Early versus delayed enteral nutrition in mechanically ventilated patients with circulatory shock: a nested cohort analysis of an international multicenter, pragmatic clinical trial
Real-world evidence on the timing and efficacy of enteral nutrition (EN) practices in intensive care unit (ICU) patients with circulatory shock is limited. We hypothesized early EN (EEN), as compared to delaye... (Source: Critical Care)
Source: Critical Care - June 9, 2022 Category: Intensive Care Authors: Luis Ortiz-Reyes, Jayshil J. Patel, Xuran Jiang, Angel Coz Yataco, Andrew G. Day, Faraaz Shah, James Zelten, Maximiliano Tamae-Kakazu, Todd Rice and Daren K. Heyland Tags: Research Source Type: research

Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein
SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin –angiotensin system (RAS) is involved in th... (Source: Critical Care)
Source: Critical Care - June 9, 2022 Category: Intensive Care Authors: Lingbing Zhang, Yandan Zhang, Xia Qin, Xuejun Jiang, Jun Zhang, Lejiao Mao, Ziqi Jiang, Yu Jiang, Gang Liu, Jingfu Qiu, Chengzhi Chen, Feng Qiu and Zhen Zou Tags: Research Source Type: research

Reply to: “Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality”
(Source: Critical Care)
Source: Critical Care - June 9, 2022 Category: Intensive Care Authors: Alessandro N. Franciosi, Cormac McCarthy and Ruth MacRedmond Tags: Correspondence Source Type: research

Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review and meta-analysis
The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis. (Source: Critical Care)
Source: Critical Care - June 8, 2022 Category: Intensive Care Authors: Guobin Wang, Chunyan Jiang, Junjun Fang, Zhitao Li and Hongliu Cai Tags: Research Source Type: research

Resilience is a dirty word: misunderstood, and how we can truly build it
Resilience is ubiquitous in everyday speech, academic literature and governmental policies. Yet it seems to have taken a narrow scope in healthcare, confined to individual and psychological resilience. This sh... (Source: Critical Care)
Source: Critical Care - June 8, 2022 Category: Intensive Care Authors: Mark Z. Y. Tan Tags: Perspective Source Type: research

Central venous catheterization: the cephalic vein access
(Source: Critical Care)
Source: Critical Care - June 8, 2022 Category: Intensive Care Authors: Shouyin Jiang, Yehua Shen and Xiaogang Zhao Tags: Correspondence Source Type: research

Lack of SARS-CoV-2-specific cellular response in critically ill COVID-19 patients despite apparent effective vaccination
(Source: Critical Care)
Source: Critical Care - June 8, 2022 Category: Intensive Care Authors: Frank Bidar, Guillaume Monneret, Franck Berthier, Anne-Claire Lukaszewicz and Fabienne Venet Tags: Correspondence Source Type: research

Early intubation and patient-centered outcomes in septic shock: a secondary analysis of a prospective multicenter study
Despite the benefits of mechanical ventilation, its use in critically ill patients is associated with complications and had led to the growth of noninvasive techniques. We assessed the effect of early intubati... (Source: Critical Care)
Source: Critical Care - June 7, 2022 Category: Intensive Care Authors: Ricard Mellado-Artigas, Carlos Ferrando, Fr édéric Martino, Agathe Delbove, Bruno L. Ferreyro, Cedric Darreau, Sophie Jacquier, Laurent Brochard and Nicolas Lerolle Tags: Research Source Type: research

Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial
Interleukin (IL)-18 is a marker of inflammasome activation, and high baseline plasma IL-18 is associated with increased mortality in patients with sepsis-induced ARDS. The aim of this analysis was to determine... (Source: Critical Care)
Source: Critical Care - June 7, 2022 Category: Intensive Care Authors: Andrew James Boyle, Peter Ferris, Ian Bradbury, John Conlon, Manu Shankar-Hari, Angela J. Rogers, Cecilia M. O ’Kane and Daniel F. McAuley Tags: Research Source Type: research

Endarterectomy treatment for patients suffering from a new episode of pulmonary embolism, after screening for chronic thromboembolic pulmonary hypertension
(Source: Critical Care)
Source: Critical Care - June 7, 2022 Category: Intensive Care Authors: Patrick M. Honore, Sebastien Redant, Pharan Djimafo, Sydney Blackman, Ibrahim Bousbiat, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Andrea Gallerani and Rachid Attou Tags: Correspondence Source Type: research

An interventional quasi-experimental study to evaluate the impact of a rapid screening strategy in improving control of nosocomial extended-spectrum beta-lactamase-producing Enterobacterales and carbapenemase-producing organisms in critically ill patients
Rapid molecular tests could accelerate the control of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and carbapenemase-producing organisms (CPO) in intensive care units (ICUs). (Source: Critical Care)
Source: Critical Care - June 7, 2022 Category: Intensive Care Authors: Romain Martischang, Patrice Fran çois, Abdessalam Cherkaoui, Gesuele Renzi, Carolina Fankhauser, Jacques Schrenzel, Jérôme Pugin and Stephan Harbarth Tags: Research Source Type: research

Respiratory distress observation scales to predict weaning outcome
Whether dyspnea is present before starting a spontaneous breathing trial (SBT) and whether it may affect the outcome of the SBT is unknown. Mechanical Ventilation —Respiratory Distress Observation Scale (MV-RDO... (Source: Critical Care)
Source: Critical Care - June 6, 2022 Category: Intensive Care Authors: Maxens Decav èle, Emmanuel Rozenberg, Marie-Cécile Niérat, Julien Mayaux, Elise Morawiec, Capucine Morélot-Panzini, Thomas Similowski, Alexandre Demoule and Martin Dres Tags: Research Source Type: research

One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial
Acute respiratory distress syndrome (ARDS) has different phenotypes and distinct short-term outcomes. Patients with non-focal ARDS have a higher short-term mortality than focal ones. The aim of this study was ... (Source: Critical Care)
Source: Critical Care - June 4, 2022 Category: Intensive Care Authors: Florian Blanchard, Thomas Godet, Stephanie Pons, Natacha Kapandji, Matthieu Jabaudon, Vincent Degos, Lucile Borao, Adrien Bougle, Antoine Monsel, Emmanuel Futier, Jean-Michel Constantin and Arthur James Tags: Research Source Type: research

Intermediate-risk pulmonary embolism: echocardiography predictors of clinical deterioration
We determine the predictive value of transthoracic echocardiographic (TTE) metrics for clinical deterioration within 5 days in adults with intermediate-risk pulmonary embolism (PE). (Source: Critical Care)
Source: Critical Care - June 4, 2022 Category: Intensive Care Authors: Anthony J. Weekes, Denise N. Fraga, Vitaliy Belyshev, William Bost, Christopher A. Gardner and Nathaniel S. O ’Connell Tags: Research Source Type: research

Association of annual hospital septic shock case volume and hospital mortality
The burden of sepsis remains high in China. The relationship between case volume and hospital mortality among patients with septic shock, the most severe complication of sepsis, is unknown in China. (Source: Critical Care)
Source: Critical Care - June 4, 2022 Category: Intensive Care Authors: Yan Chen, Xu-dong Ma, Xiao-hui Kang, Si-fa Gao, Jin-min Peng, Shan Li, Da-wei Liu, Xiang Zhou, Li Weng and Bin Du Tags: Research Source Type: research