The bloody mess of red blood cell transfusion
Red blood cell (RBC) transfusion might be life-saving in settings with acute blood loss, especially uncontrolled haemorrhagic shock. However, there appears to be a catch-22 situation reflected by the facts tha... (Source: Critical Care)
Source: Critical Care - December 28, 2017 Category: Intensive Care Authors: Susilo Chandra, Hrishikesh Kulkarni and Martin Westphal Tags: Review Source Type: research

The coming era of precision medicine for intensive care
Recent advances in technology and better understanding of mechanisms underlying disease are beginning to enable us to better characterize critically ill patients. Instead of using nonspecific syndromic groupin... (Source: Critical Care)
Source: Critical Care - December 28, 2017 Category: Intensive Care Authors: Jean-Louis Vincent Tags: Review Source Type: research

Personalized physiological medicine
This paper introduces the concept of personalized physiological medicine that is specifically directed at the needs of the critically ill patient. This differs from the conventional view of personalized medici... (Source: Critical Care)
Source: Critical Care - December 28, 2017 Category: Intensive Care Authors: Can Ince Tags: Review Source Type: research

Do we know enough to recommend corticosteroids in acute respiratory distress syndrome?
(Source: Critical Care)
Source: Critical Care - December 28, 2017 Category: Intensive Care Authors: Mathieu Blot, Arnaud Salmon-Rousseau, Pascal Chavanet and Lionel Piroth Tags: Letter Source Type: research

Subclavian oblique-axis catheterization technique
(Source: Critical Care)
Source: Critical Care - December 27, 2017 Category: Intensive Care Authors: Alessandro De Cassai and Helmut Galligioni Tags: Letter Source Type: research

Initial blood pH during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients: a multicenter observational registry-based study
When an out-of-hospital cardiac arrest (OHCA) patient receives cardiopulmonary resuscitation (CPR) in the emergency department (ED), blood laboratory test results can be obtained by using point-of-care testing... (Source: Critical Care)
Source: Critical Care - December 21, 2017 Category: Intensive Care Authors: Jonghwan Shin, Yong Su Lim, Kyuseok Kim, Hui Jai Lee, Se Jong Lee, Euigi Jung, Kyoung Min You, Hyuk Jun Yang, Jin Joo Kim, Joonghee Kim, You Hwan Jo, Jae Hyuk Lee and Seong Youn Hwang Tags: Research Source Type: research

Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study
To compare the efficacy of three antiseptic solutions [0.5%, and 1.0% alcohol/chlorhexidine gluconate (CHG), and 10% aqueous povidone-iodine (PVI)] for the prevention of intravascular catheter colonization, we... (Source: Critical Care)
Source: Critical Care - December 21, 2017 Category: Intensive Care Authors: Hideto Yasuda, Masamitsu Sanui, Takayuki Abe, Nobuaki Shime, Tetsuya Komuro, Junji Hatakeyama, Shohei Matsukubo, Shinji Kawano, Hiroshi Yamamoto, Kohkichi Andoh, Ryutaro Seo, Kyo Inoue, Eiichiro Noda, Nobuyuki Saito, Satoshi Nogami, Kentaro Okamoto & hell Tags: Research Source Type: research

Copeptin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival
Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failure, and high short-term mortality rates. Hemodynamic dysfunction and activation of e... (Source: Critical Care)
Source: Critical Care - December 21, 2017 Category: Intensive Care Authors: Annarein J. C. Kerbert, Hein W. Verspaget, Àlex Amorós Navarro, Rajiv Jalan, Elsa Solà, Daniel Benten, François Durand, Pere Ginès, Johan J. van der Reijden, Bart van Hoek and Minneke J. Coenraad Tags: Research Source Type: research

Antimicrobials for the treatment of drug-resistant Acinetobacter baumannii pneumonia in critically ill patients: a systemic review and Bayesian network meta-analysis
This study aims to compare various antimicrobial strategies and to determine the most effective ... (Source: Critical Care)
Source: Critical Care - December 20, 2017 Category: Intensive Care Authors: Su Young Jung, Seung Hee Lee, Soo Young Lee, Seungwon Yang, Hayeon Noh, Eun Kyoung Chung and Jangik I. Lee Tags: Research Source Type: research

Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients
Burn patients are prone to infections which often necessitate broad antibiotic coverage. Vancomycin is a common antibiotic after burn injury and is administered alone (V), or in combination with imipenem-cilas... (Source: Critical Care)
Source: Critical Care - December 20, 2017 Category: Intensive Care Authors: Gabriel Hundeshagen, David N. Herndon, Karel D. Capek, Ludwik K. Branski, Charles D. Voigt, Elizabeth A. Killion, Janos Cambiaso-Daniel, Michaela Sljivich, Andrew De Crescenzo, Ronald P. Mlcak, Michael P. Kinsky, Celeste C. Finnerty and William B. Norbury Tags: Research Source Type: research

The forgotten value of the clinical examination to individualize and guide fluid resuscitation in patients with sepsis
(Source: Critical Care)
Source: Critical Care - December 19, 2017 Category: Intensive Care Authors: Gentle Sunder Shrestha, Martin D ünser and Mervyn Mer Tags: Letter Source Type: research

Necessary additional steps in ultrasound guided central venous catheter placement: getting to the heart of the matter
(Source: Critical Care)
Source: Critical Care - December 19, 2017 Category: Intensive Care Authors: Thei S. Steenvoorden, Jasper M. Smit, Mark E. Haaksma and Pieter R. Tuinman Tags: Letter Source Type: research

The term “supplemental parenteral nutrition” should be restricted to studies meeting specific technical criteria
(Source: Critical Care)
Source: Critical Care - December 14, 2017 Category: Intensive Care Authors: Claude Pichard and Mette M. Berger Tags: Letter Source Type: research

Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome
Hyaluronic acid (HA), an extracellular matrix component, is degraded in response to local tissue injury or stress. In various animal models of lung injury, HA has been shown to play a mechanistic role in modul... (Source: Critical Care)
Source: Critical Care - December 14, 2017 Category: Intensive Care Authors: Anthony J. Esposito, Pavan K. Bhatraju, Renee D. Stapleton, Mark M. Wurfel and Carmen Mikacenic Tags: Research Source Type: research

Recombinant human ACE2: acing out angiotensin II in ARDS therapy
(Source: Critical Care)
Source: Critical Care - December 13, 2017 Category: Intensive Care Authors: Haibo Zhang and Andrew Baker Tags: Editorial Source Type: research

Microvascular effects of intravenous esmolol in patients with normal cardiac function undergoing postoperative atrial fibrillation: a prospective pilot study in cardiothoracic surgery
Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy using short-acting beta blockers is recommended as a first-line therapy in patients without hemodyn... (Source: Critical Care)
Source: Critical Care - December 12, 2017 Category: Intensive Care Authors: William Fornier, Matthias Jacquet-Lagr èze, Thomas Collenot, Priscilla Teixeira, Philippe Portran, Rémi Schweizer, Michel Ovize and Jean-Luc Fellahi Tags: Research Source Type: research

Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score)
Extracorporeal membrane oxygenation (ECMO) is a life-saving therapy in acute respiratory distress syndrome (ARDS) patients but is associated with complications and costs. Here, we validate various scores suppo... (Source: Critical Care)
Source: Critical Care - December 12, 2017 Category: Intensive Care Authors: Michael Hilder, Frank Herbstreit, Michael Adamzik, Martin Beiderlinden, Markus B ürschen, Jürgen Peters and Ulrich H. Frey Tags: Research Source Type: research

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
Vitamin C is an essential water-soluble nutrient which cannot be synthesised or stored by humans. It is a potent antioxidant with anti-inflammatory and immune-supportive roles. Previous research has indicated ... (Source: Critical Care)
Source: Critical Care - December 11, 2017 Category: Intensive Care Authors: Anitra C. Carr, Patrice C. Rosengrave, Simone Bayer, Steve Chambers, Jan Mehrtens and Geoff M. Shaw Tags: Research Source Type: research

A systematic approach to ultrasound-guided central venous catheter placement —desirable modifications
(Source: Critical Care)
Source: Critical Care - December 8, 2017 Category: Intensive Care Authors: Ryszard Gawda and Tomasz Czarnik Tags: Letter Source Type: research

A supplemental intravenous amino acid infusion sustains a positive protein balance for 24  hours in critically ill patients
Providing supplemental amino acids to ICU patients during a 3-h period results in improved whole-body net protein balance, without an increase in amino acid oxidation. The primary objective was to investigate ... (Source: Critical Care)
Source: Critical Care - December 6, 2017 Category: Intensive Care Authors: Martin Sundstr öm Rehal, Felix Liebau, Inga Tjäder, Åke Norberg, Olav Rooyackers and Jan Wernerman Tags: Research Source Type: research

Extracorporeal membrane oxygenation for life-threatening asthma refractory to mechanical ventilation: analysis of the Extracorporeal Life Support Organization registry
The use of extracorporeal membrane oxygenation (ECMO) in cases of near-fatal asthma (NFA) has increased, but the benefits and potential complications of this therapy have yet to be fully investigated. (Source: Critical Care)
Source: Critical Care - December 6, 2017 Category: Intensive Care Authors: Hye Ju Yeo, Dohyung Kim, Doosoo Jeon, Yun Seong Kim, Peter Rycus and Woo Hyun Cho Tags: Research Source Type: research

Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome  in the prone position under protective ventilation
Predicting fluid responsiveness may help to avoid unnecessary fluid administration during acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate the diagnostic performance of the fol... (Source: Critical Care)
Source: Critical Care - December 5, 2017 Category: Intensive Care Authors: Hodane Yonis, Laurent Bitker, Myl ène Aublanc, Sophie Perinel Ragey, Zakaria Riad, Floriane Lissonde, Aurore Louf-Durier, Sophie Debord, Florent Gobert, Romain Tapponnier, Claude Guérin and Jean-Christophe Richard Tags: Research Source Type: research

Recovery after critical illness: putting the puzzle together —a consensus of 29
In this review, we seek to highlight how critical illness and critical care affect longer-term outcomes, to underline the contribution of ICU delirium to cognitive dysfunction several months after ICU discharg... (Source: Critical Care)
Source: Critical Care - December 5, 2017 Category: Intensive Care Authors: Elie Azoulay, Jean-Louis Vincent, Derek C. Angus, Yaseen M. Arabi, Laurent Brochard, Stephen J. Brett, Giuseppe Citerio, Deborah J. Cook, Jared Randall Curtis, Claudia C. dos Santos, E. Wesley Ely, Jesse Hall, Scott D. Halpern, Nicholas Hart, Ramona O. Ho Tags: Review Source Type: research

Initial nutritional management during noninvasive ventilation and outcomes: a retrospective cohort study
Patients starting noninvasive ventilation (NIV) to treat acute respiratory failure are often unable to eat and therefore remain in the fasting state or receive nutritional support. Maintaining a good nutrition... (Source: Critical Care)
Source: Critical Care - November 29, 2017 Category: Intensive Care Authors: Nicolas Terzi, Michael Darmon, Jean Reignier, St éphane Ruckly, Maïté Garrouste-Orgeas, Alexandre Lautrette, Elie Azoulay, Bruno Mourvillier, Laurent Argaud, Laurent Papazian, Marc Gainnier, Dan Goldgran-Toledano, Samir Jamali, Anne-Sylvie Dumenil, Car Tags: Research Source Type: research

Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction
As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic ... (Source: Critical Care)
Source: Critical Care - November 29, 2017 Category: Intensive Care Authors: Matthias Klingele, Theresa Stadler, Danilo Fliser, Timo Speer, Heinrich V. Groesdonk and Alexander Raddatz Tags: Research Source Type: research

Chloral hydrate enteral infusion for sedation in ventilated children: the CHOSEN pilot study
We aimed to test a novel method of delivery of chloral hydrate (CH) sedation in ventilated critically ill young children. (Source: Critical Care)
Source: Critical Care - November 26, 2017 Category: Intensive Care Authors: Ari R. Joffe, Jessica Hogan, Cathy Sheppard, Gerda Tawfik, Jonathan P. Duff and Gonzalo Garcia Guerra Tags: Research Source Type: research

Iatrogenic hemodilution: a possible cause for avoidable blood transfusions?
(Source: Critical Care)
Source: Critical Care - November 25, 2017 Category: Intensive Care Authors: Azriel Perel Tags: Editorial Source Type: research

Longitudinal wall fractional shortening: an M-mode index based on mitral annular plane systolic excursion (MAPSE) that correlates and predicts left ventricular longitudinal strain (LVLS) in intensive care patients
Left ventricular longitudinal strain (LVLS) is a modern measurement for LV function. However, strain measurement is often difficult in critically ill patients. We sought to show LVLS can be estimated using M-m... (Source: Critical Care)
Source: Critical Care - November 25, 2017 Category: Intensive Care Authors: Stephen J. Huang, Iris Ting, Andrea M. Huang, Michel Slama and Anthony S. McLean Tags: Research Source Type: research

High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial
Sepsis and septic shock occur commonly in severe burns. Acute kidney injury (AKI) is also common and often results as a consequence of sepsis. Mortality is unacceptably high in burn patients who develop AKI re... (Source: Critical Care)
Source: Critical Care - November 25, 2017 Category: Intensive Care Authors: Kevin K. Chung, Elsa C. Coates, David J. Smith Jr, Rachel A. Karlnoski, William L. Hickerson, Angela L. Arnold-Ross, Michael J. Mosier, Marcia Halerz, Amy M. Sprague, Robert F. Mullins, Daniel M. Caruso, Marlene Albrecht, Brett D. Arnoldo, Agnes M. Burris Tags: Research Source Type: research

Video laryngoscopy does not improve the intubation outcomes in emergency and critical patients – a systematic review and meta-analysis of randomized controlled trials
There is significant controversy regarding the influence of video laryngoscopy on the intubation outcomes in emergency and critical patients. This systematic review and meta-analysis was designed to determine ... (Source: Critical Care)
Source: Critical Care - November 24, 2017 Category: Intensive Care Authors: Jia Jiang, Danxu Ma, Bo Li, Yun Yue and Fushan Xue Tags: Research Source Type: research

Age, exercise, and the outcome of sepsis
We report on the increasingly important need to diagnose and care for the elderly with sepsis as a distinct patient population. We share an overview of age-related changes in sepsis physiology and the potentia... (Source: Critical Care)
Source: Critical Care - November 23, 2017 Category: Intensive Care Authors: Debasree Banerjee and Steven M. Opal Tags: Editorial Source Type: research

Vitamin D deficiency in critically ill children: a systematic review and meta-analysis
Vitamin D deficiency (VDD) has been hypothesized not only to be common but also to represent a potentially modifiable risk factor for greater illness severity and clinical outcome during critical illness. The ... (Source: Critical Care)
Source: Critical Care - November 23, 2017 Category: Intensive Care Authors: James Dayre McNally, Nassr Nama, Katie O ’Hearn, Margaret Sampson, Karin Amrein, Klevis Iliriani, Lauralyn McIntyre, Dean Fergusson and Kusum Menon Tags: Research Source Type: research

High-flow nasal cannula versus noninvasive positive pressure ventilation in acute respiratory failure: interaction between PaO2/FiO2 and tidal volume
(Source: Critical Care)
Source: Critical Care - November 22, 2017 Category: Intensive Care Authors: Yanfei Shen and Weimin Zhang Tags: Letter Source Type: research

Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
(Source: Critical Care)
Source: Critical Care - November 21, 2017 Category: Intensive Care Authors: Mohd H. Abdul-Aziz, Jeffrey Lipman and Jason A. Roberts Tags: Editorial Source Type: research

Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized study
The objective of this study was to evaluate the impact of earplugs and eye mask ... (Source: Critical Care)
Source: Critical Care - November 21, 2017 Category: Intensive Care Authors: Alexandre Demoule, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Julien Mayaux, Isabelle Arnulf and Thomas Similowski Tags: Research Source Type: research

A clinical prediction model to identify patients at high risk of hemodynamic instability in the pediatric intensive care unit
The objective of this study was to develop a model to predict requirement for hemodynamic intervention in th... (Source: Critical Care)
Source: Critical Care - November 20, 2017 Category: Intensive Care Authors: Cristhian Potes, Bryan Conroy, Minnan Xu-Wilson, Christopher Newth, David Inwald and Joseph Frassica Tags: Research Source Type: research

Complications of regional citrate anticoagulation: accumulation or overload?
Regional citrate anticoagulation (RCA) is now recommended over systemic heparin for continuous renal replacement therapy in patients without contraindications. Its use is likely to increase throughout the worl... (Source: Critical Care)
Source: Critical Care - November 19, 2017 Category: Intensive Care Authors: Antoine G. Schneider, Didier Journois and Thomas Rimmel é Tags: Viewpoint Source Type: research

Kinetic estimated glomerular filtration rate in critically ill patients: beyond the acute kidney injury severity classification system
Although significant advances have been achieved in acute kidney injury (AKI) research following its classification, potential pitfalls can be identified in clinical practice. The nonsteady-state (kinetic) est... (Source: Critical Care)
Source: Critical Care - November 18, 2017 Category: Intensive Care Authors: Fl ávio de Oliveira Marques, Saulo Aires Oliveira, Priscila Ferreira de Lima e Souza, Wandervânia Gomes Nojoza, Maiara da Silva Sena, Taynara Muniz Ferreira, Bruno Gabriele Costa and Alexandre Braga Libório Tags: Research Source Type: research

Weekend effect: a great problem with a potential solution
(Source: Critical Care)
Source: Critical Care - November 17, 2017 Category: Intensive Care Authors: Ana Abella, Beatriz Lobo-Valbuena, Marcela H ómez and Federico Gordo Tags: Letter Source Type: research

Pearls and pitfalls in comprehensive critical care echocardiography
Critical care echocardiography is developing rapidly with an increasing number of specialists now performing comprehensive studies using Doppler and other advanced techniques. However, this imaging can be chal... (Source: Critical Care)
Source: Critical Care - November 17, 2017 Category: Intensive Care Authors: Sam Orde, Michel Slama, Andrew Hilton, Konstantin Yastrebov and Anthony McLean Tags: Review Source Type: research

Angiotensin II in vasodilatory shock: lights and shadows
(Source: Critical Care)
Source: Critical Care - November 14, 2017 Category: Intensive Care Authors: Elio Antonucci, Sara Agosta and Yasser Sakr Tags: Letter Source Type: research

Cefepime-induced neurotoxicity: a systematic review
Cefepime is a widely used antibiotic with neurotoxicity attributed to its ability to cross the blood –brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid (GABA) antagonism. Neurotoxic symptoms... (Source: Critical Care)
Source: Critical Care - November 14, 2017 Category: Intensive Care Authors: Lauren E. Payne, David J. Gagnon, Richard R. Riker, David B. Seder, Elizabeth K. Glisic, Jane G. Morris and Gilles L. Fraser Tags: Research Source Type: research

An isolated elevation in blood urea level is not ‘uraemia’ and not an indication for renal replacement therapy in the ICU
The decision to initiate renal replacement therapy (RRT) and the optimal timing for commencement is a difficult decision faced by clinicians when treating acute kidney injury (AKI) in the intensive care settin... (Source: Critical Care)
Source: Critical Care - November 13, 2017 Category: Intensive Care Authors: Jack Mackenzie and Bobby Chacko Tags: Editorial Source Type: research

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia
Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life... (Source: Critical Care)
Source: Critical Care - November 13, 2017 Category: Intensive Care Authors: Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C. Hoang, Jason T. Maynes, Daniel J. Dumont, Achim D. Gruber, Norbert Weissmann, Timothy J. Mitchell, Norbert Suttorp and Martin Witzenrath Tags: Research Source Type: research

Early psychological screening of intensive care unit survivors: a prospective cohort study
A majority of patients survive their episode of critical illness but up to 30% of patients suffer from psychological problems such as post-traumatic stress, anxiety and depression in the year after intensive c... (Source: Critical Care)
Source: Critical Care - November 9, 2017 Category: Intensive Care Authors: Anna Milton, Emily Br ück, Anna Schandl, Matteo Bottai and Peter Sackey Tags: Research Source Type: research

Does enhanced antibiotic de-escalation really have no benefit in the ICU?
(Source: Critical Care)
Source: Critical Care - November 2, 2017 Category: Intensive Care Authors: Shingo Ohki, Shinichiro Ohshimo and Nobuaki Shime Tags: Letter Source Type: research

The impact of sex and age on neurological outcomes in out-of-hospital cardiac arrest patients with targeted temperature management
There are conflicting data regarding sex-based differences in the outcomes of out-of-hospital cardiac arrest (OHCA) patients, and whether the specific sex advantage is age-specific remains unclear. We assessed... (Source: Critical Care)
Source: Critical Care - November 2, 2017 Category: Intensive Care Authors: Sang Hoon Oh, Kyu Nam Park, Jeeyong Lim, Seung Pill Choi, Joo Suk Oh, In Soo Cho, Byung Kook Lee, Yong Hwan Kim, Young-Min Kim, Han Joon Kim, Chun Song Youn and Soo Hyun Kim Tags: Research Source Type: research

Icatibant as an early rescue therapy in hypovolemic shock with converting enzyme inhibitor treatment
(Source: Critical Care)
Source: Critical Care - November 2, 2017 Category: Intensive Care Authors: H élène Charbonneau, Marie Buléon, Benoit Richard and Nicolas Mayeur Tags: Letter Source Type: research

The impact of N-acetylcysteine and ascorbic acid in contrast-induced nephropathy in critical care patients: an open-label randomized controlled study
The aim was to investigate whether the use of N-acetylcysteine and ascorbic acid reduce contrast-induced nephropathy incidence in critical care patients. (Source: Critical Care)
Source: Critical Care - October 31, 2017 Category: Intensive Care Authors: Eleni Palli, Demosthenes Makris, John Papanikolaou, Grigorios Garoufalis, Irini Tsilioni, Paris Zygoulis and Epaminondas Zakynthinos Tags: Research Source Type: research

Implementation of sepsis bundles in public hospitals in Brazil: a prospective study with heterogeneous results
Public hospitals in emerging countries pose a challenge to quality improvement initiatives in sepsis. Our objective was to evaluate the results of a quality improvement initiative in sepsis in a network of pub... (Source: Critical Care)
Source: Critical Care - October 31, 2017 Category: Intensive Care Authors: Flavia Ribeiro Machado, Elaine Maria Ferreira, Pierre Schippers, Ilusca Cardoso de Paula, Let ícia Sandre Vendrame Saes, Francisco Ivanildo de Oliveira Jr, Paula Tuma, Wilson Nogueira Filho, Felipe Piza, Sandra Guare, Cláudia Mangini, Gustavo Ziggiatti Tags: Research Source Type: research