Blocking soluble guanylate cyclase could be the present and future of NO/cGMP inhibition for vasoplegia treatment
(Source: Critical Care)
Source: Critical Care - April 20, 2018 Category: Intensive Care Authors: Paulo Roberto Barbosa Evora Tags: Letter Source Type: research

Worldwide audit of blood transfusion practice in critically ill patients
The aim was to describe transfusion practice in critically ill patients at an international level and evaluate the effects of red blood cell (RBC) transfusion on outcomes in these patients. (Source: Critical Care)
Source: Critical Care - April 19, 2018 Category: Intensive Care Authors: Jean-Louis Vincent, Ulrich Jaschinski, Xavier Wittebole, Jean-Yves Lefrant, Stephan M. Jakob, Ghaleb A. Almekhlafi, Tommaso Pellis, Swagata Tripathy, Paolo N. Rubatto Birri and Yasser Sakr Tags: Research Source Type: research

Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial)
The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant t... (Source: Critical Care)
Source: Critical Care - April 19, 2018 Category: Intensive Care Authors: Nuttha Lumlertgul, Sadudee Peerapornratana, Thananda Trakarnvanich, Wanjak Pongsittisak, Kajbundit Surasit, Anan Chuasuwan, Pleumjit Tankee, Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong, John A. Kellum and Nattachai Tags: Research Source Type: research

Effects of modifiable prehospital factors on survival after out-of-hospital cardiac arrest in rural versus urban areas
The modifiable prehospital system factors, bystander cardiopulmonary resuscitation (CPR), emergency medical services (EMS), response time, and EMS physician attendance, may affect short- and long-term survival... (Source: Critical Care)
Source: Critical Care - April 18, 2018 Category: Intensive Care Authors: Wenche Torunn Mathiesen, Conrad Arnfinn Bj ørshol, Jan Terje Kvaløy and Eldar Søreide Tags: Research Source Type: research

Fungal infections in adult patients on extracorporeal life support
Patients on extracorporeal membrane oxygenation (ECMO) are often among the most severely ill in the intensive care unit. They are often receiving broad-spectrum antibiotics; they have multiple entry points for... (Source: Critical Care)
Source: Critical Care - April 17, 2018 Category: Intensive Care Authors: Yiorgos Alexandros Cavayas, Hakeem Yusuff and Richard Porter Tags: Research Source Type: research

Association between afterhours admission to the intensive care unit, strained capacity, and mortality: a retrospective cohort study
Admission to the intensive care unit (ICU) outside daytime hours has been shown to be variably associated with increased morbidity and mortality. We aimed to describe the characteristics and outcomes of patien... (Source: Critical Care)
Source: Critical Care - April 17, 2018 Category: Intensive Care Authors: Adam M. Hall, Henry T. Stelfox, Xioaming Wang, Guanmin Chen, Danny J. Zuege, Peter Dodek, Allan Garland, Damon C. Scales, Luc Berthiaume, David A. Zygun and Sean M. Bagshaw Tags: Research Source Type: research

Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study
Sepsis remains a major cause of mortality in critical care, for which specific treatments are lacking. The dysregulated response to infection seen in sepsis includes features of lymphocyte dysfunction and exha... (Source: Critical Care)
Source: Critical Care - April 17, 2018 Category: Intensive Care Authors: Julie K. Wilson, Yuan Zhao, Mervyn Singer, Jo Spencer and Manu Shankar-Hari Tags: Research Source Type: research

Angiotensin II for the treatment of vasodilatory shock: enough data to consider angiotensin II safe?
(Source: Critical Care)
Source: Critical Care - April 16, 2018 Category: Intensive Care Authors: Nina Buchtele, Michael Schwameis and Bernd Jilma Tags: Letter Source Type: research

Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study
The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causa... (Source: Critical Care)
Source: Critical Care - April 16, 2018 Category: Intensive Care Authors: Nur Baykara, Halis Akal ın, Mustafa Kemal Arslantaş, Volkan Hancı, Çiğdem Çağlayan, Ferda Kahveci, Kubilay Demirağ, Canan Baydemir and Necmettin Ünal Tags: Research Source Type: research

Population pharmacokinetics/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients
This study estimated the micafungin proba... (Source: Critical Care)
Source: Critical Care - April 15, 2018 Category: Intensive Care Authors: Emilio Maseda, Santiago Grau, Sonia Luque, Maria-Pilar Castillo-Mafla, Alejandro Su árez-de-la-Rica, Ana Montero-Feijoo, Patricia Salgado, Maria-Jose Gimenez, Carlos A. García-Bernedo, Fernando Gilsanz and Jason A. Roberts Tags: Research Source Type: research

Route, early or energy? … Protein improves protein balance in critically ill patients
(Source: Critical Care)
Source: Critical Care - April 14, 2018 Category: Intensive Care Authors: Peter J. M. Weijs Tags: Editorial Source Type: research

Promoting and sustaining a historical and global effort to prevent sepsis: the 2018 World Health Organization SAVE LIVES: Clean Your Hands campaign
Sepsis is estimated to affect more than 30 million patients with potentially five million deaths every year worldwide. Prevention of sepsis, as well as early recognition, diagnosis and treatment, can ’t be over... (Source: Critical Care)
Source: Critical Care - April 13, 2018 Category: Intensive Care Authors: Romain Martischang, Daniela Pires, Sarah Masson-Roy, Hiroki Saito and Didier Pittet Tags: Editorial Source Type: research

Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study
General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to a... (Source: Critical Care)
Source: Critical Care - April 13, 2018 Category: Intensive Care Authors: Jilske A. Huijben, Victor Volovici, Maryse C. Cnossen, Iain K. Haitsma, Nino Stocchetti, Andrew I. R. Maas, David K. Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W. Steyerberg, Hester F. Lingsma and Mathieu van der Jagt Tags: Research Source Type: research

Cardiac output and CVP monitoring … to guide fluid removal
(Source: Critical Care)
Source: Critical Care - April 12, 2018 Category: Intensive Care Authors: Matthieu Legrand, Sabri Soussi and Fran çois Depret Tags: Letter Source Type: research

Reverse shock index multiplied by Glasgow Coma Scale score (rSIG) is a simple measure with high discriminant ability for mortality risk in trauma patients: an analysis of the Japan Trauma Data Bank
The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of shock than traditional vital signs alone. In previous literature, use of ... (Source: Critical Care)
Source: Critical Care - April 11, 2018 Category: Intensive Care Authors: Akio Kimura and Noriko Tanaka Tags: Research Source Type: research

Diagnostic and management of life-threatening Adult-Onset Still Disease: a French nationwide multicenter study and systematic literature review
Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenot... (Source: Critical Care)
Source: Critical Care - April 11, 2018 Category: Intensive Care Authors: Antoine N éel, Anaïs Wahbi, Benoit Tessoulin, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Cédric Bretonnière a Tags: Research Source Type: research

38th International Symposium on Intensive Care and Emergency Medicine
(Source: Critical Care)
Source: Critical Care - March 29, 2018 Category: Intensive Care Tags: Meeting abstracts Source Type: research

Use of a meta-analysis to assess the preventive effect of dexmedetomidine on cardiac surgery-associated acute kidney injury
(Source: Critical Care)
Source: Critical Care - March 27, 2018 Category: Intensive Care Authors: Gui-Zhen Yang, Fu-Shan Xue and Ya-Yang Liu Tags: Letter Source Type: research

Indicators of intensive care unit capacity strain: a systematic review
Strained intensive care unit (ICU) capacity represents a fundamental supply-demand mismatch in ICU resources. Strain is likely to be influenced by a range of factors; however, there has been no systematic eval... (Source: Critical Care)
Source: Critical Care - March 27, 2018 Category: Intensive Care Authors: Oleksa G. Rewa, Henry T. Stelfox, Armann Ingolfsson, David A. Zygun, Robin Featherstone, Dawn Opgenorth and Sean M. Bagshaw Tags: Research Source Type: research

Comparing fiberoptic bronchoscopy and a tracheal tube-mounted camera-guided percutaneous dilatational tracheostomy: authors' reply
(Source: Critical Care)
Source: Critical Care - March 23, 2018 Category: Intensive Care Authors: J örn Grensemann, Lars Eichler, Sophie Kähler, Dominik Jarczak, Marcel Simon, Hans O. Pinnschmidt and Stefan Kluge Tags: Letter Source Type: research

Do we need new trials of procalcitonin-guided antibiotic therapy? A response
(Source: Critical Care)
Source: Critical Care - March 23, 2018 Category: Intensive Care Authors: Jos A. H. van Oers, Maarten W. Nijsten and Dylan W. de Lange Tags: Letter Source Type: research

Acute exacerbation of idiopathic pulmonary fibrosis: lessons learned from acute respiratory distress syndrome?
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by progressive loss of lung function and poor prognosis. The so-called acute exacerbation of IPF (AE-IPF) may lead to severe hypoxem... (Source: Critical Care)
Source: Critical Care - March 23, 2018 Category: Intensive Care Authors: Alessandro Marchioni, Roberto Tonelli, Lorenzo Ball, Riccardo Fantini, Ivana Castaniere, Stefania Cerri, Fabrizio Luppi, Mario Malerba, Paolo Pelosi and Enrico Clini Tags: Review Source Type: research

Renal autoregulation and blood pressure management in circulatory shock
The importance of personalized blood pressure management is well recognized. Because renal pressure –flow relationships may vary among patients, understanding how renal autoregulation may influence blood pressu... (Source: Critical Care)
Source: Critical Care - March 22, 2018 Category: Intensive Care Authors: Emiel Hendrik Post and Jean-Louis Vincent Tags: Review Source Type: research

The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial
This study assessed the ability of mid-regional proadrenomedullin (MR-proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive protein) and clinical scores to identify disease... (Source: Critical Care)
Source: Critical Care - March 21, 2018 Category: Intensive Care Authors: Gunnar Elke, Frank Bloos, Darius Cameron Wilson, Frank Martin Brunkhorst, Josef Briegel, Konrad Reinhart, Markus Loeffler, Stefan Kluge, Axel Nierhaus, Ulrich Jaschinski, Onnen Moerer, Andreas Weyland and Patrick Meybohm Tags: Research Source Type: research

Angiotensin in Critical Care
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 20, 2018 Category: Intensive Care Authors: Anna Hall, Laurence W. Busse and Marlies Ostermann Tags: Review Source Type: research

Effects of Fluids on the Macro- and Microcirculations
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 20, 2018 Category: Intensive Care Authors: Victoria A. Bennett, Alexander Vidouris and Maurizio Cecconi Tags: Review Source Type: research

The emerging role of the microbiota in the ICU
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 20, 2018 Category: Intensive Care Authors: Nora Suzanne Wolff, Floor Hugenholtz and Willem Joost Wiersinga Tags: Review Source Type: research

Close down the lungs and keep them resting to minimize ventilator-induced lung injury
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 20, 2018 Category: Intensive Care Authors: Paolo Pelosi, Patricia Rieken Macedo Rocco and Marcelo Gama de Abreu Tags: Review Source Type: research

Respiratory Management in Patients with Severe Brain Injury
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at (Source: Critical Care)
Source: Critical Care - March 20, 2018 Category: Intensive Care Authors: Karim Asehnoune, Antoine Roquilly and Rapha ël Cinotti Tags: Review Source Type: research

Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?
Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative stress. Despite previous studies demonstrating... (Source: Critical Care)
Source: Critical Care - March 15, 2018 Category: Intensive Care Authors: Juliana Monte Real, Ludmila Rodrigues Pinto Ferreira, Gustavo Henrique Esteves, Fernanda Christtanini Koyama, Marcos Vin ícius Salles Dias, João Evangelista Bezerra-Neto, Edécio Cunha-Neto, Flavia Ribeiro Machado, Reinaldo Salomão and Luciano Cesar Po Tags: Research Source Type: research

Impact of nighttime Rapid Response Team activation on outcomes of hospitalized patients with acute deterioration
Rapid Response Teams (RRTs) are groups of healthcare providers that are used by many hospitals to respond to acutely deteriorating patients admitted to the wards. We sought to identify outcomes of patients ass... (Source: Critical Care)
Source: Critical Care - March 14, 2018 Category: Intensive Care Authors: Shannon M. Fernando, Peter M. Reardon, Sean M. Bagshaw, Damon C. Scales, Kyle Murphy, Jennifer Shen, Peter Tanuseputro, Daren K. Heyland and Kwadwo Kyeremanteng Tags: Research Source Type: research

The efficacy and safety of pre-hospital cooling after out-of-hospital cardiac arrest: a systematic review and meta-analysis
Mild therapeutic hypothermia (TH), or targeted temperature management, improves survival and neurological outcomes in patients after out-of-hospital cardiac arrest (OHCA). International guidelines strongly sup... (Source: Critical Care)
Source: Critical Care - March 13, 2018 Category: Intensive Care Authors: Patrick J. Lindsay, Danielle Buell and Damon C. Scales Tags: Research Source Type: research

Bedside ultrasound to detect central venous catheter misplacement and associated iatrogenic complications: a systematic review and meta-analysis
Insertion of a central venous catheter (CVC) is common practice in critical care medicine. Complications arising from CVC placement are mostly due to a pneumothorax or malposition. Correct position is currentl... (Source: Critical Care)
Source: Critical Care - March 13, 2018 Category: Intensive Care Authors: Jasper M. Smit, Reinder Raadsen, Michiel J. Blans, Manfred Petjak, Peter M. Van de Ven and Pieter R. Tuinman Tags: Review Source Type: research

Neuromuscular blockade is associated with the attenuation of biomarkers of epithelial and endothelial injury in patients with moderate-to-severe acute respiratory distress syndrome
Neuromuscular blockade (NMB) is a therapy for acute respiratory distress syndrome (ARDS). However, the mechanism by which NMB may improve outcome for ARDS patients remains unclear. We sought to determine wheth... (Source: Critical Care)
Source: Critical Care - March 10, 2018 Category: Intensive Care Authors: Peter D. Sottile, David Albers and Marc M. Moss Tags: Research Source Type: research

The long sepsis journey in low- and middle-income countries begins with a first step...but on which road?
(Source: Critical Care)
Source: Critical Care - March 9, 2018 Category: Intensive Care Authors: Arthur Kwizera, Inipavudu Baelani, Mervyn Mer, Niranjan Kissoon, Marcus J. Schultz, Andrew J. Patterson, Ndidiamaka Musa, Joseph Christopher Farmer and Martin W. D ünser Tags: Editorial Source Type: research

A novel method of blind bedside placement of postpyloric tubes
(Source: Critical Care)
Source: Critical Care - March 9, 2018 Category: Intensive Care Authors: Jia-Kui Sun, Xiang Wang and Shou-Tao Yuan Tags: Letter Source Type: research

Global impact of World Sepsis Day on digital awareness of sepsis: an evaluation using Google Trends
(Source: Critical Care)
Source: Critical Care - March 9, 2018 Category: Intensive Care Authors: Jelmer Savelkoel, Theodora A. M. Claushuis, Tjitske S. R. van Engelen, Luuk J. J. Scheres and W. Joost Wiersinga Tags: Letter Source Type: research

Before the ICU: does emergency room hyperoxia affect outcome?
(Source: Critical Care)
Source: Critical Care - March 8, 2018 Category: Intensive Care Authors: Martin Wepler, Julien Demiselle, Peter Radermacher, Pierre Asfar and Enrico Calzia Tags: Editorial Source Type: research

The preventive effect of antiplatelet therapy in acute respiratory distress syndrome: a meta-analysis
Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality that imposes a serious medical burden. Antiplatelet therapy is a potential strategy for preventing ARDS in patient... (Source: Critical Care)
Source: Critical Care - March 8, 2018 Category: Intensive Care Authors: Yingqin Wang, Ming Zhong, Zhichao Wang, Jieqiong Song, Wei Wu and Duming Zhu Tags: Research Source Type: research

Survival benefit of a low ratio of visceral to subcutaneous adipose tissue depends on LDL clearance versus production in sepsis
Patients with sepsis with a high ratio of visceral adipose tissue (VAT) to subcutaneous adipose tissue (SAT) have increased mortality. Our goal was to investigate the mechanism of this effect, noting that low ... (Source: Critical Care)
Source: Critical Care - March 6, 2018 Category: Intensive Care Authors: Joseph G. H. Lee, Kelly R. Genga, Chawika Pisitsak, John H. Boyd, Alex K. K. Leung, James A. Russell and Keith R. Walley Tags: Research Source Type: research

Tight glycemic control in critically ill pediatric patients: a systematic review and meta-analysis
Hyperglycemia is prevalent in patients in the pediatric intensive care unit. The purpose of this study was to describe the benefits and risks of tight glucose control (TGC) in critically ill children. (Source: Critical Care)
Source: Critical Care - March 4, 2018 Category: Intensive Care Authors: Lvlin Chen, Tiangui Li, Fang Fang, Yu Zhang and Andrew Faramand Tags: Research Source Type: research

Increases in inflammatory and CD14dim/CD16pos/CD45pos patrolling monocytes in sepsis: correlation with final outcome
Evidence on the changes in the absolute counts of monocyte subpopulations in sepsis is missing. (Source: Critical Care)
Source: Critical Care - March 3, 2018 Category: Intensive Care Authors: Gabriela Gainaru, Antonios Papadopoulos, Iraklis Tsangaris, Malvina Lada, Evangelos J. Giamarellos-Bourboulis and Aikaterini Pistiki Tags: Research Source Type: research

High-frequency percussive ventilation in acute respiratory distress syndrome: knocking at the door but can it be let in?
(Source: Critical Care)
Source: Critical Care - March 2, 2018 Category: Intensive Care Authors: Herbert Spapen, Jouke De Regt, Viola van Gorp and Patrick M. Honor é Tags: Letter Source Type: research

Feasibility, safety, and utility of bronchoscopy in patients with ARDS while in the prone position
(Source: Critical Care)
Source: Critical Care - March 2, 2018 Category: Intensive Care Authors: Or Kalchiem-Dekel, Carl B. Shanholtz, Jean Jeudy, Ashutosh Sachdeva and Edward M. Pickering Tags: Letter Source Type: research

Decision-making in the detection and management of patients with sepsis in resource-limited settings: the importance of clinical examination
(Source: Critical Care)
Source: Critical Care - March 1, 2018 Category: Intensive Care Authors: Rashan Haniffa, Abigail Beane and Arjen M. Dondorp Tags: Letter Source Type: research

Vasoplegia treatments: the past, the present, and the future
Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic, cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving various mechanisms in vascular ... (Source: Critical Care)
Source: Critical Care - February 27, 2018 Category: Intensive Care Authors: Bruno Levy, Caroline Fritz, Elsa Tahon, Audrey Jacquot, Thomas Auchet and Antoine Kimmoun Tags: Review Source Type: research

Intraoperative milrinone versus dobutamine in cardiac surgery patients: a retrospective cohort study on mortality
Several choices of inotropic therapy are available and used in relation to cardiac surgery. Comparisons are necessary to select optimal therapy. In Denmark, dobutamine and milrinone are the two inotropic agent... (Source: Critical Care)
Source: Critical Care - February 26, 2018 Category: Intensive Care Authors: Dorthe Viemose Nielsen, Christian Torp-Pedersen, Regitze Kuhr Skals, Thomas A. Gerds, Zidryne Karaliunaite and Carl-Johan Jakobsen Tags: Research Source Type: research

Feasibility and reliability of frailty assessment in the critically ill: a systematic review
For healthcare systems, an ageing population poses challenges in the delivery of equitable and effective care. Frailty assessment has the potential to improve care in the intensive care setting, but applying a... (Source: Critical Care)
Source: Critical Care - February 26, 2018 Category: Intensive Care Authors: Richard J. Pugh, Amy Ellison, Kate Pye, Christian P. Subbe, Chris M. Thorpe, Nazir I. Lone and Andrew Clegg Tags: Research Source Type: research

The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment. (Source: Critical Care)
Source: Critical Care - February 25, 2018 Category: Intensive Care Authors: Philipp K ümpers and Alexander Lukasz Tags: Viewpoint Source Type: research

Hemodynamic effects of acute hyperoxia: systematic review and meta-analysis
In clinical practice, oxygen is generally administered to patients with the intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial hyperoxia, which is associated with hemodyn... (Source: Critical Care)
Source: Critical Care - February 25, 2018 Category: Intensive Care Authors: Bob Smit, Yvo M. Smulders, Johannes C. van der Wouden, Heleen M. Oudemans-van Straaten and Angelique M. E. Spoelstra-de Man Tags: Review Source Type: research