Early nasal high-flow versus Venturi mask oxygen therapy after lung resection: a randomized trial
Data on high-flow nasal oxygen after thoracic surgery are limited and confined to the comparison with low-flow oxygen. Different from low-flow oxygen, Venturi masks provide higher gas flow at a predetermined f... (Source: Critical Care)
Source: Critical Care - February 28, 2019 Category: Intensive Care Authors: Mariano Alberto Pennisi, Giuseppe Bello, Maria Teresa Congedo, Luca Montini, Dania Nachira, Gian Maria Ferretti, Elisa Meacci, Elisabetta Gualtieri, Gennaro De Pascale, Domenico Luca Grieco, Stefano Margaritora and Massimo Antonelli Tags: Research Source Type: research

The chemical, biological, radiological and nuclear (CBRN) chain of survival: a new pragmatic and didactic tool used by Paris Fire Brigade
(Source: Critical Care)
Source: Critical Care - February 26, 2019 Category: Intensive Care Authors: Franck Calamai, Cl ément Derkenne, Daniel Jost, Stéphane Travers, Isabelle Klein, Kilian Bertho, Frédéric Dorandeu, Michel Bignand and Bertrand Prunet Tags: Commentary Source Type: research

The prognostic value of optic nerve sheath diameter in patients with subarachnoid hemorrhage
We evaluated the role of optic nerve sheath diameter (ONSD) using brain computed tomography (CT) in predicting neurological outcomes of patients with subarachnoid hemorrhage (SAH). (Source: Critical Care)
Source: Critical Care - February 26, 2019 Category: Intensive Care Authors: Sangkil Lee, Yong Oh Kim, Ji Sun Baek and Jeong-Am Ryu Tags: Research Source Type: research

Diagnostic and therapeutic approach in adult patients with traumatic brain injury receiving oral anticoagulant therapy: an Austrian interdisciplinary consensus statement
There is a high degree of uncertainty regarding optimum care of patients with potential or known intake of oral anticoagulants and traumatic brain injury (TBI). Anticoagulation therapy aggravates the risk of i... (Source: Critical Care)
Source: Critical Care - February 22, 2019 Category: Intensive Care Authors: Marion Wiegele, Herbert Sch öchl, Alexander Haushofer, Martin Ortler, Johannes Leitgeb, Oskar Kwasny, Ronny Beer, Cihan Ay and Eva Schaden Tags: Review Source Type: research

Acute neuropathological consequences of short-term mechanical ventilation in wild-type and Alzheimer ’s disease mice
Mechanical ventilation is strongly associated with cognitive decline after critical illness. This finding is particularly evident among older individuals who have pre-existing cognitive impairment, most common... (Source: Critical Care)
Source: Critical Care - February 22, 2019 Category: Intensive Care Authors: Shouri Lahiri, Giovanna C. Regis, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Elizabeth H. Kim, Mitra Mastali, Jennifer E. Van Eyk, Padmesh S. Rajput, Patrick D. Lyden, Keith L. Black, E. Wesley Ely, Heather D. Jones and Maya Koronyo-Hamaoui Tags: Research Source Type: research

Emergency department triage prediction of clinical outcomes using machine learning models
Development of emergency department (ED) triage systems that accurately differentiate and prioritize critically ill from stable patients remains challenging. We used machine learning models to predict clinical... (Source: Critical Care)
Source: Critical Care - February 22, 2019 Category: Intensive Care Authors: Yoshihiko Raita, Tadahiro Goto, Mohammad Kamal Faridi, David F. M. Brown, Carlos A. Camargo Jr. and Kohei Hasegawa Tags: Research Source Type: research

Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest: an analysis of the TTH48 trial
The aim of this study was to explore the performance and outcomes for intravascular (IC) versus surface cooling devices (SFC) for targeted temperature management (TTM) after out-of-hospital cardiac arrest. (Source: Critical Care)
Source: Critical Care - February 22, 2019 Category: Intensive Care Authors: Chiara De Fazio, Markus B. Skrifvars, Eldar S øreide, Jacques Creteur, Anders M. Grejs, Jesper Kjærgaard, Timo Laitio, Jens Nee, Hans Kirkegaard and Fabio Silvio Taccone Tags: Research Source Type: research

Prognostic accuracy of the Hamilton Early Warning Score (HEWS) and the National Early Warning Score 2 (NEWS2) among hospitalized patients assessed by a rapid response team
Rapid response teams (RRTs) respond to hospitalized patients experiencing clinical deterioration and help determine subsequent management and disposition. We sought to evaluate and compare the prognostic accur... (Source: Critical Care)
Source: Critical Care - February 21, 2019 Category: Intensive Care Authors: Shannon M. Fernando, Alison E. Fox-Robichaud, Bram Rochwerg, Pierre Cardinal, Andrew J. E. Seely, Jeffrey J. Perry, Daniel I. McIsaac, Alexandre Tran, Steven Skitch, Benjamin Tam, Michael Hickey, Peter M. Reardon, Peter Tanuseputro and Kwadwo Kyeremanteng Tags: Research Source Type: research

The role of impaired brain perfusion in septic encephalopathy
(Source: Critical Care)
Source: Critical Care - February 19, 2019 Category: Intensive Care Authors: Lucia Rivera-Lara Tags: Editorial Source Type: research

Impact of acute renal failure on plasmatic levels of cleaved endocan
(Source: Critical Care)
Source: Critical Care - February 19, 2019 Category: Intensive Care Authors: Alexandre Gaudet, Erika Parmentier, Nathalie De Freitas Caires, Lucie Portier, Sylvain Dubucquoi, Julien Poissy, Thibault Duburcq, Maxence Hureau, Philippe Lassalle and Daniel Mathieu Tags: Letter Source Type: research

Letter on “Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial”
(Source: Critical Care)
Source: Critical Care - February 19, 2019 Category: Intensive Care Authors: Alexander Reisinger and Vanessa Stadlbauer Tags: Letter Source Type: research

Authors ’ response to letter “Prediction of acute kidney injury in intensive care unit patients”
(Source: Critical Care)
Source: Critical Care - February 19, 2019 Category: Intensive Care Authors: Hiroyuki Naruse, Hiroshi Takahashi and Junnichi Ishii Tags: Letter Source Type: research

Response to “Are fluids resuscitation the “Keyser Soze” of acute kidney injury in trauma patients?”
(Source: Critical Care)
Source: Critical Care - February 19, 2019 Category: Intensive Care Authors: Anatole Harrois, Benjamin Soyer, Tobias Gauss, Sophie Hamada, Mathieu Raux and Jacques Duranteau Tags: Letter Source Type: research

Association of preadmission metformin use and mortality in patients with sepsis and diabetes mellitus: a systematic review and meta-analysis of cohort studies
Recent studies have reported that preadmission metformin users had lower mortality than non-metformin users in patients with sepsis and diabetes mellitus; however, these results are still controversial. Theref... (Source: Critical Care)
Source: Critical Care - February 18, 2019 Category: Intensive Care Authors: Huoyan Liang, Xianfei Ding, Lifeng Li, Tian Wang, Quancheng Kan, Lexin Wang and Tongwen Sun Tags: Research Source Type: research

Invasive and non-invasive diagnostic approaches for microbiological diagnosis of hospital-acquired pneumonia
Data on the methods used for microbiological diagnosis of hospital-acquired pneumonia (HAP) are mainly extrapolated from ventilator-associated pneumonia. HAP poses additional challenges for respiratory samplin... (Source: Critical Care)
Source: Critical Care - February 18, 2019 Category: Intensive Care Authors: Otavio T. Ranzani, Tarek Senussi, Francesco Idone, Adrian Ceccato, Gianluigi Li Bassi, Miquel Ferrer and Antoni Torres Tags: Research Source Type: research

The clinical impacts and risk factors for non-central line-associated bloodstream infection in 5046 intensive care unit patients: an observational study based on electronic medical records
This study was performed t... (Source: Critical Care)
Source: Critical Care - February 18, 2019 Category: Intensive Care Authors: Shichao Zhu, Yan Kang, Wen Wang, Lin Cai, Xin Sun and Zhiyong Zong Tags: Research Source Type: research

NephroCheck: should we consider urine osmolality?
(Source: Critical Care)
Source: Critical Care - February 14, 2019 Category: Intensive Care Authors: Alberto Noto, Andrea Cortegiani and Antonio David Tags: Letter Source Type: research

Assessment of intestinal perfusion by a new balloon-tipped transpyloric probe
(Source: Critical Care)
Source: Critical Care - February 14, 2019 Category: Intensive Care Authors: Samir G. Sakka Tags: Letter Source Type: research

Predicting clinical outcome in patients undergoing VA-ECMO
(Source: Critical Care)
Source: Critical Care - February 14, 2019 Category: Intensive Care Authors: Antoine Kimmoun and Bruno Levy Tags: Editorial Source Type: research

Current place of probiotics for VAP
(Source: Critical Care)
Source: Critical Care - February 13, 2019 Category: Intensive Care Authors: Harjeet Singh Virk and W. Joost Wiersinga Tags: Editorial Source Type: research

Cerebral metabolism is not affected by moderate hyperventilation in patients with traumatic brain injury
Hyperventilation-induced hypocapnia (HV) reduces elevated intracranial pressure (ICP), a dangerous and potentially fatal complication of traumatic brain injury (TBI). HV decreases the arteriolar diameter of in... (Source: Critical Care)
Source: Critical Care - February 13, 2019 Category: Intensive Care Authors: Giovanna Brandi, Nino Stocchetti, Alberto Pagnamenta, Federica Stretti, Peter Steiger and Stephanie Klinzing Tags: Research Source Type: research

Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury
The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar... (Source: Critical Care)
Source: Critical Care - February 13, 2019 Category: Intensive Care Authors: Yue Zhou, Pengfei Li, Andrew J. Goodwin, James A. Cook, Perry V. Halushka, Eugene Chang, Basilia Zingarelli and Hongkuan Fan Tags: Research Source Type: research

Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis
With the development of new techniques to easily obtain lower respiratory tract specimens, bronchoalveolar lavage fluid and other lung fluids are gaining importance in pulmonary disease diagnosis. We aimed to ... (Source: Critical Care)
Source: Critical Care - February 12, 2019 Category: Intensive Care Authors: Yishan Wang, Huijuan Wang, Chunfang Zhang, Chao Zhang, Huqin Yang, Ruiyue Gao and Zhaohui Tong Tags: Research Source Type: research

Thromboxane –prostaglandin receptor antagonist, terutroban, prevents neurovascular events after subarachnoid haemorrhage: a nanoSPECT study in rats
Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane –prostaglandin (TP) receptors,... (Source: Critical Care)
Source: Critical Care - February 11, 2019 Category: Intensive Care Authors: David Lagier, David Tonon, Philippe Garrigue, Benjamin Guillet, Laura Giacomino, Jean-Charles Martin, Marie-Christine Alessi, Nicolas Bruder and Lionel J. Velly Tags: Research Source Type: research

Low-dose atrial natriuretic peptide for prevention or treatment of acute kidney injury: a systematic review and meta-analysis
In this study, we examined whether low-dose ANP is effective in preventing or treating AKI ... (Source: Critical Care)
Source: Critical Care - February 11, 2019 Category: Intensive Care Authors: Hiroyuki Yamada, Kent Doi, Tatsuo Tsukamoto, Hideyasu Kiyomoto, Kazuto Yamashita, Motoko Yanagita, Yoshio Terada and Kiyoshi Mori Tags: Research Source Type: research

Letter on “Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock: a systematic review and meta-analysis”
(Source: Critical Care)
Source: Critical Care - February 8, 2019 Category: Intensive Care Authors: Venu M. Velagapudi and Dennis A. Tighe Tags: Letter Source Type: research

Passive leg cycling and electrical stimulation cannot preserve strength in sepsis
(Source: Critical Care)
Source: Critical Care - February 8, 2019 Category: Intensive Care Authors: Pierre-Fran çois Laterre, Cheryl Hickmann and Diego Castanares-Zapatero Tags: Letter Source Type: research

The ELSO Maastricht Treaty for ECLS Nomenclature: abbreviations for cannulation configuration in extracorporeal life support - a position paper of the Extracorporeal Life Support Organization
The Extracorporeal Life Support Organization (ELSO) Maastricht Treaty for Nomenclature in Extracorporeal Life Support (ECLS) established consensus nomenclature and abbreviations for ECLS to ensure accurate, co... (Source: Critical Care)
Source: Critical Care - February 8, 2019 Category: Intensive Care Authors: Lars Mikael Broman, Fabio Silvio Taccone, Roberto Lorusso, Maximilian Valentin Malfertheiner, Federico Pappalardo, Matteo Di Nardo, Mirko Belliato, Melania M. Bembea, Ryan P. Barbaro, Rodrigo Diaz, Lorenzo Grazioli, Vincent Pellegrino, Malaika H. Mendonca Tags: Research Source Type: research

The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study
This study aimed to ... (Source: Critical Care)
Source: Critical Care - February 8, 2019 Category: Intensive Care Authors: Kordo Saeed, Darius Cameron Wilson, Frank Bloos, Philipp Schuetz, Yuri van der Does, Olle Melander, Pierre Hausfater, Jacopo M. Legramante, Yann-Erick Claessens, Deveendra Amin, Mari Rosenqvist, Graham White, Beat Mueller, Maarten Limper, Carlota Clemente Tags: Research Source Type: research

Is fluid resuscitation the “Keyser Soze” of acute kidney injury in trauma patients?
(Source: Critical Care)
Source: Critical Care - February 8, 2019 Category: Intensive Care Authors: Matthieu Jamme and Omar Ben Hadj Salem Tags: Letter Source Type: research

Electrophysiological investigations of peripheral nerves and muscles: a method for looking at cell dysfunction in the critically ill patients
(Source: Critical Care)
Source: Critical Care - January 29, 2019 Category: Intensive Care Authors: Nicola Latronico and Oliver Friedrich Tags: Editorial Source Type: research

Organizational factors associated with target sedation on the first 48  h of mechanical ventilation: an analysis of checklist-ICU database
Although light sedation levels are associated with several beneficial outcomes for critically ill patients on mechanical ventilation, the majority of patients are still deeply sedated. Organizational factors m... (Source: Critical Care)
Source: Critical Care - January 29, 2019 Category: Intensive Care Authors: Antonio Paulo Nassar Jr, Fernando G. Zampieri, Jorge I. Salluh, Fernando A. Bozza, Fl ávia Ribeiro Machado, Helio Penna Guimarães, Lucas P. Damiani and Alexandre Biasi Cavalcanti Tags: Research Source Type: research

The adrenal-vitamin C axis: from fish to guinea pigs and primates
(Source: Critical Care)
Source: Critical Care - January 28, 2019 Category: Intensive Care Authors: Michael H. Hooper, Anitra Carr and Paul E. Marik Tags: Letter Source Type: research

Humanizing the intensive care unit
(Source: Critical Care)
Source: Critical Care - January 28, 2019 Category: Intensive Care Authors: Michael E. Wilson, Sarah Beesley, Amanda Grow, Eileen Rubin, Ramona O. Hopkins, Negin Hajizadeh and Samuel M. Brown Tags: Editorial Source Type: research

Sigh maneuver to enhance assessment of fluid responsiveness during pressure support ventilation
Assessment of fluid responsiveness is problematic in intensive care unit (ICU) patients, in particular for those undergoing modes of partial support, such as pressure support ventilation (PSV). We propose a ne... (Source: Critical Care)
Source: Critical Care - January 28, 2019 Category: Intensive Care Authors: Antonio Messina, Davide Colombo, Federico Lorenzo Barra, Gianmaria Cammarota, Giacomo De Mattei, Federico Longhini, Stefano Romagnoli, Francesco DellaCorte, Daniel De Backer, Maurizio Cecconi and Paolo Navalesi Tags: Research Source Type: research

The effect of diabetes on burn patients: a retrospective cohort study
Hyperglycemia during the acute phase after burn is associated with increased morbidity and mortality. There is little knowledge regarding the effect of pre-existing hyperglycemia in the form of diabetes on the... (Source: Critical Care)
Source: Critical Care - January 28, 2019 Category: Intensive Care Authors: Reinhard Dolp, Sarah Rehou, Ruxandra Pinto, Rachel Trister and Marc G. Jeschke Tags: Research Source Type: research

Associations between partial pressure of oxygen and neurological outcome in out-of-hospital cardiac arrest patients: an explorative analysis of a randomized trial
Exposure to hyperoxemia and hypoxemia is common in out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation (ROSC), but its effects on neurological outcome are uncertain, and ... (Source: Critical Care)
Source: Critical Care - January 28, 2019 Category: Intensive Care Authors: Florian Ebner, Susann Ull én, Anders Åneman, Tobias Cronberg, Niklas Mattsson, Hans Friberg, Christian Hassager, Jesper Kjærgaard, Michael Kuiper, Paolo Pelosi, Johan Undén, Matt P. Wise, Jørn Wetterslev and Niklas Nielsen Tags: Research Source Type: research

Host genetic variants in sepsis risk: a field synopsis and meta-analysis
Published data revealed that host genetic variants have a substantial influence on sepsis susceptibility. However, the results have been inconsistent. We aimed to systematically review the published studies an... (Source: Critical Care)
Source: Critical Care - January 25, 2019 Category: Intensive Care Authors: Hongxiang Lu, Dalin Wen, Xu Wang, Lebin Gan, Juan Du, Jianhui Sun, Ling Zeng, Jianxin Jiang and Anqiang Zhang Tags: Research Source Type: research

A smartphone comes to the rescue during tracheostomy
(Source: Critical Care)
Source: Critical Care - January 24, 2019 Category: Intensive Care Authors: Animesh Ray, Bharath, Sanjeev Sinha and Saurav Sekhar Paul Tags: Letter Source Type: research

Bronchoalveolar lavage fluid dilution in ICU patients: what we should know and what we should do
(Source: Critical Care)
Source: Critical Care - January 24, 2019 Category: Intensive Care Authors: Yuetian Yu, Chunyan Liu, Zhongheng Zhang, Hui Shen, Yujie Li, Liangjing Lu and Yuan Gao Tags: Letter Source Type: research

The aftermath of acute kidney injury: a narrative review of long-term mortality and renal function
Acute kidney injury (AKI) is a frequent complication of hospitalization and is associated with an increased risk of chronic kidney disease (CKD), end-stage renal disease (ESRD), and mortality. While AKI is a k... (Source: Critical Care)
Source: Critical Care - January 24, 2019 Category: Intensive Care Authors: Gijs Fortrie, Hilde R. H. de Geus and Michiel G. H. Betjes Tags: Review Source Type: research

Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients: a systematic review and meta-analysis
Regional citrate anticoagulation (RCA) is a widely used strategy for continuous renal replacement therapy (CRRT). Most of the current guidelines recommend liver failure as one of the contraindications for citr... (Source: Critical Care)
Source: Critical Care - January 24, 2019 Category: Intensive Care Authors: Wei Zhang, Ming Bai, Yan Yu, Lu Li, Lijuan Zhao, Shiren Sun and Xiangmei Chen Tags: Research Source Type: research

Cerebrospinal fluid procalcitonin predicts Gram-negative bacterial meningitis in patients with empiric antibiotic pretreatment
(Source: Critical Care)
Source: Critical Care - January 23, 2019 Category: Intensive Care Authors: Wen Li, Fang Yuan, Xiaolong Sun, Zhihan Zhao, Yaoyao Zhang and Wen Jiang Tags: Letter Source Type: research

How to understand real net ultrafiltration and its association with low blood pressure in critically ill patients with renal replacement therapy
The concept of net ultrafiltration (UFNET) mentioned in the paper by Murugan et al. in a recent issue of Critical Care does not equate to the real UFNET in patients with renal replacement therapy initiation. Furt... (Source: Critical Care)
Source: Critical Care - January 23, 2019 Category: Intensive Care Authors: Wei Li, Jinsong Zhang and Xufeng Chen Tags: Letter Source Type: research

Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury
Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial perme... (Source: Critical Care)
Source: Critical Care - January 18, 2019 Category: Intensive Care Authors: Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache and Lorraine B. Ware Tags: Research Source Type: research

The effects of passive leg raising may be detected by the plethysmographic oxygen saturation signal in critically ill patients
A passive leg raising (PLR) test is positive if the cardiac index (CI) increased by> 10%, but it requires a direct measurement of CI. On the oxygen saturation plethysmographic signal, the perfusion index (PI)... (Source: Critical Care)
Source: Critical Care - January 18, 2019 Category: Intensive Care Authors: Alexandra Beurton, Jean-Louis Teboul, Francesco Gavelli, Filipe Andre Gonzalez, Valentina Girotto, Laura Galarza, Nadia Anguel, Christian Richard and Xavier Monnet Tags: Research Source Type: research

Potential confounders for the effect of high-flow nasal cannula oxygen therapy
(Source: Critical Care)
Source: Critical Care - January 17, 2019 Category: Intensive Care Authors: Satoshi Yamaga, Shinichiro Ohshimo and Nobuaki Shime Tags: Letter Source Type: research

Vancomycin pharmacokinetics in critically ill obese patients: can the clinician sit back and relax?
(Source: Critical Care)
Source: Critical Care - January 17, 2019 Category: Intensive Care Authors: Patrick M. Honore, David De Bels, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and Herbert D. Spapen Tags: Letter Source Type: research

To remove and replace —a role for plasma exchange in counterbalancing the host response in sepsis
(Source: Critical Care)
Source: Critical Care - January 17, 2019 Category: Intensive Care Authors: S. David and K. Stahl Tags: Letter Source Type: research

The glycocalyx: a novel diagnostic and therapeutic target in sepsis
The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It is comprised of membrane-attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma p... (Source: Critical Care)
Source: Critical Care - January 17, 2019 Category: Intensive Care Authors: Ryo Uchimido, Eric P. Schmidt and Nathan I. Shapiro Tags: Review Source Type: research