Early EEG for outcome prediction of postanoxic coma: prospective cohort study with cost-minimization analysis
We recently showed that electroencephalography (EEG) patterns within the first 24  hours robustly contribute to multimodal prediction of poor or good neurological outcome of comatose patients after cardiac arre... (Source: Critical Care)
Source: Critical Care - May 15, 2017 Category: Intensive Care Authors: Lotte Sondag, Barry J. Ruijter, Marleen C. Tjepkema-Cloostermans, Albertus Beishuizen, Frank H. Bosch, Janine A. van Til, Michel J. A. M. van Putten and Jeannette Hofmeijer Source Type: research

Pre-admission functional status impacts the performance of the APACHE IV model of mortality prediction in critically ill patients
Functional status (FS) before intensive care unit (ICU) admission is associated with short-term and long-term outcomes among critically ill patients. However, measures of FS are generally not integrated into I... (Source: Critical Care)
Source: Critical Care - May 15, 2017 Category: Intensive Care Authors: James S. Krinsley, Thomas Wasser, Gina Kang and Sean M. Bagshaw Source Type: research

Erratum to: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions
(Source: Critical Care)
Source: Critical Care - May 15, 2017 Category: Intensive Care Authors: Crist óbal León, Sergio Ruiz-Santana, Pedro Saavedra, Carmen Castro, Ana Loza, Ismail Zakariya, Alejandro Úbeda, Manuel Parra, Desirée Macías, José Ignacio Tomás, Antonio Rezusta, Alejandro Rodríguez, Frederic Gómez and Estrella Martín-Mazuelos Source Type: research

Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis
A decrease in blood lactate levels (Lac)>10% during the first hours of resuscitation in sepsis is associated with better outcomes, but the mechanisms are unclear. Our objective was to investigate the relation... (Source: Critical Care)
Source: Critical Care - May 12, 2017 Category: Intensive Care Authors: Thiago Domingos Corr êa, Adriano José Pereira, Sebastian Brandt, Madhusudanarao Vuda, Siamak Djafarzadeh, Jukka Takala and Stephan Mathias Jakob Source Type: research

Association between fluid intake and mortality in critically ill patients with negative fluid balance: a retrospective cohort study
Compared to positive fluid balance (FB), negative FB is associated with improved clinical outcomes in critically ill patients. However, as to whether achieving more negative FB can further improve outcomes has... (Source: Critical Care)
Source: Critical Care - May 12, 2017 Category: Intensive Care Authors: Yanfei Shen, Xinmei Huang and Weimin Zhang Source Type: research

Understanding the null hypothesis (H0) in non-inferiority trials
(Source: Critical Care)
Source: Critical Care - May 6, 2017 Category: Intensive Care Authors: Jihad Mallat Source Type: research

A brief comment on vaccinations for opportunistic microorganisms
(Source: Critical Care)
Source: Critical Care - May 5, 2017 Category: Intensive Care Authors: Ferhat Arslan and Haluk Vahabo ğlu Source Type: research

Blood pressure deficits in acute kidney injury: not all about the mean arterial pressure?
Acute kidney injury (AKI) is associated with increased morbidity and mortality. Although there are many causes of AKI, it is known that patients undergoing high-risk surgery are known to be at significant risk... (Source: Critical Care)
Source: Critical Care - May 4, 2017 Category: Intensive Care Authors: Lui G. Forni and Michael Joannidis Source Type: research

Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine
(Source: Critical Care)
Source: Critical Care - May 4, 2017 Category: Intensive Care Authors: Sangeeta Mehta, John Granton, Anthony C. Gordon, Deborah J. Cook, Stephen Lapinsky, Gary Newton, Kris Bandayrel, Anjuli Little, Chuin Siau, Dieter Ayers, Joel Singer, Terry C. K. Lee, Keith R. Walley, Michelle Storms, D. James Cooper, Cheryl L. Holmes & h Source Type: research

Blood pressure deficits in acute kidney injury: not all about the mean arterial pressure?
Acute kidney injury (AKI) is associated with increased morbidity and mortality. Although there are many causes of AKI, it is known that patients undergoing high-risk surgery are known to be at significant risk... (Source: Critical Care)
Source: Critical Care - May 4, 2017 Category: Intensive Care Authors: Lui G. Forni and Michael Joannidis Source Type: research

Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine
(Source: Critical Care)
Source: Critical Care - May 4, 2017 Category: Intensive Care Authors: Sangeeta Mehta, John Granton, Anthony C. Gordon, Deborah J. Cook, Stephen Lapinsky, Gary Newton, Kris Bandayrel, Anjuli Little, Chuin Siau, Dieter Ayers, Joel Singer, Terry C. K. Lee, Keith R. Walley, Michelle Storms, D. James Cooper, Cheryl L. Holmes & h Source Type: research

Bacteriophage lysins as antibacterials
(Source: Critical Care)
Source: Critical Care - May 3, 2017 Category: Intensive Care Authors: Umender Sharma and Vivek D. Paul Source Type: research

Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)
Fluid therapy in severely malnourished children is hypothesized to be deleterious owing to compromised cardiac function. We evaluated World Health Organization (WHO) fluid resuscitation guidelines for hypovola... (Source: Critical Care)
Source: Critical Care - May 3, 2017 Category: Intensive Care Authors: Nchafatso Obonyo, Bernadette Brent, Peter Olupot-Olupot, Michael Boele van Hensbroek, Irene Kuipers, Sidney Wong, Kenji Shiino, Jonathan Chan, John Fraser, Job B. M. van Woensel and Kathryn Maitland Source Type: research

Bacteriophage lysins as antibacterials
(Source: Critical Care)
Source: Critical Care - May 3, 2017 Category: Intensive Care Authors: Umender Sharma and Vivek D. Paul Source Type: research

Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia
Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic t... (Source: Critical Care)
Source: Critical Care - April 19, 2017 Category: Intensive Care Authors: Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Anand Kumar, Sachin Yende, Derek C. Angus and Brent W. Winston Source Type: research

New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as... (Source: Critical Care)
Source: Critical Care - April 14, 2017 Category: Intensive Care Authors: Frank Kroschinsky, Friedrich St ölzel, Simone von Bonin, Gernot Beutel, Matthias Kochanek, Michael Kiehl and Peter Schellongowski Source Type: research

Early predictors of poor outcome after out-of-hospital cardiac arrest
Early identification of predictors for a poor long-term outcome in patients who survive the initial phase of out-of-hospital cardiac arrest (OHCA) may facilitate future clinical research, the process of care a... (Source: Critical Care)
Source: Critical Care - April 13, 2017 Category: Intensive Care Authors: Louise Martinell, Niklas Nielsen, Johan Herlitz, Thomas Karlsson, Janneke Horn, Matt P. Wise, Johan Und én and Christian Rylander Source Type: research

Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model
Hypoxic ischemic brain injury (HIBI) after cardiac arrest (CA) is a leading cause of mortality and long-term neurologic disability in survivors. The pathophysiology of HIBI encompasses a heterogeneous cascade ... (Source: Critical Care)
Source: Critical Care - April 13, 2017 Category: Intensive Care Authors: Mypinder S. Sekhon, Philip N. Ainslie and Donald E. Griesdale Source Type: research

Feasibility and safety of whole-body vibration therapy in intensive care patients
(Source: Critical Care)
Source: Critical Care - April 13, 2017 Category: Intensive Care Authors: Peter Alter, Tobias Boeselt, Christoph Nell, Marc Spielmanns, Klaus Kenn and A. Rembert Koczulla Source Type: research

Erratum to: Pre-hospital management of mass casualty civilian shootings: a systematic literature review
(Source: Critical Care)
Source: Critical Care - April 13, 2017 Category: Intensive Care Authors: Conor D. A. Turner, David J. Lockey and Marius Rehn Source Type: research

Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis
This study aimed to investigate whether cardiac troponin T (cTnT), cardiac troponin I (cTnI) and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with acute kidney injury (AKI) and nee... (Source: Critical Care)
Source: Critical Care - April 12, 2017 Category: Intensive Care Authors: Ryan Haines, Siobhan Crichton, Jessica Wilson, David Treacher and Marlies Ostermann Source Type: research

Erratum to: Can calculation of energy expenditure based on CO2 measurements replace indirect calorimetry?
(Source: Critical Care)
Source: Critical Care - April 12, 2017 Category: Intensive Care Authors: Taku Oshima, S éverine Graf, Claudia-Paula Heidegger, Laurence Genton, Jérôme Pugin and Claude Pichard Source Type: research

Renal function and oxygenation are impaired early after liver transplantation despite hyperdynamic systemic circulation
Acute kidney injury (AKI) occurs frequently after liver transplantation and is associated with the development of chronic kidney disease and increased mortality. There is a lack of data on renal blood flow (RB... (Source: Critical Care)
Source: Critical Care - April 11, 2017 Category: Intensive Care Authors: Jenny Skytte Larsson, Gudrun Bragadottir, Bengt Redfors and Sven-Erik Ricksten Source Type: research

The future of critical care: renal support in 2027
Since its inception four decades ago, both the clinical and technologic aspects of continuous renal replacement therapy (CRRT) have evolved substantially. Devices now specifically designed for critically ill p... (Source: Critical Care)
Source: Critical Care - April 11, 2017 Category: Intensive Care Authors: William R. Clark, Mauro Neri, Francesco Garzotto, Zaccaria Ricci, Stuart L. Goldstein, Xiaoqiang Ding, Jiarui Xu and Claudio Ronco Source Type: research

The hospital of tomorrow in 10 points
Technology has advanced rapidly in recent years and is continuing to do so, with associated changes in multiple areas, including hospital structure and function. Here we describe in 10 points our vision of som... (Source: Critical Care)
Source: Critical Care - April 11, 2017 Category: Intensive Care Authors: Jean-Louis Vincent and Jacques Creteur Source Type: research

Retinal arterial blood flow and retinal changes in patients with sepsis: preliminary study using fluorescein angiography
Although tissue perfusion is often decreased in patients with sepsis, the relationship between macrohemodynamics and microcirculatory blood flow is poorly understood. We hypothesized that alterations in retina... (Source: Critical Care)
Source: Critical Care - April 10, 2017 Category: Intensive Care Authors: Kristo Erikson, Janne Henrik Liisanantti, Nina Hautala, Juha Koskenkari, Remi Kamakura, Karl Heinz Herzig, Hannu Syrj älä and Tero Ilmari Ala-Kokko Source Type: research

VCO2-derived energy expenditure: do not throw the baby out with the bath water!
(Source: Critical Care)
Source: Critical Care - April 5, 2017 Category: Intensive Care Authors: Sandra N. Stapel, Paul W. G. Elbers and Heleen M. Oudemans-van Straaten Source Type: research

Determinants of the calibration of SAPS II and SAPS 3 mortality scores in intensive care: a European multicenter study
The aim of the Simplified Acute Physiology Score (SAPS) II and SAPS 3 is to predict the mortality of patients admitted to intensive care units (ICUs). Previous studies have suggested that the calibration of th... (Source: Critical Care)
Source: Critical Care - April 4, 2017 Category: Intensive Care Authors: Antoine Poncet, Thomas V. Perneger, Paolo Merlani, Maurizia Capuzzo and Christophe Combescure Source Type: research

Anatomic changes after repair of traumatic bilateral diaphragmatic rupture impede bi-caval dual lumen catheter insertion for veno-venous extracorporeal membrane oxygenation treatment
(Source: Critical Care)
Source: Critical Care - April 4, 2017 Category: Intensive Care Authors: Alexa Hollinger, Daniel Tuchscherer, Jens Bremerich and Martin Siegemund Source Type: research

A path to precision in the ICU
Precision medicine is increasingly touted as a groundbreaking new paradigm in biomedicine. In the ICU, the complexity and ambiguity of critical illness syndromes have been identified as fundamental justificati... (Source: Critical Care)
Source: Critical Care - April 3, 2017 Category: Intensive Care Authors: David M. Maslove, Francois Lamontagne, John C. Marshall and Daren K. Heyland Source Type: research

Lice, rodents, and many hopes: a rare disease in a young refugee
(Source: Critical Care)
Source: Critical Care - April 3, 2017 Category: Intensive Care Authors: Salvatore L. Cutuli, Gennaro De Pascale, Teresa Spanu, Antonio M. Dell ’Anna, Maria G. Bocci, Federico Pallavicini, Fabiola Mancini, Alessandra Ciervo and Massimo Antonelli Source Type: research

Inhaled nitric oxide and acute kidney injury: new insights from observational data
(Source: Critical Care)
Source: Critical Care - March 31, 2017 Category: Intensive Care Authors: Laveena Munshi and Neill K. J. Adhikari Source Type: research

Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation
Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to re... (Source: Critical Care)
Source: Critical Care - March 28, 2017 Category: Intensive Care Authors: Fillipo Corsi, Guillaume Lebreton, Nicolas Br échot, Guillaume Hekimian, Ania Nieszkowska, Jean-Louis Trouillet, Charles-Edouard Luyt, Pascal Leprince, Jean Chastre, Alain Combes and Matthieu Schmidt Source Type: research

Corticosteroids in septic shock: a systematic review and network meta-analysis
Multiple corticosteroids and treatment regimens have been used as adjuncts in the treatment of septic shock. Qualitative and quantitative differences exist at cellular and tissular levels between the different... (Source: Critical Care)
Source: Critical Care - March 28, 2017 Category: Intensive Care Authors: Ben Gibbison, Jos é A. López-López, Julian P. T. Higgins, Tom Miller, Gianni D. Angelini, Stafford L. Lightman and Djillali Annane Source Type: research

Hemoadsorption by CytoSorb in septic patients: a case series
Septic shock, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a highly lethal condition that causes substantial morbidity and mortality among critically il... (Source: Critical Care)
Source: Critical Care - March 27, 2017 Category: Intensive Care Authors: Klaus Kogelmann, Dominik Jarczak, Morten Scheller and Matthias Dr üner Source Type: research

Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA... (Source: Critical Care)
Source: Critical Care - March 26, 2017 Category: Intensive Care Authors: Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pab ón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi and Ilias I. Siempos Source Type: research

Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis
Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), inducers of G1 cell cycle arrest, are two recently discovered good biomarkers for early diagnosis of acu... (Source: Critical Care)
Source: Critical Care - March 25, 2017 Category: Intensive Care Authors: Hui-Miao Jia, Li-Feng Huang, Yue Zheng and Wen-Xiong Li Source Type: research

Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study
The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in ea... (Source: Critical Care)
Source: Critical Care - March 24, 2017 Category: Intensive Care Authors: Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller and Philipp Schuetz Source Type: research

Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study
The aim was to determine predictors of hospital and 1-year mortality in patients with intensive care unit (ICU)-treated refractory status epilepticus (RSE) in a population-based study. (Source: Critical Care)
Source: Critical Care - March 23, 2017 Category: Intensive Care Authors: Anne-Mari Kantanen, Reetta K älviäinen, Ilkka Parviainen, Marika Ala-Peijari, Tom Bäcklund, Juha Koskenkari, Ruut Laitio and Matti Reinikainen Source Type: research

What is the risk of acquiring bacteria from prior intensive care unit bed occupants?
(Source: Critical Care)
Source: Critical Care - March 22, 2017 Category: Intensive Care Authors: Vincenzo Russotto, Andrea Cortegiani, Santi Maurizio Raineri, Pasquale Iozzo, Cesare Gregoretti and Antonino Giarratano Source Type: research

Intestinal T lymphocyte homing is associated with gastric emptying and epithelial barrier function in critically ill: a prospective observational study
Impaired gastric emptying is common in critically ill patients. Intestinal dysmotility, a major cause of feed intolerance, may foster infectious complications due to mucosal barrier disruption. However, little... (Source: Critical Care)
Source: Critical Care - March 22, 2017 Category: Intensive Care Authors: Christian Greis, Zohal Rasuly, Rolf A. Janosi, Lambros Kordelas, Dietrich W. Beelen and Tobias Liebregts Source Type: research

Medicating patients during extracorporeal membrane oxygenation: the evidence is building
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 21, 2017 Category: Intensive Care Authors: Amy L. Dzierba, Darryl Abrams and Daniel Brodie Source Type: research

Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 21, 2017 Category: Intensive Care Authors: Sheila Nainan Myatra, Xavier Monnet and Jean-Louis Teboul Source Type: research

Anemia and blood transfusion in the critically ill patient with cardiovascular disease
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 21, 2017 Category: Intensive Care Authors: Annemarie B. Docherty and Timothy S. Walsh Source Type: research

Assessing preoperative plasma growth-differentiation factor-15 for prediction of acute kidney injury in patients undergoing cardiac surgery
(Source: Critical Care)
Source: Critical Care - March 17, 2017 Category: Intensive Care Authors: Wei Zhang, Hai Chen Chu and Feng Xue Source Type: research

Point-of-care ultrasonography and liberation from mechanical ventilation
(Source: Critical Care)
Source: Critical Care - March 16, 2017 Category: Intensive Care Authors: Gentle Sunder Shrestha Source Type: research

Effect of an automated notification system for deteriorating ward patients on clinical outcomes
Delayed response to clinical deterioration of ward patients is common. (Source: Critical Care)
Source: Critical Care - March 14, 2017 Category: Intensive Care Authors: Christian P. Subbe, Bernd Duller and Rinaldo Bellomo Source Type: research

Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis
We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intra... (Source: Critical Care)
Source: Critical Care - March 13, 2017 Category: Intensive Care Authors: Herbert Sch öchl, Martijn van Griensven, Stefan Heitmeier, Volker Laux, Ulrike Kipman, Jan Roodt, Soheyl Bahrami and Heinz Redl Source Type: research