewpoint Source Type: research

Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risk markers for sepsis survival
Nitric oxide (NO) regulates processes involved in sepsis progression, including vascular and immune function. NO is generated by nitric oxide synthases (NOS) from L-arginine. Cellular L-arginine uptake is inhi... (Source: Critical Care)
Source: Critical Care - September 19, 2018 Category: Intensive Care Authors: Martin Sebastian Winkler, Axel Nierhaus, Gilbert R ösler, Susanne Lezius, Olaf Harlandt, Edzard Schwedhelm, Rainer H. Böger and Stefan Kluge Tags: Research Source Type: research

Ethical aspects of sudden cardiac arrest research using observational data: a narrative review
Sudden cardiac arrest (SCA) accounts for half of all cardiac deaths in Europe. In recent years, large-scale SCA registries have been set up to enable observational studies into risk factors and the effect of t... (Source: Critical Care)
Source: Critical Care - September 13, 2018 Category: Intensive Care Authors: Marieke A. R. Bak, Marieke T. Blom, Hanno L. Tan and Dick L. Willems Tags: Review Source Type: research

Massive increase in monocyte HLA-DR expression can be used to discriminate between septic shock and hemophagocytic lymphohistiocytosis-induced shock
(Source: Critical Care)
Source: Critical Care - September 11, 2018 Category: Intensive Care Authors: Solenn Remy, Morgane Gossez, Alexandre Belot, Jack Hayman, Aurelie Portefaix, Fabienne Venet, Etienne Javouhey and Guillaume Monneret Tags: Letter Source Type: research

We should avoid the term “fluid overload”
(Source: Critical Care)
Source: Critical Care - September 11, 2018 Category: Intensive Care Authors: Jean-Louis Vincent and Michael R. Pinsky Tags: Editorial Source Type: research

Women in Intensive Care study: a preliminary assessment of international data on female representation in the ICU physician workforce, leadership and academic positions
Despite increasing female enrolment into medical schools, persistent gender gaps exist in the physician workforce. There are limited published data on female representation in the critical care medicine workfo... (Source: Critical Care)
Source: Critical Care - September 10, 2018 Category: Intensive Care Authors: Bala Venkatesh, Sangeeta Mehta, Derek C. Angus, Simon Finfer, Flavia R. Machado, John Marshall, Imogen Mitchell, Sandra Peake and Janice L. Zimmerman Tags: Research Source Type: research

Value of variation index of inferior vena cava diameter in predicting fluid responsiveness in patients with circulatory shock receiving mechanical ventilation: a systematic review and meta-analysis
Respiratory variations in the inferior vena cava diameter ( ΔIVCD) have been studied extensively with respect to their value in predicting fluid responsiveness, but the results are conflicting. The aim of this ... (Source: Critical Care)
Source: Critical Care - August 21, 2018 Category: Intensive Care Authors: Haijun Huang, Qinkang Shen, Yafen Liu, Hua Xu and Yixin Fang Tags: Research Source Type: research

Predicting the requirement for renal replacement therapy in intensive care patients with sepsis
(Source: Critical Care)
Source: Critical Care - August 20, 2018 Category: Intensive Care Authors: Axel Nierhaus, Frank Bloos, Darius Cameron Wilson, Gunnar Elke and Patrick Meybohm Tags: Letter Source Type: research

Reassessing access to intensive care using an estimate of the population incidence of critical illness
The consistently observed male predominance of patients in intensive care units (ICUs) has raised concerns about gender-based disparities in ICU access. Comparing rates of ICU admission requires choosing a nor... (Source: Critical Care)
Source: Critical Care - August 20, 2018 Category: Intensive Care Authors: Allan Garland, Kendiss Olafson, Clare D. Ramsey, Marina Yogendranc and Randall Fransoo Tags: Research Source Type: research

Investigation of microcirculation in patients with venoarterial extracorporeal membrane oxygenation life support
Microcirculatory dysfunction develops in both septic and cardiogenic shock patients, and it is associated with poor prognosis in patients with septic shock. Information on the association between microcirculat... (Source: Critical Care)
Source: Critical Care - August 19, 2018 Category: Intensive Care Authors: Yu-Chang Yeh, Chen-Tse Lee, Chih-Hsien Wang, Yu-Kang Tu, Chien-Heng Lai, Yin-Chin Wang, Anne Chao, Chi-Hsiang Huang, Ya-Jung Cheng and Yih-Sharng Chen Tags: Research Source Type: research

Feasibility of biventricular 3D transthoracic echocardiography in the critically ill and comparison with conventional parameters
Transthoracic 3D cardiac analysis is enticing in its potential simplicity and wealth of data available. It has been suggested to be accurate vs magnetic resonance imaging in relatively stable patients, but fea... (Source: Critical Care)
Source: Critical Care - August 19, 2018 Category: Intensive Care Authors: Sam Orde, Michel Slama, Nicola Stanley, Stephen Huang and Anthony Mclean Tags: Research Source Type: research

Loop diuretic use in patients with AKI: different severity, different response
(Source: Critical Care)
Source: Critical Care - August 19, 2018 Category: Intensive Care Authors: Yanfei Shen and Muying Wu Tags: Letter Source Type: research